SU461926A1 - The method of obtaining -glycidylimidazole - Google Patents
The method of obtaining -glycidylimidazoleInfo
- Publication number
- SU461926A1 SU461926A1 SU1942659A SU1942659A SU461926A1 SU 461926 A1 SU461926 A1 SU 461926A1 SU 1942659 A SU1942659 A SU 1942659A SU 1942659 A SU1942659 A SU 1942659A SU 461926 A1 SU461926 A1 SU 461926A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- glycidylimidazole
- imidazole
- obtaining
- dioxane
- derivatives
- Prior art date
Links
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- Plural Heterocyclic Compounds (AREA)
Description
1one
Изобретение относитс к способу получени новых производных имидазола, которые могут быть использованы дл синтеза биологически активных соединений.The invention relates to a process for the preparation of novel imidazole derivatives which can be used for the synthesis of biologically active compounds.
Известный способ получени N-глипидильных производных замещенных имидазолов основан на взаимодействии эпихлоргидрипа с замещеппым имидазолом в щелочной среде при температуре кппени смеси.A known method for the preparation of N-glypidyl derivatives of substituted imidazoles is based on the interaction of epichlorohydride with substituted imidazole in an alkaline medium at the mixture's spin point.
Однако применение этого способа не приводит к получению глипидильных производных незамещенного имидазола.However, the application of this method does not lead to the preparation of glypidyl derivatives of unsubstituted imidazole.
По предлагаемому способу имидазол подвергают взаимодействию с 1-1, 7 мол рным избытком эпихлоргидрина при температуре 35-7ЬС в диоксане. Исходпые продукты и N-глицидилимидазол хорощо растворимы в диоксане, а побочные продукты реакпии выдел ютс в виде осадка.In the proposed method, the imidazole is reacted with a 1-1, 7 molar excess of epichlorohydrin at a temperature of 35-7 ° C in dioxane. The end products and N-glycidylimidazole are horizontally soluble in dioxane, and the reaction by-products are precipitated.
Пример. 13,6 г (0,2 моль) имидазола раствор ют в 75 мл диоксана при 50°С и прикапывают 23 мл (0,3 моль) эппхлоргидрипа.Example. 13.6 g (0.2 mol) of imidazole are dissolved in 75 ml of dioxane at 50 ° C and 23 ml (0.3 mol) of epphlorohydride are added dropwise.
Перемешивают 12 час при 50°С. Продукт выдел ют на хроматографической колонке с окисью алюмини , в качестве элюента исполозуют хлороформ, насыщенный аммиаком. Выход 4 г (12,5%). Строение полученного продукта подтверждено масс-спектрометрическими методами ПК и ПМР.Stirred for 12 hours at 50 ° C. The product is isolated on an alumina chromatographic column, chloroform saturated with ammonia is used as eluent. Yield 4 g (12.5%). The structure of the obtained product was confirmed by mass spectrometry methods of PC and PMR.
Пикрат N-глицидилимидазола, т. пл. 92-ЭЗ С. 10 Пайдено, %: С 40,90; П 3,24; N 19,60.Picrate of N-glycidylimidazole, m.p. 92-EZ C. 10 Paideno,%: C 40.90; P 3.24; N 19.60.
CisnuNsOg.CisnuNsOg.
Вычислено, %: С 40,80; Н 3,14; N 19,82.Calculated,%: C 40.80; H 3.14; N 19.82.
15Предмет изобретени 15 of the invention
Способ получени N-глипидилимидазола, отличающийс тем, что, имидазол подвергаю взаимодействию с 1,0-1,7 мол рным избытком эпихлоргидрина в среде диоксана при 35-75°С с выделением пелевого продукта известными приемами.A method for producing N-glypidylimidazole, characterized in that the imidazole is reacted with a 1.0-1.7 molar excess of epichlorohydrin in a dioxane medium at 35-75 ° C, with the release of a pellet product by known methods.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU1942659A SU461926A1 (en) | 1973-07-06 | 1973-07-06 | The method of obtaining -glycidylimidazole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU1942659A SU461926A1 (en) | 1973-07-06 | 1973-07-06 | The method of obtaining -glycidylimidazole |
Publications (1)
Publication Number | Publication Date |
---|---|
SU461926A1 true SU461926A1 (en) | 1975-02-28 |
Family
ID=20559578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU1942659A SU461926A1 (en) | 1973-07-06 | 1973-07-06 | The method of obtaining -glycidylimidazole |
Country Status (1)
Country | Link |
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SU (1) | SU461926A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0030371A1 (en) * | 1979-12-05 | 1981-06-17 | Sumitomo Chemical Company, Limited | N-substituted imidazole derivatives, a process for their preparation, antifungal compositions comprising them and their use for preparing such compositions |
-
1973
- 1973-07-06 SU SU1942659A patent/SU461926A1/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0030371A1 (en) * | 1979-12-05 | 1981-06-17 | Sumitomo Chemical Company, Limited | N-substituted imidazole derivatives, a process for their preparation, antifungal compositions comprising them and their use for preparing such compositions |
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