SU1734353A1 - Method of synthesis of amino acid phosphorylated conjugates - Google Patents

Method of synthesis of amino acid phosphorylated conjugates

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Publication number
SU1734353A1
SU1734353A1 SU4812436/04A SU4812436A SU1734353A1 SU 1734353 A1 SU1734353 A1 SU 1734353A1 SU 4812436/04 A SU4812436/04 A SU 4812436/04A SU 4812436 A SU4812436 A SU 4812436A SU 1734353 A1 SU1734353 A1 SU 1734353A1
Authority
SU
USSR - Soviet Union
Prior art keywords
synthesis
conjugates
products
chor
palmitoyl
Prior art date
Application number
SU4812436/04A
Other languages
Russian (ru)
Inventor
А.А. Озеров
А.К. Брель
М.С. Новиков
Original Assignee
А.А. Озеров
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by А.А. Озеров filed Critical А.А. Озеров
Priority to SU4812436/04A priority Critical patent/SU1734353A1/en
Application granted granted Critical
Publication of SU1734353A1 publication Critical patent/SU1734353A1/en

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Abstract

FIELD: organophosphorous compounds. SUBSTANCE: products: phosphorylated conjugates of amino acids of the formulawhere X a residue of glycine, β-alanine, g-aminobutyric acid, DL-aspartic acid, DL-glutamic acid, L-proline, L-leucine, DL-methionine or b-phenyl-b-alanine; R-CH, CHor 1-adamantyl; R-H H or palmitoyl; R-CHor CH, n 1 or 2. Synthesis is carried out by reaction of N-acyl-derivatives of amino acids of the formulawith 3-dialkoxyphosphorylpropylglycidyl esters of the formula. R, X, n and Rhave indicated meanings, at molar ratio of reagents 1.0:(1.0-2.5) in the medium of polar aprotonic solvent dimethylformamide or dimethylsulfoxide at 80-155 C in atmosphere of inert gas. Product is isolated where Rhydrogen or product is converted to palmitoyl-derivative where Rpalmitoyl. The yield of products is 62.5-91.4% Synthesized products show vascular and psychotropic activities and can be used in medicine and pharmacology. EFFECT: improved method of synthesis. 3 tbl
SU4812436/04A 1990-04-09 1990-04-09 Method of synthesis of amino acid phosphorylated conjugates SU1734353A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4812436/04A SU1734353A1 (en) 1990-04-09 1990-04-09 Method of synthesis of amino acid phosphorylated conjugates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4812436/04A SU1734353A1 (en) 1990-04-09 1990-04-09 Method of synthesis of amino acid phosphorylated conjugates

Publications (1)

Publication Number Publication Date
SU1734353A1 true SU1734353A1 (en) 1995-12-20

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ID=60530859

Family Applications (1)

Application Number Title Priority Date Filing Date
SU4812436/04A SU1734353A1 (en) 1990-04-09 1990-04-09 Method of synthesis of amino acid phosphorylated conjugates

Country Status (1)

Country Link
SU (1) SU1734353A1 (en)

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