SK500592021U1 - Kit containing biologically active preparation - Google Patents

Abstract

Described is a kit comprising a base foil (1) formed by at least one bulge (2) and a cover foil (4) which is attached to the base foil (1) so that to seal the bulge (2) hermetical and/or impermeable to water, wherein at least one slice or leaf of the biologically active preparation (3) is deposited in the bulge (2).

Description

Field of technology

The technical solution relates to a kit which contains a biologically active preparation in the form of a system of slices or leaves.

Prior art

Cosmetic preparations are known from the prior art, for example in the form of a liquid or cream, the usual mode of application of which is once or twice a day. The disadvantage of cosmetic preparations in the form of a liquid or cream is that it is difficult to separate hygienically and subsequently transport a smaller amount of cosmetic preparation. For possible several-day trips, the user must take the entire cosmetic container. In such a case, the container is both unnecessarily bulky and unnecessarily heavy in terms of the planned consumption of the cosmetic product. In addition, creams and liquids always carry a risk of damage to their packaging or container and leakage of cream or liquid into their luggage, which may result in contamination and / or damage to other items being transported. In addition, in the case of air transport, users are restricted by safety regulations regarding the carriage of liquids in hand luggage.

Furthermore, cosmetically active preparations in the form of flakes or petals which are soluble in a small amount of water are known. The preparation of a cosmetic preparation is described in PV2013-822 (respectively WO / 2015/058734). If they are packaged in a common package in several pieces at the same time, contamination of the formulations could occur after opening the package, and in addition they would need to have a container for dissolving / mixing the formulation in water / solvent.

The essence of the technical solution

These disadvantages of the prior art are largely eliminated by a kit comprising a biologically active preparation 3 in the form of a slice or a leaf, where the kit further comprises a base film 1 comprising at least one bulge 2 and a cover film 4 which is attached to the base film. 1 by closing the bulge 2 impermeable and / or impermeable to water, wherein at least one slice or leaf of the biologically active preparation 3 is stored in the bulge 2.

According to a preferred embodiment of the technical solution, the kit comprises a set of cavities 2, wherein at least one slice or a leaf of the biologically active preparation 3 is stored in each of the cavities 2.

Preferably, the base film 1 is transparent at least in the bulge / bulge region 2 and / or comprises at least one material selected from the group consisting of polyvinyl chloride, polypropylene, polytetrafluoroethylene (PTFE) films or multilayer materials, preferably polypropylene in combination with aluminum.

According to another preferred embodiment of the kit according to the technical solution, the bulge / cavities 2 have a volume in the range of 1.5 to 4 ml.

Preferably, the cover film 4 comprises a material selected from the group consisting of aluminum foil, nonwoven polyethylene fabric (Tyvek), paper with adhesive and is removable from the base foil 1.

According to yet another preferred embodiment of the technical solution, the biologically active preparation 3 has a total weight of 3 to 20 mg and / or a basis weight of 1 to 50 g / m ² , preferably 4 to 20 g / m ² .

Preferably, the slice or leaf of the biologically active preparation 3 contained in the kit according to the invention comprises nanofibers which contain hyaluronic acid or a pharmaceutically acceptable salt thereof.

Preferably, the biologically active composition 3 is a cosmetically active composition comprising nanofibers containing hyaluronic acid or a pharmaceutically acceptable salt thereof in the range of 50 to 90% by weight, having a molecular weight in the range of 1 x 10 ⁴ to 3 x 10 ⁵ g / mol, and at least one carrier polymer selected from the group consisting of polyethylene oxide and polyvinyl alcohol. The preparation of a cosmetically active preparation is described in PV2013-822 (WO / 2015/058734, respectively), which is incorporated herein by reference. The carrier polymer content in the nanofiber dry matter is in the range of 5 to 49% by weight. The molecular weight of the carrier polymer is in the range of 1x10 ⁴ to 3 x 10 ⁵ g / mol.

