SK6894Y1 - Ointment for healing selected skin diseases with anti-inflammatory and disinfecting effect - Google Patents

Abstract

An ointment for healing selected skin diseases with anti-inflammatory and disinfecting effect containing a uniform mixture 1.5 to 4 % by weight of salicylic acid, 4 to 7 % by weight of zinc oxide, 4 to 6 % by weight ichthammol, 3 to 10.5 % by weight of beeswax and the remainder to 100% by weight of olive oil.

Description

Technical field

The technical solution relates to a healing ointment for healing selected skin diseases with anti-inflammatory and disinfectant effect. The ointment has a healing effect in skin inflammation, it acts against itching and scaling (antiseboroic effect) and acts as a disinfectant.

BACKGROUND OF THE INVENTION

Skin diseases affect a significant part of the population. This condition is caused by several factors, but one is the undeniable high consumption and consequently exposure to many irritants, chemicals that penetrate the skin into the body. They can cause various damage to the skin or internal organs. Such diseases include:

Chronic contact dermatitis (Dermatitis contacta chronica, Cumulative irritant contact dermatitis), i. j. a non-infectious inflammatory skin disease that is treated by topical treatment of the affected skin with corticosteroid ointments and the like.

Microbial eczema (Eczema microbiale nummulare), t. j. non-infectious inflammatory dermatosis with a characteristic clinical picture likely to be involved in the immunopathogenetic mechanism and treated with local compresses after corticosteroid bleeding has subsided.

Atopic dermatitis (Dermatitis atopica) is a chronic or chronically recurrent inflammatory skin disease. In this case, the treatment of atopic dermatitis must be complex, with corticosteroid ointments being used topically according to the intensity of the inflammation.

Seborrheic dermatitis (Dermatitis seborrhoica) is a chronic non-allergic inflammatory skin disease that occurs in children and adults. Its treatment is the local application of mild corticosteroids to the unmanaged part of the skin.

Erythroderma (erythrodermia), t. j. inflammation of the entire skin surface, usually in conjunction with its peeling, which is treated by topical application of corticosteroids.

Psoriasis (psoriasis), a frequently occurring chronic or chronically recurrent non-infectious inflammatory dermatosis that is treated by treating the affected area with corticosteroid ointment.

Itching (pruritus) is not a disease, but a concomitant symptom of some skin diseases, dermatoses, e.g. eczema, eczematitis, prurigo, neurodermatitis and others that are treated with cortisone preparations.

For skin diseases against skin inflammation, itching, antiseboroic, antiseptic and keratoplastic with indication, e.g. erysipeloid, superficial thrombophlebitis, beginning fúrunkel, phlegmona, decubitus, erythema nodosum, erythema chronicum migrans, acne vulgaris, acne picea, acne cosmetica, acne chlorina, rosacea, acrocianosis, psoriasis, eczema and eczema, dermatycosis and dermatomycosis. , various ointments containing corticosteroids (e.g. Bellosalic ung, Diprosalic ung., Triamcinolon ung., Triamcinolon S ung., and others) are currently topically applied topically.

In dermatovenerology, the use of the drug in an ointment is one of the most common forms of application to the affected area of the skin. In local therapy, the importance of the excipient (vehicle) is generally of little value. It is often forgotten that the ointment base itself can also act as a therapeutic agent at the site of application.

In bulk ointments, in most cases, preservatives and carbohydrate ointment bases (eg vaselinum flavum, vaselinum album, etc.) derived from petroleum are used. It has been clinically proven that these oil products in ointments can cause many skin lesions, e.g. dermatitis, acne and others. In the past, imperfect refined oil products in ointments have even produced skin cancers. This problem is currently solved by the synthetic production of an ointment base, petrolatum, which is obtained by the synthesis of hydrocarbons. However, the process is complex and costly.

Many skin diseases are treated locally with a wide range of ointments containing various corticosteroids and antibiotics. Corticosteroids can also have adverse effects on the patient's skin, e.g. skin atrophy, teleangiectase formation, etc.

Also known is a medicament ointment for the healing of several skin diseases according to SK DE 5647, consisting of a uniform mixture of 1.5 to 5% by weight salicylic acid, 4 to 8% by weight zinc oxide, 4 to 10% by weight ichthamol and the remainder to 100% by weight lanolin, which is not suitable for patients with hypersensitivity to the lanolin component and does not contain vitamins A and E, antioxidants that accelerate the healing of the skin surface.

The essence of the technical solution

The above-mentioned deficiencies are remedied to a great extent by the pharmaceutical ointment for the healing of selected skin diseases with anti-inflammatory and disinfecting effect according to the technical solution, which consists of a uniform mixture

SK 6894 Υ1

1.5 to 4 wt.% Salycilic acid, 4 to 7 wt.% Zinc oxide, 4 to 6 wt.% Ichtamol, 3 to 10.5 wt.% Beeswax, and the remainder to 100 wt.% Olive oil.

