SU424348A3 - - Google Patents
Info
- Publication number
- SU424348A3 SU424348A3 SU1717552A SU1717552A SU424348A3 SU 424348 A3 SU424348 A3 SU 424348A3 SU 1717552 A SU1717552 A SU 1717552A SU 1717552 A SU1717552 A SU 1717552A SU 424348 A3 SU424348 A3 SU 424348A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- formula
- compounds
- ethanoanthracene
- ethano
- residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
1one
Изобретение относитс к способу получени новых этаноантраценов общей формулы IThis invention relates to a process for the preparation of new ethanoanthracene of the general formula I
CHrCH -CH RCHrCH -CH R
где R обозначает монометиламинную, диметиламинную , моноэтиламинную или диэтиламинную групну, содержащих в ароматических кольцах минимум 1 атом хлора. Соединение формулы I обладают фармакологической активностью и в св зи с этим могут найти применение в фармацевтической нромышленности, в медицине и ветеринарии, а также в качестве исходных или нромежуточных продуктов в органическом синтезе.where R denotes monomethylamine, dimethylamine, monoethylamine or diethylamine group containing at least 1 chlorine atom in aromatic rings. The compound of formula I possesses pharmacological activity and, therefore, can be used in the pharmaceutical industry, in medicine and veterinary medicine, as well as starting or intermediate products in organic synthesis.
Известен способ получени аминоалкилированных 9,10-дигидроантраценов восстановлением соответствующих антраценов водородом или комплексными гидридами металлов. Однако сведени о получении этаноантраценов общей формулы I в литературе отсутствуют. A known method for producing aminoalkylated 9,10-dihydroanthracene is by reducing the corresponding anthracene with hydrogen or complex metal hydrides. However, information on the production of ethanoanthracene of general formula I is absent in the literature.
Иовые соединени указанной выще формулы , в соответствии с изобретением, получают введепием в соединение формулы IIThe latter compounds of the above formula, in accordance with the invention, are prepared by introducing into the compound of formula II
CHo-CHj-CHrRCHo-CHj-CHrR
где R имеет вышеупом нутое значение п которое содержит один атом хлора в одном из положений 1-8, остатка 9,10-этано-(1,2).where R has the above-mentioned value n which contains one atom of chlorine in one of the positions 1-8, residue 9,10-ethano- (1,2).
Введение остатка 9.10-этано-(1,2) производ т известным способом, например использованием этилена в соответствии с реакцией Дильса-Альдера, причем в зависимости от реакционной способности антраценовых соединений возникает необходимость в повышении температуры и/или давлени , а также в применении катализатора. Реакцию провод т в присутствии или в отсутствии разбавителей, конденсирующих средств и/или каталитически действующих соединений при понилсенной, обыкновенной или повышенной температуре. Новые соединени формулы I могут быть получены в свободном виде или в виде их солей . Соли этих соединений могут быть обычным путем переведены в свободные основани . Иолученные вторичные амины обычным снособом , например восстановительным алкилиThe introduction of the 9.10-ethano- (1,2) residue is carried out in a known manner, for example, using ethylene in accordance with the Diels-Alder reaction, and depending on the reactivity of the anthracene compounds, it is necessary to increase the temperature and / or pressure, and also to use . The reaction is carried out in the presence or in the absence of diluents, condensing agents and / or catalytically active compounds at low, normal or elevated temperature. The novel compounds of formula I can be obtained in free form or in the form of their salts. The salts of these compounds can be converted into free bases in the usual manner. I secondary secondary amines by conventional cleavage, for example, reductive alkyl
