JPS5452047A - Preparation of aromatic unsaturated ketones - Google Patents
Preparation of aromatic unsaturated ketonesInfo
- Publication number
- JPS5452047A JPS5452047A JP11918577A JP11918577A JPS5452047A JP S5452047 A JPS5452047 A JP S5452047A JP 11918577 A JP11918577 A JP 11918577A JP 11918577 A JP11918577 A JP 11918577A JP S5452047 A JPS5452047 A JP S5452047A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- halogen
- reaction
- pref
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the title compound useful as an intermediate of pharmaceuticals such as remedies of skin diseases, in a short process, from a raw material which can be obtained economicaly, easily and in high yield, by the thermal isomerization of a substituted propargyl-type alcohol.
CONSTITUTION: A substituted propargyl-type alcohol of formula I [R is V(R1-5 are H, halogen, lower alkyl, lower alkoxy)] is isomerized to the corresponding unsaturated ketone of formula II (one of the dotted lines is double bond) by heating. The reaction temperature is pref. 130-230°C in the liquid phase reaction, and 250- 400°C in the gas phase reaction. The reaction is pref. carried out in an inert gas atmosphere such as N2, He, etc., and in the presence of a polar organic compound. The compound I, which is a novel compound, is obtained by the ethynylation of ketones III and IV which are prepared by the reacftion of the compounds VI and VII with a halogen compound of formula R-halo (halo is halogen)
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11918577A JPS5452047A (en) | 1977-10-03 | 1977-10-03 | Preparation of aromatic unsaturated ketones |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11918577A JPS5452047A (en) | 1977-10-03 | 1977-10-03 | Preparation of aromatic unsaturated ketones |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5452047A true JPS5452047A (en) | 1979-04-24 |
JPS612051B2 JPS612051B2 (en) | 1986-01-22 |
Family
ID=14755005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11918577A Granted JPS5452047A (en) | 1977-10-03 | 1977-10-03 | Preparation of aromatic unsaturated ketones |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5452047A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5910539A (en) * | 1982-06-16 | 1984-01-20 | チバ・ガイギ−・アクチエンゲゼルシヤフト | Hydroquinone ether compounds |
JPH062575U (en) * | 1992-06-11 | 1994-01-14 | 光南 謝 | safety plug |
CN103113188A (en) * | 2011-11-17 | 2013-05-22 | 河北百灵威超精细材料有限公司 | Novel low-cost synthesis method of alkynol compounds |
-
1977
- 1977-10-03 JP JP11918577A patent/JPS5452047A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5910539A (en) * | 1982-06-16 | 1984-01-20 | チバ・ガイギ−・アクチエンゲゼルシヤフト | Hydroquinone ether compounds |
JPH062575U (en) * | 1992-06-11 | 1994-01-14 | 光南 謝 | safety plug |
CN103113188A (en) * | 2011-11-17 | 2013-05-22 | 河北百灵威超精细材料有限公司 | Novel low-cost synthesis method of alkynol compounds |
Also Published As
Publication number | Publication date |
---|---|
JPS612051B2 (en) | 1986-01-22 |
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