SU513981A1 - The method of obtaining sulfonylamino-bismethylphosphonic acids - Google Patents

The method of obtaining sulfonylamino-bismethylphosphonic acids

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Publication number
SU513981A1
SU513981A1 SU2038118A SU2038118A SU513981A1 SU 513981 A1 SU513981 A1 SU 513981A1 SU 2038118 A SU2038118 A SU 2038118A SU 2038118 A SU2038118 A SU 2038118A SU 513981 A1 SU513981 A1 SU 513981A1
Authority
SU
USSR - Soviet Union
Prior art keywords
acids
bismethylphosphonic
sulfonylamino
obtaining
salts
Prior art date
Application number
SU2038118A
Other languages
Russian (ru)
Inventor
Анатолий Михайлович Орлов
Владимир Георгиевич Яковлев
Любовь Сергеевна Морозова
Original Assignee
Институт биофизики
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт биофизики filed Critical Институт биофизики
Priority to SU2038118A priority Critical patent/SU513981A1/en
Application granted granted Critical
Publication of SU513981A1 publication Critical patent/SU513981A1/en

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Description

окончании прнбавлеии  раствор упаривают и смешивают с ацетоиом и метанолом. Получеииый осадок раствор ют в 50 мл воды и иропускают через колонку с КУ-2-8 (Н+) с последующим элюированием водой. Элюент упаривают и осадок виовь раствор ют в смеси ацетона и метапола. Получают 22,6 (72%) продукта с т. пл. 110°С (разл.). Содержание основного вещества 99-100% (комнлексометрическое титрование).at the end of the solution, the solution is evaporated and mixed with acetome and methanol. The resulting precipitate is dissolved in 50 ml of water and sprayed through a column of KU-2-8 (H +), followed by elution with water. The eluent is evaporated and the precipitate is dissolved in a mixture of acetone and metapol. Get 22,6 (72%) of the product with so pl. 110 ° C (decomp.). Content of the main substance is 99-100% (komlexometric titration).

Найдено, %: С 14,50; Н 4,56; N 4,28; Р 20,26; НгО -5,78 C4Hi3NO9SP2-H2O.Found,%: C 14.50; H 4.56; N 4.28; P 20.26; HgO -5.78 C4Hi3NO9SP2-H2O.

Вычислено, %: С 14,13; Н 4,34; N 4,28; Р 18,72, НаО -5,75.Calculated,%: C 14.13; H 4.34; N 4.28; R 18.72, NaO -5.75.

Аналогично получают:Similarly, receive:

3-Сульфонилпропиламино - N,N - бнсметилфосфоновую и3-Sulfonylpropylamino - N, N - bnsmethylphosphonic and

З-сульфоиил-2 - оксипропиламнно-Ы,Ы-бисметилфосфоновую кислоты.Z-sulfoiyl-2 - hydroxypropylamino-S, N-bismethylphosphonic acid.

Соли указанных кислот и элементов I и II групп получают нейтрализацией их соответствующими гидроокис ми металлов. 3-Сульфонилпроиилами ю - N,N - бнсдметилфосфонова  кислота, выход 67%, т. пл. 120°С (разл). Найдено, %: С 18,60; Н 4,71; Р 18,73.Salts of the indicated acids and elements of groups I and II are obtained by neutralization with their corresponding metal hydroxides. 3-Sulfonylproyls o - N, N - bnsdmethylphosphonic acid, yield 67%, t. Pl. 120 ° C (dec). Found,%: From 18.60; H 4.71; P 18.73.

CsHisNOgSPz.CsHisNOgSPz.

Вычислено, %: С 18,35; Н 4,62; Р 18,93.Calculated,%: C 18.35; H 4.62; R 18.93.

З-Сульфонил-2 - оксипропиламино - N,N-6HCметилфосфонова  кислота (выход 43%, т. пл. 70°С (разл.).3-Sulfonyl-2 - hydroxypropylamino - N, N-6HC methylphosphonic acid (yield 43%, mp. 70 ° C (decomp.).

Найдено, %; С 17,86, Н 4,70, N 4,35, Р 17,68.Found,%; C 17.86, H 4.70, N 4.35, P 17.68.

CsHisNOioSP.CsHisNOioSP.

Вычислено, %: С 17,50; Н 4,40; N 4,08; Р 18,05.Calculated,%: C 17.50; H 4.40; N 4.08; P 18.05.

Claims (1)

Формула изобретени Invention Formula Способ получени  сульфонилалкиламиноN ,N-биcмeтилфocфoнoвыx кислот, отличающийс  тем, что аминоалкилсульфоновые кислоты подвергают взаимодействию с фосфористой кислотой и формальдегидом с последующим выделением целевого продукта в виде свободных кислот или нх солей.A process for preparing sulfonylalkylaminoN, N-bismethylphosphonic acids, wherein aminoalkylsulfonic acids are reacted with phosphorous acid and formaldehyde, followed by isolation of the desired product in the form of free acids or nx salts.
SU2038118A 1974-06-27 1974-06-27 The method of obtaining sulfonylamino-bismethylphosphonic acids SU513981A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU2038118A SU513981A1 (en) 1974-06-27 1974-06-27 The method of obtaining sulfonylamino-bismethylphosphonic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU2038118A SU513981A1 (en) 1974-06-27 1974-06-27 The method of obtaining sulfonylamino-bismethylphosphonic acids

Publications (1)

Publication Number Publication Date
SU513981A1 true SU513981A1 (en) 1976-05-15

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SU2038118A SU513981A1 (en) 1974-06-27 1974-06-27 The method of obtaining sulfonylamino-bismethylphosphonic acids

Country Status (1)

Country Link
SU (1) SU513981A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53121722A (en) * 1977-03-29 1978-10-24 Benckiser Knapsack Gmbh Nnsulfoalkane aminoalkane sulfonate alkali salts thereof and process for preparing same
US4250107A (en) 1977-12-27 1981-02-10 Benckiser-Knapsack Gmbh N-(Sulfoalkane) amino alkane phosphonic acids and their water-soluble salts
US5051532A (en) * 1989-12-15 1991-09-24 W. R. Grace & Co.-Conn. N,N-bis-phosphonomethyl taurine N-oxide and water-soluble salts thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53121722A (en) * 1977-03-29 1978-10-24 Benckiser Knapsack Gmbh Nnsulfoalkane aminoalkane sulfonate alkali salts thereof and process for preparing same
US4216163A (en) * 1977-03-29 1980-08-05 Benckiser-Knapsack Gmbh N-Sulfo alkane amino alkane phosphoric acids and their alkali metal salts, and a process of producing same
US4250107A (en) 1977-12-27 1981-02-10 Benckiser-Knapsack Gmbh N-(Sulfoalkane) amino alkane phosphonic acids and their water-soluble salts
US5051532A (en) * 1989-12-15 1991-09-24 W. R. Grace & Co.-Conn. N,N-bis-phosphonomethyl taurine N-oxide and water-soluble salts thereof

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