SU571061A1 - Method of producing n-benzyl-beta-chloropropinamide - Google Patents
Method of producing n-benzyl-beta-chloropropinamide Download PDFInfo
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- SU571061A1 SU571061A1 SU762339466A SU2339466A SU571061A1 SU 571061 A1 SU571061 A1 SU 571061A1 SU 762339466 A SU762339466 A SU 762339466A SU 2339466 A SU2339466 A SU 2339466A SU 571061 A1 SU571061 A1 SU 571061A1
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Abstract
I. СПОСОБ ПОЛУЧЕНИЯ N-БЕН- ЗШ1->&-ХЛОРПРОПИОНАМИДА взаимодействи» ем N-бензиламинопроизводных соединений с хлорсодержащими реагентами, отличающийс тем, что, с целью усовершенствовани технологии и расширени сырьевой базы, N- бензилакриламид обрабатьшают хлористым водородом в смеси непол рных растворителей при 70-75 С.2. Способ поп. l,oтличaю- щ и и с тем, что в качестве смеси непол рных растворителей используют смесь дихлорэтана и ксилола .при объемном соотношении 1:1.I. METHOD OF OBTAINING N-BEN-SH1- > & HLORPROPIONAMIDA by reacting N-benzylamine derivatives of compounds with chlorine-containing reagents, characterized in that, in order to improve the technology and expand the raw material base, N-benzyl acrylamide is treated with chlorine chloride and its chlorine chloride can be treated with chlorine chloride, which can be used in order to improve technology and expand the raw materials rny solvents at 70-75 C.2. Way pop l, differing from the fact that a mixture of dichloroethane and xylene is used as a mixture of non-polar solvents at a volume ratio of 1: 1.
Description
Изобретение относитс к способу получени Ы-беизил- &-хлорпропионамида , примен емого в медицинской практике в качестве препарата противосудорожного действи (хлоракон, хибикон ). The invention relates to a method for the preparation of N-beisyl-& -chloropropionamide used in medical practice as an anticonvulsant drug (chloracon, hibicone).
I Известен способ получени N-бензил-р-хлорпропионамида взаимодействием хлорангидрида -хлорпропионовой кислоты с бензиламином в водной среде при рН 7т9,5 с последуклцей фильтрацией его из метанола.I A known method of producing N-benzyl-p-chloropropionamide by reacting the α-chloropropionic acid chloride with benzyl amine in an aqueous medium at pH 7t9.5 followed by filtering it from methanol.
.Описан также способ получени Nбензил- -хлорпропионамида взаимодействием К-оксиметил-р-хлорпропионамида с бензолом в присутствии концентрированной серной кислоты . A method for producing Nbenzyl-chloropropionamide by reacting K-hydroxymethyl-p-chloropropionamide with benzene in the presence of concentrated sulfuric acid is also described.
Ы-оксиметил-/&-хлорпропионамид получают взаимодействием /Ь-хлорпропионамида с формальдегидом в присутст- .ВИИ сол ной кислоты или углекислого кали . Реакцию провод т в двухфазной системе бензол - вода. L-hydroxymethyl - / & - chloropropionamide is obtained by reacting / L-chloropropionamide with formaldehyde in the presence of hydrochloric acid or potassium carbonate. The reaction is carried out in a benzene-water two-phase system.
Однако указанные способы в промьпленности вл ютс многостадийными и трудоемкими.However, these industrial methods are multistage and time consuming.
Прототипом изобретени вл етс способ получени N-бeнзил-J5-xлopпропионамида взаимодействием хлоранг рида f -хлорпропионовой кислоты с бензиламином в двухфазной системе бензол - вода в присутствии NaOH при с последующим фильтрованием осадка и очисткой его путем растворени в изопропиловом спирте, перемешивани при нагревании с активированным углем, фильтровани и осаждени при добавлении воды.The prototype of the invention is a method for producing N-benzyl-J5-chloropropionamide by reacting chlorinated f-chloropropionic acid with benzylamine in a benzene-water two-phase system in the presence of NaOH, followed by filtering the precipitate and purifying it by dissolving in isopropyl alcohol, mixing under heating. carbon, filtering and precipitating with the addition of water.
Однако исходные реагенты не выпускаютс в промьшшенных масштабах и получение их трудоемко и многостадийно . Кроме того, хлорангидрид -хлорпропионовой кислоты нестойкий при хранении и его необходимо получать непосредственно перед син . целевого продукта.However, the initial reagents are not produced on an industrial scale and are laborious and multistage. In addition, the acid chloride-chloropropionic acid is unstable during storage and must be obtained immediately before syn. target product.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU762339466A SU571061A1 (en) | 1976-03-30 | 1976-03-30 | Method of producing n-benzyl-beta-chloropropinamide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU762339466A SU571061A1 (en) | 1976-03-30 | 1976-03-30 | Method of producing n-benzyl-beta-chloropropinamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU571061A1 true SU571061A1 (en) | 1989-07-30 |
Family
ID=20654014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762339466A SU571061A1 (en) | 1976-03-30 | 1976-03-30 | Method of producing n-benzyl-beta-chloropropinamide |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU571061A1 (en) |
-
1976
- 1976-03-30 SU SU762339466A patent/SU571061A1/en active
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