SK165898A3 - Use of inhibitors of the cellular na+/h+ exchanger (nhe) for preparing a medicament for normalizing serum lipids - Google Patents

Abstract

The active substances identified as inhibitors of the cellular Na<+>/H<+> exchanger (NHE) are used to prepare a medicament for normalizing serum lipids. They are used in the preparation of a medicament which reduces lipid levels in the blood and can be administered for treating diseases caused by lipid levels which are too high, and for alleviating the endothelial dysfunctional syndrome and for treating diseases caused thereby.

Description

Technical field

The invention relates to the use of Na * / H * exchanger inhibitors for the manufacture of a medicament for the normalization of serum lipids. This is true for all substances that show efficacy as Na- / H * exchanger inhibitors.

Known active substances which have been identified as inhibitors of Na 2 / H ¹ exchange are guanidine derivatives, preferably acylguanidines, which are described, inter alia, in the following publications and patent documents: Edward J. Crgoe, Jr., Diuretics, Chemistry, Pharmacology and Medicine, J. Wiley and Sons (1983), 303-341, in addition to the compounds of the following formulas:

I. (a) Benzoylguanidine of the formula I (HOE 89 / F 288-US 5292755)

wherein one of R ¹ or ^{R, and} R ^e is a group - S (O) nalebo group R ⁷ R "N-0aS- and the other of R ¹ or R ^A is H, F, Cl, bromo, (C 1 -C 4) alkyl, (C 1 -C 4) alkoxy, or phenoxy which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, methyl group and methoxy group or the other of the substituents R ¹ or R ³ represents a group R ⁵ -S (O) _n or a group R ⁷ R ⁸ N- wherein n represents 0, 1 or 2,

R ⁸ represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, a cyclopentylmethyl group, a cyclohexylmethyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, methyl a group and a methoxy group, R ⁷ and R ⁸ , which are the same or different, represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or R ⁷ represents a phenyl- (CH ₂ ) _{m group} , wherein m represents 1 to 4, or

R ⁷ represents a phenyl group which is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group, or

R ⁷ and R ⁸ together represent a straight or branched chain containing 4 to 7 carbon atoms, which chain may in addition be interrupted by an oxygen atom, a sulfur atom or a group R ⁹ where

R ⁹ represents a hydrogen atom or a methyl group, or R ⁷ and R ⁸ together with the nitrogen atom to which they are attached represent a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system,

R ³ , R ⁴ , and R ⁵ independently of one another represent a hydrogen atom or an alkyl group containing 1 or 2 carbon atoms, or

R ³ and R ⁴ together represent an alkylene chain containing from 2 to 4 carbon atoms or

R ⁴ and R ⁵ together represent an alkylene chain containing 4 to 7 carbon atoms, as well as pharmaceutically acceptable salts thereof,

b) benzoylguanidine of general formula I (HOE 92 / F 34-US 5373924)

in which

R ¹ is a group R ⁴ -SO 2 or a group R ⁵ R ⁸ N-SO 2 -, wherein m is 0, 1 or 2,

R ⁴ and R ⁵ are C 1 -C 8 alkyl, C 3 -C 6 alkenyl or -C _n H _{2 n} -R ⁷ , where n is 0, 1, 2, 3 or 4,

R ⁷ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, CF 3 group, methyl group, methoxy group and NR ⁸ R ^{9 group} , where

R ⁸ and R ⁹ represent a hydrogen atom or a C 1 -C 4 alkyl group, or R ⁵ represents a hydrogen atom,

R ⁸ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or

R ⁵ and R ⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH _{3 group} or an N-benzyl group,

R ² is H, F, Cl, Br, alkyl having 1 to 4 carbon atoms, the group 0- _{(CH2) m} CpF ₂ p _{+ 1,} or a group -XR ¹⁰ in which m is 0 or 1, p is 1 , 2 or 3

X is O, S or NR ^11,

R ¹⁰ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, a cyclohexylmethyl group, a cyclopentylmethyl group or a group - ^C n ^H 2n - ^{R 12} 'n is 0, 1, 2, 3 or 4 .

R ¹² represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, aq group

CF ₃ , methyl, methoxy and NR R 'where

R ⁸ and R ⁹ represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms; or

R ¹⁰ and R ¹¹ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl;

R ³ is as R ¹ or is C 1 -C 6 alkyl, nitro, cyano, trifluoromethyl, fluoro, chloro, bromo, iodo, or -XR ¹⁸ , wherein:

X is O, S or NR ^11, R ¹⁸ is H, alkyl having 1 to 6 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, cyclohexylmethyl, cyclopentylmethyl or -C _n H 2 _N-R ¹² n is 0 to 4,

R ¹² represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a CF ₃ group, a methyl group, a methoxy group and an NR ⁸ R ⁹ group wherein

R ⁸ and R ⁹ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ¹¹ represents an alkyl group having 1 to 3 carbon atoms, or

R ¹⁸ and R ¹¹ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _N-CH3 or sku5 Pina N-benzyl, and their pharmaceutically acceptable salts,

(c) ortho-substituted benzoylguanidine of the formula I (HOE 92 / F 035 EP-OS 556673)

in which

R ¹ represents a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an alkyl group having 1 to 6 carbon atoms or a -XR ⁶ group, wherein:

X is O, S, NR ⁷ or Y-ZO,

Y is O or NR ^7,

Z represents a carbon atom or a SO group,

R ⁶ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, a cyclohexylmethyl group, a cyclopentylmethyl group, a - (CH ₂ ) _m CpF ₂ p ₊₁ or a -C _n H _2n - R ⁸ , m is 0 or 1, p is 1 to 3, n is 0 to 4,

R ⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a CF ₃ group, a methyl group, a methoxy group and an NR ⁹ R ¹⁰ group wherein

R ⁹ and R ¹⁰ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ⁷ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, or

R ⁶ and R ⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ³ represents a hydrogen atom or a group -XR ⁸ where

X is O, S, NR ⁷ or Y-ZO,

R ⁷ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms,

Y is O or NR ^7, wherein Y is bonded to the phenyl radical of the formula I,

Z represents a carbon atom or a SO group,

R ⁶ is H, alkyl of 1 to 6 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, cyclohexylmethyl, cyclopentylmethyl, - (CH _{2) m} CpF _{2p + 1} or -C _n H _2n -R , m is 0 or 1, p is 1 to 3, n is 0 to 4,

R ⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a CF ₃ group, a methyl group, a methoxy group and an NR ⁹ R ¹⁰ group wherein

R ⁹ and R ¹⁰ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or

R ⁶ and R ⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ² and R 4, which are the same or different, represent a group R ¹¹ -SOg- or a group R ¹² R ¹³ N-SO ₂ -, g is 0 to 2,

R ¹¹ represents an alkyl group having 1 to 4 carbon atoms which is unsubstituted or which bears as a substituent a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, CF ₃ group, methyl group, methoxy group a group and a group NR ⁹ R ¹⁰ wherein

R ⁹ and R ¹⁰ are hydrogen or (C 1 -C 4) -alkyl,

R ¹² and R ¹³ have the meanings as R ⁶ and R ⁷ , or one of the two radicals R ² or R ⁴ is hydrogen or has the meaning of R ¹ and

R ⁵ represents a hydrogen atom, a methyl group, a fluorine atom, a chlorine atom or a methoxy group, as well as pharmaceutically acceptable salts thereof,

d) benzoylguanidine of the formula I (HOE 92 / F 036-US 5364868)

in which

R ¹ or R ² represents an amino group -NR ³ R ⁴ wherein R ³ and R ⁴ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a cycloalkyl group having 3 to 7 carbon atoms, or

R ³ is phenyl- (CH ₂ ) p -, wherein p is 0, 1, 2, 3 or 4 or

R ³ represents a phenyl group which is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group, or

R ³ and R ⁴ together represent a straight or branched methylene chain having 4 to 7 carbon atoms, wherein one member of the -CH ₂ -methylene chain may be replaced by an oxygen atom, a sulfur atom or a NR ⁵ group where

R ⁵ represents a hydrogen atom or a lower alkyl group, and the other of the substituents or R 6 represents a hydrogen atom, a fluorine atom, a chlorine atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a CF ₃ group, ^c m ^F 2m + 1 " ^CH 2" · benzyl or phenoxy, wherein the phenyl residue is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of methyl, methoxy, fluoro and chloro, m represents 1 , 2 or 3, as well as pharmaceutically acceptable salts thereof,

(e) benzoylguanidine of the formula I (92 / F 197 K-NZ 248013)

in which

R ¹ is a group R ⁴ -SO 2 or a group R ⁵ R ⁶ N-SO 2 wherein m is 0, 1 or 2,

R ⁴ and R ⁵ are C 1 -C 8 alkyl, C 3 -C 6 alkenyl or -C _n H _{2 n} -R ⁷ , where n is 0, 1, 2, 3 or 4,

R ⁷ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, CF ₃ group, methyl group, methoxy group and NR ⁸ R ^{9 group} , where

R ⁸ and R ⁹ represent a hydrogen atom or a (C 1 -C 4) alkyl group;

R5 represents a hydrogen atom,

R ⁶ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms; or

R ⁵ and R ® together represent 4 or 5 methylene groups, of which one CH 2 group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ² is H, straight or branched alkyl of 5 to 8 carbon atoms, -CR ¹³ = CHR ¹² group, or -CaCR ^12,

R ¹² represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, CF ₃ group, methyl group, methoxy group and NR ¹⁴ -R ¹⁵ group wherein

R ( ¹⁴⁾ and R ( ¹⁵⁾ are hydrogen or (C1-C4) -alkyl;

R ¹² represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group, or

R ¹² represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups, or

R ¹² represents a cycloalkyl group having 3 to 8 carbon atoms,

R ¹³ represents a hydrogen atom or a methyl group or R ¹² represents a cycloalkyl group containing 3 to 8 carbon atoms, a cycloalkylalkyl group in which the cycloalkyl radical contains 3 to 8 carbon atoms and the alkyl radical contains 1 to 4 carbon atoms, a phenyl group, a C 8 H 8 -alkyl wherein the alkyl moiety contains 1 to 4 carbon atoms, naphthyl, biphenylyl, 1,1-diphenylalkyl, wherein the alkyl moiety contains 1 to 4 carbon atoms, cyclopentadienyl, pyridyl, pyrrolyl, furanyl, thienyl thiazolyl, oxazolyl, indenyl, quinolyl, indolyl, benzofuranyl, benzothienyl, benzothiazolyl, benzoxazolyl, imidazolyl, pyrazolyl, triazolyl, israzolyl, isoxazolyl, isoxazolyl, isoxyl, isoxyl, isoxyl, isoxyl, isoxyl, isoxyl, isoxyl a pin, pyrazinyl, pyrimidinyl, pyridazinyl, indazolyl, isoquinolyl, phthalazinyl, quinoxalinyl, quinazolinyl or cinolinyl group,

R ³ is defined as R ^2, where the aromatic radicals R ² or R ³ is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of F, Cl, CFG, alkyl of 1 to 4 carbon atoms, alkoxy containing 1 to 4 carbon atoms or NR ¹⁰ R ^{1: 1} , wherein R ¹⁰ and R ¹¹ are hydrogen or C 1 -C 4 alkyl, and pharmaceutically acceptable salts thereof,

f) benzoylguanidine of the formula I (HOE 92 / F 303 K-EP-OS 589336, NZ 248 703)

I

X, h ₂ fi o

, N = C nh ₂ (I) wherein

R ¹ or R ² is R ³ S (O) _n ^R 4 radical, or \ _Step-O2S

5 /

R 1 and the other of R ¹ or R ² are hydrogen, hydroxy, fluorine, chlorine, iodine, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, benzyloxy or a phenoxy group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, methyl group, methoxy group, hydroxy group or benzyloxy group, R 6 -S (O) _n , an -NR ⁴ R ^{6 group} or a 3,4-dehydropiperidine group wherein

R1 represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, a cyclopentylmethyl group, a cyclohexylmethyl group or a phenyl group which is unsubstituted or substituted by one to three substituents selected from the group consisting of fluorine atom, chlorine atom, a group and a methoxy group,

R ⁴ and R ⁵ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or

R ⁴ represents a phenyl- (C 1-4) _{m group} , wherein m represents 1, 2, 3 or 4, or

R ⁴ represents a phenyl group which is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group; or

R ⁴ and r ⁵ together represent a straight or branched chain containing 4 to 7 carbon atoms, which chain may additionally be interrupted by an oxygen atom, a sulfur atom or an NR ⁶ group where

R ⁶ represents a hydrogen atom or a methyl group, or R ⁴ and R ⁵ together with the nitrogen atom to which they are attached represent a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system, n represents 0, 1 or 2, and pharmaceutically acceptable salts thereof,

(g) isoquinoline of general formula I (92 / F 304-US 5416094)

in which

R ¹ represents a hydrogen atom, an alkyl group, a cycloalkyl group, an arylalkyl group, an alkenyl group, a substituted aminoalkyl group or an aryl or heteroaryl ring, said rings being unsubstituted or substituted by 1 to 3 groups selected from halogen, nitro, amino a group, a mono (lower alkyl) amino group, a di (lower alkyl) amino group, a lower alkyl group, a benzyloxy group, a phenoxy group, a hydroxy group, a trifluoromethyl group,

R ² represents a hydrogen atom, a halogen atom, an alkyl group or an aryl group which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of halogen, nitro, amino, mono (lower alkyl) amino, di ( lower alkyl) amino, lower alkyl, lower alkoxy, benzyloxy, phenoxy, hydroxy,

G is a group of formula VII

-n = c n:

n:

(VII)

X ^2, X ² and X ⁴ independently of one another are hydrogen, halogen, nitro, amino, alkyl, sulfonamide, mono (lower alkyl) amino, di (lower alkyl) amino; , lower alkyl, benzyloxy, hydroxy,

X ¹ is hydrogen, oxygen, sulfur or NR 7 where

R ⁷ represents a hydrogen atom, an alkyl group, a cycloalkyl group, an arylalkyl group, an alkenyl group, a substituted aminoalkyl group or an aryl or heteroaryl ring, said rings being unsubstituted or substituted by 1 to 3 substituents selected from halogen, nitro, amino a mono (lower alkyl) amino group, a di (lower alkyl) amino group, a lower alkyl group, a lower alkoxy group, a benzyloxy group, a phenoxy group, a hydroxy group and a trifluoromethyl group, wherein each alkyl group in said substituents chain or alkenyl chain can be interrupted by O, S or NR ^8,

R ⁸ represents a hydrogen atom, an alkyl group, a cycloalkyl group, an arylalkyl group, an alkenyl group, a substituted aminoalkyl group or an aryl or heteroaryl ring, said rings being unsubstituted or substituted by 1 to 3 substituents selected from halogen, nitro, amino a group, a mono (lower alkyl) amino group, a di (lower alkyl) amino group, a lower alkyl group, a lower alkoxy group, a benzyloxy group, a phenoxy group, a hydroxy group and a trifluoromethyl group, and pharmaceutically acceptable salts thereof salt,

(h) compounds of the formula I (92 / F 404-EP 602 522;

NZ 250 438}

In which

R ¹ represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an -NO 2 group, a cyano group, a trifluoromethyl group, an R ⁴ -SOm group or an R 1 R 5 -N-SO ₂ - group where m is 0 , 1 or 2

R ⁴ and R ⁵ are C 1 -C 8 alkyl, C 3 -C 6 alkenyl, -C _n H _{2 n} -R ⁷ or trifluoromethyl, n is 0, 1, 2, 3 or 4,

R ⁷ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁸ R ^{9 group} , where

R ⁸ and R 5 represent a hydrogen atom or a C 1 -C 4 alkyl group, or R ⁵ represents a hydrogen atom;

R is hydrogen or C 1 -C 4 alkyl; or

R ⁵ and R ⁶ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH-j group or an N-benzyl group,

R ² is -SR ^10, -OR ^10, -NHR ^10, -NR ¹⁰ R ^11, -CHR ¹⁰ R ^12, a group - / CR ¹² R ¹³ OR ¹³ '/, a - / C / CH 2 -OR ¹³ · (R ¹² R ¹³ ) or - (CR ¹⁸ R ¹⁷ ) p -CO- / CR ¹⁹ R ²⁰ / g R ¹⁴ , where R ¹⁰ and R ¹¹ , which are the same or different, are - / CHR ¹⁶ / - (CH ₂ ) _p - (CHOH) _q - (CH ₂ ) _r - (CHOH) _t -R ²¹ or - (CH ₂ ) _ -O- (CH ₂ -CH ₂ O) - R ²¹ , n

R is hydrogen or methyl, p, g, r, which are the same or different, are 0, 1, 2, or 4, s is 0 or 1, t is 1, 2, 3 or 4,

R ( ²⁾ and R ( ³⁾ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or together with the carbon atom to which they are attached a cycloalkyl group having 3 to 8 carbon atoms,

R ¹³ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ¹⁴ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or a group -C _and H _2a -R ¹⁵ , and is 0, 1, 2, 3 or 4,

R ^ ¹ is phenyl, which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy and NR ⁸ R ^9, wherein

R ⁸ and R ⁹ represent a hydrogen atom or a (C 1 -C 4) alkyl group;

R ¹⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group,

R ¹⁵ represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups,

R ¹⁶ , R ¹⁷ , R ¹⁸ , R ¹⁹ and R ²⁰ represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms,

R ³ is as R 6 or

R ³ represents an alkyl group having 1 to 6 carbon atoms or a -XR group wherein

X represents an oxygen atom, a sulfur atom or an NR *** ⁸ group, wherein r 3 * ⁸ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, or

Those?

