SU1178408A1 - Method of differential diagnosis of the primary and secondary hypogonadism of the male - Google Patents

Method of differential diagnosis of the primary and secondary hypogonadism of the male Download PDF

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SU1178408A1
SU1178408A1 SU833648537A SU3648537A SU1178408A1 SU 1178408 A1 SU1178408 A1 SU 1178408A1 SU 833648537 A SU833648537 A SU 833648537A SU 3648537 A SU3648537 A SU 3648537A SU 1178408 A1 SU1178408 A1 SU 1178408A1
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primary
patient
increase
secondary hypogonadism
hypogonadism
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SU833648537A
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Russian (ru)
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Александр Григорьевич Резников
Степан Васильевич Варга
Елена Абрамовна Беникова
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Киевский научно-исследовательский институт эндокринологии и обмена веществ
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Abstract

СПОСОБ ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКИ ПЕРВИЧНОГО И ВТОРИЧНОГО ГИПОГОНАДИЗМА У ЛИЦ МУЖСКОГО ПОЛА .путем введени  больному лекарствен-ных препаратов, воздействующих на секрецию лютинизирующего гормоотличающийс  на. тем. что, с целью повьшени  точности диагностики, больному ввод т нифтолид перорально в дозе 10 мг/кг массы тела в сутки, определ ют суточную экскрецию лютеинизирующего гормона с мочой через 3-5 сут и при увеличении этого показател  более чем в 1,5 раза от исходного уровн  диагностируют первичный гипогонасл дизм, а при увеличении менее, чем в 1,5 раза - вторичньш гипогонадизм .METHOD OF DIFFERENTIAL DIAGNOSTICS OF PRIMARY AND SECONDARY HYPOGONADISM IN THE FACE OF THE MALE FLOOR. By administering drugs to the patient that affect the secretion of lutealizing hormone that is different. topics that, in order to improve the accuracy of diagnosis, the patient was administered nifolide orally at a dose of 10 mg / kg of body weight per day, determine the daily excretion of luteinizing hormone in urine after 3-5 days and with an increase of more than 1.5 times the initial level is diagnosed with primary hypogonasdism, and with an increase of less than 1.5 times, secondary hypogonadism.

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00 4 1 Изобретение относитс  к медици й в частности к эндокринологии, и может быть использовано дл  диагностики мужского гипогонадизма. Целью изобретени   вл етс  повышение точности диагностики. П р и м е р 1. Больной 19 лет, поступил в клинику дл  уточнени  диагноза гипогонадизма. У больного была собрана суточна  моча и в ее аликвоте бьшо определено содержание лютеинизирующего гормона (ЛГ) по методу Wide. Результат 58 ,1 МЕ/сут. В течение трех дней больной принимал внутрь через 20 мин после еды нифтолид по полтаблетки (125 мг) 3 раза в день. На третьи сутки приема нифтолида у больного собирали суточную мочу. Пр повторном определении ЛГ бьшо установлено , что зкскреци  гормона составл ла 87 МЕ/сут. Таким образом, увеличение экскреции ЛГ превысило исходньй уровень в 1,54 раза. На основании результатов пробы был 8 поставлен диагноз первичного гипогонадизма . Последующее комплексное клинико-лабораторное исследование подтвердило диагноз первичного гипогонадизма . Пример 2. Больной 16 лет, поступил в клинику с целью уточнени  диагноза и назначени  патогенетической терапии. В собранной суточной моче было определено содержание ЛГ, по Wide - 8,2 МЕ/сут. Больной в течение 5 дней принимал нифтолид по 3/4 таблетки (180 мг) 3 раза в день через 20 мин после еды. В суточной моче, собранной на п тые сутки приема нифтолида, вновь было проведено определение ЛГ. Результат:9,0 МЕ/сут на п тые сутки. Отсутствие прироста экскреции ЛГ свидетельствует об истощении функциональных резервов гипоталамо-гипофизарной системы. На основании полученных данных бьш поставлен диагноз вторичного гипогонадизма .00 4 1 The invention relates to medicine, in particular, to endocrinology, and can be used to diagnose male hypogonadism. The aim of the invention is to improve the accuracy of diagnosis. PRI me R 1. A patient, 19 years old, was admitted to the clinic to clarify the diagnosis of hypogonadism. The patient was collected daily urine and in its aliquot was determined by the content of luteinizing hormone (LH) according to the method of the Wide. Result 58, 1 IU / day. For three days, the patient took orally 20 minutes after eating nifolid half a tablet (125 mg) 3 times a day. On the third day of taking niftolide, daily urine was collected from the patient. In the repeated determination of LH, it was established that the hormone secretion was 87 IU / day. Thus, the increase in LH excretion exceeded the baseline level by 1.54 times. Based on the test results, 8 was diagnosed with primary hypogonadism. A subsequent comprehensive clinical and laboratory study confirmed the diagnosis of primary hypogonadism. Example 2. A 16-year-old patient was admitted to the clinic for the purpose of clarifying the diagnosis and prescribing pathogenetic therapy. The content of LH in the collected daily urine was determined; for Wide - 8.2 IU / day The patient took nftolid 3/4 tablets (180 mg) 3 times a day 20 minutes after meals for 5 days. In the daily urine collected on the 5th day of nifoldide intake, the LH was again determined. Result: 9.0 IU / day for the fifth day. The lack of increase in the excretion of LH indicates the depletion of the functional reserves of the hypothalamic-pituitary system. Based on the data obtained, secondary hypogonadism was diagnosed.

Claims (1)

СПОСОБ ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКИ ПЕРВИЧНОГО И ВТОРИЧНОГО ГИПОГОНАДИЗМА У ЛИЦ МУЖСКОГО ПОЛА путем введения больному лекарствен-ных препаратов, воздействующих на секрецию лютинизирующего гормона, отличающийся тем, что, с целью повышения точности диагностики, больному вводят нифтолид перорально в дозе 10 мг/кг массы тела в сутки, определяют суточную экскрецию лютеинизирующего гормона с мочой через 3-5 сут и при увеличении этого показателя более чем в 1,5 раза от исходного уровня $ диагностируют первичный гипогонадизм, а при увеличении менее, чем в 1,5 раза - вторичный гипогонадизм.METHOD FOR DIFFERENTIAL DIAGNOSIS OF PRIMARY AND SECONDARY HYPOGONADISM IN MEN FACILITIES by administering to the patient medications that affect the secretion of lutinizing hormone, characterized in that, in order to increase the accuracy of diagnosis, 10 mg of nifolide per day is administered to the patient in body weight per day , determine the daily excretion of luteinizing hormone with urine after 3-5 days and with an increase of this indicator more than 1.5 times from the initial level $, primary hypogonadism is diagnosed, and with an increase in e than 1.5 times the - secondary hypogonadism. S-U 1178408S-U 1178408 I 1178408 2I 1178408 2
SU833648537A 1983-07-27 1983-07-27 Method of differential diagnosis of the primary and secondary hypogonadism of the male SU1178408A1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2712180C1 (en) * 2019-07-25 2020-01-24 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Diagnostic method of central hypogonadism in females

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M.E.Shoep, H.Doorenbos, W.S.de Zande: The effect of LK-RH infusion on serum LH, FSH, and tesbosterone .in boys with advanced Puberty, delayed puberty and hypogona dotrophic hypogonadiem, Acto and ocrind, (KGh) , 1978, 89, 2, 209-216. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2712180C1 (en) * 2019-07-25 2020-01-24 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Diagnostic method of central hypogonadism in females

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