SU115905A1 - Drug gangleron - Google Patents

Drug gangleron

Info

Publication number
SU115905A1
SU115905A1 SU597760A SU597760A SU115905A1 SU 115905 A1 SU115905 A1 SU 115905A1 SU 597760 A SU597760 A SU 597760A SU 597760 A SU597760 A SU 597760A SU 115905 A1 SU115905 A1 SU 115905A1
Authority
SU
USSR - Soviet Union
Prior art keywords
acid
gangleron
ester
drug
chloride
Prior art date
Application number
SU597760A
Other languages
Russian (ru)
Inventor
Н.Е. Акопян
н Н.Е. Акоп
В.Г. Африкян
н В.Г. Африк
М.Т. Григорян
н М.Т. Григор
А.Л. Мнджоян
н А.Л. Мнджо
Original Assignee
Н.Е. Акопян
н Н.Е. Акоп
В.Г. Африкян
н В.Г. Африк
М.Т. Григорян
н М.Т. Григор
А.Л. Мнджоян
н А.Л. Мнджо
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Н.Е. Акопян, н Н.Е. Акоп, В.Г. Африкян, н В.Г. Африк, М.Т. Григорян, н М.Т. Григор, А.Л. Мнджоян, н А.Л. Мнджо filed Critical Н.Е. Акопян
Priority to SU597760A priority Critical patent/SU115905A1/en
Application granted granted Critical
Publication of SU115905A1 publication Critical patent/SU115905A1/en

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

Предлагаетс  ганглерон-хлоргидрат а, Р-диметил-у-Диэтиламинопропилового эфира п-изобутоксибензойной кислоты как лекарственное средство, оказывающее блокирующее вли ние на Н-холинореактивные системы организма, избирательно блокиру  Н-холинорецепторы вегетативных ганглиев, а также мозгового вещества надпочечников и каротидных клубочков; его блокирующее действие распростран етс  н на Н-холннореактивные структуры центральной нервной системы. Препарат действует также на холинорецепторы поперечно-полосатых мыщц и обладает выраженными гипотензивными свойствами.Provided gangleron hydrochloride a, P-dimethyl-y-Dietilaminopropilovogo ester p-izobutoksibenzoynoy acid as a drug, has a blocking effect on the H-holinoreaktivnye body system selectively blocking the N-cholinergic receptors of autonomic ganglia and adrenal medulla and carotid glomeruli; its blocking effect extends to the H-choline-reactive structures of the central nervous system. The drug also acts on the cholinergic receptors of the striated muscles and has pronounced hypotensive properties.

Препарат разрешен к применению фармакологическим Комитетом Министерства здравоохранени  СССР.The drug is approved for use by the Pharmacological Committee of the USSR Ministry of Health.

Предмет изобретени Subject invention

Claims (2)

1.Препарат ганглерон, отличающийс  тем, что дл  его изготовлени  из п-оксибензойной кислоты последовательно получают метиловый эфир этой кислоты, п-изобутоксибензойную кислоту и хлорангидрид п-изобутоксибензойной кислоты, в отдельных стади х получают «- Рдиметил - Y - Диэтиламинопропанол, кип чением которого с хлорангидридом п-изобутоксибензойной кислоты в среде абсолютного бензола получают а,Р диметил-у-диэтиламинопропиловый эфир п-изобутоксибензойной кислоты, из последнего эфирным раствором хлористого водорода .выдел ют хлоргидрат а, Рдиметил -у-диэтиламинопропиловый эфир п-изобутоксибензойной кислоты - ганглерон.1. A preparation of gangleronone, characterized in that for its production from p-hydroxybenzoic acid, methyl ester of this acid is obtained successively, p-isobutoxy benzoic acid and p-isobutoxy benzoic acid chloride, in separate stages, get "- Rdimethyl - Y - Diethylaminopropanol, boiling which, with p-isobutoxybenzoic acid chloride in absolute benzene, gives a, P p-isobutoxybenzoic acid d-methyl-y-diethylaminopropyl ester, and the chlorine is extracted from the latter with ethereal hydrogen chloride. rat a, y-Rdimetil dietilaminopropilovy ester p-izobutoksibenzoynoy acid - gangleron. 2.Применение препарата по п. 1 дл  лечени  стенокардии.2. The use of the preparation according to claim 1 for the treatment of angina pectoris.
SU597760A 1958-04-19 1958-04-19 Drug gangleron SU115905A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU597760A SU115905A1 (en) 1958-04-19 1958-04-19 Drug gangleron

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU597760A SU115905A1 (en) 1958-04-19 1958-04-19 Drug gangleron

Publications (1)

Publication Number Publication Date
SU115905A1 true SU115905A1 (en) 1958-11-30

Family

ID=48388166

Family Applications (1)

Application Number Title Priority Date Filing Date
SU597760A SU115905A1 (en) 1958-04-19 1958-04-19 Drug gangleron

Country Status (1)

Country Link
SU (1) SU115905A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds

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