R and R · ¹ · ^O together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ²² is as R ¹⁴ as well as their pharmaceutically acceptable salts,

(i) benzoylguanidine of the formula I (HOE 92 / F 405-EP 602523, NZ 250 437)

in which

R ¹ represents a hydrogen atom, a fluorine atom, a bromine atom, an iodine atom, a nitro group, a cyano group, a group R ¹⁸ -CpH ² p -Oq, a group R ⁴ -SOm or a group R ⁵ R ⁸ N-SO ₂ where m represents 0, 1 or 2, p is 0 or 1, g is 0, 1, 2 or 3,

R ¹⁶ represents a group C _r F _{2r + 1} , r represents 1, 2 or 3,

R ⁴ and R ⁵ are alkyl of 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, -C _n H _2n -R ¹⁷ or trifluoromethyl, n is 0, 1, 2, 3 or 4,

R ⁷ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and a NR R group;

R ⁸ and R ⁹ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms or R ⁵ represents a hydrogen atom,

R ⁸ represents a hydrogen atom or a C 1 -C 4 alkyl group or r ⁵ and R ⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH 3 group or N-benzyl

R is a C 1 -C 9 heteroaryl group which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methoxy, hydroxy, amine a methylamino group and a dimethylamino group; or

R ² is -SR ^10, -OR ^10, -NR ¹⁰ R ^11, -CR ¹⁰ R ¹¹ R ^12, wherein

R ¹⁰ represents a -C _and H _2a -heteroaryl group in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group, hydroxy group a group, an amino group, a methylamino group and a dimethylamino group, and is 0, 1 or 2,

R ¹¹ and R ¹² independently of one another have the meaning of R ¹⁰ or represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ³ is defined as R ¹ or alkyl of 1 to 6 carbon atoms or a group -XR ^13,

X represents an oxygen atom, a sulfur atom or an NR ¹⁴ group, R ¹⁴ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms,

R ¹³ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or a group " ^c b ^H 2b" ^{R 15} 'b is 0, 1, 2, 3 or 4 or

R ¹³ and R ¹⁴ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, N-CH3 or N-benzyl;

R ¹⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁸ R ^{9 group} ,

R ⁸ and R ⁹ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, as well as pharmaceutically acceptable salts thereof,

k) benzolyguanidine of general formula I (HOE 92 / F 411-NZ 250450, EP 603650)

wherein one of R ¹ , R ² , R ³ or R ⁴ is an amino group of formula (I)

-N, C 6 h ₂ -r

R ⁵ is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, n is 0, 1, 2, 3 or 4,

R ⁸ represents a hydrogen atom or a (C 1 -C 4) alkyl group, where one CH ₂ group may be replaced by one sulfur atom or NR * ⁷ group,

R ⁷ represents a hydrogen atom, a methyl group or an ethyl group;

R ⁸ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a bromine atom, a methyl group, a methoxy group, a group

-NR ⁸ R ⁹

R ⁸ and R ⁹ represent a hydrogen atom, a methyl group or an ethyl group, or r ⁵ and R ® together with the nitrogen atom represent 5-, 6- or

A 7-membered ring in which one carbon atom can be replaced by a sulfur atom, an oxygen atom, or an NR 6 · ^{8 group} ,

R ¹⁸ is hydrogen, alkyl having 1 to 3 carbon atoms or benzyl, and another of R ¹ , R ² , R ³ or R ⁴ is hydrogen, fluoro, chloro, bromo, iodo, cyano a group, a trifluoromethyl group, a nitro group, a CF-10- group, a C _m F _{2m + 1} -CH ₂ -O- group or a C 1 -C 6 g-Xpm group being 1, 2 or 3, g being 0, 1, 2, 3 or 4, p is 0 or 1,

X represents an oxygen atom or an NR ¹² group,

R ¹² represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms,

R ¹¹ is H, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or phenyl, which is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, methyl , methoxy and NR ¹³ R ^14,

R ¹³ and R - * - ⁴ represent a hydrogen atom, a methyl group or an ethyl group, as well as pharmaceutically acceptable salts thereof,

1) a benzoylguanidine of the formula I (HOE 92 / F

422-EP 604852

O (I) in which

R ¹ represents a group R ⁴ R ⁵ NC (X) -,

X is O, S or NR ^8,

R ⁴ and R ⁵ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 6 carbon atoms or a -C n ^H 2n -R ⁷ 'n group being 0, 1, 2 , 3 or 4

R ⁷ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methoxy group and an alkyl group having 1 to 4 carbon atoms;

R ⁴ and R ⁵ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by: an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ⁶ is as R ⁴ or is an amidine group,

R ² represents H, F, Cl, Br, I, alkyl having 1 to 8 carbon atoms, 1-alkenyl and 1-alkynyl, cycloalkyl having 3 to 8 carbon atoms, a cycloalkylalkyl group, in which a cycloalkyl radical having 3 to 8 carbon atoms and an alkyl radical having 1 to 4 carbon atoms, a phenyl group, a C8H5 _- alkyl group in which the alkyl radical contains 1 to 4 carbon atoms, a naphthyl group, a biphenylyl group, a 1,1-diphenylalkyl group wherein the alkyl moiety contains 1 to 4 carbon atoms, cyclopentadienyl, pyridyl, thiopyridyl, pyrrolyl, furanyl, thienyl, thiazolyl, oxazolyl, indenyl, quinolyl, indolyl, benzofuranyl, benzofuranyl , benzothiazolyl, benzoxazolyl or -WR ⁸ ,

W represents an oxygen atom, a sulfur atom or an NR ⁹ group,

R ⁸ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, a cyclohexylmethyl group, a cyclopentylmethyl group, a - (CH 2) m ^c p ^F 2p + 1 ^and - - ^{e e} ° group - ^CgH2q-R10 ,, m is 0 or 1, p is 1, 2 or 3, g is 0, 1, 2, 3 or 4,

R ¹⁰ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an NR ¹² R ^{12 group} ,

R ( ¹¹⁾ and R ( ¹²⁾ are hydrogen or (C1-C4) -alkyl,

R ⁹ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms; or

R ⁸ and R ⁹ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ³ represents H, F, Cl, Br, I, alkyl having 1 to 6 carbon atoms or -WR® which is as defined for R ^2, and a pharmaceutically-acceptable salt thereof,

m) benzoylguanidine of the formula I (93 / F 054-NZ 250919, EP-OS 612 723)

in which

R ¹ , R ² , R ³ are hydrogen, fluorine, chlorine, bromine, iodine or C 1 -C 12 alkyl, one of R ¹ , R ² or R ³ is N ₃ , cyano, a hydroxy group or an alkyloxy group having 1 to 10 carbon atoms, when at least one of the remaining substituents R ¹ , R ² or R ³ represents a sufficiently lipophilic alkyl radical containing 3 to 12 carbon atoms or one of the substituents R ¹ , R ² or R ³ is a group m is 0 or 1, n is 0, 1, 2 or 3,

R ⁴ is CpF ₂ p ₊₁ , p is 1, 2 or 3 when n is 0 or 1 or

R ⁴ represents a cycloalkyl group having 3 to 12 carbon atoms, a phenyl group, a pyridyl group, a quinolyl group or an isoquinolyl group, said aromatic and heteroaromatic ring systems being unsubstituted or substituted by one substituent selected from fluorine, chlorine, trifluoromethyl , methyl, methoxy and NR ⁵ R ^8,

R ⁵ and R ⁸ are hydrogen or C 1 -C 4 alkyl or one of R ¹ , R ² or R ³ is -C =CR ⁵ or -C (R ⁶ ) = CR ⁵ , r ⁵ is a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group and heteroaryl group (C 1 -C 9) group which is unsubstituted or substituted as a phenyl group;

R ⁵ represents an alkyl group having 1 to 6 carbon atoms 23 which is unsubstituted or substituted by 1 to 3 hydroxy groups, or

R ⁵ represents a cycloalkyl group having 3 to 8 carbon atoms,

R ⁶ represents a hydrogen atom or a methyl group, as well as pharmacologically acceptable salts thereof,

(o) benzoylguanidine of the formula I (93 / F 153-EP-OS 627413, NZ 260660

(I) in which a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a nitro group, a cyano group, a group is a group

R ⁵ -COR ⁵ -SO ₂ ) _p - (CF ₂ ) g-CF ₃ , R ⁷ R ⁷ N-SO ₂ -, represents an oxygen atom, a sulfur atom or an NR ¹⁴ group, represents 0, 1 or 2, is 0 or 1, is 0, 1 or 2, is 0, 1, 2, 3, 4, 5 or 6,

R ³ and R 0 are C 1 -C 8 alkyl, C 3 -C 6 alkenyl X _o - (CH

X m

about

P q

m 'or trifluoromethyl atoms, n is 0, 1, 2, 3 or 4,

R ⁸ represents a C 3 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ¹⁰ , ^c n ^H 2n- *

R ⁹ and R ¹⁰ are hydrogen or C 1 -C 4 alkyl or R ⁶ is hydrogen,

R ⁷ represents a hydrogen atom or a C 1 -C 4 alkyl group;

R ⁶ and R ⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ² is ^- (CHOHJp-tCHdj- (CHOH) -R ¹¹ or a group //% (C) J (CHOH) j (CH2) i- (CHOH) -R ¹¹ or a group -Y // (C 1 - (CHOH) - (CH ₂ ) 3 - (CHOH) R ¹¹

Y-

Y represents an oxygen atom, a sulfur atom or an -NR ¹² - group,

R ¹¹ and R ¹² represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, h is 0 or 1, i, independently of one another, being 0, 1, 2, 3 or 4, but h while not simultaneously 0 .

R ³ is defined as R ¹ or is an alkyl group having I to 6 carbon atoms, or a group -XR ^13,

X represents an oxygen atom, a sulfur atom or an NR ¹⁴ group, R ¹⁴ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms,

R ¹³ is alkyl of 1 to 6 carbon uhlíko25 dumping, cycloalkyl having 3 to 8 carbon atoms or -Ο ^ ^ Η -Η ^19, b is 0, 1, 2, 3 or 4, or R ³ and R ⁴ together is 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl;

R ¹⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ^{18 group} ,

R ⁹ and R ¹⁸ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ⁴ represents a hydrogen atom, -OR ¹⁶ or -NR ¹⁶ R ¹⁷ R ¹⁶ and R ^17, independently of one another, represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, as well as pharmaceutically acceptable salts thereof,

(p) benzoylguanidine of the formula I (HOE 93 / F 154-EP-OS 628543, NZ 260 681)

in which

R ¹ is R ⁶ -CO or R ⁷ R ⁸ N-CO,

R ⁶ is C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl or C _n H _2n -R ⁹ , n is 0, 1, 2, 3 or 4 .

R ⁹ represents a cycloalkyl group having 3 to 8, 26 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, the aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy - and NR @ ¹¹ R @ ¹¹ ;

R ¹⁰ and R ¹ ! are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl;

R ⁷ is H, alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms or -C _n H _2n -R ^12, n is 0, 1, 2 , 3 or 4

R ¹² represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ¹³ R ^14,

R ¹³ and R ¹⁴ represent a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group,

Q

R represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a perfluoroalkyl group having 1 to 4 carbon atoms, or

R ⁷ and R ® together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH 2 group or an N-benzyl group,

R ² is as R ¹ or is hydrogen, fluoro, chloro, bromo, iodo, cyano, nitro, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, an alkenyl group having 3 to 8 carbon atoms or -C _n H _{2 n} R ^15, n is 0, 1, 2, 3, 4,

R ¹⁵ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ¹⁸ R ^17,

R ( ¹⁶⁾ and R ( ¹⁷⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or

R ² is a heteroaryl group having 1 to 9 carbon atoms which is linked via carbon or nitrogen and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methoxy, hydroxy, amino, methylamino and dimethylamino; or

R ² is SR ^18, -OR ^18, -NR ¹⁸ R ^19, -CR ¹⁸ R ¹⁹ R ^20, t_ least

R is -C _and H 2 _and -heteroaryl wherein the heteroaryl radical contains 1 to 9 carbon atoms, which radical is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -hydroxy, amino, methylamino and dimethylamino, and is 0, 1 or 2,

R ¹⁹ and R ²⁰ independently of one another have the meaning of R ¹⁸ or are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, or

R ² is R ²¹ -SO 2 or R ²² R ²³ N-SO 2 -, m is 1 or 2,

R ²¹ represents an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, the group " ^c n ^H 2n ^{R 24} 'n" means 0, 1, 2, 3 or 4,

R ²⁴ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR R group,

R ²⁷ and R ²⁸ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ²² is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl, -C _n H 2 _n -R ²⁹ , n is 0, 1, 2 , 3 or 4

R ²⁹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ³⁰ R ³¹ ,

R ( ³⁰⁾ and R ( ³¹⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ²³ represents a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group, or

R ²² and R ²³ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl,

R ² is R ³³ -X-,

X is O, S, NR ³⁴ , (DO) A-, NR ³⁴ C = MNR ³⁵ M is O or S,

A represents an oxygen atom or a group NR ³⁴ ,

D represents a carbon atom or an SO group,

R ³³ is alkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms, ^(CH2 ^ ^ b ^c d 2 d + L is -C _n H _2n -R ^38, n is 0 or 1, d is 1, 2, 3, 4, 5, 6 or 7, n is 0, 1, 2, 3 or 4,

R ³⁶ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group -group and NR ^J R,

R ( ³⁷⁾ and R ( ³⁸⁾ are hydrogen, (C1-C4) -alkyl or (C1-C4) perfluoroalkyl,

R ³⁴ represents a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group,

R ³⁸ is as R ³³ or

R ³³ and R ³⁴ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, N-CH or N-benzyl, where A and are attached to the phenyl ring a basic benzoylguanidine backbone, or

R ² is -SR ^48, -OR ^48, -NHR ^48, -NR ⁴ R ° ^41, -CHR ⁴⁸ R ^42, -C / R ⁴² R ⁴³ OH /, -C 'CR ⁴⁵ , - / CR ⁴⁷ R ⁴⁸ / U- (CO) - / CR ⁴⁹ R ⁵⁰ / in R ⁴⁴ , R ⁴⁸ and R ⁴¹ , which are the same or different, is - (CH 2) p - (CHOH) (CH 2) r- (CHOH) t R ⁵¹ or - (CH 2) _p -O- (CH ₂ -CH ₂ O) _q -R ⁵¹

R ⁵¹ is a hydrogen atom or a methyl group, u is 1, 2, 3 or 4, v is 0, 1, 2, 3 or 4, p, q, r, which are the same or different, are 0, 1, 2, 3 or 4, t is 1, 2, 3 or 4,

R ⁴² and R ⁴³ , which are the same or different, represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or

R ( ⁴²⁾ and R ( ⁴³⁾ together are the carbon atom to which they are attached a cycloalkyl group containing 3 to 8 carbon atoms,

R ⁴⁴ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having up to 8 carbon atoms or a group -c _e H _2e -R ⁴⁵ , e being 0, 1, 2, 3 or 4,

R ⁴⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁵² group R ⁵³ ,

R ( ⁸²⁾ and R ( ⁸³⁾ are hydrogen, (C1-C4) -alkyl or (C1-C4) -alkyl;

R ⁴⁵ represents a C 1 -C 9 heteroaryl group which is unsubstituted or substituted as a phenyl group, or

R ⁴⁵ represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups,

R ⁴⁸ , R ⁴⁷ , R ⁴⁸ , R ⁴⁹ and R ⁸⁰ are hydrogen or methyl;

R ² is R ⁵⁵ -NH-SO ₂ -,

R ⁵⁵ is R ⁵⁸ R ⁵⁷ N- (C = Y) -,

Y is O, S or NR ^58, R ⁵⁸ and R ⁵⁷ are the same or different, are H, alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms or -C _f H _2f -R ⁵⁹ , f is 0, 1, 2, 3 or 4,

R ⁵⁹ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethoxy group and an alkyl group having 1 to carbon atoms, or

R ⁵⁶ and R ⁵⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ⁵⁸ is as R ⁵⁶ or is an amidino group, R ³ , R ⁴ and R ⁵ independently of one another have the meanings as R ¹ or

R ^2, and a pharmaceutically-acceptable salt thereof,

q) benzoylguanidine of general formula I (HOE 93 / F 220-EP-OS 640593, NZ 264 117)

in which

R ¹ represents a hydrogen atom, a fluorine atom, a bromine atom, an iodine atom, a nitro group, a cyano group, a -Χθ- (CH ₂ ) _q -CF ₃ group, an R ⁸ -SO 2 - group, an R ⁸ -CO- group, R ⁸ R ⁷ -CO- or R ⁶ R ⁷ N-SO 2 -

X is O, S or NR ^14, m is 0, 1 or 2, o is 0 or 1, p is 0, 1 or 2; q is 0, 1, 2, 3, 4, 5 or 6,

R ⁵ and R ⁸ are C 1 -C 8 alkyl, C 3 -C 6 alkenyl, -C _n H _{2 n} -R ⁸ or trifluoromethyl, n is 0, 1, 2, 3 or 4,

R ⁸ represents a C 3 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ^{18 group} ,

R ⁹ and R ¹⁸ are hydrogen or C 1 -C 4 alkyl or R 7 is hydrogen,

R ⁷ represents a hydrogen atom or a C 1 -C 4 alkyl group;

R® and R ⁷ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl;

R ² is a group

Y-

R ¹¹ represents a heteroaryl group having 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group , hydroxy, amino, methylamino, dimethylamino and benzyl,

Y represents an oxygen atom, a sulfur atom or an NR ¹² group, R ¹² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms,

R ³ is as R ¹ or

R ³ represents an alkyl group having 1 to 6 carbon atoms or -XR ¹³ ;

X represents an oxygen atom, a sulfur atom or an NR ¹⁴ group, R ¹⁴ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms,

R ¹³ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a group -C 1 H ^{6 '} , -R ¹⁵ , b being 0, 1, 2, 3 or 4;

R ¹³ and R ¹⁴ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, N-Chg or N-benzyl;

R ¹⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ^{10 group} ,

R ⁹ and R ¹⁰ represent an alkyl group having 1 to 4 carbon atoms,

R ⁴ represents a hydrogen atom, -OR ¹⁶ , -NR ¹⁶ R ^17, or C _r F _{2r + 1} ,

R ¹⁶ and R ¹⁷ independently of one another are H, alkyl having 1 to 3 carbon atoms, r is 1, 2, 3 or 4, and pharmaceutically acceptable salts thereof,

(r) 5-membered benzene ring fused heterocycle of formula I (HOE 93 / F 223 K-EP 639573,

NZ 264130)

