SU576115A1 - Method of preparing "propoceum" propolis ointment - Google Patents

Description

one

The invention relates to the pharmaceutical industry, namely to the manufacture of drugs, and can be used in the preparation of an ointment preparation containing a complex of biologically active substances in nneo iHiioro propolis glue.

There is a known method of preparing ointment preparations from 10% or 20% alcoholic tincture of propolis on a petroleum jelly or petroleum jelly base by heating the ointment base, adding propolis and mixing 1.

However, the propolis ointment preiarates made by this method have a non-uniform consistency and are not stable enough during storage.

There is also known a method for preparing npono: insov ointment by injecting propolis into a fat base - petrolatum followed by filtration by filtering 2.

The disadvantage of the existing method is the impossibility of obtaining a homogeneous, stable NRP storage of an ointment preparation that provides good absorption of drugs.

To increase the absorbability of the target product according to the proposed method, propolis extract is dispersed at 70 ° -75 ° C in an emulsifier medium: a mixture of hydrogenated alcohols of capialous fat and the sodium salt of sulfonic acids of the same alcohols (La 1 emulsifier) and nolnoxyethylene sorbitan monooleate (twin-80), with the ratio components: 10: 5: 1 to form a fine suspension and its subsequent introduction into the base, additionally containing glycerin and water, at a temperature of 90 -95 ° C.

Example. In the first reactor with a stirrer and a jacket for heating or cooling load 8 kg of petroleum jelly, 5 kg of emulsifier AO 1 and 2 kg of glycerin. The mixture is heated to. At the same time, a second reactor with a stirrer and a jacket for heating is charged with 5 kg of emulsifier. Up to 1, 1 kg of tween-80, 10 kg of purified propolis extract, are heated to and mixed. Then, 69 kg of distilled water cakes are poured into the first reactor, mixed and the suspension prepared in the second reactor is gradually added to the reactor containing 90 ° –95 ° C, and the mixing is continued for 7–10 mn, maintaining the temperature in the reactor within 90 ° -95C, after which

cooling. When

the reactor is switched to 27 ° - the temperature in the reactor decreases to 29 ° C, the ointment is ready, it is discharged and sent to the packing.

Claims (2)

The proposed method of preparation of the ointment preparation Propoceum provides 3 obtaining a therapeutic preparation with high therapeutic efficacy. Claims of the invention H: and R.W.Id MduupticHWM A method of obtaining propolis ointment Yi-5 by introducing propolis into vaseline, characterized in that, in order to increase the absorption of the target product, the propolis extract is dispersed at 70-75 ° C in an emulsifier medium: mixtures of hydrogenated alcohol sperm fat and sodium salt of sulfonic acids of the same alcohols and polyoxy ethylene 4 sorbitan monooleate, with a ratio of comonants of 10/5/1 to form a suspension and then its introduction j basis, additionally containing glyceria and water, with The temperature is 90 -95 ° C. Sources of information taken into account during the examination 1. V. Kivalkin, V. I. Gorshunova, “Atibiotics 1973, v. 18, No. 3. 2. Kazakova I. F. Savina K. N. “Bee and human health Rosselkhozizdat, M. 1966, p. 247.