SU1826901A3 - Chewing gum exhibiting anticarious effect - Google Patents

Description

The invention relates to medicine, namely to dentistry and relates to therapeutic prophylactic chewing gums used to strengthen blood vessels, for the prevention of caries and periodontal inflammation.

The purpose of the invention is to increase the activity of the gum.

Ascorbic acid is used to prevent dental caries in children. However, it is used internally in large quantities, exerting action through participation in the body's metabolism. The effect of vitamin C in the gum is affected by the formation of new compounds with its other components and elements containing in saliva. In this case, blood vessels are strengthened and an anti-inflammatory effect is manifested.

Ethyl alcohol was introduced into the composition of chewing gum - 2.0-3.0 wt.% As a solvent and a bactericidal component.

As a flavoring, you can use, for example, essential oil (0.51.0 wt.%).

To obtain a preventive effect, chewing gum is chewed for 15-20 minutes. During this time, the ascorbic acid containing it enters the saliva and into the body as a whole through the gastrointestinal tract, into the periodontal tissue and by diffusion onto the tooth enamel.

Chewing gum is made as follows.

A mass of chewing gum is produced in a batch process. The vinyl acetate oligomer is subjected to heat treatment by continuous stirring in a heating mixer at a temperature of 80 ° -90 ° C. After its melting, an aqueous solution of ascorbic acid is added in a prescription amount, without stopping mixing, alcohol is added, then an NLW food alloy (beeswax, paraffin, margarine), all these components are mixed with the base until a homogeneous mass of chewing gum is obtained at a temperature of 1826901 AZ re 50 ^о -65 ° C. essential oil and aromatic essences are added, the whole mass is mixed until homogeneous, the chewing mass with a temperature of 5065 ° C is transferred to a cooling table and cooled to 40-42 ° C. Shaping and wrapping gum is made on forming equipment.

P. Example 1. A study was carried out of tooth decay of 2 groups of workers working in industrial enterprises under the conditions of using organic and inorganic compounds.

Persons of the control group are assigned to group 1, and persons who received chewing gum containing wt.%:

Wax 1.5 Paraffin 1,5 Margarine 3,5 Ethanol rectified n / a 2.0 Shock absorber 0.5 Ascorbic acid 1.0 Basis 90.0 Chewing offered elastic

applied 1 piece per day for a month, twice a year.

The data are given in table 1,.

From table 1 it is seen that the intensity of dental caries is significantly less in individuals who use the inventive chewing gum.

PRI me R 2, Investigations of some biochemical parameters of saliva in 40 student volunteers before and after 10, 15, 40 minutes after chewing gum containing wt.%:

Wax 2.0 Paraffin 2.0 Margarine 5,0 Ethanol rectified n / a ' 3.0 Flavoring 1,0 Ascorbic acid 2.0 The foundation 85.0

The data are presented in table 2 ,.

From table 2 it is seen that the use of the inventive chewing gum leads to an increase in buffer capacity, the content of inorganic phosphorus and calcium, as well as ascorbic acid in saliva, which favorably affects the state of organs and tissue of the oral cavity.

Example Z. The study of the periodontal status in dynamics, using the indices and criteria for bleeding, proposed by WHO, in individuals who received chewing gum containing, wt.%:

Wax 1.7

Paraffin 1.7

Margarine 4.0

Rectified ethyl alcohol in / about 2.5

Flavor0.7

Ascorbic acid 1.5

Base87.9

The data are given in table.3.

From table.Z it is seen that the use of the inventive chewing gum leads to a decrease in bleeding gums.

Thus, the proposed gum has a higher carioprophylactic activity.

Claims (1)

Claim Chewing gum, possessing a carioprophylactic action, containing a base, an active substance and a flavor, characterized in that, in order to increase activity, it contains wax, paraffin, margarine, ethyl alcohol and ascorbic acid as the active substance in the following, with respect to components, wt .%: Wax 1.5-2.0: Paraffin 1.5-2.0; Margarine 3.5-5.0: Ethanol 2-3; Flavoring 0.5-1.0: Ascorbic acid 1-2: The foundation Rest. Table 1 Survey Group workers Duration of observation year ....... The number of persons examined CPU tooth Intensity R 1 2 62 687 11.08 ± 0.68 P <0.001 2 2 63 494 7.84 ± 0.51 1 4 66 1011 15.32 ± 0.52 P <0.00g 2 4 69 721 10.45 ± 0.66 table 2 n / a Experience Conditions Buffer capacity, meq / l Calcium, mmol / L Φοόφορ, mmol / l ' ...........1·. BIT Γ · ι Vitamin C kmol / L 1. Background saliva 6.46 ± 0.15 2.03 ± 0.09 0.64 ± 0.03 6.55 ± 0.67 2. Saliva through 10 min same vania 6.60 ± 0.14 3.01 ± 0.16 0.73 ± 0.04 10.1 ± 0.81 P <0.001 P <0.01 3 Saliva after 15 minutes. after chewing NII 7.13 ± 0.17 3.03 ± 0.14 0.81 ± 0.04 7.93 ± 0.50 P <0.05 P <0.01 P <0.05 4. Saliva through 40 min after chewing 6.65 ± 0.12 2.81 ± 0.16 0.75 ± 0.04 6.18 ± 0.45 P <0.01 Table 3 Multiplicity of examination with an interval of 6 months Number of workers surveyed Gum bleeding index by segments for workers aged 35-44 years R 1 20 0.85 ± 0.28 2 20 0 3.04 3 P <0.01 3 20 0 3.04 3 P <0.01 4 20 0,053 ± 0,05 3.8 2.6 P <0.01 5 20 0.15 ± 0.15 2.2 2 P <0.05 6 20 0 3.04 3 P <0.01