SU570598A1 - Method of preparing erythro-and treo-4-hydroxy-di-glutaminic acids - Google Patents
Method of preparing erythro-and treo-4-hydroxy-di-glutaminic acidsInfo
- Publication number
- SU570598A1 SU570598A1 SU7602354976A SU2354976A SU570598A1 SU 570598 A1 SU570598 A1 SU 570598A1 SU 7602354976 A SU7602354976 A SU 7602354976A SU 2354976 A SU2354976 A SU 2354976A SU 570598 A1 SU570598 A1 SU 570598A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- hydroxy
- treo
- erythro
- acids
- preparing
- Prior art date
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Гидролиз провод т раствором минеральной кислоты, например 20%-ион ПС1 при кип чении в течение 5-6 ч. Выдел ют целевые продукты известными методами.The hydrolysis is carried out with a solution of a mineral acid, for example, 20% -Pl1 with boiling for 5-6 hours. The desired products are isolated by known methods.
Общий выход эритро- и трео-4-гидрокси )1,-глутамииовых кислот составл ет 80-82%.The total yield of erythro and threo-4-hydroxy) 1, β-glutamic acids is 80-82%.
Природа иолученпых соединений подтверждаетс даииыми элемеитиого анализа, сравнением с образцами, иолучепными известиыми методами. Темиературы плавлени эритро- и тpeo-4-rидpoкcи-Z)L-глyтaминoвыx кислот - 166 и 172-173°С соответственно, совпадают с литературными даиными.The nature of the observed compounds is confirmed by day-to-day analysis, comparison with samples, and by means of lime methods. The melting points of erythro- and thpeo-4-hydroxy-Z) L-glutamic acids 166 and 172-173 ° С, respectively, coincide with the literature data.
Пробы смешени иолученных соедииений не дают депрессии температуры плавлеии с соответствующими известными веществами.Samples of mixing compounds did not give a depression in the melting temperature with the corresponding known substances.
Пример. К Юг диметилового эфира 4-бром-Л -фталил-Д,-глутаминовой кнслоты приливают 60 мл 20%-иой НС1 и кип т т с обратным холодильником 6 ч. Реакционную массу охлаждают и отфильтровывают выпадающую в осадок фталевую кислоту. Гидролнзат упаривают в вакууме и далее раздел ют эритро- и тpeo-4-гидpoкcи-DL-глyтaминoвые кислоты известными методами.Example. To the South of 4-bromo-L-phthalyl-D, -glutamic acid dimethyl ester, 60 ml of 20% HC1 are added and refluxed for 6 hours. The reaction mixture is cooled and the phthalic acid precipitated is filtered off. The hydrollate is evaporated in vacuo and then the erythro and treo-4-hydroxy-DL-glutamic acids are separated by known methods.
Трео-4-гидрокси-О/.-глутамииова кислота представл ет собой бесцветное кристаллическое вещество с т. пл. 172-173°С (литературные данные 172-173°С) и не дает депрессии температуры плавлеии ири смешении с известным соедииением.Treo-4-hydroxy-O /. - Glutamic acid is a colorless crystalline substance with mp. 172-173 ° С (literature data is 172-173 ° С) and does not give a depression of the melting temperature and mixture with the known compound.
Найдено, %: С 33,4; П 5,97; N 7,70.Found,%: C 33.4; P 5.97; N 7.70.
CsHgOsN-HjO.CsHgOsN-HjO.
Вычислено, %: С 33,14; Ы 6,07; N 7J3.Calculated,%: C 33.14; Ы 6.07; N 7J3.
Выход аналитически чистой трео-4-гидроксн-й1-глутам1П1овой кислоты 1,79 i (38% от теории). Эритро-4-гидрокси-ЙЬ-глутамицова кислота представл ет собой бесцветное кристаллическое вещество с т. пл. 166°С (с разложением ). Литературные данные: 166°С (с разложением) и не дает деирессии температуры плавлени ири с соедине1П1ем, полученным известным путем. Найдено, %: С 3(5,76; Н 5,49; N 8,6.The yield of analytically pure threo-4-hydrox-y1-glutam1P1 acid is 1.79 i (38% of theory). Erythro-4-hydroxy-B-glutamic acid is a colorless crystalline substance with mp. 166 ° C (with decomposition). Literature data: 166 ° С (with decomposition) and does not de-mory the melting temperature of the ir with the compound obtained by a known method. Found,%: C 3 (5.76; H 5.49; N 8.6.
CsHgOsN.CsHgOsN.
Вычислено, %: С 36,81; Н 5,56; N 8,59.Calculated,%: C 36.81; H 5.56; N 8.59.
Выход эритро-4-гидроксиглутамииовой кислоты составл ет 1,78 г (42% от теории). Таким образом, общий выход эритро- и трео-4-гидрокси-1)-глутамнновых кнслот составл ет 80% от теории.The yield of erythro-4-hydroxyglutamic acid is 1.78 g (42% of theory). Thus, the total yield of erythro and threo-4-hydroxy-1) -glutamine residues is 80% of theory.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU7602354976A SU570598A1 (en) | 1976-05-03 | 1976-05-03 | Method of preparing erythro-and treo-4-hydroxy-di-glutaminic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU7602354976A SU570598A1 (en) | 1976-05-03 | 1976-05-03 | Method of preparing erythro-and treo-4-hydroxy-di-glutaminic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU570598A1 true SU570598A1 (en) | 1977-08-30 |
Family
ID=20659511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU7602354976A SU570598A1 (en) | 1976-05-03 | 1976-05-03 | Method of preparing erythro-and treo-4-hydroxy-di-glutaminic acids |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU570598A1 (en) |
-
1976
- 1976-05-03 SU SU7602354976A patent/SU570598A1/en active
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