SU1833612A3 - Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity - Google Patents

Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity

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Publication number
SU1833612A3
SU1833612A3 SU4359472/04A SU4359472A SU1833612A3 SU 1833612 A3 SU1833612 A3 SU 1833612A3 SU 4359472/04 A SU4359472/04 A SU 4359472/04A SU 4359472 A SU4359472 A SU 4359472A SU 1833612 A3 SU1833612 A3 SU 1833612A3
Authority
SU
USSR - Soviet Union
Prior art keywords
phenyl
piperidino
diethylamino
pentane
amino
Prior art date
Application number
SU4359472/04A
Other languages
Russian (ru)
Inventor
М.Д. Машковский
Р.Г. Глушков
С.Я. Скачилова
Е.В. Дородникова
Л.В. Розенштраух
В.Г. Воронин
Н.К. Желтухин
Е.П. Анюховский
В.В. Нестеренко
Е.М. Черкасова
Original Assignee
Центр по химии лекарственных средств
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Центр по химии лекарственных средств filed Critical Центр по химии лекарственных средств
Priority to SU4359472/04A priority Critical patent/SU1833612A3/en
Application granted granted Critical
Publication of SU1833612A3 publication Critical patent/SU1833612A3/en

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Abstract

FIELD: medicine. SUBSTANCE: hydrochloride of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(N-piperidino)pentane having essential formulaand hydrochloride of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(N-diethylamino)pentane having essential formulaare prepared in acetone medium at 0-5 C. 1-phenyl-1-amino-5-(N-piperidino)- or (N-diethylamino)pentane dihydrochloride is used as reagent 1, p-nitrobenzoyl chloride being used as reagent 2. Their interaction is carried out in the presence of aqueous solution of NaOH. Yield of hydrochloride of 1-phenyl-1-(p-nitrobenzoylamino)-5-(N-piperidino)pentane is 67.3 %, its melting point being 128-130 C. Yield of hydrochloride of 1-phenyl-1-(p-nitrobenzoylamino)-5-(N-diethylamino)pentane is 62 %, its melting point being 59-61 C. EFFECT: improves quality of desired product. 4 tbl
SU4359472/04A 1987-12-08 1987-12-08 Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity SU1833612A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4359472/04A SU1833612A3 (en) 1987-12-08 1987-12-08 Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4359472/04A SU1833612A3 (en) 1987-12-08 1987-12-08 Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity

Publications (1)

Publication Number Publication Date
SU1833612A3 true SU1833612A3 (en) 1996-02-27

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ID=60541339

Family Applications (1)

Application Number Title Priority Date Filing Date
SU4359472/04A SU1833612A3 (en) 1987-12-08 1987-12-08 Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity

Country Status (1)

Country Link
SU (1) SU1833612A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2566818C2 (en) * 2013-11-15 2015-10-27 Вадим Альбертович Макаров Method of obtaining (±)n-[1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]-4-nitrobenzamide or its pharmaceutically acceptable salts and intermediate compound for obtaining thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2566818C2 (en) * 2013-11-15 2015-10-27 Вадим Альбертович Макаров Method of obtaining (±)n-[1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]-4-nitrobenzamide or its pharmaceutically acceptable salts and intermediate compound for obtaining thereof

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