SU1584341A1 - Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity - Google Patents

Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity

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Publication number
SU1584341A1
SU1584341A1 SU4667841/04A SU4667841A SU1584341A1 SU 1584341 A1 SU1584341 A1 SU 1584341A1 SU 4667841/04 A SU4667841/04 A SU 4667841/04A SU 4667841 A SU4667841 A SU 4667841A SU 1584341 A1 SU1584341 A1 SU 1584341A1
Authority
SU
USSR - Soviet Union
Prior art keywords
stage
piperazine
activity
chlorocarbazolyl
hydroxypropyl
Prior art date
Application number
SU4667841/04A
Other languages
Russian (ru)
Inventor
А.Т. Долженко
Л.И. Костенко
Т.Ф. Ларина
А.А. Мирошниченко
Д.Д. Мысык
Л.А. Перельман
Л.В. Тарнопольская
Н.А. Харин
Original Assignee
Институт физико-органической химии и углехимии АН УССР
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Институт физико-органической химии и углехимии АН УССР filed Critical Институт физико-органической химии и углехимии АН УССР
Priority to SU4667841/04A priority Critical patent/SU1584341A1/en
Application granted granted Critical
Publication of SU1584341A1 publication Critical patent/SU1584341A1/en

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Abstract

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out by interaction of 3-chloro-9-(2,3-epoxypropyl)-carbazole and piperazine or 4-methylpiperazine in ethanol medium at boiling following by treatment of prepared compound with HCl in ether medium. Yield, %; m. p. C; empirical formula: a) 82 (1-st stage), 86 (2-d stage); 250-251; CHClNO; b) 84 (1-st stage), 85 (2-d stage); 271-273; CHClNO. Anxiolytic activity of new compounds exceeds that of ipsapiron, muscle-relaxing activity is equal with latter, they show less expressed total depressing effect at lower toxicity LD= 130-145 mg/kg as compared with that 105 mg/kg for ipsapiron. EFFECT: synthesis of new compounds with increased activity and decreased toxicity. 4 tbl
SU4667841/04A 1989-02-06 1989-02-06 Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity SU1584341A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4667841/04A SU1584341A1 (en) 1989-02-06 1989-02-06 Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4667841/04A SU1584341A1 (en) 1989-02-06 1989-02-06 Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity

Publications (1)

Publication Number Publication Date
SU1584341A1 true SU1584341A1 (en) 1995-03-20

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ID=60527646

Family Applications (1)

Application Number Title Priority Date Filing Date
SU4667841/04A SU1584341A1 (en) 1989-02-06 1989-02-06 Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity

Country Status (1)

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SU (1) SU1584341A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512371A (en) * 1999-10-18 2003-04-02 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 9- (Piperazinylalkyl) carbazole as BAX modifier

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512371A (en) * 1999-10-18 2003-04-02 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 9- (Piperazinylalkyl) carbazole as BAX modifier
US8053436B1 (en) 1999-10-18 2011-11-08 Merck Serono Sa 9-(piperazinylalkyl) carbazoles as bax-modulators
US8410110B2 (en) 1999-10-18 2013-04-02 Merck Serono Sa 9-(piperazinylalkyl) carbazoles as Bax-modulators

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