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1708665A CH448069A (en) | 1960-11-29 | 1965-12-10 | Process for the production of new amines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU424348A3 true SU424348A3 (en) | 1974-04-15 |
Family
ID=4422644
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1717552A SU424348A3 (en) | 1965-12-10 | 1966-12-10 | |
| SU1118632A SU414785A3 (en) | 1965-12-10 | 1966-12-10 | METHOD OF OBTAINING ETHANOANTHRACENES |
| SU1717378A SU549076A3 (en) | 1965-12-10 | 1971-11-24 | The method of obtaining aminoethanol or their salts |
| SU1717390A SU549077A3 (en) | 1965-12-10 | 1971-11-24 | The method of obtaining aminoetanoanthracene or their salts |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1118632A SU414785A3 (en) | 1965-12-10 | 1966-12-10 | METHOD OF OBTAINING ETHANOANTHRACENES |
| SU1717378A SU549076A3 (en) | 1965-12-10 | 1971-11-24 | The method of obtaining aminoethanol or their salts |
| SU1717390A SU549077A3 (en) | 1965-12-10 | 1971-11-24 | The method of obtaining aminoetanoanthracene or their salts |
Country Status (11)
| Country | Link |
|---|---|
| AT (12) | AT273946B (en) |
| BE (3) | BE690939A (en) |
| BR (3) | BR6685268D0 (en) |
| DE (1) | DE1568355A1 (en) |
| DK (3) | DK130175B (en) |
| FR (6) | FR6436M (en) |
| GB (2) | GB1149557A (en) |
| GT (1) | GT197119100A (en) |
| NL (3) | NL6617368A (en) |
| SE (2) | SE354850B (en) |
| SU (4) | SU424348A3 (en) |
-
1966
- 1966-12-02 DE DE19661568355 patent/DE1568355A1/en active Pending
- 1966-12-09 AT AT173468A patent/AT273946B/en active
- 1966-12-09 AT AT1135566A patent/AT272327B/en active
- 1966-12-09 DK DK638766A patent/DK130175B/en unknown
- 1966-12-09 BE BE690939D patent/BE690939A/xx unknown
- 1966-12-09 BE BE690940A patent/BE690940A/xx unknown
- 1966-12-09 BR BR18526866A patent/BR6685268D0/en unknown
- 1966-12-09 SE SE1690766A patent/SE354850B/xx unknown
- 1966-12-09 AT AT173968A patent/AT276364B/en active
- 1966-12-09 AT AT1135266A patent/AT271459B/en active
- 1966-12-09 AT AT174068A patent/AT271462B/en active
- 1966-12-09 DK DK638866A patent/DK130176B/en unknown
- 1966-12-09 AT AT1966A patent/AT278766B/en not_active IP Right Cessation
- 1966-12-09 DK DK638666A patent/DK130786B/en unknown
- 1966-12-09 BE BE690941D patent/BE690941A/xx unknown
- 1966-12-09 NL NL6617368A patent/NL6617368A/xx unknown
- 1966-12-09 AT AT173868A patent/AT272328B/en active
- 1966-12-09 AT AT196568A patent/AT273085B/en active
- 1966-12-09 BR BR18526666A patent/BR6685266D0/en unknown
- 1966-12-09 NL NL6617369A patent/NL6617369A/xx unknown
- 1966-12-09 BR BR18526766A patent/BR6685267D0/en unknown
- 1966-12-09 AT AT1135366A patent/AT272326B/en active
- 1966-12-09 AT AT174168A patent/AT271463B/en active
- 1966-12-09 AT AT173568A patent/AT271461B/en active
- 1966-12-09 SE SE1690666A patent/SE324788B/xx unknown
- 1966-12-09 AT AT196468A patent/AT273084B/en active
- 1966-12-09 NL NL6617367A patent/NL6617367A/xx unknown
- 1966-12-10 SU SU1717552A patent/SU424348A3/ru active
- 1966-12-10 SU SU1118632A patent/SU414785A3/en active
- 1966-12-12 GB GB5555466A patent/GB1149557A/en not_active Expired
- 1966-12-12 GB GB5555366A patent/GB1143999A/en not_active Expired
-
1967
- 1967-03-02 FR FR97135A patent/FR6436M/fr not_active Expired
- 1967-03-02 FR FR97138A patent/FR6355M/fr not_active Expired
- 1967-03-02 FR FR97140A patent/FR6357M/fr not_active Expired
- 1967-03-02 FR FR97137A patent/FR6354M/fr not_active Expired
- 1967-03-02 FR FR97139A patent/FR6356M/fr not_active Expired
- 1967-03-02 FR FR97136A patent/FR6353M/fr not_active Expired
-
1971
- 1971-01-18 GT GT197119100A patent/GT197119100A/en unknown
- 1971-11-24 SU SU1717378A patent/SU549076A3/en active
- 1971-11-24 SU SU1717390A patent/SU549077A3/en active
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