JPS5452047A - Preparation of aromatic unsaturated ketones - Google Patents

Preparation of aromatic unsaturated ketones

Info

Publication number
JPS5452047A
JPS5452047A JP11918577A JP11918577A JPS5452047A JP S5452047 A JPS5452047 A JP S5452047A JP 11918577 A JP11918577 A JP 11918577A JP 11918577 A JP11918577 A JP 11918577A JP S5452047 A JPS5452047 A JP S5452047A
Authority
JP
Japan
Prior art keywords
compound
formula
halogen
reaction
pref
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11918577A
Other languages
Japanese (ja)
Other versions
JPS612051B2 (en
Inventor
Takashi Onishi
Yoshiji Fujita
Michihiro Ishiguro
Takeo Hosogai
Takuji Nishida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Original Assignee
Kuraray Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co Ltd filed Critical Kuraray Co Ltd
Priority to JP11918577A priority Critical patent/JPS5452047A/en
Publication of JPS5452047A publication Critical patent/JPS5452047A/en
Publication of JPS612051B2 publication Critical patent/JPS612051B2/ja
Granted legal-status Critical Current

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  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound useful as an intermediate of pharmaceuticals such as remedies of skin diseases, in a short process, from a raw material which can be obtained economicaly, easily and in high yield, by the thermal isomerization of a substituted propargyl-type alcohol.
CONSTITUTION: A substituted propargyl-type alcohol of formula I [R is V(R1-5 are H, halogen, lower alkyl, lower alkoxy)] is isomerized to the corresponding unsaturated ketone of formula II (one of the dotted lines is double bond) by heating. The reaction temperature is pref. 130-230°C in the liquid phase reaction, and 250- 400°C in the gas phase reaction. The reaction is pref. carried out in an inert gas atmosphere such as N2, He, etc., and in the presence of a polar organic compound. The compound I, which is a novel compound, is obtained by the ethynylation of ketones III and IV which are prepared by the reacftion of the compounds VI and VII with a halogen compound of formula R-halo (halo is halogen)
COPYRIGHT: (C)1979,JPO&Japio
JP11918577A 1977-10-03 1977-10-03 Preparation of aromatic unsaturated ketones Granted JPS5452047A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11918577A JPS5452047A (en) 1977-10-03 1977-10-03 Preparation of aromatic unsaturated ketones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11918577A JPS5452047A (en) 1977-10-03 1977-10-03 Preparation of aromatic unsaturated ketones

Publications (2)

Publication Number Publication Date
JPS5452047A true JPS5452047A (en) 1979-04-24
JPS612051B2 JPS612051B2 (en) 1986-01-22

Family

ID=14755005

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11918577A Granted JPS5452047A (en) 1977-10-03 1977-10-03 Preparation of aromatic unsaturated ketones

Country Status (1)

Country Link
JP (1) JPS5452047A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5910539A (en) * 1982-06-16 1984-01-20 チバ・ガイギ−・アクチエンゲゼルシヤフト Hydroquinone ether compounds
JPH062575U (en) * 1992-06-11 1994-01-14 光南 謝 safety plug
CN103113188A (en) * 2011-11-17 2013-05-22 河北百灵威超精细材料有限公司 Novel low-cost synthesis method of alkynol compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5910539A (en) * 1982-06-16 1984-01-20 チバ・ガイギ−・アクチエンゲゼルシヤフト Hydroquinone ether compounds
JPH062575U (en) * 1992-06-11 1994-01-14 光南 謝 safety plug
CN103113188A (en) * 2011-11-17 2013-05-22 河北百灵威超精细材料有限公司 Novel low-cost synthesis method of alkynol compounds

Also Published As

Publication number Publication date
JPS612051B2 (en) 1986-01-22

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