In which

X represents a nitrogen atom or a CR 6 group,

Y is O, S or NR ^7,

A, B together represent a bond or

A, B are both hydrogen when X is CR ⁶ and Y is NR ⁷ at the same time, one of R ¹ -R 6 is -CO-N = C (NH ₂ ) ₂ / other R ¹ -R ⁶ are a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom or an alkyl group containing 1 to 6 carbon atoms, at most two of the other substituents R ¹ to R ^{6 being} cyano, nitro, N ₃ , alkoxy containing 1-4 carbon atoms or trifluoromethyl, at most one of the other substituents being R ⁸ -C _n H _2n -Z, n being 0-10, wherein the alkylene chain-C _n H _2n is straight or branched and the carbon atom can be replaced an oxygen atom, a sulfur atom or a nitrogen atom,

R ⁸ represents a hydrogen atom, a C 2 -C 6 alkenyl group or a C 3 -C 10 cycloalkyl group which is unsubstituted or substituted by 1 to 4 methylene groups or a hydroxy group, or may contain an ethylene group CH = CH, wherein the methylene group the group may be replaced by an oxygen atom or a sulfur atom or a nitrogen atom, or

R ⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, trifluoromethyl group, CH ₃ -S (O) _s or R ⁹ -Wy- , s is 0, 1, or 2,

R ⁹ represents a hydrogen atom, a methyl group or an ethyl group,

W represents an oxygen atom or an NR ¹⁰ group,

R ¹⁰ represents a hydrogen atom or a methyl group,

Y is 0 or 1;

R ⁸ is C _m F 2m + 1 m is 1 to 3 or

R @ 1 is 1- or 2-naphthyl, pyridyl, quinolyl or isoquinolyl,

Z is -CO-, -CH ₂ - or - / CR ¹¹ (OH) / _q , g is 1, 2 or 3,

R ¹¹ represents a hydrogen atom or a methyl group or Z represents an oxygen atom or a group -NR ¹² -,

R ¹² represents a hydrogen atom or a methyl group, or

Z is -S (O) _s -, s is 0, 1 or 2, or

Z is -SO ₂ -NR ¹³ -,

R ¹³ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ⁷ represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 10 carbon atoms or a group R ⁸ -C _n H _2n - as well as pharmaceutically acceptable salts thereof,

(s) benzoylguanidine of the formula I (HOE 93 / F 236-EP-OS 638548, NZ 264216)

in which

R ¹ , R ³ or R ⁴ is -NR ⁶ C = X NR ⁷ R ⁸ ,

X represents an oxygen atom or a sulfur atom,

R ⁶ is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl or "C _n H _{2 n} -R ⁹ , n is Ο, 1, 2, 3 or 4

R ⁹ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ¹⁰ R ^11,

R ¹⁰ and R ¹¹ represent hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ⁷ is H, alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms or -C _a H _{2 O-R} ^12, o is 0, 1, 2 , 3 or 4

R ¹² is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy and NR ¹³ R ^14,

R ¹³ and R ¹⁴ represent a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group,

R is as R or

R ⁷ and R ⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH 2 group or an N-benzyl group, the remaining R ² , R ³ , R ⁴ , R ⁵ or R ¹ , R ² , R ⁴ , R ⁵ or R ¹ , R ² , R ³ , R ⁵ independently of one another represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a group -Ota-alkyl in which the alkyl portion contains 1-8 carbon atoms, -O t Bu-alkenyl, wherein the alkenyl group contains 3 to 8 carbon atoms, -Otc (CH2) bCdF2d + 1, ^Item ₂ L ^inu -OtdCpH -R ¹⁸ , or at most two CN, NO ₂ , NR ¹⁶ R ¹⁷ ,

b means 0 or 1 D means 1, 2, 3, 4, 5, 6, or 7 the means 0 or 1 tb means 0 or 1 tc means 0 or 1 td means 0 or 1 P means 0, 1, 2, 3 or 4 R ¹⁸ means cycloalkyl containing

carbon atoms, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group,. Methoxy and NRR,

R ( ¹⁹⁾ and R ( ²⁰⁾ are hydrogen or (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ¹⁶ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms or a CqH ₂ qR ^{21 group} , g being 0, 1, 2, 3 or 4 .

R ²¹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy - NR ²² R ²³ ,

R ( ²²⁾ and R ( ²³⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ¹⁷ is H, alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms or the group C _r H _2r -R ^24, r is 0, 1, 2, 3 or 4,

R ²⁴ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy and NRR,

R 5 and R @ ^{2 28,} H, an alkyl group having 1 to 4 carbon atoms or perfluoroalkyl of 1 to 4 carbon atoms, or

R ¹⁸ and R ¹⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, and pharmaceutically acceptable salts thereof,

(t) diacyl-substituted guanidines of formula I (HOE 93 / F 249-EP-OS 640587, NZ 264282)

T T T <*>

O NH O in which

X ¹ and X ² represent a group of the general formula

in which

T1 is 0, 1, 2, 3 or 4

R ^a and R ^b independently of one another represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group.

OR ^108, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, θζ] ς (ΟΙ2) ^ZI change ^F 2ZM + L f ^en Y ^fishing accounts or benzyl, wherein the aromatics are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁰⁹ R ^{110 group} ,

R ¹⁸⁹ a. R ( ¹⁸⁾ is hydrogen, (C 1 -C 4) alkyl or (C 1 -C 4) perfluoroalkyl, Z 1 is 0, 1, 2, 3 or 4, Z is 0 or 1, Z is 1, 2, 3, 4, 5, 6, 7 or 8

R ¹⁰⁸ is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl, C 3 -C 8 cycloalkyl, phenyl or benzyl; the aromatic groups are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and a NR ^{11: L} R ^{112 group} ,

R ( ¹¹¹⁾ and R ( ¹¹²⁾ are hydrogen, (C1-C4) -alkyl or perfluoroalkyl;

R ¹⁰⁷ and R ¹⁰⁸ are independently of one another as R ¹⁰⁸ or R ¹⁰⁸

R ⁸⁷ and R ^3-88 together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, or 1 2

X and X are a group of formula

in which

T 2A and T 2b independently of one another represent 0, 1 or 2, wherein the double bond may be of the (E) or (Z) configuration, or

X ¹ and X ² represent a group of the general formula

in which

T3 is 0, 1 or 2,

U, YY and Z independently represent a carbon atom or a nitrogen atom, wherein U, YY, Z may carry the following number of substituents:

U, YY or Z Bound in a double bond Number of possible substituents C Yes 1 C not 2 N Yes 0 N not 1

R ^d represents a hydrogen atom, an alkyl group containing 1 to 8 carbon atoms or a perfluoroalkyl group containing 1 to 8 carbon atoms,

R ^U1, R ^U2, R ^Y1, R ^Y2, R ^Z1, R ^Z2, independently of one another are hydrogen, F, Cl, ACOM Br, I, cyano, OR ^114, C 1 -C 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, ° LA ^{(GH 2)} zla ^C zma ^F 2zma 'NR ^{11 S} R ^116, phenyl or benzyl, wherein the aromatics are unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, NR ¹¹⁷ R ¹¹⁸ ,

R ¹¹⁷ and R ¹¹⁸ are hydrogen, alkyl of 1 to 4 carbon atoms or perfluoroalkyl of 1 to 4 carbon atoms, z is 0 or 1, evil is 0, 1, 2, 3 or 4, grains are 1, 2 , 3, 4, 5, 6, 7, or 8,

R ¹¹⁴ is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl, C 3 -C 8 cycloalkyl, phenyl or benzyl; the aromatic groups are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹¹⁹ R ^{120 group} ,

R ¹¹⁹ and R ¹²⁰ represent a hydrogen atom, a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group,

R ¹¹⁵ and R ¹¹⁶ independently of one another have the meanings as R ¹¹⁴ or R ¹¹⁴ ;

R ¹¹⁵ and R ¹¹⁶ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, the constitution being excluded a nitrogen atom, YY is a nitrogen atom, and Z is a carbon atom,

R ¹⁰¹ , R ¹⁸² , R ¹⁸³ , R ¹⁰⁴ and R ^{188 are,} independently of one another, a hydrogen atom, a fluorine atom, a bromine atom, an iodine atom, a cyano group _Xaa ^(CH 2 ⁾ b ^{( F} 2zqa + 1 ⁾ ' R110a_SOzbm group, a group R ^110b, R ^110c, the N-CO group, R ,, R @ ^IIIa -COalebo ^112a R ^113a N-SO 2, wherein the perfluoroalkyl group is straight or branched,

X is O, S or NR ⁴ ^^.

R ^114a represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms,

Zoa means 0 or 1, ZBM means 0, 1 or 2, ZPA means 0, 1, 2, 3 or 4, zqa means 1, 2, 3, 4, 5, 6, 7 or 8, R ^110a , _R 110b, _R 111a _and J 1 H 2a independently of each other

represent an alkyl group having 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms, -C H _{2 Zn marks} ^{118a and} R ^e l ° a perfluoroalkyl group having 1 to 8 carbon atoms, is marked 0, 1, 2, 3 or 4,

R ^115a represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group - NR ^{116a and} R ^117a ,

R ^118a and R ^117a are hydrogen, C 1 -C 4 perfluoroalkyl or C 1 -C 4 alkyl or _R 110b, _R 116 _and R 12a are hydrogen,

R ( ^110c) and R ( ^113a) independently of one another are hydrogen, perfluoroalkyl or (C1-C4) -alkyl or

RÍlOb _{and R} ll0c, _aJc0 rIL2 _{and j, and R} p _is li3a _The lu means 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _NCH3 or the group N benzyl, or R ^101, R ^102, R ^103, R ^104, R ^105, independently of one another are alkyl having 1 to 8 carbon atoms, C ₂ H _2ZA] _R ¹¹ ® ^and or alkenyl, zal is 0, 1, 2, 3 or 4

R ^{11 Sa} represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy - a group or a group NR 6 ' ^{9a and} R 6' ^9b ,

R ^119a and R ^119b represent a hydrogen atom, a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group, or

R ¹⁸¹ , R ^{82 82} , R ¹⁸³ , R ¹⁸⁴ , R ^{89 89} independently of one another are a heteroaryl group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, or

R ¹⁸¹ , R ¹⁸² , R ¹⁸³ , R ¹⁸⁴ , R ¹⁸⁹ independently of one another denote the group -CeC-R ¹⁹³ ,

R ¹⁹³ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group or NR ¹⁹⁴ R ^{199 group} ,

R ¹⁹⁴ and R ¹⁹⁹ represent a hydrogen atom or a methyl group, or

R ¹⁸¹ , R ¹⁸² , R ¹⁸³ , R ¹⁸⁴ , R ¹⁸⁹ independently of one another are a group

-Y-para- _Cg H ₄ - (CO) _z - - (CHOH) _z - (CH ₂ ) _z - (CHOH) _z -R ¹²³ or a group

-y-meta-C ₆ H ₄ - (C 0) _{the back} - (CHOH) _zae - _{(CH2) zaf} - (CHOH) _zag-R ^124, 101, or a group

-Y-ortho-C ₆ H ₄ - (CO) _z - (CHOH) _2ao - (CH ₂ ) _2ap - (CHOH) _{Za] c} -R ¹²⁵ ,

Y represents an oxygen atom, a sulfur atom or the group -NR ^122d -, zh, back, and independently of one another are 0 or 1, zi, zz, zk, zae, zaf, zag, zao, zap and zak independently of one another 0, 1, 2, 3 or 4, where zh, zi and zk do not simultaneously mean 0, back, zae and zag do not simultaneously mean 0 and za, zao and zak do not mean 0,

R ( ¹²³⁾ , R ( ¹²⁴⁾ , R ( ¹²⁵⁾ and R ( ^122d) independently of one another are hydrogen or alkyl having 1 to 3 carbon atoms, or

R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ^105, independently of one another, are SR · ¹ · ²⁹ , -OR ¹³⁸ , -NR ¹³¹ R ¹³² or -CR ¹³³ R ¹³⁴ R ¹³⁵ ,

R ^129, R ^130, R ¹³¹ and R ¹³³ independently of one another are ~ ^c kill ^ 2zabheteroaryl, wherein the aryl portion contains 1 to 9 carbon atoms, unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, a chlorine atom, a group, a methyl group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, k and n are 0, 1 or 2,

R ( ¹³²⁾ , R ( ¹³⁴⁾ and R ( ¹³⁵⁾ independently of one another have the meaning of R ( ¹²⁹⁾ or are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, or, R ( ¹⁰²⁾ , R ( ¹⁰³⁾ , R ( ¹⁰⁴⁾ R ¹⁰⁵ independently of one another are -W-para- (CGH ₄₎ R ^198, a group -W-meta | 197, _ur_zw M_ ^ * / r> ts \ _nl98 trifluoromethyl methoxy, 101 (CGH ₄ ) R ^{A:, /} or a group -W-ortho- (C _g H ₄₎ -R ^J, 196

R ¹⁹⁷ and R ¹⁹⁸ independently of one another denote a heteroaryl group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl a methyl, methoxy, hydroxy, amino, methylamino, dimethylamino and benzyl group,

W represents an oxygen atom, a sulfur atom or a group NR ¹³⁶ R ¹³⁶ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or

R ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ¹⁰⁵ independently of one another are R ¹⁴⁸ X ^1a -,

X ^1a represents an oxygen atom, a sulfur atom, NR ¹⁴⁷ , (D = O) A-, NR ¹⁴⁸ C = MN * R ¹⁴⁹ -,

M represents an oxygen atom or a sulfur atom,

A represents an oxygen atom or a group NR ¹⁵⁰ ,

D represents a carbon atom or an SO group,

R ¹⁴⁸ represents an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a (CH ₂ ) ^b moiety from ^{F 2} z d + 1 ^{or a} group

The C-p? 51 ^c ZXA "2zxa" ZBZ is 0 or 1, the DTC is 1, 2, 3, 4, 5, 6 or 7, ZXA is 0, 1, 2, 3 or 4,

R ¹⁵¹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ¹⁵² -R ¹⁵³ ,

R ( ¹⁵²⁾ and R ( ¹⁵³⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ( ¹⁴⁷⁾ , R ( ¹⁴⁸⁾ and R ( ^150), independently of one another, are hydrogen, (C1-C4) -alkyl, (C1-C4) -fluoroalkyl,

R ¹⁴⁹ is as R ¹⁴⁶ or

R ¹⁴⁶ and R ¹⁴⁷ and R ¹⁴⁶ and R ¹⁴⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, A and N are attached to the phenyl core of the alkanoyl backbone, or

R ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ¹⁰⁵ independently of one another are -SR ¹⁶⁴ , -OR ¹⁶⁵ , -NHR ¹⁶⁶ ,

-NR ¹⁶⁷ R ¹⁶⁸ , -CHR ¹⁶⁹ R ¹⁷⁸ , -CR ¹⁵⁴ R ¹⁵⁵ OH, -C-CR ¹⁵⁶ , -CR ¹⁵⁸ R ¹⁵⁷ or - (CR ¹⁵⁹ R ¹⁶⁰ ) z- (C = 0) ) - / cr ¹⁶¹ r ¹⁶² / zv-r ¹⁶³ ,

R ¹⁶⁴ , R ¹⁶⁵ , R ¹⁶⁶ , R ¹⁶⁷ , R ¹⁶⁹ , which are the same or different, represent a group

- (CH _{2) Z} y (CHOH) _zz - _{(CH2) zaa} - (CHOH) _Zt-R ¹⁷¹ or a group - (read ^ ab-O-'Oh-N 'Zac- ^11172'

R ¹⁷¹ and R ¹⁷² are hydrogen or methyl, zu is 1, 2, 3 or 4, z is 0, 1, 2, 3 or 4, zy, zz, z, z, z, z, z are the same or different, are 0, 1, 2, 3 or 4, t is 1, 2, 3 or 4,

R ¹⁶⁸ , R ¹⁷⁰ , R ¹⁵⁴ , R ¹⁵⁵ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or

R ¹ and R ⁹ ® ^178, or R ¹⁸⁴ and R ¹⁸⁸ represent together with the carbon atom to which they are attached, a cycloalkyl radical containing 3 to 8 carbon atoms,

® R ^{1 3} is H, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or -C _{2 e j 22 e} H] _5-R ^173, zeb is 0, 1, 2, 3 or 4.

R @ ¹⁵⁶ , R @ ¹⁵⁷ and R @ ¹⁷³ independently of one another represent a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁷⁴ group R ¹⁷⁵ .

R ( ¹⁷⁴⁾ and R ( ¹⁷⁵⁾ are hydrogen or (C1-C4) -alkyl or

R ¹⁵⁶ , R ¹⁵⁷ and R ^158, independently of one another, are a heteroaryl group containing 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group,

R ¹⁵⁸ , R ¹⁵⁹ , R ¹⁸⁰ , R ¹⁸¹ and R ¹⁸² are hydrogen or methyl;

R ¹⁸¹ , R ³ · ⁸² , R ¹⁸³ , R ⁸⁴ , R ¹⁸⁵ independently of one another represent a group R ¹⁷⁶ -NH-SO ₂ -,

R ¹⁷⁸ is R ¹⁷⁷ R ¹⁷⁸ N- (C-Y '),

Y ¹ represents an oxygen atom, a sulfur atom or NR ¹⁷⁹ R ¹⁷⁷ and R ¹⁷⁸ , which are the same or different, represent a hydrogen atom, a C 1 -C 8 alkyl group, a C 3 -C 6 alkenyl group or a -C _z group; f _and H _2z f _and -R ¹⁸⁸ , zfa means 0, 1, 2, 3 or 4,

R ¹⁸⁸ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy or C 1 -C 4 alkyl group, or

R ¹⁷⁷ and R ¹⁷⁸ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl;

R ¹⁷⁹ is as R ¹⁷⁷ or is an amidine group, or

R ¹⁸¹ , R ¹⁸² , R ¹⁸³ , R ¹⁸⁴ , R ^185, independently of one another, are NR ^184a, R ¹⁸⁵ , OR ^184b , SR ^184c or _{-Cn x} H _2znx -R ^184d , n x is 0, 1, 2 , 3 or 4

R ^184d _{A is} cycloalkyl having 3 to 7 carbon atoms or phenyl, which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy and NR ^118k R ^117k .