According to yet another preferred embodiment of the technical solution, the cosmetically active preparation comprises at least one cosmetically active substance which is selected from the group consisting of

- water-soluble peptides, preferably selected from the group consisting of acetyl-hexapeptide-8, sh-hexapeptide- (GSPAGS; trade name Cellcon), whey protein or soy protein,

- water-soluble polysaccharides preferably selected from the group consisting of schizophyllate, sodium carboxymethylbeta-glucan, sodium caproylhyaluronate or glucomannan,

- water-soluble plant extracts, preferably selected from the group consisting of aboveground parts of Epilobium angustifolium, green seed extract of Coffea arabica, Camellia Sinensis leaf extract,

SK 50059-2021 U1 Panax Ginseng root extract, Aloe Barbadensis extract, plankton extract, Aloe Vera extract, Vilín extract, kostihoja extract;

water-soluble polyols preferably selected from the group consisting of propylene glycol, butylene glycol, glycerol;

water-soluble vitamins, preferably selected from the group consisting of D-panthenol, ascorbic acid ethyl ester, vitamin C;

- Micrococcus lysate, creatine, 1-methylhydantoin-2-imide, sodium lactate, glycine sodium pyroglutamic acid, fructose, urea, niacinamide, inositol, sodium benzoate or lactic acid, vitamin E, coenzyme Q10, further ceramides, vitamin A, collagen ;

vegetable oils, preferably argan oil, macadamia oil, almond oil.

The content of cosmetically active substance in the dry matter of nanofibers is in the range of 0.001 to 45% by weight.

The bulge 2 or at least some of the bulges 2 of the kit according to the technical solution containing the biologically, preferably cosmetically active preparation are provided with a line, mark or shoulder to indicate the optimal level of liquid to dissolve or partially dissolve the active preparation 3 in water.

A kit comprising a cosmetically active preparation according to the technical solution comprises at least one pair of cavities 2, wherein in the first cavity 2 of said pair there is arranged at least one slice or leaf of a cosmetically active preparation 3 comprising at least one active substance selected from the group consisting of vitamins C, vitamin E, D -panthenol, glycerol, urea, coenzyme Q10 and in the second cavity 2 of said pair there is arranged at least one slice or leaf of cosmetically active preparation 3 containing at least one active substance selected from the group consisting of vegetable oils, preferably argan oil, macadamia oil, almond oil, extracts from plants, preferably Aloe vera extract, Vilín extract, kostihoja extract, ceramides, vitamin A, collagen. The cosmetically active preparation, which is found in the first cavity 2 of said pair, is intended for morning application of the preparation. The cosmetically active preparation, which is located in the second cavity 2 of said pair, is intended for the evening application of the preparation.

The great advantage is that we store the biologically active preparation in dry form in a kit according to the technical solution, because the stability of most of the active substances contained in it is significantly higher than that of preparations which are stored in liquid form for a long time. The biologically active preparation according to the technical solution is transformed in the cavity 2 just before its use into a gel, solution or emulsion. The cavity 2 of the kit according to the technical solution is intended not only for storing the biologically active preparation in a dry state, but also for preparing the application form of the preparation, ie the gel, solution or emulsion form.

The biologically active preparation contained in the system according to the technical solution is preferably soluble in water from at least 80% by weight, preferably from 100% by weight.

The weight percentage is based on the total weight of the biologically active preparation. A biologically active preparation is a preparation which contains active substances which have a positive effect on a living organism or parts thereof, in particular a cosmetic or therapeutic one. Preferably it is a cosmetically active preparation as described above.

Overview of figures in the drawings

Exemplary embodiments of the technical solution are further schematically illustrated in the drawings, where in FIG. 1 is a perspective view of a kit according to the technical solution, FIG. 2 is a front view and FIG. 3 is a side view of an example of a kit according to the technical solution.

Examples of embodiments

Example 1

An exemplary embodiment of a kit according to this technical solution comprises a plastic transparent base film 1 with a set of cavities 2 (so-called blisters) in the shape of an open cylinder, a truncated cone, a cylinder with bevelled edges along the bottom, or generally in the shape of a bowl. In this exemplary embodiment, the base foil 1 is substantially planar outside the area of the cavities 2 and all the cavities 2 have the edges of their inlet openings arranged in one plane.

