SK387892A3 - Method of production 1-bromine-3-chlorpropane and device for its realization - Google Patents
Method of production 1-bromine-3-chlorpropane and device for its realization Download PDFInfo
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- SK387892A3 SK387892A3 SK387892A SK387892A SK387892A3 SK 387892 A3 SK387892 A3 SK 387892A3 SK 387892 A SK387892 A SK 387892A SK 387892 A SK387892 A SK 387892A SK 387892 A3 SK387892 A3 SK 387892A3
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- oxygen
- hydrogen bromide
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- allyl chloride
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Description
Spôsob sa uskutočňuje antimarkovnikovskou hydrobromáciou alylchloridu pri teplote -10 až + 50°C, pri mólovom pomere alylchlorid: bromovodik -1 : 0,7 až 5 v kvapalnom bezvodnom prostredí, za prítomnosti kyslíka alebo zmesi kyslíka s organickým peroxidom a/alebo hydroperoxidom, v množstve 0,05 až 10 % hmota., počítané na hmotnosť alylchloridu. Hlavný produkt sa oddelí destiláciou a/alebo rektifikáciou. Spôsob možno uskutočňovať diskontinuálne, polokontinuálne i kontinuálne.The process is carried out by antimarker hydrobromination of allyl chloride at -10 to + 50 ° C, at a molar ratio of allyl chloride: hydrogen bromide of -1: 0.7 to 5 in a liquid anhydrous medium, in the presence of oxygen or a mixture of oxygen with organic peroxide and / or hydroperoxide. 0.05 to 10% by weight, calculated on the weight of allyl chloride. The main product is separated by distillation and / or rectification. The process can be carried out batchwise, semi-continuously and continuously.
Pv 1ÍÍÍ-J2PvIII-J2
-1- 1 -1- 1
Spôsob výro.by. I-hróm-3-chlórpropánu. a zariadenie na jeho uskutočnenie.Method of production. I-bromo-3-chloropropane. and an apparatus for carrying it out.
OblasrK technikyTechnique area
Vynález sa· týka spôsobu výroby, l-bróm-3-chlórpropánu ako významného organického medziproduktu, vysokoselektívnou hydrabaromácio.u; alylchloridu, ako: aj., zariadenia na jeho. najma· kontinuálnu výrobu.The invention relates to a process for the production of 1-bromo-3-chloropropane as an important organic intermediate, by a high-selective hydrabaromation; allyl chloride such as: i. especially continuous production.
Doterajší stav techniky.BACKGROUND OF THE INVENTION.
l-Bróm-3-chlórpropán je. významným medziproduktom , využiteľným najma v.o výrobe farmaceuti k, ako aj viacerých dôležitých organických produktov.1-Bromo-3-chloropropane is. an important intermediate, useful especially in the manufacture of pharmacists, as well as several important organic products.
Možno ho· vyrobiť, telomerizáciou etylénu s brómchlopaetánom (Afanase.v. I. B., Beer A. A.: Žur. Vsesojuz. chim. obšč. i. Menďeleeva 1962,s'. 595; autorské osvedčenie ZSSSR 187 749)·. Vyžaduje si však technicky ťažšie, dostupný brómchlórme.tán' a výťažky. nie: sú uspokojivé. A tak najviac pozornosti sa venovalo adícii suchého bromovodíka proti Markovnikovovmu pravidlu na alylchlorid:It can be produced by telomerization of ethylene with bromochlopoethane (Afanase v. I.B., Beer A. A .: Žur. Vsesojuz. Chim. Ob. I. Mendeleleeva 1962, p. 595; USSR Authorized Certificate 187 749). However, it requires technically more difficult, available bromochloromethane and yields. no: they are satisfactory. So most attention was paid to the addition of dry hydrogen bromide against Markovnikov's rule to allyl chloride:
ClCňgCfcCH^ +-HBr -ClCH2CH2CH2Br, pričom1, vo väčšej, alebo v menšej miere v súlade S Markovnikovovým pravidlom vzniká aj l-chlór-2-b.rómpropán CHCí^Cl—2»ClCH2CH(Br)CH^/Kharasch M. S., Mayo F. R.: J. Am. Chenu Soc. 55. 2468 (1933); tamtiež 62, 2047 (1940); Beilsteins HančLbuch der organischen Chemie, I. vydanie, I. zväzok, No. 10, s:· 1Ô9; Beisteins- II., dodatky, I. zväzok E IIIIL, s. 75; tamtiež III, dodatky, i. zvzok E III 1, s·. 245; Kirk- Othmer : Ency-clopedia- of. Chemical Technology , 3· vydanie , 1. zväzok, s.ClCl 2 Cl 2 + -HBr -ClCH 2 CH 2 CH 2 Br, wherein 1 , to a greater or lesser extent in accordance with Markovnikov's rule, also produces 1-chloro-2-bromopropane CHCl 3 Cl 2 · ClCH 2 CH ( Br) CH 2 / Kharasch MS, Mayo FR: J. Am. Chenu Soc. 55, 2468 (1933); ibid. 62, 2047 (1940); Beilsteins HanchLuch der organischen Chemie, I. edition, I. vol. 10, s: 1Ô9; Beisteins- II., Appendices, Volume I III III, p. 75; Ibid. III, Appendices, i. Volume E III 1, p. 245; Kirk-Othmer: Ency-clopedia-of. Chemical Technology, 3th edition, Volume 1, p.