RllSk _N 117k _znam Enaje H or alkyl of 1 to 4 carbon atoms,

R ^184a , R ^184b , R ^184c , R ^185, independently of one another, are hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl or (CH ₂ ) _o -R ^184g , zao is 0, 1, 2, 3 or 4; ^r1884 is cycloalkyl having 3 to 7 carbon atoms or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ^184u R ^184v, _r 184u _ar 184v _mean Ju H or alkyl of 1 to 4 carbon atoms and R ^184a and R ¹⁸⁵ together are 4 or 5 methylene groups, of which one CH ₂ it may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, as well as their pharmaceutically acceptable salts,

u) benzoylguanidine of the formula I (HOE 93 / F 254-EP-OS 640588, NZ 264307)

in which

R ¹ represents H, F, Cl, Br, I, cyano, nitro, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or a group X _a - (CH ₂ ) _b- cf ₂ ) _c -CF ₃ ,

X is O, S or NR ^5, and a is 0 or 1, b is 0, 1 or 2, c is O, 1, 2 or 3,

R ⁵ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a -C _d H _{2 d} R ^{6 group} , d represents 0, 1, 2, 3 or 4,

R ⁶ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ⁷ R ⁸ ,

R ⁷ and R ⁸ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or

R ¹ is -SR ^18, -OR ^18, or -CR ¹⁰ R ¹¹ R ^12,

R ¹⁸ is -CfH ₂ f -cycloalkyl wherein the cycloalkyl radical contains 3 to 8 carbon atoms, heteroaryl containing 1 to 9 carbon atoms or phenyl, said aromatic systems being unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methylene group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, f represents 0, 1 or 2,

R ¹¹ and R ¹² independently of one another have the meaning of R ¹⁸ or represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms or

R ¹ represents a phenyl group, a naphthyl group, a biphenylyl group or a heteroaryl group having 1 to 9 carbon atoms, the latter being bonded via a carbon atom or a nitrogen atom and said groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino and dimethylamino, or

R ¹ is -SR 1 R ³ , -OR 1 R ³ , -NHR ³ R ³ , -NR ¹³ R ¹⁴ , -CHR ¹³ R ¹⁵ , -C (R ¹⁵ R ¹⁶ OH), -C RCR ¹⁸ , -C (R ¹⁹ ) -CR ¹⁸ , - (CR ²⁰ R ²¹ ) k - (CO) - / CR ²² R ²³ R ²⁴ / 1f

R ¹³ and R ¹⁴ , which are the same or different, represent - (CH 2) g - (CHOH) h - (CH 2) 1 - (CHOH) j R ¹⁷ , wherein R ¹⁷ represents a hydrogen atom or a methyl group, or - ( CH 2) g ° "(CH ₂ -CH ₂ O) _to -R ²⁴ · Where g, h, i, which are the same or different, are 0, 1, 2, or 4, j is 1, 2, 3 or 4 , R 15 _and R ¹⁸ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or together with the carbon atom to which they are attached a cycloalkyl group having 3 to 8 carbon atoms,

R ¹⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ²⁵ R ^{26 group} ,

R ( ²⁾ and R ( ²⁸⁾ are hydrogen or (C1-C4) -alkyl, or

R represents a C 1 -C 9 heteroaryl group which is unsubstituted or substituted as a phenyl group, or

R ¹⁸ represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups, or

R ¹⁸ represents a cycloalkyl group having 3 to 8 carbon atoms,

R ¹⁹ , R ²⁸ , R ²¹ , R ²² and R ²³ are hydrogen or methyl, k is 0, 1, 2, 3 or 4, is 0, 1, 2, 3 or 4,

R ²⁴ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having up to 8 carbon atoms or a group-C _m ^H 2m ^B · m being 1, 2, 3 or 4,

R ² and R ³ independently of one another are defined as R ¹

R ⁴ represents an alkyl group having 1 to 3 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group or a - (CH ₂ ) _n - (CF ₂ ) _O -CF _{3 group} , n being 0 or 1 , o is 0, 1 or 2, as well as pharmaceutically acceptable salts thereof,

(v) acylguanidine of the formula I (HOE 93 / F 436-EP-OS 659748, NZ 270 264)

in which

X represents a carbonyl group or a sulfonyl group,

R ¹ represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms which is unsubstituted or substituted by a hydroxy group, a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluoro, chloro, trifluoromethyl, methyl, hydroxy, amino, methyl amino or dimethylamino,

R ² is H or alkyl of 1 to 4 carbon atoms, and the pharmaceutically acceptable salts thereof,

w) phenyl-substituted alkylcarboxylguanidide which carries perfluoroalkyl groups of formula I (HOE 94 / F

014K-EP-OS 666252 ΝΖ 270370)

wherein R is H, fluoro, chloro, bromo, iodo, cyano, OR ^8, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, O _r, or a group NR ⁷ R ⁸ , r is 0 or 1, and is 0, 1, 2, 3 or 4, b is 1, 2, 3, 4, 5, 6, 7 or 8,

R ⁸ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group or a benzyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NRR group,

R ⁹ and R ¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ⁷ and R ⁸ independently of one another have the meaning as R ⁸ ,

R ^b is independently as r 1

X is 1, 2 or 3,

R ¹ is H, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, _t -0 (CH ₂₎ d ^C e ^F 2e + ^l of ^m ^ F, Cl, Br, iodine or cyano, t is 0 or 1, d is 0, 1, 2, 3 or 4, e is 1, 2, 3, 4, 5, 6, 7 or 8,

R ² , R ³ , R ⁴ and R ⁵ independently of one another mean the meanings defined for R ¹ , provided, however, that at least one of the substituents R ¹ , R ² , R ³ , R ⁴ , R ³ , rA and R ® means the group -O _t (CH ₂ ) _d C _e F _{2 e + 1} or the group O _r (CH ₂ ) _a C _b F _{2b + 1} as well as its pharmaceutically acceptable salts,

(x) heteroaroylguanidine of formula I (HOE 94 / F 094-EP 676395, NZ 270894)

(I) wherein HA represents SO _m , an oxygen atom or an NR ⁵ group, m represents 0, 1 or 2,

R ⁵ is H, alkyl of 1 to 8 carbon atoms or ^-C AM 2am ^{H R 81} Am is 0, 1 or 2,

R ⁸¹ represents a carbon-containing or phenyl-substituted cycloalkyl group having 1 to 3 substituents including a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and the group Nr 82r 83 and unsubstituted,

R ⁸² and R ⁸³ represent a hydrogen atom or a methyl group, or up to 8 group selected from the group consisting of

R ⁸¹ represents a heteroaryl group having 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group , hydroxy, amino, methylamino and dimethylamino, one of R ¹ and R ² being -CO-NC- (NH ₂ ) ₂ and the other of which is hydrogen, fluorine, Cl, Br, I, alkyl having 1 to 3 carbon atoms, -OR ^{6, C} r ^F 2r + L is -CO-N = C (NH _{2) 2,} or -NR ⁶ R ^7,

R ⁶ and R ⁷ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, r represents 1, 2, 3 or 4,

R ³ and R ⁴ independently of one another represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a X- (CH 2) p- (C 8 -C ¹² q + 1) group, an R ⁸ -SObm group R ⁹ R ¹⁰ N-CO, R ¹¹ -CO- or R ¹² R ¹³ N-SO ₂ -, wherein the perfluoroalkyl group is straight or branched,

X is O, S or NR ^14, R ¹⁴ is H or alkyl of 1 to 3 carbon atoms, bm = 0, 1, or 2, p is 0, 1 or 2, g is 0, 1, 2 , 3, 4, 5 or 6

R ⁸ , R ⁹ , R ¹¹ and R ¹² independently of one another are C 1 -C 8 alkyl, C 3 -C 6 alkenyl, C _n H _2n -R ¹⁵ or trifluoromethyl, n is 0, 1, 2, 3 or 4

R ¹⁵ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group or NR ¹⁶ R ^{17 group} ,

R ¹⁶ and R ¹⁷ are hydrogen or C 1 -C 4 alkyl or R ⁹ , R ¹¹ and R ¹² are hydrogen,

R ( ¹⁰⁾ and R ( ¹³⁾ independently of one another are hydrogen or (C1-C4) -alkyl or

R ⁹ and R ¹⁸ as well as R ¹² and R ¹³ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, or

R ³ and R ⁴ independently of one another are C 1 -C 8 alkyl or -CaA ¹ R ¹⁸ , a 1 is 0 or 1 or 2,

R ¹⁸ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁹ R ^{28 group} ,

R ¹⁹ and R ²⁰ represent a hydrogen atom or a methyl group, or

R ³ and R ⁴ independently of one another represent a heteroaryl group which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy- a hydroxy group, an amino group, a methylamino group and a dimethylamino group; or

R ³ and R ^4, independently of one another, are ^{- (CHOH)} i - ^{(CH 2)} r ^(CHO, V ^{R 13} or ^iCl 2 CHOH 4 CH 2 CH 4 R ²⁴ -Y or (C 6 H 6 CH 3) -CH 2 CHOH R ^

Y-

Y represents an oxygen atom, a sulfur atom or the group -NR ²² -, h, ad, and h independently of one another represent 0 or 1, i, j, k, ae, af, ag, ao, ap and if independently of one another they represent 0, 1, 2, 3, 4, where h, however, do not simultaneously mean 0, ad, ae and g do not simultaneously mean 0 and ah, and o and if they do not mean simultaneously 0,

R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁸⁾ and R ( ²²⁾ independently of one another are alkyl having 1 to 3 carbon atoms, or

R ³ and R ^4, independently of one another, are hydrogen, fluorine, chlorine, bromine, iodine, cyano, (C 1 -C 8) alkyl, (C 1 -C 8) perfluoroalkyl, (C 3 -C 8) alkenyl group 8 carbon atoms or -CgH ₂ grams _of ^28, g is 0, 1, 2, 3 or 4,

R ²⁸ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ²⁷ R ²⁸ ,

R ( ²⁷⁾ and R ( ²⁸⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or

R ³ and R ⁴ independently of one another are SR ²⁹ , -OR ³⁸ , -NR ³¹ R ³² or -CR ³³ R ³⁴ R ³⁸ ,

R ²⁹ , R ³⁸ , R ³¹ and R ^{33 are} independently of one another

A -C _and H _2a -heteroaryl group in which the heteroaryl residue has 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy, amino, methylamino and dimethylamino, and is 0, 1 or 2,

R ( ³²⁾ , R ( ³⁴⁾ and R ( ³⁵⁾ independently of one another have the meanings defined for R ²⁹ or are C, C 1-4 alkyl or C 1-4 perfluoroalkyl, or

R ³ and R ⁴ independently of one another represent a group

or a group

W-

R ( ⁹⁶⁾ , R ( ⁹⁷⁾ and R ( ⁹⁸⁾ independently of one another are a heteroaryl group containing 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine , trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino, dimethylamino or benzyl, W represents an oxygen atom, a sulfur atom or an NR ³⁶ - group, R represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms; or

R ³ and R ^4, independently of one another, are R ³⁷ -SO _cm or R ³⁸ R ³⁹ N-SO ₂ - cm means 1 or 2,

R ³⁷ represents an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms or a group -c _s h _{2 s} r ⁴⁰ , s being 0, 1, 2, 3 or 4 .

R ⁴⁰ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ⁴¹ R ⁴² ,

R ( ⁴¹⁾ and R ( ⁴²⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ³⁸ is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl or -C _w H _2w -R ⁴³ , w is 0, 1, 2 , 3 or 4

R ⁴³ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic group being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ⁴⁴ R ⁴⁵ ,

R ⁴⁴ and R ⁴⁸ represent hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ³⁹ represents a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group, or

R ³⁸ and R ³⁹ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or p sku59 other N-benzyl, or

R ³ and R ⁴ independently of one another represent a group R ⁴⁸ X ¹ -,

X ¹ represents an oxygen atom, a sulfur atom, an NR ⁴⁷ group, a (D 10 O) A- group, an NR ⁴⁸ C-MN * R ^{49 group} ,

M represents an oxygen atom or a sulfur atom,

A is O or NR ^50,

D represents a carbon atom or an SO group,

R ⁴⁶ represents an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a (CH ₂ ) b ^c d ^F 2d + 1 group or a - ^{c Ax 51-5} b group being 0 or 1, d is 1 , 2, 3, 4, 5, 6, or 7, x is 0, 1, 2, 3, or 4,

R ⁵¹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy -group and NR ⁵² R ⁵³ ,

R ( ⁵²⁾ and R ( ⁵³⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ( ⁴⁷⁾ , R ( ⁴⁸⁾ and R ( ⁵⁰⁾ independently of one another are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ⁴⁹ is as R ⁴⁶ or

R ⁴⁸ and R ^47, or R ⁴⁸ and R ⁴⁸ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, ΝΉ, _N-CH3 or N-benzyl, A and N * are attached to the phenyl core of the benzoylguanidine backbone, or

R ³ and R ^4, independently of one another are -SR ^84, -OR ^85, -NHR ^88, NR ⁶⁷ R ^68, -CHR ⁸⁹ R ^70, -C (OH) R ⁵⁴ R ⁵⁵ group, -CeCR ⁵⁸ , group

-CR ⁵⁸ = CHR ⁵⁷ , - / CR ⁵⁹ R ⁶⁰ / u - (CO) - / CR ⁶¹ R ⁸² / VR ⁶³

R ⁶⁴ , R ⁶⁵ , R ⁶⁶ , R ⁶⁷ and R ⁶⁹ , which are the same or different, represent a group

- (CH ₂ ) _y - (CHOH) ₂ - (CH ₂ ) _aa - (CH ₂ OH) _t -R ⁷¹ or a group

- (CH ₂ ) α 1 -O- (CB ₂ -CH ₂ O) _and -R ⁷² ,

R ⁷¹ and R ⁷² are hydrogen or methyl, u is 1, 2, 3 or 4, v is 0, 1, 2, 3 or 4, y, z, and a, which are the same or different, are 0, 1 , 2, 3 or 4, t is 1, 2, 3 or 4,

R ⁶⁸ , R ⁷⁰ , R ⁵⁴ and R ⁵⁵ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or

R ⁶⁹ and R ⁷⁰ , or R ⁵⁴ and R ⁵⁵ together with the carbon atom to which they are attached, represent a cycloalkyl group containing 3 to 8 carbon atoms,

R ⁸³ is hydrogen, C 3 -C 8 alkyl or -C _e H _2e -R ⁷³ , e is 0, 1, 2, 3 or 4,

R ⁵⁸ , R ⁵⁷ and R ⁷³ independently of one another represent a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁷⁴ R ^{75 group} .

R ⁷⁴ and R ⁷⁵ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or

R ⁵⁸ , R ⁵⁷ and R ^73, independently of one another, represent a heteroaryl group containing 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group,

R ⁵⁸ , R ⁵⁹ , R ⁸⁰ , R ⁸¹ and R ⁸² are hydrogen or methyl;

R ³ and R ⁴ independently of one another represent the group r ⁷⁶ -nh-s ₂ -,

R ⁷⁸ is R ⁷⁷ R ⁷⁸ N- (C = Y ') -,

Y 'is O, S or NR ⁷⁹ ,

R ⁷⁷ and R ⁷⁸ are the same or different, are H, alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms or CFH ₂ £ R ^88, f is 0, 1, 2 , 3 or 4

R ⁸⁰ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group and an alkyl group having 1 to 4 carbon atoms, or

R ⁷⁷ and R ⁷⁸ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, N-Chg or N-benzyl;

R ⁷⁹ is as R ⁷⁷ or is an amidine group, or

R ³ and R ⁴ independently of one another are NR ⁸⁴ R ⁸⁵ ,

R ⁸⁴ and R ⁸⁸ independently of one another are H, alkyl having 1 to 4 carbon atoms, or together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, or wherein one or two CH ₂ groups may be replaced by CH-C _m H, _{i.e. 2 (j + m 1,} and a pharmaceutically-acceptable salt thereof,

(y) a bicyclic heteroaroylguanidine of the formula I (HOE 94 / F 123-EP-OS 682017, NZ 272058)

In which

T, U, V, W, X, Y, and Z independently of one another are nitrogen or oxygen, provided that X and Z together are not nitrogen, and that T, U, V, W, X, Y, and Z bear no substituents when they are nitrogen, and that no more than four of them together are nitrogen,

R ^{@ 1} and R @ ² independently of one another represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a C1 -C3 alkyl group, a C1 -C3 perfluoroalkyl group, an OR8 group, an NR @ ⁸ group R ⁹ or C (= O) NC (NH ₂ ) ₂ ,

R ⁸ and R ⁹ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, or

R ⁸ and R ⁹ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R @ ³ , R @ ⁴ , R @ ⁸ , R @ ⁸ and R @ ⁷ independently of one another represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group; 1), R ^10a -SObm, R ^10b R ^10c N-CO, R ¹¹ -CO- or R ¹² R ¹³ N-SO ₂ , wherein the perfluoroalkyl group is straight or branched,

X is O, S or NR ^14, R ¹⁴ is H or alkyl of 1 to 3 carbon atoms, bm = 0, 1, or 2, p is 0, 1 or 2, k is 0 or 1, q means 1, 2, 3, 4, 5 or 6

R ^10a, R ^10b, R ¹¹ and R ¹² independently of one another are alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, -C _n H _2n -R ¹⁵ or a perfluoroalkyl group having 1 to 8 carbon atoms, n is 0, 1, 2, 3 or 4,

R ¹⁵ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁶ R ¹⁷ .

