SU1622016A1 - Centrifuge for cleaning sterile liquid - Google Patents

Abstract

The invention relates to medical biotechnology equipment, in particular to flow centrifuges from sampling of sterile fluid during the course of rotation of the rotor. The aim of the invention is to ensure the sterility of the product. A centrifuge for cleaning sterile liquid contains a cylindrical rotor 1 mounted on the vertical shaft 4 in the casing 12. The rotor 1 has a crossbar with blades 5 for unraveling

Description

Invented from relates to medical biotechnology equipment, in particular to flow-through centrifuges with the selection of sterler on the course of rotation of the rotor,

The aim of the invention is to ensure the sterility of the product during the cleaning.

From FIG. 1 shows a centrifuge, a cross section along the axis of the rotor; in fig. 2 - fastening of the rotor with a shutter before heat sterilization.

A centrifuge for cleaning a sterile liquid (FIG. 1) consists of a cylindrical rotor 1, the internal cavity of which is closed by a lid 2 with a neck 3 for outputting the purified product. The cover 2 is screwed on the thread at the end of the rotor. The rotor 1 is mounted on a vertical shaft 4. A cross with blades 5 is installed inside the rotor for unwinding and centrifugally pumping out the initial fluid entering through the feed pipe b. In the center of the cross, you have a hole with a thread 7, which contributes to the ohhachka. The fluid moves along the thread 7 as the rotor rotates. The diameter of the screw hole is smaller than the internal diameter of the neck 3. A receiver of the purified liquid is installed on top of the rotor, which is also a gate valve to prevent penetration of contaminating microflora into the rotor. The receiver is made in the form of a cup, having a shell 8 in the center, and a bottom 9 below. Between the bottom of the cup and the rotor cover, as well as between its shell and the neck 3, there is an air gap for the passage of sterile air with the formation of an air seal. Inside the cup there is a partition 15, which divides the cavity of the cup into two parts: the top one to collect the cleaned liquid thrown from the rotating neck, and the bottom one to form a laminar

gas flow. The purified liquid flows out through the elastic tube 16. Channel 17 is designed to remove randomly accumulating liquid at the bottom of the glass. On the outer surface of the bottom there is a groove in which the gasket 18 is pressed in to seal the valve against the rotor during sterilization (Fig. 2). Pressing the gate to the rotor for the period of their sterilization is carried out with the help of bolts-grips 19.

Centrifuge parts for precise alignment during assembly have guide grooves, which ensures uniform air gaps between the neck 3,

shell 8 and overheating 15. In the casing 12, holes 20 are made to allow air to escape from the valve.

The centrifuge works as follows.

Initially, the rotor is assembled, the cover 2 is screwed on. A shutter is installed on the top of the rotor and bolted with hooks 19. The fittings of the inlet and outlet pipelines are closed with paper

caps, Sterilize the rotor with the valve in the steam sterilizer. Then the pipes are connected under sterile conditions and the rotor with the gate is installed in the centerfuge. Overlap the pipelines with clamps and supply sterile air to the nozzle 13, creating an overpressure in the rotor cavity and the valve. The bolts are released and the rotor moves away from the bottom 9 and lowers onto the shaft 4, opening a continuous

the movement of sterile air to the outside of the rotor along the gap between the neck and the shell, the bottom of the glass and the rotor cover. The sterile gas stream pushes microorganisms diffusing into the gap, as a result of which air bacteria do not penetrate into the rotor. When the sterile protection is working, the catch bolts are removed, the cover 11 is fixed. Then the initial preparation is injected into the rotor, fill it with

2/3 volume, so that the liquid does not leak when the rotor rotates. The rotor is accelerated to 3000 rpm and more and the preparation is centrifuged to a clean state, and then served

source fluid continuously. The cleaned product flows out of the collar of the neck 3 and is thrown by centrifugal force onto the partition 15, and from there along the tube 1b flows into a sterile container (not shown). Small amounts of product from channel 17 are diverted to this capacity,

Claims (1)

The invention allows the creation of sterile closures without mechanical friction, ensuring the sterility of the target product with continuous centrifugation and eliminating the need for sterilizing filtration after cleaning. Claims of the invention A centrifuge for cleaning a sterile liquid containing a cylindrical cylinder mounted in a casing on a vertical shaft. a rotor comprising a spider with paddles for spinning the liquid and a lid with a throat for withdrawing the purified liquid, feeding pipe and receiver of the purified liquid, characterized in that, in order to ensure the sterility of the product during cleaning, the receiver of the purified liquid is attached to the casing cover and in the form of a glass having a shell in the center and provided with a nozzle for supplying sterile air to the lower part of the glass, while the glass is installed to form a rotor between its bottom and rotor cover, as well as between its shell and the mouth of the rotor gap for the passage of sterile air with the formation of air shutters.