SU210868A1 - METHOD OF OBTAINING N, N'-MALOHIL-? ЯC- NOVOKAINDICHLOROHYDRAT - Google Patents
METHOD OF OBTAINING N, N'-MALOHIL-? ЯC- NOVOKAINDICHLOROHYDRATInfo
- Publication number
- SU210868A1 SU210868A1 SU1117560A SU1117560A SU210868A1 SU 210868 A1 SU210868 A1 SU 210868A1 SU 1117560 A SU1117560 A SU 1117560A SU 1117560 A SU1117560 A SU 1117560A SU 210868 A1 SU210868 A1 SU 210868A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- obtaining
- novokaindichlorohydrat
- malohil
- novocaine
- benzene
- Prior art date
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 10
- 229940053973 Novocaine Drugs 0.000 description 4
- MFDFERRIHVXMIY-UHFFFAOYSA-N Procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000003247 radioactive fallout Substances 0.000 description 1
Description
Изобретение может найти применение в качестве фармакологически активного соединели .The invention may find use as a pharmacologically active compound.
Предлагаемый способ получени М,М-малонил-бг с-новокаиндихлоргидрата заключаетс в том, что основание новокаина конденсируют с недОКисью углерода в 1бензоле и затем леревод т полученный продукт в дихлоргидрат обычным способом.The proposed method for the production of M, M-malonyl-BG with novocaine dichlorohydrate consists in the fact that the base of novocaine is condensed with carbon dioxide in 1 benzene and then the resulting product is transferred to the dihydrochloride in the usual way.
Указанное соединение, же ка.к и способ его .получени , в литературе не описаны.The indicated compound, as well as its method of preparation, is not described in the literature.
Способ состоит в следующем. Через раствор 10 г основани новокаина в 220 мл безводного бензола пропускают двукратный избыток газообразной недокиси углерода, полученной ранее описанным методом. Реакцию лровод т при обычной температуре. Постепенно раствор окрашиваетс в красный цвет, что объ сн етс образованием некоторого количества «красного полимера недокиси углерода. После выстаивани смеси в течение суток бензол сливают, а оставшийс смолообразный остаток обрабатывают Зо/о-ным едким натром при нагревании на вод ной бане. Затем делают четыре выт жки диэтиловым эфиром (поThe method consists in the following. Through a solution of 10 g of base of novocaine in 220 ml of anhydrous benzene, a two-fold excess of gaseous carbon dioxide obtained by the previously described method is passed. The reaction is carried out at ordinary temperature. Gradually, the solution turns red, which is due to the formation of a certain amount of red carbon-dioxide polymer. After allowing the mixture to stand for 24 hours, the benzene is poured off, and the remaining gummy residue is treated with 30% sodium hydroxide when heated in a water bath. Then do four stretches with diethyl ether (according to
50 мл и раствор упаривают до 1/4 первоначального объема. После его охлаждени выпадают кристаллы Ы,М-малонил-быс-новокаина с т. пл. 108-110°С (из бензола). Полученный50 ml and the solution is evaporated to 1/4 of the original volume. After it is cooled, crystals of N, M-malonyl-byc-novocaine with m. Pl fall out. 108-110 ° C (from benzene). Received by
продукт раствор ют в небольшом количестве спирта и к смеси доливают рассчитанное количество спиртового раствора НС1. После некоторого сто ни выоавшие кристаллы отфильтровывают и сушат под вакуумом.the product is dissolved in a small amount of alcohol and a calculated amount of an alcoholic solution of HCl is added to the mixture. After some standing, the dried crystals are filtered and dried under vacuum.
Выход продукта около 40о/о, т. лл. 197- 198°С. Веш,ество хорошо растворимо в воде, хуже - Б этаноле, плохо - в органических растворител х.The product yield is about 40o / o, so l. 197-198 ° C. It is well soluble in water, worse - ethanol, poorly - in organic solvents.
С29Н420бЫ4С12.C29H420BY4S12.
Найдено, о/о: N 9,27; 9,18. Вычислено, о/о; N 9,13.Found, o / o: N 9.27; 9.18. Calculated o / o; N 9.13.
Предмет изобретени Subject invention
Способ получени N,N-мaлoнил-б«c-нoвoкаиндихлоргидрата , отличающийс тем, что основание новокаина конденсируют с недокисью углерода в бензоле с последующим переводом полученного продукта в дихлоргидратThe method of obtaining N, N-malonyl-b "c-novocaine dichlorohydrate, characterized in that the base of novocaine is condensed with carbon deficiency in benzene, followed by conversion of the obtained product into dihydrochloride
обычным способом.in the usual way.
Publications (1)
Publication Number | Publication Date |
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SU210868A1 true SU210868A1 (en) |
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