SU1833612A3 - Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity - Google Patents
Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activityInfo
- Publication number
- SU1833612A3 SU1833612A3 SU4359472/04A SU4359472A SU1833612A3 SU 1833612 A3 SU1833612 A3 SU 1833612A3 SU 4359472/04 A SU4359472/04 A SU 4359472/04A SU 4359472 A SU4359472 A SU 4359472A SU 1833612 A3 SU1833612 A3 SU 1833612A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- phenyl
- piperidino
- diethylamino
- pentane
- amino
- Prior art date
Links
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
FIELD: medicine. SUBSTANCE: hydrochloride of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(N-piperidino)pentane having essential formulaand hydrochloride of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(N-diethylamino)pentane having essential formulaare prepared in acetone medium at 0-5 C. 1-phenyl-1-amino-5-(N-piperidino)- or (N-diethylamino)pentane dihydrochloride is used as reagent 1, p-nitrobenzoyl chloride being used as reagent 2. Their interaction is carried out in the presence of aqueous solution of NaOH. Yield of hydrochloride of 1-phenyl-1-(p-nitrobenzoylamino)-5-(N-piperidino)pentane is 67.3 %, its melting point being 128-130 C. Yield of hydrochloride of 1-phenyl-1-(p-nitrobenzoylamino)-5-(N-diethylamino)pentane is 62 %, its melting point being 59-61 C. EFFECT: improves quality of desired product. 4 tbl
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4359472/04A SU1833612A3 (en) | 1987-12-08 | 1987-12-08 | Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4359472/04A SU1833612A3 (en) | 1987-12-08 | 1987-12-08 | Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity |
Publications (1)
Publication Number | Publication Date |
---|---|
SU1833612A3 true SU1833612A3 (en) | 1996-02-27 |
Family
ID=60541339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU4359472/04A SU1833612A3 (en) | 1987-12-08 | 1987-12-08 | Hydrochlorides of 1-phenyl-1-(p-nitrobenzoyl amino)-5-(n-piperidino)- or (n-diethylamino)pentanes having antiarrythmic and antifibrillation activity |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU1833612A3 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2566818C2 (en) * | 2013-11-15 | 2015-10-27 | Вадим Альбертович Макаров | Method of obtaining (±)n-[1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]-4-nitrobenzamide or its pharmaceutically acceptable salts and intermediate compound for obtaining thereof |
-
1987
- 1987-12-08 SU SU4359472/04A patent/SU1833612A3/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2566818C2 (en) * | 2013-11-15 | 2015-10-27 | Вадим Альбертович Макаров | Method of obtaining (±)n-[1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]-4-nitrobenzamide or its pharmaceutically acceptable salts and intermediate compound for obtaining thereof |
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