SU1463302A1 - Method of curing alcoholism - Google Patents

Abstract

The invention relates to medicine, in particular, to addiction therapy, and can be used for treating one and chronic alcoholism. The purpose of the invention is to shorten the periods of withdrawal of withdrawal symptoms and vcTpa some kind of Perz pathological attraction to apcohol. For this, it is considered as quality; 5e medicinal parata use. Cholecystocyschitis 5 tons

Description

The invention relates to the field of medicine, namely to the means of the treatment of alcoholism.

The aim of the invention is to shorten the periods of stopping the abstinence syndrome and the elimination of the primary pathological attraction to alcohol.

The method is carried out as follows.

The drug cholecystokinin Punk reosimine is administered once intravenously at a dose of 1.5 U per 1 kg of weight to patients with alcoholism. Clinical example of the implementation of the method.

The patient is 28 years old and was admitted to the hospital with a diagnosis of chronic apocolism, Stage II, alcohol withdrawal syndrome. He suffered from alcoholism for 9 years. Repeatedly treated for alcoholism.

There were no remissions. Before entering for a long time, the daily abuse of liquor spilled. The last of the scientific research institute used alcohol on the night before hospitalization. Entered into a state of vyshkennogo alcoholic hangover. Emotional stress, anxiety, fear, hypertension, and - for several days, persistent insomnia with rare dreams of nightmarish content. Against the background of mental discomfort pronounced pathological craving for alcohol. In a patient, motor excitation is determined, he is disturbed by the palpation of weakness, headache, unsteadiness of gait, pronounced tremor, tonic spasms of the muscles of the limbs, nausea with urging to gag, sweating. The patient is diagnosed with tachycardia, a blood pressure of 150/95 mm Hg.

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The patient was intravenously slowly on C59% physiological saline. 95 VD Pancreozyminum was administered. Immediately after the drug administration, it noted with a significant improvement in the patient's physical AND mental state, as well as an improvement in state of health, subject to disability of the pathological result in alcohol. psycho-emotional stress weakens, anxiety disappears, fear, sleep is restored without nightmares. The patient remains weak, but is absent 1 | Agenic systemic tremor, tonic convulsions, urge to vomit, tahi |: arda. arterial hypertension (D 135/85 mm). The dopamine ypOBWi in the blood (ng / mp) before the administration of cholecystokinin 220, after 1 hour - 120, in a day - 100 in 3 days 135, in 7 days SZO Any side effects

Pancreozymina is not noted, Sam L: and the patient notes that, with the anticipation of the impurities in other medical institutions, the alcoholism has never been so complete and quickly removed the hangovers. Subsequently, a course of stationary treatment was discharged in a satisfactory shhh

Cholecystokinin administered to patients in a dosage in acute ukazashoy Abe tinentnom period causes of suppressing the craving for Cogolo al, removes psychomotor WHO buzhdenie3 gives trankviliziruyuschey ef fect, relieves anxiety and excitation intensity reduces postintoksika- tional autonomic disorders, smart creases .tremor normalizes index . blood pressure (table 1)

The preparation of cholecystokinin Punk reosimine, after a single intravenous administration in a dose of 1.5 U / kg of body weight for patients with alcoholism with aggravated pathological inclination to alcohol, in a short time helped to eliminate the desire to drink alcohol, reduced psycho motor, arousal, reduced anxiety and exhilaration rendered tranqui. lysing effect, did, more ordered the behavior of patients and

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most prevented breakdowns and relapses (table 2).

The patient, 44 years old, is observed ambulatory with a diagnosis of chronic alcoholism, Stage II

Suffering from alcoholism for 13 years. Repeatedly mistreated about chronic alcoholism. Relapse of abuse of alcohol occurred on the background. exacerbation of the pathological inclination to alcohol in remission. He complained about the appearance of increased irritability, conflict in relations with others, mental stress in combination with anxiety, agitation, lack of restraint, accompanied by a clearly expressed desire to drink alcohol. The patient's sleep worsened, deteriorated Arterial pressure of 145/90 mm

95 U of Cholecystokinin Pancreozyminin 0, physiological saline was administered to the patient intravenously. Physiological solution was significantly improved during the administration of the drug and during the hour after the administration. The patient's condition significantly decreased, and then the desire to drink alcohol disappeared, psychomotor agitation stopped, sedation The patient noted subjectively the feeling of great relief, mental clarity Significantly improved sleep, performance was fully restored Indicators of dopamine concentration in cr Before the introduction of the drug, 175 ng / MP, 3 hours after the injection, 100 ng / ml. During the follow-up, the craving for alcohol was not observed.

The reduction of AAS with cholecystokinin is carried out in a shorter period of less than 1 day (TX, 20.01, p = 0.01).

Coupling of AAS with cholecystokinin is carried out in a shorter time — less than 1 day (x 2--. 6,797, p: 0.05).

The reduction of the exacerbation of pathological absorption of alcohol with the help of cholecystokinin is carried out with a shorter period of less than 1 day (11., 728, p 0.01).

Thus, as can be seen from the tables, cholecystokinin is effective in treating patients with alcoholism and relieves the main manifestations of the disease in a short time - “less than 1 day, compared to baseline objects — seduxen and pyrroxane from 2 to 7 days

1463302

Claims (1)

The invention of the method of treating alcoholism, including the administration of drugs to the patient, is necessary in order to shorten the duration of withdrawal of the withdrawal syndrome and eliminate the primary pathological craving for alcohol, as a medicine cholecystokinin is administered Table 1 Duration of cholecystokinin withdrawal of alcohol withdrawal syndrome in patients with alcoholism table 2 Terms of stopping cholecystokinin pathological craving for alcohol in patients with alcoholism Table3 Comparison of the periods of relief of symptoms of alcohol withdrawal syndrome (AAS) using cholecystokinin and using traditional therapy (seduxen or pyroxan) in patients with stage II chronic alcoholism Group 1 (cholecystok nin) p-1 4 Group 2 (traditional treatment and seduksen or pirroksan) p-14 where n is the total number of patients in the group. 14 12 Table 4 Comparison of the periods of relief of symptoms of AAS using choledystokinin and using traditional therapy (seduxen or pirroksan) in patients with stage III chronic alcoholism patient group duration AAS one one less than 1 day more than 1 day Group 1 (cholecystitis NIN) ppl Group 2 (traditional treatment and seduksen or pirroksan) p-10 Table 5 Comparison of terms for stopping the symptoms of exacerbation of the pathological craving for alcohol (1№A) with the help of cholecystokinin and with the help of basic drugs (seduxen or pyroxan) in patients with stage II chronic alcoholism group of patients Group 1 (cholecystokinin) pp 2group (seduxen or pyr11 pp rock san) pp t Table 5 PVA duration less than 1 day more than 1 day