SU458966A3 - The method of producing tablets - Google Patents
The method of producing tabletsInfo
- Publication number
- SU458966A3 SU458966A3 SU1247008A SU1247008A SU458966A3 SU 458966 A3 SU458966 A3 SU 458966A3 SU 1247008 A SU1247008 A SU 1247008A SU 1247008 A SU1247008 A SU 1247008A SU 458966 A3 SU458966 A3 SU 458966A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- core
- producing tablets
- tablets
- pressure
- ascorbic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
- C04B41/45—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements
- C04B41/50—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials
- C04B41/5025—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements with inorganic materials with ceramic materials
- C04B41/5042—Zirconium oxides or zirconates; Hafnium oxides or hafnates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ceramic Engineering (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Structural Engineering (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ ТАБЛЕТОК(54) METHOD FOR GETTING TABLETS
Изобретение относитс к фармацевтической промышлеииости.This invention relates to the pharmaceutical industry.
Известен способ получени таблеток путем прессовани дра с веществом, замедл ющим растворимость оболочки.A known method of producing tablets by pressing a core with a substance that slows the solubility of the shell.
Целью изобретени вл етс улучшение распадаемости таблеток.The aim of the invention is to improve the disintegration of tablets.
Дл этого дро прессуют под давлением 225-600 кг/см, первый слой - под давлением 450-750 кг/см2, а второй -900-1200 кг/см. For this, the cores are pressed under a pressure of 225-600 kg / cm, the first layer - under a pressure of 450-750 kg / cm2, and the second one –900-1200 kg / cm.
Ядро таблетки окружено одной или несколькими оболочками. В одну или в несколько из них ввод т ингредиенты-замедлители, измен ющие количество, в котором они присутствуют , и/или его природу таким образом, чтобы двум соседним элементам соответствовали различные длительности расслоени . В.качестве ингредиентов-замедлителей могут быть использованы гуммилак, стеаринова кислота и ее соли и эфиры, например стеарат .магни , белый воск, растительные воска, такие как воск Карноба, полиалкиленгликоли, полиэтиленгликоль 4000, диоктилсульфосукцинат натри , ацетофталат целлюлозы, в некоторых случа х вместе с фталевым эфиром, таким как этиловый или бутиловый эфир фталевой кислоты .The core of the tablet is surrounded by one or more shells. In one or more of them, inhibitor ingredients are introduced, varying the amount in which they are present and / or its nature in such a way that the different elements of stratification correspond to the two adjacent elements. C. Gummilac, stearic acid and its salts and esters can be used as moderating ingredients, e.g. magnesium stearate, white wax, vegetable waxes such as Carnoba wax, polyalkylene glycols, polyethylene glycol 4000, dioctyl sodium sulfosuccinate, cellulose acetal phthalate, in some cases together with phthalate ester, such as phthalic acid ethyl or butyl ester.
Каждый элемент таблетки, который должен отслоитс с малой скоростью, может содержать один или несколько ингредиентов-замедлителеи и одно или несколько активных начал. Аскорбиновую кислоту гранулируют с лаковой камедью (3 вес. %) в спиртовом растворе при перемешивании. Оставшийс раствор используют дл гранулировани остальных компонентов . Два гранул та высушивают на воздухе , а затем смешивают и таблетируют дро весом 0,110 т под давлением 7 т/см.Each element of the tablet, which should exfoliate at low speed, may contain one or more inhibiting ingredients and one or more active principles. Ascorbic acid is granulated with lacquer gum (3 wt.%) In an alcohol solution with stirring. The remaining solution is used to granulate the remaining components. The two granules are air dried, and then a core weighing 0.110 tons is mixed and tableted under a pressure of 7 tons / cm.
