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FIELD: organophosphorous compounds. SUBSTANCE: products: phosphorylated conjugates of amino acids of the formulawhere X a residue of glycine, β-alanine, g-aminobutyric acid, DL-aspartic acid, DL-glutamic acid, L-proline, L-leucine, DL-methionine or b-phenyl-b-alanine; R-CH, CHor 1-adamantyl; R-H H or palmitoyl; R-CHor CH, n 1 or 2. Synthesis is carried out by reaction of N-acyl-derivatives of amino acids of the formulawith 3-dialkoxyphosphorylpropylglycidyl esters of the formula. R, X, n and Rhave indicated meanings, at molar ratio of reagents 1.0:(1.0-2.5) in the medium of polar aprotonic solvent dimethylformamide or dimethylsulfoxide at 80-155 C in atmosphere of inert gas. Product is isolated where Rhydrogen or product is converted to palmitoyl-derivative where Rpalmitoyl. The yield of products is 62.5-91.4% Synthesized products show vascular and psychotropic activities and can be used in medicine and pharmacology. EFFECT: improved method of synthesis. 3 tbl
SU4812436/04A1990-04-091990-04-09Method of synthesis of amino acid phosphorylated conjugates
SU1734353A1
(en)
Process for the preparation of D-maltose monoesters with a high content of 6-0'-esters and their use in cosmetics, dentifrices, pharmaceuticals and food
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