The medicament ointment for the healing of selected skin diseases with anti-inflammatory and disinfectant effect according to the invention does not contain antibiotics, corticosteroids, preservatives, lanolin or hydrocarbon bases, thus contributing to reducing allergic reaction and other undesirable changes on the patient's skin (such as erythema, acne changes etc. .). Therefore, the treatment of skin disease is more physiological and perfectly tolerable for humans and animals. It is used against itching, inflammation of the skin, against the formation of scales (antiseboroic effect), has a disinfectant effect, has a beneficial effect in the sanding of wounds (keratoplastic effect). Treatment of skin disease with this ointment is perfectly tolerable.

Medicinal ointment for the healing of selected skin diseases with anti-inflammatory and disinfecting effect according to the technical solution is suitable for the treatment of various skin diseases and dermatoses (indicated indications), itching, skin inflammation with the ability to harden wounds (keratoplastic effect) and anti-scaling ), also with disinfectant effect. The medicinal ointment also has a beneficial effect on eczema induced by mineral oils.

Other advantages of the medicament ointment according to the invention include the fact that it is cheaper for patients and thus more affordable than the ointments used so far. Such a pharmaceutical ointment contains ichtamol, which acts antiphlogistically, antipruriginous, antiseboroic, keratoplastic, antiproliferative, weakly antimicrobial and antifungal. Increases skin blood circulation. Zinc oxide binds secretion in the wound and forms a protective film over areas of the skin with disease changes. The antioxidant zinc contained in it promotes healing. In particular, salicylic acid has a keratoplastic effect. Relieves pain and itching at the site of inflammation. Helps to remove scabs, scales, dead tissue and ragged skin. It facilitates penetration of other active substances into the skin. It is easily absorbed by intact skin. Beeswax with olive oil, pure natural products serve as a vehicle, ointment base for other medicinal ingredients of ointment. By their specific, also medicinal properties, they multiply the healing effect of the other components of the ointment. Beeswax contains a lot of vitamin A, it is used for thickening ointments, binds oils. The olive oil is preferably rich in vitamin E.

EXAMPLES

Specific examples of ointments according to the invention consist of the following uniform mixture:

Example 1

-1.5% by weight of salicylic acid (acidum salicylicum), m.p. j. in an amount of 1.5 g,

- 4.0% by weight of zinc oxide (zinci oxidati), m.p. j. 4 g,

- 4.0% by weight of ichtamol (ichtamol), m.p. j. 4 g,

- 10.5% by weight of beeswax (cera alba), t. j. 10.5 g,

- 80,0% by weight of olive oil (olleum olive), t. j. in an amount of 80 g.

Example 2

- 2.0% by weight salicylic acid (acidum salicylicum), i. j. in an amount of 2 g, -5.0% by weight of zinc oxide (zinci oxidati), m.p. j. in an amount of 5 g,

- 5.0% by weight of ichtamol (ichtamol), m.p. j. in an amount of 5 g,

- 8.0% by weight of beeswax (cera alba), t. j. 8 g,

- 80,0% by weight of olive oil (olleum olive), t. j. in an amount of 80 g.

Example 3

- 4.0% by weight salicylic acid (acidum salicylicum), i. j. 4 g,

- 7.0% by weight of zinc oxide (zinci oxidati), m.p. j. 7 g,

6.0% by weight of ichtamol (ichtamol), m.p. j. 6 g,

- 3.0% by weight of beeswax (cera alba), t. j. in an amount of 3 g,

- 80,0% by weight of olive oil (olleum olive), t. j. in an amount of 80 g.

It is also possible to provide other examples of a healing ointment for the healing of selected skin diseases with anti-inflammatory and disinfectant effects according to the invention in the form of a uniform mixture of substances formed by a possible combination of the chemical composition of the weight% of its components.

The person skilled in the art may also, based on the individual approach to the patient or animal and the particular skin disease, determine the appropriate chemical composition of the healing ointment for the healing of selected skin diseases with anti-inflammatory and disinfectant effect within the chemical composition set forth in the claims.

SK 6894 Υ1

The medicinal ointment is applied (applied) to the affected areas in a small amount in the evening. The proven efficacy of curing patients with the medicated ointment according to the invention was up to 80% of the cases, and the medicament ointment must not be used if the patient reacts excessively sensitively to any of its components.

Claims (1)

PROTECTION REQUIREMENTS Medicinal ointment for the healing of selected skin diseases with anti-inflammatory and disinfectant effect, characterized in that it contains a uniform mixture of 1.5 to 4% by weight of salicylic acid, 4 to 7% by weight of zinc oxide, 4 to 6% by weight of ichtamol, 3 to 10% 5% by weight of beeswax and the remainder up to 100% by weight of olive oil.