SU566842A1 - Method of preparing substituted imidazopyridines - Google Patents
Method of preparing substituted imidazopyridinesInfo
- Publication number
- SU566842A1 SU566842A1 SU7602310356A SU2310356A SU566842A1 SU 566842 A1 SU566842 A1 SU 566842A1 SU 7602310356 A SU7602310356 A SU 7602310356A SU 2310356 A SU2310356 A SU 2310356A SU 566842 A1 SU566842 A1 SU 566842A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- preparing substituted
- substituted imidazopyridines
- imidazopyridines
- pyridip
- imidazo
- Prior art date
Links
Description
Пример 1. Получение 2-фенилимидазо 4,5-с пиридина (соединение № 1).Example 1. The preparation of 2-phenylimidazo 4,5-c pyridine (compound No. 1).
Смесь, состо вшую из эквимолекул рных количеств 3,4-диаминопиридина, бензальдегида и серы, нагревают 4 ч ири 170-175°С, охлаждают до комнатной темиературы и продукт реакции кристаллизуют из водного спирта. Т. пл. 227°С. Выход 91%.A mixture consisting of equimolecular amounts of 3,4-diaminopyridine, benzaldehyde and sulfur is heated for 4 hours with 170-175 ° C, cooled to room temperature and the reaction product is crystallized from aqueous alcohol. T. pl. 227 ° C. Yield 91%.
В случае проведени реакции в растворителе (мезитилен) на 1 вес. ч. серы берут 25 вес. ч. мезитилена. Реакцию провод т при температуре кипепи реакционной массы 2-4 ч. Осадок после охлаждени отфильтровывают и очищают кристаллизацией.If the reaction is carried out in a solvent (mesitylene) by 1 weight. h. sulfur take 25 weight. h. mesitylene. The reaction is carried out at the boiling point of the reaction mass for 2-4 hours. After cooling, the precipitate is filtered off and purified by crystallization.
Аналогично примеру 1 с использованием соответствующих исходных продуктов при нагревании в течение 1-6 ч при 150-175°С получены следующие целевые соединени :Analogously to Example 1, using the corresponding starting materials, the following target compounds were obtained by heating for 1-6 hours at 150-175 ° C:
№22- (4 - диметиламинофенил) -имидазо 4,5-с пиридип;No. 22- (4 - dimethylaminophenyl) -imidazo 4,5-c pyridip;
№ 3 2 - (4-метоксифенил)-имидазо 4,5-с пиридин;No. 3 2- (4-methoxyphenyl) -imidazo 4,5-c pyridine;
№ 4 1 - метил-2-(1-метилиндолил-2)-имидазо 4 ,5-Ь пиридип;No. 4 1 - methyl-2- (1-methylindolyl-2) -imidazo 4, 5-b pyridip;
№ 5 2 - фенилимидазо 4,5-Ь пиридип;No. 5 2 - phenylimidazo 4,5-b pyridip;
№ 6 2 - 4-(диметиламино)-фенил -5-хлоримидазо 4,5-& пиридин.No. 6 2 - 4- (dimethylamino) -phenyl-5-chlorimidazo 4,5- & pyridine.
Свойства полученных соединений приведены в таблице.Properties of the compounds obtained are shown in the table.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU7602310356A SU566842A1 (en) | 1976-01-06 | 1976-01-06 | Method of preparing substituted imidazopyridines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU7602310356A SU566842A1 (en) | 1976-01-06 | 1976-01-06 | Method of preparing substituted imidazopyridines |
Publications (1)
Publication Number | Publication Date |
---|---|
SU566842A1 true SU566842A1 (en) | 1977-07-30 |
Family
ID=20644302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU7602310356A SU566842A1 (en) | 1976-01-06 | 1976-01-06 | Method of preparing substituted imidazopyridines |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU566842A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4603139A (en) * | 1981-11-10 | 1986-07-29 | Burroughs Wellcome Co. | Bicycle compounds, processes for their preparation and pharmaceutical formulations containing compounds |
US4616090A (en) * | 1981-08-19 | 1986-10-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 2-arylimidazopyridines intermediates |
RU2498984C2 (en) * | 2007-09-12 | 2013-11-20 | Сентр Насьональ Де Ла Решерш Сьентифик | Perharidines as cdk inihibitors |
-
1976
- 1976-01-06 SU SU7602310356A patent/SU566842A1/en active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4616090A (en) * | 1981-08-19 | 1986-10-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 2-arylimidazopyridines intermediates |
US5104881A (en) * | 1981-08-19 | 1992-04-14 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 2-arylimidazopyridines |
US4603139A (en) * | 1981-11-10 | 1986-07-29 | Burroughs Wellcome Co. | Bicycle compounds, processes for their preparation and pharmaceutical formulations containing compounds |
RU2498984C2 (en) * | 2007-09-12 | 2013-11-20 | Сентр Насьональ Де Ла Решерш Сьентифик | Perharidines as cdk inihibitors |
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