SU393828A3 - - Google Patents
Info
- Publication number
- SU393828A3 SU393828A3 SU1651104A SU1651104A SU393828A3 SU 393828 A3 SU393828 A3 SU 393828A3 SU 1651104 A SU1651104 A SU 1651104A SU 1651104 A SU1651104 A SU 1651104A SU 393828 A3 SU393828 A3 SU 393828A3
- Authority
- SU
- USSR - Soviet Union
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5289169 | 1969-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU393828A3 true SU393828A3 (xx) | 1973-08-10 |
Family
ID=10465723
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1496136A SU419026A3 (ru) | 1969-10-29 | 1970-10-29 | СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННОЙ ИЗОТИОЛ1ОЧЕВИНЫ1Изобретение относитс к способу получени производных амидов, в частности замещенной изотиомочевины, обладающей фармакологической активностью.Известные соединени , содержащие 2-ами- ноалкилимидазолиновую груп-пировку, обладают антигистаминной .активностью, но действуют только на один вид гистаминного рецептора, не затрагива другие.Предлагаемый способ получени замещенной изотиомочевины общей формулы.-^^-(^Е,},т^'(^^^^'«Х_ЛАSR^где X — водород, низший алкил, амино- или низша алкилтиогруппа;ь-^1;п — 2—5;R—водород, Ci—€4-, алкил, арил или аралкил;R* — насыщенный или ненасыщенный Ci—Сб-алкил или (CH2)mZ, где т—1—3;Z — замещенный или незамещенный арил, гидроксил, карбоксил, алкила^мино- или циа- ногруппа;R и R^ вместе могут образовывать 5-член- ное кольцо;2А вместе с примыкающими атомами углерода и азота представл ет собой ненасыщенное 5—6-членное гетероциклическое кольцо, основан на общеизвестной реакции алкилировани 5 группы —C = S и состоит в том, что тиомоче- вину общей формулы/?НК. «юг":'™'^^Агде А, X, Ь, п и R имеют вышеуказанные значени , обрабатывают соединением общей 15 формулы R'Y, где R' — как указано выше; Y — галоид или гидроксил, и выдел ют целевой продукт в виде соли или перевод т в основание известными приемами.20 Исходную тиомочевину используют в виде кислотноаддитивной соли, например с галоид- водородной, серной, пикриновой или малеино- вой кислотой, или ведут процесс в присутствии одной из этих кислот. Реакцию провод т25 в среде органического растворител , например этилового спирта, диметилформамида или ацетона.Образующиес аддитивные соли изотиомочевины перевод т в основание при обработке,30 например, карбонатом кали . |
| SU1651104A SU393828A3 (xx) | 1969-10-29 | 1970-10-29 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1496136A SU419026A3 (ru) | 1969-10-29 | 1970-10-29 | СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННОЙ ИЗОТИОЛ1ОЧЕВИНЫ1Изобретение относитс к способу получени производных амидов, в частности замещенной изотиомочевины, обладающей фармакологической активностью.Известные соединени , содержащие 2-ами- ноалкилимидазолиновую груп-пировку, обладают антигистаминной .активностью, но действуют только на один вид гистаминного рецептора, не затрагива другие.Предлагаемый способ получени замещенной изотиомочевины общей формулы.-^^-(^Е,},т^'(^^^^'«Х_ЛАSR^где X — водород, низший алкил, амино- или низша алкилтиогруппа;ь-^1;п — 2—5;R—водород, Ci—€4-, алкил, арил или аралкил;R* — насыщенный или ненасыщенный Ci—Сб-алкил или (CH2)mZ, где т—1—3;Z — замещенный или незамещенный арил, гидроксил, карбоксил, алкила^мино- или циа- ногруппа;R и R^ вместе могут образовывать 5-член- ное кольцо;2А вместе с примыкающими атомами углерода и азота представл ет собой ненасыщенное 5—6-членное гетероциклическое кольцо, основан на общеизвестной реакции алкилировани 5 группы —C = S и состоит в том, что тиомоче- вину общей формулы/?НК. «юг":'™'^^Агде А, X, Ь, п и R имеют вышеуказанные значени , обрабатывают соединением общей 15 формулы R'Y, где R' — как указано выше; Y — галоид или гидроксил, и выдел ют целевой продукт в виде соли или перевод т в основание известными приемами.20 Исходную тиомочевину используют в виде кислотноаддитивной соли, например с галоид- водородной, серной, пикриновой или малеино- вой кислотой, или ведут процесс в присутствии одной из этих кислот. Реакцию провод т25 в среде органического растворител , например этилового спирта, диметилформамида или ацетона.Образующиес аддитивные соли изотиомочевины перевод т в основание при обработке,30 например, карбонатом кали . |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS4946307B1 (xx) |
| DK (1) | DK140938B (xx) |
| ES (2) | ES385015A1 (xx) |
| FI (1) | FI56001C (xx) |
| IE (1) | IE34882B1 (xx) |
| IL (1) | IL35518A (xx) |
| NO (1) | NO133197C (xx) |
| PH (1) | PH10563A (xx) |
| SE (1) | SE376613B (xx) |
| SU (2) | SU419026A3 (xx) |
| ZA (1) | ZA707151B (xx) |
-
1970
- 1970-10-19 DK DK531370AA patent/DK140938B/da unknown
- 1970-10-19 IE IE1346/70A patent/IE34882B1/xx unknown
- 1970-10-20 ZA ZA707151A patent/ZA707151B/xx unknown
- 1970-10-22 SE SE7014260A patent/SE376613B/xx unknown
- 1970-10-23 IL IL35518A patent/IL35518A/xx unknown
- 1970-10-28 FI FI2901/70A patent/FI56001C/fi active
- 1970-10-29 SU SU1496136A patent/SU419026A3/ru active
- 1970-10-29 NO NO4129/70A patent/NO133197C/no unknown
- 1970-10-29 ES ES385015A patent/ES385015A1/es not_active Expired
- 1970-10-29 SU SU1651104A patent/SU393828A3/ru active
- 1970-10-29 JP JP45095831A patent/JPS4946307B1/ja active Pending
-
1971
- 1971-01-08 ES ES387088A patent/ES387088A1/es not_active Expired
-
1973
- 1973-02-09 PH PH14382A patent/PH10563A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL35518A (en) | 1978-07-31 |
| FI56001C (fi) | 1979-11-12 |
| PH10563A (en) | 1977-06-28 |
| FI56001B (fi) | 1979-07-31 |
| IE34882B1 (en) | 1975-09-17 |
| JPS4946307B1 (xx) | 1974-12-09 |
| DK140938C (xx) | 1980-05-19 |
| DK140938B (da) | 1979-12-10 |
| SU419026A3 (ru) | 1974-03-05 |
| NO133197B (xx) | 1975-12-15 |
| ZA707151B (en) | 1971-07-28 |
| ES385015A1 (es) | 1973-03-16 |
| ES387088A1 (es) | 1973-06-16 |
| IL35518A0 (en) | 1970-12-24 |
| IE34882L (en) | 1971-04-29 |
| SE376613B (xx) | 1975-06-02 |
| NO133197C (xx) | 1976-03-24 |