SU1232260A1 - Method of obtaining substance possessing antinicotine activity - Google Patents

Description

The invention relates to medicine, in particular to the pharmaceutical industry, and relates to methods for producing medicinal products from vegetable raw material.

The purpose of the invention is to obtain a substance possessing anti-nicotine activity from seed oats, due to the use of freshly harvested stems, leaves and inflorescences of seed oats as a source of raw material at the stage of milky-wax ripeness, and obtaining juice with a later temperature condition.

The method is carried out as follows.

Freshly harvested, washed stalks, leaves and inflorescence of oats in the stage of milky-wax ripeness are cut on a travoreek, then pressed under high pressure. The resulting juice is filtered through gauze filters, poured into bottles and frozen in an alcohol bath of the KS-30 sublimation unit at (-24) - (-30) C. After freezing, the product

stabilized in the bunker of the refrigeration unit for 18 hours at

(-18) - (- 25) C. In the subsequent pro - g.

water drying under vacuum conditions with the inclusion of heating, gradually bringing the final drying temperature of the product to 38-40 C.

Example 1. 100.5 kg of washed and dried in the air stalks with leaves and inflorescences of a seed oats in the stage of milky-wax ripeness are cut in a cutter, pressed under high pressure. Half-1nsh 1st juice in the amount of 28.3 liters is filtered through gauze filters, poured into 250 ml vials and frozen. Composer L. Pashuk Editor E. Papp Tehred I.Popovtsch Proofreader L. Pilipenko

Order 2722/6 Circulation 660 Subscription

VNIIPY USSR State Committee

for inventions and discoveries 113035, Moscow, Zh-35, Raushsk nab., 4/5

-Production and printing company, Uzhgorod, st. Project, 4

watered in an alcohol bath

Yield of sublimation apparatus

CS-30 for 25 min.

Then the product is stabilized in the bunker of the refrigeration unit for 18 hours at -18 s. Under the conditions of an initial vacuum of 45 µm with constant heating to 38 ° C and with a final vacuum of 55 µm, it is dried. The yield of the desired product is 8.4 kg, or 8.8% of the fresh raw material.

. Example 2. 100.0 kg of washed and dried in the air stalks with leaves and inflorescences of seed oats

in the period of the immature stage (up to the stage of milky-wax ripeness), cut by a cutting knife and pressed under high pressure. The resulting juice in the amount of 35.2 l is filtered through gauze filters, poured into 250 ml bottles and frozen in an alcohol bath of the KS-30 sublimation unit at the temperature of the alcohol. Then stabilization is carried out.

product in the bunker of the refrigeration unit for 18 hours at. The stabilized juice in uncorked vials is dried under vacuum not less than 60 microns with the inclusion of heating with a final temperature of 40 C. The final moisture content of the dry target product is up to 2%, its output is 6.8 kg, which corresponds to 6.3% of fresh raw material .

Obtained by the proposed method

the substance has a pronounced anti-nicotine activity: the consumption of chewing gum by smokers, which contains 0.5 oats juice lyophillate, has led to a reduction in daily cigarette consumption by 80% of the initial level.

Claims (1)

METHOD FOR PRODUCING ANTINICOTINE ACTIVE SUBSTANCE KNIFE, characterized in that the crushed leaves, stems and inflorescences of the oats are squeezed out, the juice is filtered, lyophilized at a temperature of (-24) - (-30) ⁱⁿ C, kept at a temperature of (-18) - (- 25) ⁱⁿ C for 18 hours, and then dried in vacuum with a gradual increase in temperature to 38-40 ° C.