SU1584341A1 - Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity - Google Patents
Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activityInfo
- Publication number
- SU1584341A1 SU1584341A1 SU4667841/04A SU4667841A SU1584341A1 SU 1584341 A1 SU1584341 A1 SU 1584341A1 SU 4667841/04 A SU4667841/04 A SU 4667841/04A SU 4667841 A SU4667841 A SU 4667841A SU 1584341 A1 SU1584341 A1 SU 1584341A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- stage
- piperazine
- activity
- chlorocarbazolyl
- hydroxypropyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
FIELD: organic chemistry. SUBSTANCE: synthesis is carried out by interaction of 3-chloro-9-(2,3-epoxypropyl)-carbazole and piperazine or 4-methylpiperazine in ethanol medium at boiling following by treatment of prepared compound with HCl in ether medium. Yield, %; m. p. C; empirical formula: a) 82 (1-st stage), 86 (2-d stage); 250-251; CHClNO; b) 84 (1-st stage), 85 (2-d stage); 271-273; CHClNO. Anxiolytic activity of new compounds exceeds that of ipsapiron, muscle-relaxing activity is equal with latter, they show less expressed total depressing effect at lower toxicity LD= 130-145 mg/kg as compared with that 105 mg/kg for ipsapiron. EFFECT: synthesis of new compounds with increased activity and decreased toxicity. 4 tbl
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4667841/04A SU1584341A1 (en) | 1989-02-06 | 1989-02-06 | Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4667841/04A SU1584341A1 (en) | 1989-02-06 | 1989-02-06 | Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
SU1584341A1 true SU1584341A1 (en) | 1995-03-20 |
Family
ID=60527646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU4667841/04A SU1584341A1 (en) | 1989-02-06 | 1989-02-06 | Derivatives of 1-((3-chlorocarbazolyl-9)-3-(2-hydroxypropyl))-piperazine showing anxiolytic activity |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU1584341A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003512371A (en) * | 1999-10-18 | 2003-04-02 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 9- (Piperazinylalkyl) carbazole as BAX modifier |
-
1989
- 1989-02-06 SU SU4667841/04A patent/SU1584341A1/en active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003512371A (en) * | 1999-10-18 | 2003-04-02 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 9- (Piperazinylalkyl) carbazole as BAX modifier |
US8053436B1 (en) | 1999-10-18 | 2011-11-08 | Merck Serono Sa | 9-(piperazinylalkyl) carbazoles as bax-modulators |
US8410110B2 (en) | 1999-10-18 | 2013-04-02 | Merck Serono Sa | 9-(piperazinylalkyl) carbazoles as Bax-modulators |
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