254; 2. vydanie. , 3. zvzok , s. 774/· Dosahujú sa však výťaž,ky l-bróm-3-chlorpropánu neprevyšujúce. 43 %· Pokrok sa dosiahol, pri.ožiarovaní.alylchloridu ultrafialovým sveilom /Ancus L. I.: 2ur. prikl. chim. 2053 (1936); Magidson S. Ju. e.t. al.: tamtiež s. 317/, kedy výťažok dosahuje až 85 %* Reačná rýchlosť je však nižšia a uskutočnenie v technickom meradle je aj z bezpečnostného hľadiska náročné. Podobné technické problémy a níz5254; 2nd edition. , 3rd volume, p. However, a yield not exceeding 1-bromo-3-chloropropane is achieved. 43% · Progress has been made in the irradiation of ultraviolet light of analyl chloride / Ancus L. I .: 2ur. Ex. chim. 2053 (1936); Magidson S. Ju. E.T. al .: ibid. However, the reaction rate is lower and the technical scale is also demanding from a safety point of view. Similar technical problems and low5
-2ka sellektivita znižujú príťažlivosť aj iných, postupov prípravyThe selectivity reduces the attractiveness of other preparation procedures as well
ľénehloriď za katalytického účinku bromidu hlinitého pri 2 ažAluminium chloride under the catalytic effect of aluminum bromide at 2 to
5°C , ako aj reakcia alylchloridu s plynným hromovodíkom za katalytického účinku chloridu, bizmutitého pri teplote 21 °C (USA pat» 2 302 228 a 2 255 605) alebo paraldehydu i iných nízkomole.kul ových aldehydov (USA pat. 2 303 549). Z novších pa tentov zaujímavá je hydrobromácia olefinicky nenasýtených zlúčenín. pôsobením žiarenia na zmes bromovodíka a organickej zlúčeniny; svetlom o vlnovej dĺžke 335 až 500 nm / Zelovich J. et.5 ° C as well as the reaction of allyl chloride with a gas of lightning gas under the catalytic action of chloride, bismuth at 21 ° C (U.S. Pat. Nos. 2,302,228 and 2,255,605) or Paraldehyde and other low-molecular aldehydes (U.S. Pat. ). Of newer patents, hydrobromation of olefinically unsaturated compounds is of interest. radiation treatment to the mixture and hydrogen bromide and organic compound; by light with a wavelength of 335 to 500 nm / Zelovich J. et.
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CS923878A CZ280614B6 (en) | 1992-12-28 | 1992-12-28 | Process for preparing 1-bromo-3-chloropropane and apparatus for making the same |
Publications (2)
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SK387892A3 true SK387892A3 (en) | 1995-03-08 |
SK279360B6 SK279360B6 (en) | 1998-10-07 |
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SK3878-92A SK279360B6 (en) | 1992-12-28 | 1992-12-28 | Method of 1-bromine-3-chloropropane preparation and apparatus for processing thereof |
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SK (1) | SK279360B6 (en) |
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CN103709004A (en) * | 2014-01-15 | 2014-04-09 | 大连龙泰科技发展有限公司 | Preparation method of 1, 3-propanediol |
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- 1992-12-28 SK SK3878-92A patent/SK279360B6/en unknown
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CZ387892A3 (en) | 1995-02-15 |
SK279360B6 (en) | 1998-10-07 |
CZ280614B6 (en) | 1996-03-13 |
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