The base film 1 with a hollow system 2 is made, for example, of PVC, preferably with a thickness of 0.15 to 0.4 mm, and can additionally be covered with a layer of PVDC (polyvinylidene chloride) or PCTFE (polychlorotrifluoroethylene) or cyclic olefin polymers or copolymers, and the like.

The individual cavities 2 preferably have a volume of 1.5 to 4.5 ml, more preferably 2 to 3.5, most preferably 2 to 3 ml.

A cover foil 4 is fastened to the base foil 1 on the side of the recess openings 2 to close the recess openings 2 and form closed cavities, the cover foil 4 being, for example, in the form of an aluminum or plastic foil or a combination thereof. The cover foil 4 is fixed to the base foil 1 so that the individual cavities 2 are cover

SK 50059-2021 U1 foil 4 waterproof, preferably also gas-tight closed.

The base film 1 can be joined to the cover film 4, for example by gluing or thermoplastic welding, preferably so that the cover film 4 is removable / peelable in order to open the cavity 2.

For example, in thermoplastic welding, it is possible to form further shaped elements on the base film 1, such as grooves, ribs, protrusions, depressions and the like, in order to better adhere the cover film 4 to the base film 1.

Preferably, the base film 1 and optionally also the cover film 4 is provided with weakened areas, for example continuous or interrupted linear notches 5, for easy separation of the parts of the kit. These weakened areas are best arranged in such a way that they always define one cavity 2 between them and thus allow the assembly to be divided into several parts, each of which contains one cavity 2, without opening the cavity 2.

In addition, the kit preferably comprises at least one gripping part 6 in each recess 2, in which the cover foil 4 is not connected to the base foil 1 and which thus allows the cover foil 4 to be gripped and torn from the base foil 1 so as to expose the interior of the respective recess. 2.

Inside each cavity 2 is a freely stored dried, water-soluble cosmetically active preparation 3, in the form of a slice or a leaf, resp. in the form of a layer, where the basis weight of the layer is in the range of 1 to 50 g / m ² , preferably 4 to 20 g / m ² .

The cosmetically active preparation 3 is indicated by a dashed line in the drawings.

Cosmetically active composition 3 preferably comprises nanofibers containing hyaluronic acid or a pharmaceutically acceptable salt thereof in the range of 50 to 90% by weight, having a molecular weight in the range of 1 x 10 ⁴ to 3 x 10 ⁵ g / mol, and at least one carrier polymer selected from a group consisting of polyethylene oxide and polyvinyl alcohol.

The nanofibers preferably further comprise a cosmetically active substance, which may for example be selected from the group consisting of:

- water-soluble peptides, preferably selected from the group consisting of acetyl-hexapeptide-8, sh-hexapeptide1, whey protein or soy protein,

- water-soluble polysaccharides preferably selected from the group consisting of schizolylate, sodium carboxymethylbeta-glucan, sodium caproylhyaluronate or glucomannan,

water-soluble plant extracts, preferably selected from the group comprising the extract from the above-ground parts of Epilobium angustirolium. Coffea arabica green seed extract, Camellia Sinensis leaf extract, Panax Ginseng root extract, Aloe Barbadensis extract, plankton extract, Aloe Vera extract, Vilín extract, kostihoja extract;

water-soluble polyols preferably selected from the group consisting of propylene glycol, butylene glycol, glycerol;

water-soluble vitamins, preferably selected from the group consisting of D-panthenol, ascorbic acid ethyl ester, vitamin C;

- Micrococcus lysate, creatine, 1-methylhydantoin-2-imide, sodium lactate, glycine sodium pyroglutamic acid, fructose, urea, niacinamide, inositol, sodium benzoate or lactic acid, vitamin E, coenzyme Q10, further ceramides, vitamin A, collagen ;

oils, preferably argan oil, macadamia oil, almond oil.

The nanofibers may further comprise an excipient, preferably carboxymethylcellulose, and a lipophilic substance in the form of micelles, the lipophilic substance preferably being selected from the group consisting of resin extract from Commiphora Mukul tree, Lavadula Stoechas extract in octanoic and decanoic acid triglycerides, coenzyme Q10, palmitate ascorbic acid, pyridoxine dipalmitate, tocopheryl acetate, glycyrrhetinic acid, cholesterol.