R ( ¹⁶⁾ and R ( ¹⁷⁾ are hydrogen or (C1-C4) -alkyl or R ( ^10b) , R ( ¹¹⁾ and R ( ¹²⁾ are hydrogen,

R ( ^10c) and R ( ¹³⁾ independently of one another are hydrogen or (C1-C4) -alkyl or

R ¹⁰ * ^5, and R ^10c, and R ¹² and R ¹³ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, N-Chg or N-benzyl or

R ³ , R ⁴ , R ⁵ , R ⁶ and R ^7, independently of one another, represent an alkyl group having 1 to 8 carbon atoms, a group ^c and ^H 2 and ^{R 18 an alao} alkenyl group having 3 to 8 carbon atoms, a 1 is 0, 1 or 2

R ¹⁸ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluoro, chloro, trifluoromethyl, methyl, methoxy and NR ^19a R ^19b,

R ^19a and R ^19b are H, alkyl having 1 to 4 carbon atoms or perfluoroalkyl of 1 to 4 carbon atoms, or

R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a heteroaryl group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of including a fluorine atom, a chlorine atom, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group or a dimethylamino group, or

R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a group

—Y or _O

O - (-) - (CHOH) CH 2 R ²⁵

Y-

Y represents an oxygen atom, a sulfur atom or the group -NR ²² h, ad, and h independently of one another represent 0 or 1, i, j, k, aa, af, ag, ao, ap and if independently of one another represent 0, 1, 2, 3 or 4, where h, although not simultaneously 0, ad, ae and g do not simultaneously mean 0 and ah, and o and if not simultaneously 0,

R ( ²³⁾ , R ( ²⁴⁾ , R ( ²³⁾ and R ( ²²⁾ independently of one another are hydrogen or alkyl having 1 to 3 carbon atoms, or

R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent SR ²⁹ , -OR ³⁰ , -NR ³¹ R ³² or -CR ³³ R ³⁴ R ³⁵ ,

R ²⁹ , R ³⁰ , R ³¹ and R ³³ independently of one another denote a -C _and H _2a -heteroaryl group in which the heteroaryl radical contains 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methoxy, hydroxy, amino, methylamino and dimethylamino

-group, and is 0, 1 or 2,

R ( ³²⁾ , R ( ³⁴⁾ and R ( ³⁵⁾ independently of one another are as defined for R ( ²⁹⁾ or are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or

R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a group

w

R ( ⁹⁶⁾ , R ( ⁹⁷⁾ and R ( ⁹⁸⁾ independently of one another are a heteroaryl group containing 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine , trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino, dimethylamino or benzyl, W is O, S or NR ³⁶ -, R ³⁶ is hydrogen or alkyl a group containing from 1 to 4 carbon atoms; or

R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a group R ⁴⁶ X ¹ -,

X ¹ represents an oxygen atom, a sulfur atom, a group NR ⁴⁷ , a group (DO) A- or a group NR ⁴⁸ C = MN * R ⁴⁹ -,

M represents an oxygen atom or a sulfur atom,

Ά. represents an oxygen atom or a group NR ⁵⁰ ,

D represents a carbon atom or an SO group,

R ⁴⁶ represents an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a group ^CHCH 2 b b ^c d ^F 2d + 1 or a group -C ^-R ⁵¹ , b represents 0 or 1, d represents 1, 2, 3, 4, 5, 6 or 7, x being 0, 1, 2, 3 or 4,

R ⁵ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group a methoxy group and a NR ⁵² R ^{53 group} ,

R ( ⁸²⁾ and R ( ³³⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ( ⁴⁷⁾ , R ( ⁴⁸⁾ and R ( ⁵⁰⁾ independently of one another are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ⁴⁹ is as R ⁴⁶ , or

R ⁴⁶ and R ^47, or R ⁴⁶ and R ⁴⁸ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _NCH3 or N-benzyl, wherein Ά and N ^x are attached to the phenyl core of the basic heteroaroylguanidine skeleton, or

R ³ , R ⁴ , R ⁵ , R ⁶ and R ^{7 are} each independently -SR ⁶⁴ , -OR ⁶⁵ , -NR ⁶⁷ R ⁶⁸ , -CHR ⁶⁹ R ^70, or -CR ⁵⁴ R ⁵⁵ OH , -C «CR ⁵⁶ , -CR ⁵⁸ = CR ^57, or

- / cr ⁵⁹ r ⁶⁰ / u-co- / cr ⁶¹ r ⁶² / vr ⁶³ ,

R ⁶⁴ , R ⁶⁵ , R ⁶⁶ , R ⁶⁷ and R ⁶⁹ , which are the same or different, represent a group

- (CH _{2) y} - (CHOH) _z - (CH _{2) aa} - (CHOH) _t -R ⁷¹ or a group

- (CH ₂ ) ab -O- (CH ₂ -CH ₂ O) _and -R ⁷² ,

R ⁷¹ and R ⁷² independently of one another represent a hydrogen atom or a methyl group, u represents 1, 2, 3 or 4, v represents 0, 1, 2, 3 or 4, y, z, aa which are the same or different, are 0, 1, 2, 3 or 4, t is 1, 2, 3 or 4,

R ⁸⁸ , R ⁷⁰ , R ⁵⁴ and R ⁵⁵ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or

R ⁸⁹ and R ⁷⁰ or R ⁵⁴ and R ⁵⁵ together with the carbon atom to which they are attached represent a cycloalkyl group containing 3 to 8 carbon atoms,

R ⁸³ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or a group - ^c e ^H 2e - ^{R 73} 'e being 0, 1, 2, 3 or 4,

R ⁵⁸ , R ⁵⁷ and R ⁷³ independently of one another represent a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁷⁴ R ^{75 group} .

R ( ⁷⁴⁾ and R ( ⁷⁵⁾ are hydrogen or (C1-C4) -alkyl or

R ⁵⁸ , R ⁵⁷ and R ^73, independently of one another, represent a heteroaryl group containing 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group,

R ⁵⁸ , R ⁵⁹ , R ⁸⁸ , R ⁸¹ and R ⁸² are hydrogen or methyl;

R ³ , R ⁴ , R ⁵ , R ⁸ and R ⁷ independently of one another are R ⁷⁶ -NH-SO ₂ - or R ⁷⁸ R ⁷⁷ R ⁷⁸ N- (C = Y ') -,

Y ¹ represents an oxygen atom, a sulfur atom or a group NR ⁷⁹ , R ⁷⁷ and R ⁷⁸ which are the same or different, represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 6 carbon atoms or a -CfH group ₂ f R ⁸⁰ , f is 0, 1, 2, 3 or 4,

R ⁸⁰ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group and an alkyl group having 1 to 4 carbon atoms, or

R ⁷⁷ and R ⁷⁸ together are 4 or 5 methylene groups, of which one methylene group can be replaced by oxygen, S, NH, _NCH3 or N-benzyl;

R ⁷⁹ is as R ⁷⁷ or is an amidino group;

R ⁴ , R ⁸ , R ⁸ and R ⁷ independently of one another are NR ^{84a and} R ⁸⁵ , OR ⁸⁴ ^, SR ^84c or

CH _n®4d ^{Step H} 2n ^C n is 0, 1, 2, 3 or 4,

R ^84d represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁸ R ^{17 group} ,

R ( ¹⁸⁾ and R ( ¹⁷⁾ are hydrogen or (C1-C4) -alkyl,

R ( ^84a) , R ( ^84b) , R ( ^84c) and R ( ^85), independently of one another, are hydrogen, (C 1 -C 8) alkyl, (C 1 -C 8) perfluoroalkyl or (CH ₂ ) _ax -R ^84g , ax being 0 , 1, 2, 3, or 4,

R ^84g represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ^84u group R ^84v ,

R ( ^84u) and R ( ^84v) are hydrogen or (C1-C4) -alkyl or

R ^84a and R ⁸⁹ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, as well as pharmaceutically acceptable salts thereof,

(z) benzoylguanidine of the formula I (HOE 94 / F 134-EP-OS 686627, NZ 272 103)

in which

R ¹ represents a group R ⁶ -SO _m , m represents 0, 1 or 2,

R ⁶ represents a perfluoroalkyl group having 1, 2, 3, 4, 5 or 6 carbon atoms which is straight or branched,

R ² and R ³ independently of one another represent H, F, Cl, Br, I, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms or a phenoxy group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group; or

R ² and R ³ independently of one another are pyrrol-l-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of F, Cl, a bromine atom, an iodine atom, a cyano group, an alkanoyl group containing 2, 3, 4, 5, 6, 7 or 8 carbon atoms, an alkoxycarbonyl group containing 2, 3, 4, 5, 6, 7 or 8 carbon atoms; carboxyl, trifluoromethyl, methyl and methoxy, R 5 and R ⁸ independently of one another are H, alkyl having 1, 2 or 3 carbon atoms, fluorine, chlorine, bromine, cyano, OR ⁷ , NR ⁸ R ⁹ or - (CH ₂ ) _n - (CF ₂ ) _Q -CF ₃ , R ⁷ , R ⁸ and R ^9, independently of one another, represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, n is 0 or 1, and is 0 and b) a phenyl-substituted alkenylcarboxylguanidide bearing perfluoroalkyl groups of the formula I (HOE 94 / F 168-EP-OS 690048, NZ 272373)

in which

R ^a is hydrogen, fluoro, bromo, iodo, cyano, hydroxy, OR ^6, alkyl of 1 to 8 carbon atoms, O _{r (CH2) a} C _b F _{2b + 1} , cycloalkyl having 3 to 8 carbon atoms or NR ⁷ R ^8, r is 0 or 1, a is 0, 1, 2, 3 or 4, b is 1, 2, 3, 4, 5, 6, 7, or 8

R ⁶ represents an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group or a benzyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ^{10 group} ,

R ⁹ and R ¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl;

R and R independently of one another are as defined for R ⁶ or R ⁶

R ⁷ and R ⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or a benzyl group,

R ® independently has the meaning as r \

X is 0, 1 or 2,

Y is 0, 1 or 2,

R is H, fluoro, bromo, iodo, cyano, OR ^12, alkyl of 1 to 8 carbon atoms, 0 _{p (CH2) f} Cgl _{2 g + 1,} or cycloalkyl having 3 to 8 carbon atoms, p is 0 or 1, f is 0, 1, 2, 3 or 4, g is 1, 2, 3, 4, 5, 6, 7 or 8,

R ¹² is C 1 -C 8 alkyl, C 1 -C 4 perfluoroalkyl, C 3 -C 8 alkenyl, C 3 -C 8 cycloalkyl, phenyl or benzyl, said aromatic groups being: unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹³ R ^{14 group} ,

R ¹³ and R ^14, independently of one another, are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ^{d is} independently as R ^c ,

R ¹ is H, alkyl of 1 to 8 carbon atoms, _t -0 (CH ₂₎ d ^C e ^F 2e + I 'cycloalkyl having 3 to 8 carbon atoms, F, Cl, Br, I or cyano, t is 0 or 1, d is 0, 1, 2, 3 or 4, e is 1, 2, 3, 4, 5, 6, 7 or 8,

R ^2, R ^3, R ⁴ and R ⁸ independently of one another are as defined for R ^1, with the proviso that at least one of R ^A, R ^B, R ^C, R ^1, R ^2, R ⁴ and R ⁸ is oR (CH2)% and F2b + 1 group, Op (CH2) fCgF2g + 1-0 t or a group (CH 2) d ^C e ^F 2e + l and the R ³ does not represent 0 t _(CH2) d ^G e ^F 2e + and its pharmaceutically acceptable salts, and c) ortho-amino-substituted benzoylguanidine of formula I (HOE 94 / F 182-EP-OS 690048, NZ 272449)

in which

R ¹ is NR ⁸⁰ R ⁶ ,

R ⁸⁸ and R ^8, independently of one another, are hydrogen, C 1 -C 8 alkyl or C 1 -C 8 perfluoroalkyl,

R ² , R ³ , R ⁴ and R ⁸ independently of one another represent a group

R ¹⁰ -SO a -f R ¹¹ R ¹² N-CO-, Ŕ ¹³ -CO- or r ¹⁴ r ¹⁵ n -so 2 -, and is 0, 1 or 2,

R ( ¹⁸⁾ , R ( ¹⁹⁾ , R ( ¹⁹⁾ , R ( ¹³⁾ , R ( ⁴⁾ and R ( ¹⁹⁾ independently of one another denote an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 6 carbon atoms atoms or the group "C 8 H 11 -R ^16" , ab is 0, 1, 2, 3 or 4,

R ¹⁸ represents a cycloalkylene having 3 to 7 carbon atoms, phenyl which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy or NR ¹⁷ R ¹⁸

R ( ¹⁷⁾ and R ( ¹⁸⁾ independently of one another are hydrogen, trifluoromethyl or (C1 -C4) -alkyl or

R ^11, R ¹² and R ¹⁴ and R ¹⁵ together are 4 or 5 methylene groups, of which one methylene group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, or

R ^11, R ^12, R ¹⁴ and R ¹⁵ independently of one another are hydrogen or

R ² , R ³ , R ⁴ and R ⁵ independently of one another represent a group

SR ²¹ , -OR ²² , -NR ²³ R ^24, or -CR ²⁵ R ²⁶ R ²⁷ ,

R ²¹ , R ²² , R ²³ and R ^{25 are} independently of one another

-C 1 H 3 -heteroaryl wherein the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino - a group, a methylamino group and a dimethylamino group, b represents 0, 1 or 2,

R ( ²⁴⁾ , R ( ²⁸⁾ and R ( ²⁷⁾ independently of one another are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or

R ^2, R ^3, R ⁴ and R ⁵ independently of one another represent H, F, Cl, I, a cyano group, a group - (X) _d ^c that G ^H 2da + l · radical

- (Xb) _dh - (CH _{2) db} -C _de F _{Ed + 1,} alkenyl having 3 to 8 carbon atoms or C ~ _d f H _2dt R ^30, (Xa) is oxygen, S or NR ³³ , R ³³ is hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, dg is 0 or 1, (Xb) is oxygen, sulfur or NR ³⁴ , R ³⁴ is hydrogen , (1-4C) alkyl or (1-4C) perfluoroalkyl,

dh means 0 or 1, will give means 0 1 2 3 4 5 6 7 8 db means 0 1/2 3 4 de means 0 1 2 3 4 5 6 7 df means 0 1 2 3 4 R ³⁰ means cycloalkyl containing

a phenyl, biphenylyl or naphthyl group, said aromatic groups comprising a phenyl, biphenylyl or naphthyl group being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methyl group, and NR ³¹ R ³² ,

R ( ³¹⁾ and R ( ³²⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or

R ^2, R ^3, R ⁴ and R ⁵ independently of one another are NR ⁴⁰ R ⁴¹ or - (Xe) - _(CH2) g ^ R ^45,

R ( ⁴⁰⁾ and R ( ^41), independently of one another, are hydrogen, (C 1 -C 8) alkyl, (C 1 -C 8) perfluoroalkyl or (CH ₂ ) _e -R ⁴² , e is 0, 1, 2, 3 or 4,

R ⁴² represents a cycloalkyl group having 3 to 7 carbon atoms, a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁴³ R ^{44 group} ,

R ( ⁴³⁾ and R ( ^44), independently of one another, are hydrogen, trifluoromethyl or (C1 -C4) -alkyl or

R ⁴⁰ and R ⁴¹ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, (Xe) is oxygen, sulfur or NR ⁴⁷ , R ⁴⁷ represents a hydrogen atom, a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group, where eb is 0, 1, 2, 3 or 4,

R ⁴⁵ represents a cycloalkyl group having 3 to 7 carbon atoms, a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, NR ⁵⁰ R ⁵¹ and is - (Xfa) - _{(CH2) ed} - (XFB) R ^46,

Xfa is CH ₂ , oxygen, sulfur or NR ⁴⁸ ,

X fb represents an oxygen atom, a sulfur atom or an NR ⁴⁹ group, and ed represents 1, 2, 3 or 4,

R ⁴⁶ represents a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group,

R ⁴⁸ , R ⁴⁹ , R ⁵⁰ and R ⁵¹ independently of one another represent a hydrogen atom or a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group, where R ³ and R ⁴ do not represent a hydrogen atom or its pharmaceutically acceptable salts, and d) benzoylguanidine of formula I (HOE 94 / F

265-NZ 272946, EP-OS 700904

wherein one of the three substituents R ¹ , R ² and R ³ represents a heteroaryl-N-oxide group in which the heteroaryl radical contains 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 9 carbon atoms 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group or one of three substituents R ¹ , R ² and R ³ is -SR ^10, -OR ^10, -NR ¹⁰ R ¹¹ or -CR ¹⁰ R ^{and L} R ¹² R ¹⁰ is -C _a H _2a -heteroaryl-N-oxide group in which the heteroaryl portion contains 1-9 which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group a group and a dimethylamino group, and is 0, 1 or 2,

R ¹¹ and R ^12, independently of one another, are as defined for R ¹⁰ or are hydrogen or C 1 -C 4 alkyl, and the other substituents R ¹ , R ² and R ^{3 are,} independently of one another, C 1 -C 4 alkyl; 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms or a _-Ctn H _2m R ^{14 group} , m being 0, 1 or 2,

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁸ R ^{18 group} ,

R ¹⁵ and R ¹⁶ are hydrogen or methyl and the other substituents R ¹ represent a hydrogen atom, cyano group, L ³ is F, Br, X (CH _{2) p} - (C ^ F _{2q + 1),} group

R ^J independently of one another

R ² a

R ² -SO 2, R ²³ R ²⁴ N-CO, R ² -CO or

U '26 R ²⁷ N-SO ₂ -, wherein the perfluoroalkyl group is straight or branched,

X is a bond, oxygen, sulfur or NR ²⁸ , u is 0, 1 or 2, p is 0, 1 or 2, g is 0, 1, 2, 3, 4, 5 or 6,

R ( ²²⁾ , R ( ²³⁾ , R ( ²¹ ) and R ( ²⁶⁾ independently of one another denote an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a group ^{- {} n2n ^ ^ or a trifluoromethyl group, n being 0 , 1, 2, 3, or 4,

R ²⁸ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms,

R ²⁹ represents a cycloalkyl group having 3 to 7 carbon atoms, a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ³⁰ R ^{31 group} ,

R ( ³⁰⁾ and R ( ³¹⁾ are hydrogen or (C1-C4) -alkyl or R ( ²³⁾ , R ( ²⁵⁾ and R ( ²⁸⁾ are also hydrogen,

R ²⁴ and R ²⁷ independently of one another represent an alkyl group containing 1 to 4 carbon atoms or R ²³ and R ²⁴ as well as R ² and R ²⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced an oxygen atom, a sulfur atom, an NH group, an N-CH2 group or an N-benzyl group, or the other substituents R ^{@ 1} , R ^{@ 2} and R @ ³ independently of one another are OR ³⁵ or NR ³⁸ R ³ ,

R &lt; ³⁸ &gt; and R &lt; ³ &gt; independently of one another represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or

R ³⁸ and R ³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ⁴ and R ^8, independently of one another, are hydrogen, C 1 -C 4 alkyl, fluoro, chloro, -OR ³² , -NR ³³ R ^34, or C _r F _{2r + 1} ,

R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1 to 3 carbon atoms, r is 1, 2, 3 or 4 and pharmaceutically acceptable salts thereof; and (e) benzoylguanidine of the formula I (HOE) 94 / F

266-EP-OS 702001, NZ 272 948

in which

R ¹ represents a hydrogen atom, a fluorine atom, a bromine atom, an iodine atom, a cyano group, a nitro group, a hydroxy group, an alkyl group having 1 to 8 carbon atoms.