Компоненты первого сло предварительно обрабатывают и смешивают таким же образом , как и компоненты дра, но количество лаковой камеди, примен емой дл гранулировани аскорбиновой кислоты, составл ет 0,15 вес.%. Смесь нанос т на дро п таблетируют на нем первый слой весом 0,120 г под давлением 5 т/см. Пример 1. Состав дра, т:The components of the first layer are pretreated and mixed in the same manner as the core components, but the amount of lacquer gum used for granulating ascorbic acid is 0.15% by weight. The mixture is applied to the core and the first layer weighing 0.120 g is pressed on it under a pressure of 5 tons / cm. Example 1. The composition of the core, t:
Хлоргидрат папаверина 0,034 Этоксазорутин0,025Papaverine hydrochloride 0.034 Ethoxazorutine 0.025
Аскорбинова кислота0,025Ascorbic Acid
Лакова камедьLakova gum
(в 95%-ном спирте)0,015(in 95% alcohol) 0.015
Стеарат магни 0,010Magnesium stearate 0,010
Тальк0,001Talc0.001
Первый слой, т:The first layer, t:
Хлоргидрат папаверина0,033Papaverine hydrochloride0,033
Этоксазорутин0,025Ethoxazorutin0.025
Аскорбинова кислота0,025Ascorbic Acid
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR110534A FR1545612A (en) | 1967-06-15 | 1967-06-15 | Tablet manufacturing process |
Publications (1)
Publication Number | Publication Date |
---|---|
SU458966A3 true SU458966A3 (en) | 1975-01-30 |
Family
ID=8633106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU1247008A SU458966A3 (en) | 1967-06-15 | 1968-06-14 | The method of producing tablets |
Country Status (10)
Country | Link |
---|---|
BE (1) | BE716530A (en) |
DE (1) | DE1767765A1 (en) |
ES (1) | ES355054A1 (en) |
FR (1) | FR1545612A (en) |
GB (1) | GB1233055A (en) |
IL (1) | IL30165A (en) |
IT (1) | IT954035B (en) |
LU (1) | LU56264A1 (en) |
NL (1) | NL151902B (en) |
SU (1) | SU458966A3 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8022032B2 (en) | 2004-11-19 | 2011-09-20 | Smithkline Beecham Corporation | Method for customized dispensing of variable dose drug combination products for individualizing of therapies |
RU2531553C2 (en) * | 1994-07-08 | 2014-10-20 | Астразенека Аб | Tabletted multiunit dosage form, method for preparing it, pack and method for inhibiting gastric acid secretion and/or treating gastrointestinal inflammatory diseases |
RU2538511C2 (en) * | 1994-07-08 | 2015-01-10 | Астра Актиеболаг | Tabletted multiunit dosage, method of its obtaining and method for inhibiting gastric acid secretion or treating gastrointestinal diseases in mammals and humans |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5138412A (en) * | 1974-09-24 | 1976-03-31 | Nippon Kayaku Kk | Kokoseizai no seiho |
US4076804A (en) * | 1975-07-18 | 1978-02-28 | Abbott Laboratories | Erythromycin therapy |
SE418247B (en) * | 1975-11-17 | 1981-05-18 | Haessle Ab | SET TO MAKE BODIES WITH REGULATED RELEASE OF AN ACTIVE COMPONENT |
US4704284A (en) * | 1982-08-12 | 1987-11-03 | Pfizer Inc. | Long-acting matrix tablet formulations |
US4503031A (en) * | 1982-12-17 | 1985-03-05 | Glassman Jacob A | Super-fast-starting-sustained release tablet |
DK62184D0 (en) * | 1984-02-10 | 1984-02-10 | Benzon As Alfred | DIFFUSION COATED POLYDEPOT PREPARATION |
US5032406A (en) * | 1989-02-21 | 1991-07-16 | Norwich Eaton Pharmaceuticals, Inc. | Dual-action tablet |
US5213807A (en) * | 1990-05-03 | 1993-05-25 | Chemburkar Pramod B | Pharmaceutical composition containing ibuprofen and a prostaglandin |
-
1967
- 1967-06-15 FR FR110534A patent/FR1545612A/en not_active Expired
-
1968
- 1968-06-12 IL IL30165A patent/IL30165A/en unknown
- 1968-06-13 BE BE716530D patent/BE716530A/xx unknown
- 1968-06-13 LU LU56264A patent/LU56264A1/xx unknown
- 1968-06-13 NL NL686808312A patent/NL151902B/en unknown
- 1968-06-14 DE DE19681767765 patent/DE1767765A1/en active Pending
- 1968-06-14 IT IT52034/68A patent/IT954035B/en active
- 1968-06-14 SU SU1247008A patent/SU458966A3/en active
- 1968-06-14 GB GB1233055D patent/GB1233055A/en not_active Expired
- 1968-06-15 ES ES355054A patent/ES355054A1/en not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2531553C2 (en) * | 1994-07-08 | 2014-10-20 | Астразенека Аб | Tabletted multiunit dosage form, method for preparing it, pack and method for inhibiting gastric acid secretion and/or treating gastrointestinal inflammatory diseases |
RU2538511C2 (en) * | 1994-07-08 | 2015-01-10 | Астра Актиеболаг | Tabletted multiunit dosage, method of its obtaining and method for inhibiting gastric acid secretion or treating gastrointestinal diseases in mammals and humans |
US8022032B2 (en) | 2004-11-19 | 2011-09-20 | Smithkline Beecham Corporation | Method for customized dispensing of variable dose drug combination products for individualizing of therapies |
US8383579B2 (en) | 2004-11-19 | 2013-02-26 | GlaxoSmithKline, LLC | Method for customized dispensing of variable dose drug combination products for individualizing of therapies |
Also Published As
Publication number | Publication date |
---|---|
ES355054A1 (en) | 1969-11-16 |
BE716530A (en) | 1968-11-04 |
DE1767765A1 (en) | 1972-03-30 |
LU56264A1 (en) | 1968-09-23 |
NL151902B (en) | 1977-01-17 |
IL30165A0 (en) | 1968-08-22 |
FR1545612A (en) | 1968-11-15 |
IL30165A (en) | 1973-04-30 |
IT954035B (en) | 1973-08-30 |
NL6808312A (en) | 1968-12-16 |
GB1233055A (en) | 1971-05-26 |
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