Example 2

An exemplary embodiment of the kit according to this technical solution comprises a plastic transparent base foil 1 with a set of cavities 2 (so-called blisters) in the shape of a bowl. In this exemplary embodiment, the base film 1 is substantially planar outside the area of the cavities 2 and all the cavities 2 have the edges of their inlet openings arranged in one plane.

The base film 1 with a system of bulges 2 is made, for example, of PVC with a thickness of 0.15 mm, while it is additionally covered with a layer of PVDC (polyvinylidene chloride).

The individual cavities 2 preferably have a volume of 1.5 ml.

A cover foil 4 is fastened to the base foil 1 on the side of the recess openings 2 to close the recess openings 2 and form closed cavities, the cover foil 4 being in the form of an aluminum foil. The cover foil 4 is fixed to the base foil 1 so that the individual cavities 2 are watertight, preferably also gas-tight, closed by the cover foil 4.

The base film 1 is glued to the cover film 4 so that the cover film 4 is removable / peelable in order to open the cavities 2.

Preferably, the base film 1 and optionally also the cover film 4 are provided with weakened areas, for example con

SK 50059-2021 U1 continuous or interrupted linear notches 5 for easy separation of kit parts. These weakened areas are best arranged in such a way that they always define one cavity 2 between them and thus allow the assembly to be divided into several parts, each of which contains one cavity 2, without opening the cavity 2.

In addition, the kit preferably comprises a gripping part 6 at each recess 2, in which the cover foil 4 is not connected to the base foil 1 and which thus allows the cover foil 4 to be gripped and torn from the base foil 1 so as to expose the interior of the respective recess 2. .

Inside each cavity 2, a dried, water-soluble cosmetically active preparation 3 is placed in the form of a slice, where the basis weight of the layer is 1 g / m ² .

The cosmetically active preparation 3 is indicated by a dashed line in the drawings.

The cosmetically active preparation 3 preferably contains nanofibers containing 74% by weight. sodium hyaluronate, having a molecular weight in the range of 1 x 10 ⁴ g / mol, polyethylene oxide with a concentration of 20% by weight. in the dry matter of nanofibers and with a molecular weight of 9 x 10 ⁵ g / mol. The nanofibers also contain cosmetically active substances such as whey protein with a concentration of 0.5% by weight, acetylhexapeptide-8 with a concentration of 3% by weight, green seed extract Coffea Arabica, butylene glycol with a concentration of 0.1% by weight, extract from aboveground parts Epilobium angustifolium, butylene glycol at a concentration of 0.1% by weight, Panax Ginseng root extract, propylene glycol at a concentration of 0.01% by weight, Camellia Sinensis leaf extract, propylene glycol at a concentration of 0.01% by weight, Aloe Barbadensis at a concentration of 1% allantoin at a concentration of 0.2% by weight,

D-panthenol at a concentration of 0.5% by weight, glucomannan at a concentration of 0.1% by weight, sh-hexapeptide-1 at a concentration of 0.0001% by weight. and ketoglutaric acid hexyl ester at a concentration of 0.01% by weight.

Example 3

An exemplary embodiment of the kit according to this technical solution comprises a plastic transparent base foil 1 with a set of cavities 2 (so-called blisters) in the shape of a bowl. In this exemplary embodiment, the base film 1 is substantially planar outside the area of the cavities 2 and all the cavities 2 have the edges of their inlet openings arranged in one plane.

The base film 1 with a system of cavities 2 is made, for example, of PVC with a thickness of 0.4 mm, while it is additionally covered with a layer of PCTFE (polychlorotrifluoroethylene).

The individual cavities 2 preferably have a volume of 4.5 ml.

A cover film 4 is fastened to the base film 1 on the side of the cavity openings 2 to close the cavity openings 2 and form closed cavities, the cover film 4 being in the form of a plastic film. The cover foil 4 is fixed to the base foil 1 so that the individual cavities 2 are watertight, preferably also gas-tight, closed by the cover foil 4.

The base film 1 is joined to the cover film 4 by thermoplastic welding so that the cover film 4 is removable / peelable in order to open the cavities 2.