C 3 -C 8 cycloalkyl or O _and - (CH ₂ ) (CF ₂ ) _c -CF ₃ , a represents 0 or 1, b represents 0, 1 or 2, c represents 0, 1 or 3, or

R ¹ is R ⁸ -SO 2 or R ⁸ R ⁷ N-SO 2 -, m is 0, 1 or 2,

R ⁵ and R ⁶ independently of one another denote an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 6 carbon atoms, a trifluoromethyl group

Or Q is -C _n H _2n -R c, n is 0, 1, 2, 3 or 4,

R ⁷ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ⁸ represents a C 3 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an NR * R group .

R ( ⁹⁾ and R ( ¹⁰⁾ independently of one another are hydrogen or (C1-C4) -alkyl or

R ⁶ represents a hydrogen atom;

R ⁸ and R ⁷ together are 4 or 5 methyl ene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, or R? is -SR ^, -OR ^ · ¹ or -cr ^^ ¹³ ,

^R11 is -CpH ₂ p-cycloalkyl group in which the cycloalkyl portion contains 3 to 8 carbon atoms, heteroaryl of 1 to 9 carbon atoms or phenyl, where the aromatics are unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group,

R ¹² and R ¹³ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, p represents 0, 1 or 2, or

R ¹ represents a phenyl group, a naphthyl group, a biphenylyl group or a heteroaryl group having 1 to 9 carbon atoms, the latter group being bonded via a carbon or hydrogen atom and said groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine , a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methyl amino group and a dimethylamino group,

R ² is -CF ₂ R ^14, -CF / R ¹⁵ // R ¹⁸ / group

-CF / _{(CH2) q} -CF ₃ // ¹⁵ R /, -C / (CF _{2) y} -CF ₃ / »CR ¹⁵ R ^{1 S,}

R ¹⁴ represents an alkyl group having 1 to 4 carbon atoms or a cycloalkyl group having 3 to 5 carbon atoms,

R ( ¹⁵⁾ and R ( ¹⁶⁾ independently of one another are hydrogen or (C1-C4) -alkyl, g is 0, 1 or 2, r is 0, 1 or 2,

R ³ is as defined for R ^1,

R ⁴ represents a hydrogen atom, an alkyl group containing 1 to 3 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a - (CH ₂ ) θ- (CF ₂ ) _t -CF _{3 group} ; 0 or 1, t is 0, 1 or 2, even if pharmaceutically acceptable salts thereof; and f) benzoylguanidine of formula I (HOE 94 / F).

267-EP-OS 700899 NZ 272947

wherein one of the three substituents R ¹ , R ² and R ³ is -Y-4 - / (CH 2) k -CHR ⁷ - (C-O) R ⁸ / -phenyl or -Y-3 - / (CH 2) ) _of -CHR ⁷ - (C = 0) ^R8 / phenyl or -Y-2 - / _{(CH2) k} -CHR ⁷ - (C ') R ⁸ / phenyl, wherein the phenyl methyl group a residue unsubstituted or substituted by 1 to 2 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group or -NR ³⁷ R ^{38 group} ,

R ( ³⁷⁾ and R ( ^38), independently of one another, are hydrogen or methyl,

Y represents a bond, an oxygen atom, a sulfur atom or an -NR ⁹ group,

R ⁹ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ⁷ is -OR ¹⁸ or -NR ¹⁸ R ¹¹ ,

R ( ¹⁸⁾ and R ( ^11), independently of one another, are hydrogen, (C 1 -C 8) alkyl, (C 1 -C 8) alkanoyl, (C 1 -C 8) alkoxycarbonyl, benzyl or benzyloxycarbonyl or

R ⁸ is -OR ¹² or -NR ¹² R ¹³ ,

R ¹² and R ^13, independently of one another, are hydrogen, C 1 -C 8 alkyl or benzyl, k is 0, 1, 2, 3 or 4, and the other substituents R ¹ , R ² and R ^{3 are} independently one on the other, they are C 1 -C 8 alkyl, C 2 -C 8 alkenyl or - (CH ₂ ) _m R ¹⁴ , m is 0, 1 or 2,

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and a -NR ¹⁹ R group ¹⁸

R ( ¹⁵⁾ and R ( ¹⁶⁾ are hydrogen or methyl or the other substituents R ( ¹⁾ , R ( ²⁾ and R ( ³⁾ independently of one another are R ( ¹⁸⁾ R ( ¹⁹⁾ -N (C (Y ') -NH-SO ₂₎ ,

Y 'represents an oxygen atom, a sulfur atom or the group -NR ²⁰ R ¹⁸ and R ¹⁹ independently of one another represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group or a - (CH ₂ ) _t -R ²¹ , t group means 0, 1, 2, 3 or 4,

R ²¹ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group and C 1 -C 4 alkyl group, or

R ¹⁸ and R ¹⁹ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl;

R ²⁰ is as R ¹⁸ or is amidino or the other substituents R ¹ , R ² and R ³ independently of one another are hydrogen, fluorine, chlorine, bromine, iodine, cyano, X- (CH 2) p - (C 8 F 2 g + 1), R ²² -SOU, R ²³ R ²⁴ N-CO-, r ²⁵ -CO-, or R ²⁶ R ²⁷ N-SO ₂ - wherein the perfluoroalkyl group is direct or branched,

X is a bond, oxygen, sulfur or -NR ²⁸ , u is 0, 1 or 2, p is 0, 1 or 2, g is 1, 2, 3, 4, 5 or 6,

R ^22, R ^23, R ²⁹ and R ²⁸ independently of one another are alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, - (CH _{2) n} R ²⁹ or trifluoromethyl, n is 0, 1, 2, 3 or 4

R ²⁸ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms,

R ²⁹ is cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and -NR ³⁰ R ³¹ ,

R ( ³⁰⁾ and R ( ³¹⁾ are hydrogen or (C1-C4) -alkyl or R ( ²³⁾ , R ( ²⁵⁾ and R ( ²⁶⁾ are hydrogen,

R ( ²⁴⁾ and R ( ^27), independently of one another, are hydrogen or (C1-C4) -alkyl or

R ²³ and R ²⁴ as well as R ²⁶ and R ²⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -N-CH ₃ group or a - N-benzyl, or the other substituents R ¹ , R ² and R ^3, independently of one another, represent -OR ³⁵ or -NR ³³ R ³⁶ ,

R ³⁵ and R ³⁶ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or

R ³³ and R ³³ together are 4-7 methylene groups, of which one _CH2 group can be replaced by oxygen, S, -NH-, _-N-CH3 or -N-benzyl;

R ⁴ and R ³ independently of one another are H, alkyl having 1 to 4 carbon atoms, F, Cl, -OR ^32, NR ³³ R ³⁴ or ^- C _r F _{2r +} i,

R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1 to 3 carbon atoms, r is 1, 2, 3 or 4 and pharmaceutically acceptable salts thereof; and (g) benzoylguanidine of the formula I (HOE). 94 / F 352-EP-OS 713684, NZ 280 517

in which

R ¹ is R ⁸ -CO or R ⁷ R ⁸ -N-CO,

R ⁸ is C 1 -C 8 alkyl, C 1 -C 3 perfluoroalkyl, C 3 -C 8 alkenyl or -C _n H _2n -R ⁹ , n is 0, 1, 2, 3 or 4.

R ⁹ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ¹ ^ ^11,

R ¹⁰ and R ¹¹ represent hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ⁷ is H, alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms or -C _n H _2n -R ^12, n is 0, 1, 2 , 3 or 4

R ¹² represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic group being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy and NR ¹³ R ^14,

R ¹³ and R ¹⁴ represent a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group,

R ⁸ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a perfluoroalkyl group having 1 to 4 carbon atoms, or

R ⁷ and R ⁸ together represent 4 or 5 methyl groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ² is as R ¹ or is hydrogen, hydroxy, fluorine, chlorine, bromine, iodine, cyano, nitro, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl atoms, a C 3 -C 8 alkenyl group or a -C _n H _{2 n} R ^{15 group} , n being 0, 1, 2, 3 or 4,

R ¹⁵ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NRR group,

R ( ¹⁶⁾ and R ( ¹⁷⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or

R ² is a heteroaryl group having 1 to 9 carbon atoms which is linked via carbon or nitrogen and which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methoxy, hydroxy a group, an amino group, a methylamino group, and a dimethylamino group; or

R ² is SR ^18, -OR ^18, -NR ¹⁸ R ¹⁹ or -CR ¹⁸ R ¹⁹ R ^20,

R ¹⁸ is -C _and H _2a -heteroaryl wherein the heteroaryl radical contains 1 to 9 carbon atoms and is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group -hydroxy, amino, methylamino and dimethylamino, and is 0, 1 or 2,

R ( ¹⁹⁾ and R ( ²⁰⁾ independently of one another are as defined for R ( ¹⁸⁾ or are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or

R ² is R ²¹ -SO _m or R ²² R ²³ N-SO 2 m is 1 or 2,

R ²¹ is alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, an alkenyl radical containing 3 to 8 carbon atoms or - ^C n ^H 2n ^{R 24} n is 0, 1, 2, 3 or 4 .

R ²⁴ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ²⁷ R ²⁸ ,

R ²⁷ and R ²⁸ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ²² is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl, or C _n H _2n R ²⁹ , n is 0, 1, 2, 3 or 4,

R ²⁹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic group being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy and NR ³⁰ R ³¹ ,

R ( ³⁰⁾ and R ( ³¹⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ²³ represents a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group, or

R ²² and R ²³ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, or

R ² is R ³³ -X-,

X is O, S, NR ³⁴ , (D = O) A- or NR ³⁴ C = MN * R ³⁵ -,

M represents an oxygen atom or a sulfur atom,

A represents an oxygen atom or a group NR ³⁴ ,

D represents a carbon atom or an SO group,

R ³³ represents an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a (CH ₂ ) b ^c d ^F 2d + 1 group or a - ^c n ^H 2n - ^{R 3e} · b group being 0 or 1, d is 1, 2, 3, 4, 5, 6 or 7, n is 0, 1, 2, 3 or 4,

R ³ ® represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy and NR ³⁷ R ³⁸ ,

Q * 7 Ofl

R and R are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ³⁵ is as R ³³ , or

R ³³ and R ³⁴ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, A and N * being bound to a phenylalkyl core of the benzoylguanidine backbone; or

R ² is -SR ^48, -OR ^40, -NHR ^40, -NR ⁴⁰ R ^41, CHR ⁴⁰ R ^42, -CR ⁴² R ⁴³ OH, -CeCR ^45, -CR ⁴⁶ = CR ⁴⁵ or - / cr ⁴⁷ r ⁴⁸ / u-co- (CR ⁴⁹ R ⁵⁰ / v R ⁴⁴⁾ ,

R ⁴⁰ and R ⁴¹ independently of one another are - (CH 2) p - (CHOH) q - (CH 2) r - (CHOH) t -R ⁵¹ or - (CH 2) _p -O- (CH ₂ -CH ₂₎ O) gR ⁵¹

R ⁵¹ represents a hydrogen atom or a methyl group, u represents 1, 2, 3 or 4, v represents 0, 1, 2, 3 or 4, p, g and independently of one another represent 0, 1, 2, 3 or 4; means 1, 2, 3 or 4,

R ( ⁴²⁾ and R ( ⁴³⁾ independently of one another are hydrogen or (C1-C6) -alkyl or

R ⁴² and R ⁴³ together with the carbon atom to which they are attached represent a C 3 -C 8 cycloalkyl group,

R ⁴⁴ is H, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or -C _e H _2e -R ^45, e is 0, 1, 2, 3 or 4,

R ⁴⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁵² group R ⁵³ ,

CO CO

R @ 1 and R @ 2 are hydrogen or (C1 -C4) alkyl or

R ⁵⁴ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group, or

R ⁴⁵ represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups; r ⁴⁶ , R ⁴⁷ , R ⁴ ®, R ⁴⁹ and R ⁹⁰ independently of one another represent a hydrogen atom or a methyl group; or

R ² is R ⁸⁸ -NH-SO ₂ -,

R ⁸⁸ represents a group R ⁸⁶ R ⁸⁷ N- (CY) -,

Y is O, S or NR ⁵⁸ , R ⁸⁶ and R ^87, independently of one another, are hydrogen, C 1 -C 8 alkyl, C 3 -C 6 alkenyl or -C 6 H ₂ R ⁵⁹ f means 0, 1, 2, 3 or 4,

R ⁸⁹ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group and C 1 -C 4 alkyl group or

R ⁸⁶ and R ⁸⁷ together are 4 or 5 methylene groups, of which one CH2 group can ^be replaced by oxygen, S, NH, N-CH3 or N-benzyl;

R ⁸⁸ is as R ⁸⁸ or is an amidino group, R ³ , R ⁴ and R ⁸ are independently of one another as R ¹ or

R ^2, wherein at least one of R ^2, R ^3, R ⁴ and R ⁸ MUI network is hydroxy and pharmaceutically acceptable salts thereof, and h) a benzoylguanidine of the formula I (HOE 95 / F 007 K-EP- 723 956, NZ 280 887

wherein one of the three substituents R ¹ , R ² and R ³ represents a group

R ^with -A-3-D,

R ⁶ represents a basic protonatable radical, ie an amino group -NR ⁷ R ⁸ , an amidino group R ⁷ R ⁸ NC (% NR ⁹ ) or a guanidino group of the general formula

R ⁷ , R ⁸ , R ⁹ and R ¹⁰ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or

R ⁷ and R ⁸ together are a C _£ H _2, a is 4, 5, S or 7, wherein, if a = 5, 6 or 7, can be a methylene group of the group C _a H ₂ _ replaced by O , SO_ or NR ~~ or U1

R ⁸ and R ⁹ or R ⁹ and R ¹⁸ or R ⁷ and R ¹⁸ are ^c and ^H 2a 'and are 2, 3, 4 or 5, where, if a, 3, 4 or 5, replace one methylene group of groups C _and H _2a with an oxygen atom, SO _m or NR ¹¹ , m being 0, 1 or 2,

R ¹¹ represents a hydrogen atom or a methyl group, or R ⁸ represents a basic heteroaromatic ring system containing 1 to 9 carbon atoms,

A is C 1 H 2, b is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, wherein in C _b H _2b one or two methylene groups may be replaced by a group selected from the group consisting of O, -C0-, -CH / OR ²⁰ / -, -SoM- group, -NR ²⁰ -, -NR ²⁸ CO-, -NR ²⁸ -CO-NH-, -NR ²⁸ -CO -NH-SO 2 -, a group of formula (9).

aa —R NS— [NR ¹⁹ ] bb and SO _aa (NR ¹⁹ ) wherein, further in group C _b H _2b , one methylene group can be replaced by -CH-R ⁹⁹ and R ⁹⁹ together with R ^{7 form a} pyrrolidine or piperidine ring , aa is 1 or 2, bb is 0 or 1, aa + bb = 2,

R ( ¹⁹⁾ is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms,

R ²⁰ represents a hydrogen atom or a methyl group,

B is a phenylene or naphthylene radical of the formulas

R ¹² and R ¹³ independently of one another represent a hydrogen atom, a methyl group, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a trifluoromethyl group or a group -SO _W -R ¹⁴ ,

R ¹⁴ is methyl or NR ^{1 S} R ^16,

R ¹⁵ and R ^{1 S,} independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, w is 0, 1 or 2,

D is -C _d H _2d -X _f -, d is 0,

X is O, -C0-, -CH / OR ²¹ / -, a group of -S0 _m - or -NR ²¹ -, f is 0 or 1,

R ²¹ is a hydrogen atom or a methyl group, m is 0, 1 or 2, and the other substituents R ¹ , R ² and R ³ independently of one another are hydrogen, fluorine, chlorine, bromine, iodine, cyano- , alkyl of 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms, -NR ³⁵ R ³⁶ or the radical R ^17, -C H ₂ g _{of n} -, g is 0, 1, 2, 3 or 4 , h is 0 or 1,

R ( ³⁵⁾ and R ( ³⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or

R ³⁵ and R ³⁶ together are 4-7 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or -N-benzyl;

Z is -O-, -CO-, -SO _{H -,} -NR ¹⁸ -, -NR ¹⁸ CO-, -NR ¹⁸ -CO-NR ¹⁸ NHalebo radical -SO ₂ -,

R ¹⁸ represents a hydrogen atom or a methyl group, v represents 0, 1 or 2,

R ¹⁷ represents a hydrogen atom, a cycloalkyl group containing 3, 5 or 6 carbon atoms or a C group _to F _{2k + 1} , k represents 1, 2 or 3, or

R ¹⁷ represents a pyrrol-1-yl group, a pyrrol-2-yl group or a pyrrol-3-yl group which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, cyano - a group having from 2 to 8 carbon atoms, an alkoxycarbonyl group having from 2 to 8 carbon atoms, a formyl group, a carboxy group, a trifluoromethyl group, a methyl group and a methoxy group, or

R ¹⁷ represents a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group, - NR ³⁷ R ³⁸ , CH ₃ SC ₂ and E ₂ NO ₂ S-,

