SU1568480A1 - N-{4-[bis-(2- chloroethyl)- amino]- phenylacetyl} -2-(4-fluorophenyl)-dl-alanine having antitumoral effect - Google Patents

N-{4-[bis-(2- chloroethyl)- amino]- phenylacetyl} -2-(4-fluorophenyl)-dl-alanine having antitumoral effect

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Publication number
SU1568480A1
SU1568480A1 SU4475322/04A SU4475322A SU1568480A1 SU 1568480 A1 SU1568480 A1 SU 1568480A1 SU 4475322/04 A SU4475322/04 A SU 4475322/04A SU 4475322 A SU4475322 A SU 4475322A SU 1568480 A1 SU1568480 A1 SU 1568480A1
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SU
USSR - Soviet Union
Prior art keywords
chloroethyl
fluorophenyl
alanine
bis
amino
Prior art date
Application number
SU4475322/04A
Other languages
Russian (ru)
Inventor
Р.Б. Клюкене
А.В. Марозене
К.И. Карпавичюс
В.Й. Шимкявичене
В.А. Лаукайтис
Я.В. Валавичене
Р.Г. Люткене
Original Assignee
Институт биохимии АН ЛитССР
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Application filed by Институт биохимии АН ЛитССР filed Critical Институт биохимии АН ЛитССР
Priority to SU4475322/04A priority Critical patent/SU1568480A1/en
Application granted granted Critical
Publication of SU1568480A1 publication Critical patent/SU1568480A1/en

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Abstract

FIELD: medicine. SUBSTANCE: synthesis is carried out by reaction 2-(fluorophenyl)-DL-alanine with 4-[bis-(2- chloroethyl)-amino] -phenylacetylchloride in the presence of sodium hydroxide. The process takes place in the medium of aqueous dioxane at temperature (-5)- (-20) C. Desired product has empirical formula CHClFNO, its yield is 56.4% , its melting point is 129-131 C. EFFECT: produces novel compound having improved efficiency. 2 tbl
SU4475322/04A 1988-08-18 1988-08-18 N-{4-[bis-(2- chloroethyl)- amino]- phenylacetyl} -2-(4-fluorophenyl)-dl-alanine having antitumoral effect SU1568480A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU4475322/04A SU1568480A1 (en) 1988-08-18 1988-08-18 N-{4-[bis-(2- chloroethyl)- amino]- phenylacetyl} -2-(4-fluorophenyl)-dl-alanine having antitumoral effect

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU4475322/04A SU1568480A1 (en) 1988-08-18 1988-08-18 N-{4-[bis-(2- chloroethyl)- amino]- phenylacetyl} -2-(4-fluorophenyl)-dl-alanine having antitumoral effect

Publications (1)

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SU1568480A1 true SU1568480A1 (en) 1994-01-30

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Application Number Title Priority Date Filing Date
SU4475322/04A SU1568480A1 (en) 1988-08-18 1988-08-18 N-{4-[bis-(2- chloroethyl)- amino]- phenylacetyl} -2-(4-fluorophenyl)-dl-alanine having antitumoral effect

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SU (1) SU1568480A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160016994A1 (en) * 2013-03-06 2016-01-21 Brandeis University Inhibition of tumor growth with aggregates of small molecules

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160016994A1 (en) * 2013-03-06 2016-01-21 Brandeis University Inhibition of tumor growth with aggregates of small molecules
US10308682B2 (en) * 2013-03-06 2019-06-04 Brandeis University Inhibition of tumor growth with aggregates of small molecules

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