Preferably, the base film 1 and optionally also the cover film 4 is provided with weakened areas, for example continuous or interrupted linear notches 5, for easy separation of the parts of the kit. These weakened areas are best arranged in such a way that they always define one cavity 2 between them and thus make it possible to divide the set into several parts, each of which contains one cavity 2, without opening the cavity 2.

In addition, the kit preferably comprises a gripping part 6 at each recess 2, in which the cover foil 4 is not connected to the base foil 1 and which thus allows the cover foil 4 to be gripped and torn from the base foil 1 so as to expose the interior of the respective recess 2. .

Inside each cavity 2 is a freely stored dried, water-soluble cosmetically active preparation 3, in the form of a leaf, where the basis weight of the layer is 50 g / m ² .

The cosmetically active preparation 3 is indicated by a dashed line in the drawings.

The cosmetically active preparation 3 preferably contains nanofibers containing 90% by weight. hyaluronic acid, having a molecular weight in the range of 3 x 10 ⁵ g / mol, polyvinyl alcohol at a concentration of 5% by weight. in the dry matter of nanofibers and with a molecular weight of 1 x 10 ⁴ g / mol. The nanofibers further contain cosmetically active substances, which are an extract of Coffea arabica green grains with a concentration of 0.004% by weight, urea with a concentration of 0.5% by weight, creatine with a concentration of 1% by weight, allantoin with a concentration of 0.5% by weight. glucomannan with a concentration of 0.2% by weight, aloe barbadensis with a concentration of 1.5% by weight, ascorbic acid ethyl ester 1.29% by weight. and schizophyllan at a concentration of 0.006% by weight.

The nanofibers may further comprise an excipient, preferably carboxymethylcellulose, and a lipophilic substance in the form of micelles, the lipophilic substance preferably being selected from the group consisting of resin extract from Commiphora Mukul tree, Lavadula Stoechas extract in octanoic and decanoic acid triglycerides, coenzyme Q10, palmitate ascorbic acid, pyridoxine dipalmitate, tocopheryl acetate, glycyrrhetinic acid, cholesterol.

The kit according to the technical solution is used in such a way that the user removes the cover foil 4 from one

SK 50059-2021 U1 from the cavities 2, thereby opening it, and into the cavity 2 with the cosmetically active preparation 3 pours / drips water, preferably drinking water, in a volume smaller than the total volume of the cavity 2, but sufficient to dissolve the cosmetically active preparation 3. Subsequently, the contents of the bulge 2 are mixed with a finger, for example, and applied to cosmetically treated areas of the skin, for example around the eyes. The cavities 2 are thus used not only as part of the transport and storage container, but also as containers for dissolving and mixing the cosmetically active preparation 3 just before use. Due to the low basis weight of the cosmetically active preparation 3, i.e. due to the large wetting area relative to the total weight of the cosmetically active preparation 3, it dissolves very rapidly, on the order of 1 to 10 seconds.

The set can be used with great advantage, for example, when traveling, when it is not comfortable or acceptable to carry ordinary containers with cosmetic creams and cosmetic waters in the luggage compartment. The kit is much lighter than such conventional containers, the individual doses for each use are hygienically packaged and do not contain liquid or material of creamy / pasty consistency. In the event of damage to the set in the luggage, there can be no leakage of liquid or paste / cream from the set and damage to other transported objects. In addition, for shorter trips, it is possible to cut or tear off an appropriate part of the kit with a corresponding number of cavities 2 with the cosmetic active agent 3. Water for dissolving the cosmetically active preparation 3 just before its use is usually easily accessible anywhere on the road.

Although particularly preferred exemplary embodiments have been described, it will be apparent to one skilled in the art that other possible alternatives to these embodiments will be readily apparent. Therefore, the scope of protection is not limited to these exemplary embodiments, but rather is defined by the appended claims.