R ³⁷ and R ³⁸ represent a hydrogen atom or a methyl group,

R ⁴ and R ⁵ independently of one another represent a hydrogen atom, an alkyl group containing 1, 2, 3 or 4 carbon azo atoms, a fluorine atom, a chlorine atom, a -OR ³² group, an -NR ³³ R ³⁴ group or a "C _r F _2r " group ₊₁

R ³² , R ³³ and R ³⁴ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2 or 3 carbon atoms, r represents 1, 2, 3 or 4, as well as pharmacologically acceptable salts thereof, and (i) indenoylguanidine of the formula I (HOE 95 / F 072-EP 738712, NZ 286 380)

in which

R ¹ and R ² independently of one another are H, alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9, or carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms, O-alkyl containing 1, 2, 3 or 4 carbon atoms, O-C (= O) - alkyl in which the alkyl radical contains 1, 2, 3 or 4 carbon atoms, or C _m H _2m -NR ¹² R ¹³ '

R ¹² and R ^13, independently of one another, are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, m is 0, 2, 3 or 4, furthermore NH-C (O) -NH ₂ , C A (-O) -O-alkyl group in which the alkyl radical contains 1, 2, 3 or 4 carbon atoms, a C (O) -NH _{2 group} , a C (= O) -NH-alkyl group in which the alkyl radical contains 1, 2, 3 or 4 carbon atoms,

A C (= O) -N (alkyl) ₂ group in which each alkyl radical contains 1, 2, 3 or 4 carbon atoms, an alkenyl group containing 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, an alkynyl group containing 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, an alkylaryl group in which the alkyl radical contains 1, 2, 3 or 4 carbon atoms, an alkenylaryl group in which the alkenyl group the residue contains 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, an alkynylaryl group in which the alkynyl residue contains 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, an aryl group substituted with an alkyl group containing 1 to 4 carbon atoms, an alkylheteroaryl group wherein the alkyl moiety contains 1 to 4 carbon atoms, an alkenylheteroaryl group wherein the alkenyl moiety contains 2 to 4 carbon atoms, an aminoalkylaryl group wherein the alkyl moiety contains 1, 2, 3 or 4 carbon atoms, substituents an aryl, heteroaryl and substituted heteroaryl group,

R ³ , R ⁴ , R ⁵ and R ⁸ independently of one another are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, O-alkyl having 1 , 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, halogen atom such as fluorine atom, chlorine atom, bromine atom and iodine atom, aryl group, substituted aryl group, heteroaryl group, substituted heteroaryl group O- (lower alkyl), O-aryl, O- (lower alkyl) -aryl, O-substituted aryl. O- (lower alkyl) -substituted aryl, O-C (O) -alkylaryl in which the alkyl moiety contains 1 to 4 carbon atoms, OC (O) -NH-alkyl in which the alkyl moiety contains 1 up to 4 carbon atoms

OC (OO) -N (alkyl) ₂ , nitro, cyano, trifluoromethyl, NH-C (OO) -alkyl in which the alkyl radical contains 1 to 4 carbon atoms, NH-C ( = O) -NH ₂ , a carboxyl group, a C (= O) -O-alkyl group in which the alkyl moiety contains 1 to 4 carbon atoms, a C (-O) -NH ₂ group, a C (= O) -ΝΗ group -alkyl in which the alkyl radical contains 1 to 4 carbon atoms, the C (»O) -N (alkyl) _{2 group} in which each alkyl radical contains up to 4 carbon atoms, the alkyl-COOH group in which the alkyl radical contains 1 to 4 carbon atoms 4 carbon atoms, an alkyl-C (= O) -O-alkyl group in which each alkyl radical contains 1 to 4 carbon atoms, a SO ₃ H group, a SO ₂ -alkyl group, a SO ₂ -alkylaryl group, a SO ₂ -N - (alkyl) ₂ , SO ₂ -N (alkyl) (alkylaryl), C 1-6 -R ¹¹ , alkyl-C (= O) -R ¹¹ , wherein the alkyl moiety contains 1 to 10 carbon atoms, an alkenyl-C (= O) -R ^{11 group} in which the alkenyl z it contains up to 10 carbon atoms, an alkynyl-C (»O) -R ^{11 group} in which the alkynyl radical contains 2 to 10 carbon atoms, an NH-C (-O) -alkyl-C (0O) -R ^{11 group} , wherein the alkyl radical contains 1 to 10 carbon atoms, the O-alkyl-C (= O) -R ^{11 group} wherein the alkyl radical contains 1 to 11 carbon atoms,

R ¹¹ is alkyl of 1 to 4 carbon atoms, alkynyl of 1 to 4 carbon atoms, aryl, substituted aryl, NH _2, an alkyl group ΝΗ-containing 1 to 4 carbon atoms, N- (alkyl) ₂ wherein each alkyl moiety contains 1 to 4 carbon atoms, SO 3 H, SO ₂ -alkyl, SO ₂ -alkylaryl, SO ₂ -N- (alkyl) ₂ , and SO ₂ -N- (alkyl) (alkylaryl) ) group,

X represents an oxygen atom, a sulfur atom or an NH group,

R, R, R and R ^AU independently of one another are hydrogen, alkyl, cycloalkyl, aryl, alkylaryl or

R ⁸ and R ⁹ together form a 5, 6 or 7-membered heterocyclic ring,

A is absent or is a non-toxic organic or mineral acid if: a) benzyloxycarbonylguanidine of formula I (HOE 95 / F 109-ΞΡ 748 795, NZ 286 583)

in which

R ¹ , R ² and R ³ independently of one another represent -Y- (4-R®-phenyl), -Y- (3-R®-phenyl) or -Y- (2-R®-phenyl) wherein the phenyl group is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a hydroxy group, a methoxy group and an -NR R group,

R ⁹⁶ and R ⁹⁷ independently of one another are hydrogen or methylene,

Y represents a bond, a CH ₂ group, an oxygen atom, a sulfur atom or an -NR ⁹ group,

R ⁹ represents a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms,

R @ a is SO _a / NR @ ⁹⁸ / _b NR @ ⁹⁹ R @ ¹⁰ , a is 1 or 2, b is 0 or 1, a + b = 2,

R ^98, R ⁹⁹ and R ¹⁰ independently of one another are H, alkyl having 1 to 8 carbon atoms, benzyl group, -alkylene-NR ¹¹ R ^12, in which the alkylene radical contains from 2 to 8 carbon atoms, alkylene -NR ¹³ -alkylene-NR ³⁷ R ³⁸ , wherein each alkylene residue contains 2 to 8 carbon atoms, or an alkylene-CR ³⁹ R ⁴⁰ -CR ⁴¹ R ⁴² -alkylene-NR ⁴³ R ^{44 group} , wherein each alkylene residue contains 2 to 8 carbon atoms.

R ( ¹¹⁾ , R ( ¹²⁾ , R ( ¹³⁾ , R ( ³⁷⁾ , R ( ³⁸⁾ , R ( ⁴³⁾ and R ( ⁴⁴⁾ independently represent a hydrogen atom, an alkyl group containing 1 to 8 carbon atoms or a benzyl group,

R ( ³⁹⁾ , R ( ⁴⁰⁾ , R ( ⁴¹⁾ and R ( ^42), independently of one another, represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkylene phenyl group in which the alkylene radical contains 2 or 3 carbon atoms, the phenyl group being unsubstituted or substituted 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group and methoxy group, or

R ⁹⁹ and R ¹⁰ together are 4-6 methylene groups, of which one _CH2 group can be replaced by oxygen, S, -NH-, _-N-CH3 or -N-benzyl; or

R ⁸ is SOa (NR ⁹⁸ ) bNR ⁹⁵ -C = NR ⁹⁴ / -NR ⁹³ R ⁹² ,

R ( ⁹²⁾ , R ( ⁹³⁾ , R ( ⁹⁴⁾ and R ( ⁹⁵⁾ independently of one another are hydrogen or (C1-C4) -alkyl or

R ¹ , R ² and R ³ independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a C 2 -C 8 alkanoyl group, an alkoxycarbonyl group of up to 8 carbon atoms, a formyl group, a carboxy group, a trifluoromethyl group, a methyl group, a methoxy group or

R ^1, R ² and R ³ independently of one another are H, alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms or - (CH _{2) m} R ^14, m is 0, 1, or 2

R ¹⁴ represents a cycloalkyl or phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ^{1 S} R ¹⁸ ,

R ¹⁸ and R ¹⁸ represent a hydrogen atom or a methyl group;

R ¹ , R ² and R ^3, independently of one another, are -q-4 - / (CH 2) k -CHR ¹⁷ - (C-O) R ²⁰ / phenyl or -Q-3 - / (CH 2) _k - CHR ¹⁷ - (C-O) R ²⁰ / phenyl or -Q-2- / (CH ₂ ) _k -CHR ¹⁷ - (C-O) R ²⁰ / phenyl, wherein the phenyl group is unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group and -NR ³⁵ R ^{38 group} ,

R ³⁵ and R ^{38 are,} independently of one another, a hydrogen atom or a methyl group,

Q is a bond, O, S or NR ^18,

R ¹⁸ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ¹⁷ is -OR ²¹ or -NR ²¹ R ²² ,

R ²¹ and R ²² independently of one another are hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkanoyl, alkoxycarbonyl in which the alkyl radical contains 1 to 8 carbon atoms, benzyl, benzyloxycarbonyl or

R ²¹ represents a trityl group,

R ²⁰ is -OR ²³ or -NR ²³ R ²⁴ ,

R ²³ and R ^24, independently of one another, are hydrogen, C 1 -C 8 alkyl or benzyl, k is 0, 1, 2, 3 or 4, or

R ¹ , R ² and R ³ independently of one another denote a heteroaryl group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom , trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino and dimethylamino, or

R ¹ , R ² and R ³ are -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁸ , -CR ²⁵ R ²⁶ R ²⁷ ,

R ²⁵ represents a -CfH ₂ f-heteroaryl group in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy, amino, methylamino and dimethylamino, f is 0, 1 or 2,

R ( ²⁸⁾ and R ( ²⁷⁾ independently of one another are as defined for R ( ²⁵⁾ or are hydrogen or (C1-C4) -alkyl, or

R ¹ , R ² and R ^3, independently of one another, represent a heteroaryl-N-oxide group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluoro, chloro, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino and dimethylamino; or

R ¹ , R ² and R ³ independently of one another are -SR ²⁸ , -OR ²⁸ , -NR ²⁸ R ²⁹ or -CR ²⁸ R ²⁹ R ³⁰ , -C ₈ H ₂ -heteroaryl-N-oxide wherein the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino a group and a dimethylamino group, g represents 0, 1 or 2,

R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are as defined for R ( ²⁸⁾ or are hydrogen or (C1-C4) -alkyl or

R ^1, R ² and R ³ independently of one another are hydrogen, fluorine, bromine, iodine, cyano group, ^{T_ {GH} 2> h ~ 'is R ³¹ O ₁ -, a group

100

R ³² R ³³ N-CO-, R ³⁴ -CO- or R ⁴⁵ R ⁴⁶ N-SO ₂ , the perfluoroalkyl group being straight or branched,

T represents a bond, an oxygen atom, a sulfur atom or a group -NR ⁴⁷ , represents 0, 1 or 2, h represents 0, 1 or 2, i represents 1, 2, 3, 4, 5 or 6,

R ^31, R ^32, R ³⁴ and R ⁴⁵ independently of one another are alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, (CH _{2) n} R ⁴⁸ or trifluoromethyl, n is 0, 1, 2, 3 or 4

R ⁴⁷ represents a hydrogen atom or an alkyl group containing 1, 2 or 3 carbon atoms,

R ⁴⁸ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ⁴⁹ R ⁵⁰ .

R ( ⁴⁹⁾ and R ( ⁵⁰⁾ are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, or R ( ³²⁾ , R ( ³⁴⁾ and R ( ⁴⁵⁾ are hydrogen,

R ( ³³⁾ and R ( ⁴⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or

R ³² and R ³³ as well as R ⁴⁵ and R ⁴⁶ together represent 5 or 6 methyl groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH ₃ group or an -N- group benzyl or

R ¹ , R ² and R ³ independently of one another represent a group R ⁵¹ -AGD,

R ⁵¹ represents a basic protonatable radical, i.e. the amino group -NR ⁵² R ⁵³ , the amidino group R ⁵² R ⁵³ -NC (NR ⁵⁴ ) or the guanidino group R ⁵² R ⁵³ NC / NR ⁵⁴ / -NR ⁵⁵ -,

R ⁵² , R ⁵³ , R ⁵⁴ and R ⁵⁵ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3

101 or 4 carbon atoms; or

R ⁵² and R ⁵³ denote a group C _alpha K _{2 and} r _a , alpha denotes 4, 5, 6 or 7, provided that if the alpha 6 5, 6 or 7 then the carbon atom of the group ^c aifa ^H 2alpha can be replaced a hetero group selected from the group consisting of oxygen, SO _d, or NR ^SO or

R ⁵³ and R ⁵⁴ or R ⁵⁴ and R ⁵⁵ or R ⁵² and R ⁵⁵ represent an CYH _2y, y is 2, 3, 4 or 5, wherein in the case where Y 3, 4 and 5, it may be a carbon atom CyH _{2 is a} heteroaryl group selected from O, SO _d or NR ⁵⁸ , d is 0, 1 or 2,

R ⁵⁸ represents a hydrogen atom or a methyl group or R ⁵¹ represents a basic heteroaromatic ring system containing 1 to 9 carbon atoms,

A is C _e H _2e , e is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, and in C _e H _2e one carbon atom can be replaced by an oxygen atom, - CO-, -CH (OR ⁵⁷ ) -, -SO 2, -NR ⁵⁷ -CO-, -NR ⁵⁷ -CO-NH-, -NR ⁵⁷ -CO-NH-SO 2 -, or -NR ⁵⁷ -SO ₂ -, r is 0, 1 or 2,

G is a phenyl radical of formula

R ⁵⁸ and R ⁵⁹ independently of one another are hydrogen, methyl, methoxy, fluoro, chloro, bromo, iodo, trifluoromethyl or a group -SO _g R ^80,

R ⁸⁰ is methyl or NR ⁸¹ R ⁸² ,

R ⁸¹ and R ⁸² independently of one another are hydrogen

102 or an alkyl group containing 1, 2, 3 or 4 carbon atoms,

D is -C _in H ₂ in ^E w 'v is 0, 1, 2, 3 or 4,

E represents an oxygen atom, a -CO- group, a group

-CH (OR ⁸³ ) -, -SO _aa - or -NR ⁸³ -, w is 0 or 1, and a is 0, 1 or 2,

R ⁸³ represents a hydrogen atom or a methyl group, or

R ¹ , R ² and R ³ independently of one another are -CF 2 R ⁸⁴ , -CF / R ^{89 (} R ⁸⁸ ), -CF ((CF 2) q -CF ₃ ) // R ⁸⁵ ), - C / (CF ₂ ) _p -CF ₃ / = CR ⁸⁵ R ⁸⁸

R ⁸⁴ represents an alkyl group having 1, 2, 3 or 4 carbon atoms or a cycloalkyl group having 3, 4, 5, 6 or 7 carbon atoms,

R ⁸⁹ and R ⁸⁸ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, g is 0, 1 or 2, p is 0, 1 or 2, or

R ^1, R ² and R ³ independently of one another, are -OR ⁸⁷ or -NR ⁸⁷ R ^68,

R ( ⁸⁷⁾ and R ( ⁸⁸⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or

R ⁸⁷ and R ⁸⁸ together represent 4, 5, 6 or 7 methylene groups, of which one CH ₂ group may be replaced by oxygen, sulfur, SO ₂ , -NH-, -NCH ₃ or -N- benzyl,

R ⁴ and R ⁹ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, fluorine, chlorine, -OR ⁸⁹ , -NR ⁷⁰ r ⁷¹ or -C ₂ F _{2z +1}

R ⁶⁹ , R ⁷⁰ and R ^71, independently of one another, are hydrogen or alkyl having 1, 2 or 3 carbon atoms, z is 1, 2, 3 or 4;

R and R independently of one another are hydrogen or

103 alkyl having 1, 2, 3 or 4 carbon atoms,

X is O or NR ⁷² ,

R ⁷² represents a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, and a) alkenylcarboxycuanidine bearing fluorophenyl groups of the general formula I (HOE 95 / F 115-EP 744397,

NZ 286622)

in which

R ⁶ represents a hydrogen atom, a C 1 -C 8 alkyl group, a C 3 -C 8 cycloalkyl group or a phenyl group, wherein the phenyl group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group , methyl, methoxy and NR ⁹ R ¹⁰ ,

R ⁹ and R ¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, c

R is independently as R,

R ^1, R ^2, R ^3, R ⁴ and R ⁵ independently of one another are hydrogen or F, wherein at least one of R ^1, R ^2, R ^3, R ⁴ and R ⁵ has is F, as and pharmaceutically acceptable salts thereof,

104 am) benzoylguanidine of general formula I (HOE 95 / F 167-NZ 299015)

in which

R ¹ is R ⁴ -SO 2 or R ⁸ R ⁶ N-SO 2, m is 1 or 2,

R ⁴ and R ⁸ independently of one another denote alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 3, 4, 5 or S carbon atoms, trifluoromethyl or a group

-CnH _2n -R ⁷ , n is 0, 1, 2, 3 or 4,

R ⁶ represents a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms,

R * ⁷ represents a cycloalkyl group having 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group - NR ⁹ R ⁹

R ⁸ and R ⁹ are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, or R ^{8 is} also hydrogen or

R ⁸ and R ⁶ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, or

R ¹ is -O _p - (CH ₂ ) g - (CF ₂ ) _r -CF ₃ , p is 0 or 1, q is 0, i or 2,

105 r is 0, 1, 2 or 3, or

R ¹ is -SR ^10, -OR ^10, or -CR ¹⁰ R ¹¹ R ^12,

R ^10, R ¹¹ and R ¹² independently of one another are H, alkyl having 1, 2, 3, 4, 5, S, 7 or 8 carbon atoms, -C _{g of} K _{2 S} -cycloalkyl, wherein the cycloalkyl moiety it contains 3 to 8 carbon atoms, or an aromatic system selected from the group consisting of pyridyl, pyrrolyl, quinolyl, isoquinolyl, imidazolyl or phenyl, s being 0, 1 or 2, wherein said aromatic systems are selected from the group consisting of pyridyl, the pyrrolyl group, the quinolyl group, the isoquinolyl group, the imidazolyl group and the phenyl group are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino,

