SU461926A1 - The method of obtaining -glycidylimidazole - Google Patents

The method of obtaining -glycidylimidazole

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Publication number
SU461926A1
SU461926A1 SU1942659A SU1942659A SU461926A1 SU 461926 A1 SU461926 A1 SU 461926A1 SU 1942659 A SU1942659 A SU 1942659A SU 1942659 A SU1942659 A SU 1942659A SU 461926 A1 SU461926 A1 SU 461926A1
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SU
USSR - Soviet Union
Prior art keywords
glycidylimidazole
imidazole
obtaining
dioxane
derivatives
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Application number
SU1942659A
Other languages
Russian (ru)
Inventor
Николай Николаевич Суворов
Анатолий Борисович Штейнпресс
Юрий Исаевич Смушкевич
Владимир Васильевич Зуев
Original Assignee
Московский Ордена Ленина И Ордена Трудового Красного Знамени Химико-Технологический Институт Им.Д.И. Менделеева
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Application filed by Московский Ордена Ленина И Ордена Трудового Красного Знамени Химико-Технологический Институт Им.Д.И. Менделеева filed Critical Московский Ордена Ленина И Ордена Трудового Красного Знамени Химико-Технологический Институт Им.Д.И. Менделеева
Priority to SU1942659A priority Critical patent/SU461926A1/en
Application granted granted Critical
Publication of SU461926A1 publication Critical patent/SU461926A1/en

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Description

1one

Изобретение относитс  к способу получени  новых производных имидазола, которые могут быть использованы дл  синтеза биологически активных соединений.The invention relates to a process for the preparation of novel imidazole derivatives which can be used for the synthesis of biologically active compounds.

Известный способ получени  N-глипидильных производных замещенных имидазолов основан на взаимодействии эпихлоргидрипа с замещеппым имидазолом в щелочной среде при температуре кппени  смеси.A known method for the preparation of N-glypidyl derivatives of substituted imidazoles is based on the interaction of epichlorohydride with substituted imidazole in an alkaline medium at the mixture's spin point.

Однако применение этого способа не приводит к получению глипидильных производных незамещенного имидазола.However, the application of this method does not lead to the preparation of glypidyl derivatives of unsubstituted imidazole.

По предлагаемому способу имидазол подвергают взаимодействию с 1-1, 7 мол рным избытком эпихлоргидрина при температуре 35-7ЬС в диоксане. Исходпые продукты и N-глицидилимидазол хорощо растворимы в диоксане, а побочные продукты реакпии выдел ютс  в виде осадка.In the proposed method, the imidazole is reacted with a 1-1, 7 molar excess of epichlorohydrin at a temperature of 35-7 ° C in dioxane. The end products and N-glycidylimidazole are horizontally soluble in dioxane, and the reaction by-products are precipitated.

Пример. 13,6 г (0,2 моль) имидазола раствор ют в 75 мл диоксана при 50°С и прикапывают 23 мл (0,3 моль) эппхлоргидрипа.Example. 13.6 g (0.2 mol) of imidazole are dissolved in 75 ml of dioxane at 50 ° C and 23 ml (0.3 mol) of epphlorohydride are added dropwise.

Перемешивают 12 час при 50°С. Продукт выдел ют на хроматографической колонке с окисью алюмини , в качестве элюента исполозуют хлороформ, насыщенный аммиаком. Выход 4 г (12,5%). Строение полученного продукта подтверждено масс-спектрометрическими методами ПК и ПМР.Stirred for 12 hours at 50 ° C. The product is isolated on an alumina chromatographic column, chloroform saturated with ammonia is used as eluent. Yield 4 g (12.5%). The structure of the obtained product was confirmed by mass spectrometry methods of PC and PMR.

Пикрат N-глицидилимидазола, т. пл. 92-ЭЗ С. 10 Пайдено, %: С 40,90; П 3,24; N 19,60.Picrate of N-glycidylimidazole, m.p. 92-EZ C. 10 Paideno,%: C 40.90; P 3.24; N 19.60.

CisnuNsOg.CisnuNsOg.

Вычислено, %: С 40,80; Н 3,14; N 19,82.Calculated,%: C 40.80; H 3.14; N 19.82.

15Предмет изобретени 15 of the invention

Способ получени  N-глипидилимидазола, отличающийс  тем, что, имидазол подвергаю взаимодействию с 1,0-1,7 мол рным избытком эпихлоргидрина в среде диоксана при 35-75°С с выделением пелевого продукта известными приемами.A method for producing N-glypidylimidazole, characterized in that the imidazole is reacted with a 1.0-1.7 molar excess of epichlorohydrin in a dioxane medium at 35-75 ° C, with the release of a pellet product by known methods.

SU1942659A 1973-07-06 1973-07-06 The method of obtaining -glycidylimidazole SU461926A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU1942659A SU461926A1 (en) 1973-07-06 1973-07-06 The method of obtaining -glycidylimidazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU1942659A SU461926A1 (en) 1973-07-06 1973-07-06 The method of obtaining -glycidylimidazole

Publications (1)

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SU461926A1 true SU461926A1 (en) 1975-02-28

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SU (1) SU461926A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030371A1 (en) * 1979-12-05 1981-06-17 Sumitomo Chemical Company, Limited N-substituted imidazole derivatives, a process for their preparation, antifungal compositions comprising them and their use for preparing such compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030371A1 (en) * 1979-12-05 1981-06-17 Sumitomo Chemical Company, Limited N-substituted imidazole derivatives, a process for their preparation, antifungal compositions comprising them and their use for preparing such compositions

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