SU495309A1 - The method of obtaining 1- (3-arylbutyl) 6-methoxy- (or benzyloxy) -1,2,3,4 tetrahydronorharmanov - Google Patents
The method of obtaining 1- (3-arylbutyl) 6-methoxy- (or benzyloxy) -1,2,3,4 tetrahydronorharmanovInfo
- Publication number
- SU495309A1 SU495309A1 SU2051559A SU2051559A SU495309A1 SU 495309 A1 SU495309 A1 SU 495309A1 SU 2051559 A SU2051559 A SU 2051559A SU 2051559 A SU2051559 A SU 2051559A SU 495309 A1 SU495309 A1 SU 495309A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- methoxy
- tetrahydronorharmanov
- arylbutyl
- benzyloxy
- obtaining
- Prior art date
Links
Description
ток раствор ют в небольшом количестве лед ной уксусной кислоты и раствор нагревают в течение 30 мин на вод ной бане. Затем гор чий раствор фильтруют, фильтрат охлаждают и продукт осаждают добавлением водного раствора аммиака. Выделившийс продукт реакции извлекают хлороформом (3X50 мл). Получают 0,8 г продукта 1 после перекристаллизации из этилацетатгексана.the current is dissolved in a small amount of glacial acetic acid and the solution is heated for 30 minutes in a water bath. Then the hot solution is filtered, the filtrate is cooled and the product is precipitated by the addition of an aqueous solution of ammonia. The separated reaction product is extracted with chloroform (3 x 50 ml). Obtain 0.8 g of product 1 after recrystallization from ethyl acetate-hexane.
Соединени II-IV получают в аналогичных услови х.Compounds II-IV are prepared under similar conditions.
Получение 1 - (З-фенилбутил)-б-метокси (1,2,3,4 - тетрагидроноргармана) (V). К раствору 0,5 г I в 30 мл абсолютного этанола добавл ют порци ми 1,2 г металлического натри и реакционную смесь нагревают на вод ной бане в течение 30 мин. Затем раствор охлаждают и разбавл ют 50 мл воды. После отгонки этанола при пониженном давлении на вод ной бане, продукт извлекают эфиром и сушат над КгСОз. Растворитель удал ют. Получают 0,5 г соединени V лосле перекристаллизации из смеси бензола с петролейным эфиром.Preparation of 1 - (3-phenylbutyl) -b-methoxy (1,2,3,4-tetrahydron-armanman) (V). 1.2 g of sodium metal is added in portions to a solution of 0.5 g of I in 30 ml of absolute ethanol and the reaction mixture is heated on a water bath for 30 minutes. The solution is then cooled and diluted with 50 ml of water. After ethanol is distilled off under reduced pressure in a water bath, the product is taken up in ether and dried over KgSO3. The solvent is removed. 0.5 g of compound V is obtained by recrystallization from a mixture of benzene and petroleum ether.
1,2,3,4 - тетрагидроноргарманы (VI-VIII) получают в аналогичных услови х.1,2,3,4 - tetrahydronorgarmans (VI-VIII) are prepared under similar conditions.
Пропусканием газообразного хлористого водорода в метанольном растворе соединений (V-VIII) Получены и охара-ктеризованы их соответствующие хлоргидраты.Passing gaseous hydrogen chloride in a methanol solution of compounds (V-VIII) Their corresponding chlorohydrates were obtained and characterized.
Основные -показатели всех синтезированных соединений приведены в таблице.The main indicators of all synthesized compounds are given in the table.
СНз.-. СНгСНгСН-АгSNS.-. SNGNGSN-Ag
ТаблицаTable
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU2051559A SU495309A1 (en) | 1974-07-31 | 1974-07-31 | The method of obtaining 1- (3-arylbutyl) 6-methoxy- (or benzyloxy) -1,2,3,4 tetrahydronorharmanov |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU2051559A SU495309A1 (en) | 1974-07-31 | 1974-07-31 | The method of obtaining 1- (3-arylbutyl) 6-methoxy- (or benzyloxy) -1,2,3,4 tetrahydronorharmanov |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU495309A1 true SU495309A1 (en) | 1975-12-15 |
Family
ID=20593460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU2051559A SU495309A1 (en) | 1974-07-31 | 1974-07-31 | The method of obtaining 1- (3-arylbutyl) 6-methoxy- (or benzyloxy) -1,2,3,4 tetrahydronorharmanov |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU495309A1 (en) |
-
1974
- 1974-07-31 SU SU2051559A patent/SU495309A1/en active
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