SU1694063A3 - Method of obtaining derivatives of 6-fluorine-1,4-dihydro-oxo-7-substituted by piperazinylquinoline - Google Patents

Method of obtaining derivatives of 6-fluorine-1,4-dihydro-oxo-7-substituted by piperazinylquinoline Download PDF

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Publication number
SU1694063A3
SU1694063A3 SU843799807A SU3799807A SU1694063A3 SU 1694063 A3 SU1694063 A3 SU 1694063A3 SU 843799807 A SU843799807 A SU 843799807A SU 3799807 A SU3799807 A SU 3799807A SU 1694063 A3 SU1694063 A3 SU 1694063A3
Authority
SU
USSR - Soviet Union
Prior art keywords
fluorine
dihydro
piperazinylquinoline
oxo
general formula
Prior art date
Application number
SU843799807A
Other languages
Russian (ru)
Inventor
Итох Ясуо
Като Хидео
Огава Нобуо
Косинака Эйити
Сузуки Томио
Яги Нориюки
Original Assignee
Хокурику Фармасьютикал Ко, Лтд, (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP17127183A external-priority patent/JPS6064979A/en
Priority claimed from JP12378084A external-priority patent/JPS615075A/en
Application filed by Хокурику Фармасьютикал Ко, Лтд, (Фирма) filed Critical Хокурику Фармасьютикал Ко, Лтд, (Фирма)
Application granted granted Critical
Publication of SU1694063A3 publication Critical patent/SU1694063A3/en
Priority to LTRP1004A priority Critical patent/LT2516B/en
Priority to LV931192A priority patent/LV5500A3/en

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Description

Гидрохлорид. S -(-)-, Мг-34,1Hydrochloride. S - (-) -, Mg-34.1

(с-1, хлороформ).(s-1, chloroform).

Табл ца2Table2

Таблица4Table4

;Номер примера, в котором получено соединение, или препарат; Number of the example in which the compound was obtained, or the drug

0-60-6

514514

659659

344344

6363

Гидрохлорид. Свободное соединение.Hydrochloride. Loose connection

Скорость мочевой экстракции за 0-24 ч,The rate of urinary extraction for 0-24 h

Г 6-24G 6-24

30 75 41 1030 75 41 10

Т а б л и ц а- 5T a b l and c a- 5

Claims (3)

Способ получения производных 61 фтор-1,4-дигидро-4-оксо~7-замещенной ;пиперазинилхинолин—3—карбоновой кислоты общей ФормулыThe method of obtaining 61-fluoro-1,4-dihydro-4-oxo-7-substituted derivatives; piperazinylquinoline — 3 — carboxylic acid of the general Formula ОABOUT где — низший алкил с 1—4 атомами углерода, 2-фторэ1гил, винил или 2—гидроксиэтил;where is lower alkyl with 1-4 carbon atoms, 2-fluoroyl, vinyl or 2 — hydroxyethyl; 22 и К^. — каждый представляет собойand K ^. - each represents атом водорода или метйл;a hydrogen atom or a methyl; К.£ — низший алкил с 1—2 атомами углерода;K. £ is lower alkyl with 1–2 carbon atoms; К 6 - атом водорода или фтора, отличающийся тем, чтоK 6 - a hydrogen or fluorine atom, characterized in that 6-фтор—7—галоген—1,4—дигидро—4—оксохинолин—3—карбоновую кислоту общей формулы6-fluorine — 7 — halogen — 1,4 — dihydro — 4 — oxoquinoline — 3 — carboxylic acid of the general formula где и имеют указанные значения; X - атом хлора ипи фтора,where and have the specified values; X is a chlorine atom of fluorine, подвергают взаимодействию с производным пиперазина общей Формулыsubjected to interaction with a derivative of piperazine General Formula сwith ίβίβ где имеют указанные значения,where have the indicated meanings в среде органического растворителя при кипечении реакционной массы с выделением целевого продукта в сво— < бодном виде или в виде Фармацевтически приемлемой соли.in the medium of an organic solvent during the boiling of the reaction mass with the release of the target product in its free form or in the form of a pharmaceutically acceptable salt. 1694063 АЗ 1 694063 AZ 33 16940631694063 дd
SU843799807A 1983-09-19 1984-09-18 Method of obtaining derivatives of 6-fluorine-1,4-dihydro-oxo-7-substituted by piperazinylquinoline SU1694063A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
LTRP1004A LT2516B (en) 1983-09-19 1993-09-20 ACTICALLY ACCEPTABLE SALT PREPARATION 6-FLUORO-1,4-DIHYDRO-4-OXO-7-REPLACED PIPERAZINILCHINOLIN-3-CARBONINE SACRAMINE OR FUEL
LV931192A LV5500A3 (en) 1983-09-19 1993-11-11 Contribution to the production of 6-fluoro-1,4-dihydro-4-osko-7- (substituted piperazino) -quinoline-3-carbonyl derivatives or their pharmaceutically acceptable islands

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17127183A JPS6064979A (en) 1983-09-19 1983-09-19 7-piperazine-substituted-6-fluoro-4-oxo-1,4- dihydroquinoline-3-carboxylic acid derivative
JP12378084A JPS615075A (en) 1984-06-18 1984-06-18 6-fluoro-1,4-dihydro-4-oxo-7-substituted piperazinyl quinoline-3-carboxylic acid derivative

Publications (1)

Publication Number Publication Date
SU1694063A3 true SU1694063A3 (en) 1991-11-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SU843799807A SU1694063A3 (en) 1983-09-19 1984-09-18 Method of obtaining derivatives of 6-fluorine-1,4-dihydro-oxo-7-substituted by piperazinylquinoline

Country Status (3)

Country Link
GE (1) GEP19981255B (en)
SU (1) SU1694063A3 (en)
UA (1) UA6324A1 (en)

Also Published As

Publication number Publication date
GEP19981255B (en) 1998-07-07
UA6324A1 (en) 1994-12-29

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