SK 50059-2021 U1

List of reference marks

1 2 5 3 4 5 6 - base foil - You cavity - a biologically active product - cover foil - linear notch - gripping part

Claims (11)

PROTECTION REQUIREMENTS A kit comprising a biologically active preparation (3) in the form of a slice or a leaf, characterized in that it further comprises a base film (1), which contains a group of bulges (2), and a cover film (4), which is attached to the base film (1) by sealing the bulges (2) impermeable and / or impermeable to water, wherein at least one slice or a sheet of the biologically active preparation (3) is deposited in each of the bulges (2). Kit according to Claim 1, characterized in that the base film (1) is transparent and / or comprises at least one material selected from the group consisting of polyvinyl chloride, polypropylene, polytetrafluoroethylene films or multilayer materials at least in the area of the bulge (2). preferably polypropylene in combination with aluminum. Kit according to claims 1 or 2, characterized in that the bulge (s) (2) have a volume in the range of 1.5 to 4 ml. Kit according to any one of the preceding claims, characterized in that the cover foil (4) comprises a material selected from the group consisting of aluminum foil, non-woven polyethylene fabric or adhesive paper, and is removable from the base foil (1). Kit according to any one of the preceding claims, characterized in that the biologically active preparation (3) has a total weight of 3 to 20 mg and / or a basis weight of 1 to 50 g / m ² , preferably 4 to 20 g / m ² . Kit according to any one of the preceding claims, characterized in that the sheet or leaf of the biologically active preparation (3) comprises nanofibers containing hyaluronic acid or a pharmaceutically acceptable salt thereof. Kit according to any one of the preceding claims, characterized in that the biologically active preparation (3) is a cosmetically active preparation, comprising nanofibers containing hyaluronic acid or a pharmaceutically acceptable salt thereof in the range of 50 to 90% by weight, having a molecular weight in in the range of 1 x 10 ⁴ to 3 x 10 ⁵ g / mol, and at least one carrier polymer selected from the group consisting of polyethylene oxide and polyvinyl alcohol. Kit according to claim 7, characterized in that the cosmetically active preparation comprises at least one cosmetically active substance which is selected from the group consisting of water-soluble peptides, preferably selected from the group consisting of acetyl-hexapeptide-8, sh-hexapeptide-1, whey protein or soy protein; water-soluble polysaccharides preferably selected from the group consisting of schizolylate, sodium carboxymethyl-beta-glucan, sodium caproylhyaluronate or glucomannan; water-soluble plant extracts, preferably selected from the group consisting of aboveground parts Epilobium angustifolium, green seed extract Coffea arabica, Camellia Sinensis leaf extract, Panax Ginseng root extract, Aloe Barbadensis extract, plankton extract, Aloe Vera extract, Vilín extract, kostihoja extract; water-soluble polyols preferably selected from the group consisting of propylene glycol, butylene glycol, glycerol; water-soluble vitamins, preferably selected from the group consisting of D-panthenol, ascorbic acid ethyl ester, vitamin C; Micrococcus lysate, creatine, 1-methylhydantoin-2-imide, sodium lactate, glycine sodium pyroglutamic acid, fructose, urea, niacinamide, inositol, sodium benzoate or lactic acid, vitamin E, coenzyme Q10, ceramides, vitamin A, collagen; oils, preferably argan oil, macadamia oil, almond oil. Kit according to any one of the preceding claims, characterized in that the bulge (2) or at least some of the bulges (2) are provided with a line, a mark or a shoulder to indicate the optimum level of liquid for dissolving the biologically active preparation (3). Kit according to any one of claims 7 to 9, characterized in that it comprises at least one pair of bulges (2), wherein at least one slice or leaf of the water-soluble cosmetically active preparation (3) is arranged in the first bulge (2) of said pair. ) containing at least one active substance selected from the group consisting of vitamin C, vitamin E, D-panthenol, glycerol, urea, coenzyme Q10 and at least one slice or leaf of a water-soluble cosmetically active preparation (3) is arranged in the second cavity (2) of said pair ) containing at least one active substance selected from the group consisting of vegetable oils, preferably argan oil, macadamia oil, almond oil, plant extracts, preferably Aloe vera, Vilín, kostihoja, ceramides, vitamin A, collagen. Kit according to any one of the preceding claims, characterized in that the biologically active preparation is at least 80% by weight, preferably 100% by weight, soluble in water.