R is - (CH ₂ ) _u - (CF ₂ ) _t -CF ₃ , t is 0, 1, 2 or 3, u is 0 or 1,

R ³ represents a hydrogen atom or independently has the meaning defined for R ¹ as well as its pharmaceutically acceptable salts, and an) substituted ouanidide of the formula I (HOE 95 / F 173-NZ 299052)

(I)

106 wherein at least one of R ¹ , R ² , R ^4, and R ⁹ is - ^x and ' ^Y b - ^L n - ^U '

X is CR ¹⁶ R ¹⁷ , O, S or NR ¹⁸ ,

R ( ¹⁶⁾ , R ( ¹⁷⁾ and R ( ¹⁸⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms, and is 0 or 1,

Y represents an alkylene group containing 1, 2, 3, 4, 5,

6, 7 or 8 carbon atoms, an alkylene-T group in which the alkylene radical contains 1, 2, 3, 4, 5, 6, 7 or carbon atoms, a T, T-alkylene group in which the alkylene radical contains 1, 2 , 3, 4, 5, 6, 7 or 8 carbon atoms,

T represents NR ²⁸ , oxygen, sulfur or phenylene, wherein the phenylene group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group and NR ²¹ R ^{22 group} ,

R ( ²⁸⁾ , R ( ²¹⁾ and R ( ²²⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms, b being 0 or 1,

L represents an oxygen atom, a sulfur atom, a group NR ²³ or a group O ^ Η ₂ ] γ, k represents 1, 2, 3, 4, 5, 6, 7, 8, n represents 0 or 1,

U is NR ²⁴ R ²⁵ or an N-containing heterocyclic group containing 1, 2, 3, 4, 5, 6, 7, 8 or carbon atoms,

R ²⁴ and R ^25, independently of one another, are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, perfluoroalkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, or

107

R ²⁴ and R ²⁵ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, the N-containing heterocyclic group being bound through nitrogen or carbon and is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ²⁷ R ²⁸ ,

R ( ²³⁾ , R ( ²⁷⁾ and R ( ²⁸⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms and the other substituents R ¹ , R ² , R ^3, R ⁴ and R ⁵ independently of one another are hydrogen, F, Cl, cyano group, "° ^C n ^H m + 2 m -O p L is (CH ₂₎ q _{2 g} -CgF ₊ even or-C _r H _2r R ^10,

n means 0 or 1 m means 0, 1, 2, 3, 4, 5, 6, 7 or P means 0 or 1 q means 1, 2, 3, 4, 5, 6, 7, or 8, with means 0, 1, 2, 3 or 4 r means 0, 1, 2, 3 or 4

R ¹⁰ represents a cycloalkyl group having 3, 4, 5, 6, or 8 carbon atoms or a phenyl group, the phenyl group being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group -group and NR ¹¹ R ^12,

R ¹¹ and R ^12, independently of one another, are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms, gn

R and R independently of one another are hydrogen, fluorine, chlorine, bromine, cyano, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, perfluoroalkyl having 1, 2 3 4

5, 6, 7 or 8 carbon atoms, a cycloalkyl group

108 having 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR group ¹⁴ R ¹⁸ ,

R ( ¹⁴⁾ and R ( ¹⁵⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, and o) benzovlguanidine in general of Formula I (HOE 9 5 / F 220-NZ 299052)

wherein at least one of R ¹ , R ² and R ³ is a group

R ⁶ -C (OH) ₂ -,

R ⁶ represents a perfluoroalkyl group containing 1, 2 or 3 carbon atoms which is straight or branched and the other substituents R ¹ , R ² and R ^3, independently of one another, represent a hydrogen atom, a hydroxy group, a fluorine atom, a chlorine atom, an atom bromine, iodine, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms or phenoxy a group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group or the other substituents R ¹ , R ² and R ³ independently of one another denote alkyl-SO _x , -CR ^7, CR ⁸ R ^9, or -OCR ⁹ , x being 0, 1 or 2,

R ⁷ represents a hydrogen atom or a methyl group,

R ⁸ and R ⁹ independently of one another represent a hydrogen atom, an alkyl group having 1, 2, 3 or 4 carbon atoms, a cycloalkyl group having 3, 4, 5, 6, 7 or carbon atoms or a phenyl group which is unsubstituted or substituted 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl and methoxy, or the other substituents R ^1, R ² and R ³ independently of one another are phenyl, C _g H ₅ alkyl group, in which the alkyl portion contains 1 to 4 carbon atoms, naphthyl, biphenylyl, quinolinyl, isoquinolinyl or imidazolyl, wherein the quinolinyl, isoquinolinyl or imidazolyl are bonded via a carbon atom or a nitrogen atom, and phenyl, C _g H _5- alkyl, naphthyl, biphenylyl, quinolinyl, isoc hinolinyl and imidazolyl are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methoxy, hydroxy, amino, methylamino and dimethylamino or other substituents R ¹ , R ² and R ³ independently of one another are SR ^18, -OR ^18, -CR ¹⁰ R ¹¹ R ^12,

R ¹⁸ is a group -Cfl ^ f-cycloalkyl group in which the cycloalkyl portion contains 3 to 8 carbon atoms, quinolin ynyl, isoquinolinyl, pyridinyl, imidazolyl or phenyl, where the aromatic systems include quinolinyl, isoquinolinyl, pyridinyl, imidazolyl and phenyl are unsubstituted or substituted with 1 to 3 substituents

110 is selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group, f represents 0, 1 or 2,

R ¹¹ and R ¹² independently of one another are as defined for R ¹⁰ or are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms,

R ⁴ and R ^5, independently of one another, are hydrogen, alkyl having 1, 2 or 3 carbon atoms, fluorine, chlorine, bromine, iodine, cyano, OR ³ , NR ¹⁴ R ¹⁵ , -KH ₂ ) _n - (CF 2> _O - ^CF 3 ')

R ¹³ , R ¹⁴ and R ^15, independently of one another, are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, n is 0 or 1, o is 0, 1 or 2, as well as pharmacologically acceptable salts thereof, (p) sulphonamide of formula I (HOE 95 / F 253-NZ 299682)

N

O = SR ² r ⁴ A _r ³ (I) wherein at least one of the three substituents R ¹ , R ² and R ³ represents a benzoylguanidine group of the formula

About NH2

111 which is unsubstituted or substituted by 1 to 4 substituents on the phenyl moiety selected from the group consisting of alkyl having 1, 2, 3, 4, 5, 6, or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, - (CH ₂ ) _m -R ¹⁴ , fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, R ²² SO 2 -, R ²³ R ²⁴ N-CO - R ²⁵ -CO-, R ²⁶ R ²⁷ N-SO 2, -OR ³⁵ , -SR ³⁵ or -NR ³⁵ R ³⁶ , m being 0, 1 or 2,

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁵ R ¹⁶

R ¹⁵ and R ^16, independently of one another, are hydrogen or methyl,

R ( ²²⁾ , R ( ²³⁾ , R ( ²⁵⁾ and R ( ²⁶⁾ independently of one another denote alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, (CH _{2) n} R ²⁹ or trifluoromethyl, n is 0, 1, 2, 3 or 4,

R ²⁹ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ³⁰ R ³¹ .

R ( ³⁰⁾ and R ( ³¹⁾ are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or R ( ²³⁾ , R ( ²⁵⁾ and R ( ²⁶⁾ are hydrogen,

R ²⁴ and R ²⁷ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or

R ²³ and R ^24, and R ²⁶ and R ²⁷ together are 5 or 6 me112 the methylene groups of which one methylene group can be replaced by oxygen, S, -NH-, -NCH ₃ or -N-benzyl .

R ( ³⁵⁾ and R ( ³⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or

R ³⁸ and R ³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, -CH ₃ group, or -N-benzyl group, or

R ³⁸ is phenyl which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy, SO 2 R ⁸ group, a group SO 2 NR ⁸ R ^7, and -NR ³² R ³³ ,

R ⁸ represents an alkyl group having 1, 2, 3, 4, 5 or 6 carbon atoms,

R ⁶ and R ⁷ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms,

R ( ³²⁾ and R ( ³³⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or

R ³⁸ represents a heteroaryl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group and the other substituents R, R and R independently of one another are alkyl having 1, 2, 3, 4, 5, 6, or 8 carbon atoms or a (CH ₂₎ p R ¹⁰ p is 0, 1, 2, 3 or 4,

R ¹⁰ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, -SO 2 NR ¹⁷ R ¹⁸ and -SO ² R ⁹ ,

113

R ( ¹⁷⁾ and R ( ¹⁸⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms,

R ⁹ represents an alkyl group containing 1, 2, 3 or carbon atoms, or the other substituents R ¹ and R ³ represent a hydrogen atom,

R ⁴ is H or alkyl having 1,

2, 3 or 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, and (c) benzoylguanidine of formula I (HOE S5 / F 265-NZ 299739)

in which

R ¹ represents an alkyl group having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or NR ⁷ R ⁸ ,

R ( ⁷⁾ and R ( ⁸⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms,

ABOUT

R is hydrogen, alkyl having 1, 2, 3, 4.5, 6, 7 or 8 carbon atoms or -SO ₂ R ⁹ , R ^{9 is} independently as defined for R ¹ ,

R ³ represents a hydrogen atom, -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁶ or -CR ²⁵ R ²⁶ R ²⁷ ,

R ²⁵ represents a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethoxy -methyl group

Or R ²⁵ represents a heteroaryl group having 1 to 9 carbon atoms, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a hydrogen atom, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group; fluoro, chloro, trifluoromethyl, methyl, hydroxy, amino, methylamino and dimethylamino,

R ( ²⁶⁾ and R ( ^27), independently of one another, are as defined for R ( ²⁸⁾ or are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms,

R ⁴ is H, fluoro, chloro, bromo, iodo, hydroxy, cyano, trifluoromethyl, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms or - (C ^^ R ^14, m is 0, 1 or 2,

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁸ R ¹⁸ .

R ¹⁸ and R ¹⁸ independently of one another are hydrogen or methyl;

R ⁸ and R ⁸ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, fluorine atom, chlorine atom, -OR ³² , -NR ³³ R ³⁴ or trifluoromethyl,

R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms.

as well as its pharmaceutically acceptable salts,

115 (ar) a benzenedicarboxyldiguanidide of the formula I (HOE 95 / F 269 K)

wherein one of R ¹ , R ² , R ³ and R ⁴ is a group

-CO-N = C (NH ₂ ) ₂ and the other substituents R ¹ , R ² , R ³ and R ⁴ represent:

R ¹ is H, alkyl having 1, 2, or 4 carbon atoms, F, Cl, Br, I, -OR ^32, -NR ³³ R ³⁴ or trifluoromethyl,

R ( ³²⁾ , R ( ³³⁾ and R ( ^34), independently of one another, represent a hydrogen atom or an alkyl group containing 1, 2, 3 or carbon atoms,

R ² and R ⁴ independently of one another represent H, F, Cl, Br, I, hydroxy, cyano, trifluoromethyl, -CO-NC _(NH2) 2, alkyl containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, an alkenyl group containing 2, 3, 4, 5, 6, 7 or 8 carbon atoms or - (CH ₂ ) _m R ¹⁴ , m means 0, 1, or 2

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁵ R ¹⁶ .

R ¹⁵ and R ¹⁶ represent a hydrogen atom or a methyl group;

R ² and R ^4, independently of one another, are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl, which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine, chlorine , bromine, iodine, cyano, C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl, methyl and methoxy; or

R ² and R 2 are each independently R-SO 2 -, R ²³ R ²⁴ N-CO-, R ²³ -CO- or r ²⁹ R ³⁰ n -SO 2,

R ²² and R ^28, independently of one another, are methyl or trifluoromethyl,

R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁸⁾ independently of one another represent a hydrogen atom or a methyl group, or

R ² and R ⁴ independently of one another are -0R ⁱ⁵ or -NR ³⁵ R ^38,

R ( ³⁵⁾ and R ( ³⁸⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or

R ³⁵ and R ³⁸ together form 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, -CH ₃ group, or -N-benzyl group,

R ³ represents a hydrogen atom, -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁸ , -CR ²⁵ R ²⁸ R ²⁷ ,

R represents a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl , methyl, methoxy, hydroxy, amino, methylamino and dimethyl amino, or

R represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino- group a dimethylamino group,

117

R ²⁶ and R ²⁷ independently of one another have the meanings defined for R ²⁵ or are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms,

R ⁵ represents an alkyl group containing 1, 2, 3 or 4 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an X- (CH ₂ ) _y -CF ₃ group or a phenyl group which is unsubstituted or substituted 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, g 7 methoxy group and -NR R group,

R ⁸ and R ⁷ independently of one another represent a hydrogen atom or a methyl group,

X is a bond or an oxygen atom, y is 0, 1 or 2, as well as pharmaceutically acceptable salts thereof, and (a) a benzenedicarboxyldiguanidide of formula I (HOE 95 / F 269 BK)

wherein one of R ¹ , R ² , R ³ and R ³ is -CO-N = C (NH ₂ ) _2, and the other R ¹ , R ² , R ^3, and R ⁵ are:

R ¹ and R 5 independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, fluorine atom, chlorine atom, -OR ³² , -NR ³³ R ³⁴ or trifluoromethyl,

R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or

118 carbon atoms,

R ² represents H, F, Cl, Br,, hydroxy, cyano, trifluoromethyl, -CO-NC _(NH2) 2 »alkyl having 1, 2, 3, 4 , 5, 6, 7 or 8 carbon atoms, an alkenyl group containing 2, 3, 4, 5, 6, 7 or S carbon atoms or - (CE ₂ ) _m R ¹⁴ , m being 0, 1 or 2,

R ⁴ is C 3 -C 8 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy and -NR ^{1 S} R ¹⁶ ,

R ( ¹⁵⁾ and R ( ^16), independently of one another, are hydrogen or methyl;

R ² is R ²² -SO ² -, R ²³ R ²⁴ N-CO-, R ²³ -CC or R ²⁹ R ³⁰ N-SO 2.

R ²² and R ^28, independently of one another, are methyl or trifluoromethyl,

R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl; or

R ² is -OR ³⁵ or -NR ³⁸ R ³⁶

R and R independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or

R ³⁸ and R ³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH ₃ group or an -N-benzyl group,

R ³ is H, -SR ^28, -OR ^28, -NR ²⁵ R ^26, -CR ²⁶ R ^{2 s} R ^27,

R represents a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl , methyl, methoxy, hydroxy, amino,

119 methylamino and dimethylamino or R ²⁵ represents a heteroaryl group containing 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, mecyl group, methoxy group, hydroxy, amino, methylamino and dimethylamino, R ²⁸ and R ^27, independently of one another, are as defined for R ² 'or a hydrogen atom or an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms,

R ⁴ is trifluoromethyl, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3 up to 8 carbon atoms or - (CH ₂ ) _m R ¹⁴ , m being 1 or 2,

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ^{1 S} R ¹⁸ .

R ( ¹⁵⁾ and R ( ^16), independently of one another, are hydrogen or methyl;

R ⁴ represents a phenyl group which is unsubstituted or substituted by 2, 3, 4 or 5 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ^{1 S} R ¹⁸

R ¹⁵ and R ³ * ^8, independently of one another, represent a hydrogen atom or a methyl group, as well as pharmaceutically acceptable salts thereof, etc. (a) diaryldicarboxyldiguanide of the formula I (HOE 96 / F 013)

120

wherein one of R ¹ , R ² , R ³ , R ⁴ and R ⁸ is -CO-N = C (NH ₂ ) ₂ , the other substituents R ¹ and R ^8, independently of one another, are hydrogen, alkyl containing 1, 2, or 4 carbon atoms, fluorine atom, chlorine atom, -OR ³² , -NR ³³ R ³⁴ or trifluoromethyl,

R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or carbon atoms, the other substituents R ( ²⁾ and R ( ⁴⁾ independently of one another are hydrogen, fluorine or bromine, iodine atom, hydroxy group, cyano group, trifluoromethyl group, -CO-N · C (NH ₂ ) ₂ group, alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl group containing 2, 3, 4, 5, 6, 7 or 8 carbon atoms or - (CH ₂ ) _m R ¹⁴ , m being 0, 1 or 2,

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁸ R ¹⁸ .

R ¹⁸ and R ¹⁶ represent a hydrogen atom or a methyl group or the other substituents R ² and R ⁴ independently of one another represent a pyrrol-1-yl group, a pyrrol-2-yl group

121 or a pyrrol-3-yl group which is unsubstituted or substituted by from 1 to 4 substituents selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, C 2 -C 8 alkanoyl, alkoxycarbonyl 2 to 8 carbon atoms, formyl, carboxy, trifluoromethyl, methyl, methoxy or the scaling substituents R ² and R 'are R ²² -SO 2 -, R ²³ R ²⁴ N-CO, R ²³ -CO- or a group r ²⁹ r ³⁰ n -so 2,

R ²² and R ^28, independently of one another, are methyl or trifluoromethyl,

R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl or the other substituents R ( ²⁾ and R ( ⁴⁾ independently of one another are -OR ³⁹ or -NR ³⁹ R ³⁸ ,

R ( ³⁹⁾ and R ( ³⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or

R ³⁵ and R ³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH ₃ group or an -N-benzyl group, the last R ³ being an atom hydrogen, -OR ²⁹ , -SR ²⁹ , -NR ²⁹ R ^{2 S} , -CR ²⁹ R ²⁶ R ²⁷ ,

R represents a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl , methoxy, methyl, hydroxy, amino, methylamino and dimethylamino, or R represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom , chlorine, trifluoromethyl, methyl, methoxy, hydroxy,

122 amino, methylamino and dimethylamino, R ²⁶ and R ²⁷ independently of one another have the meanings defined for R ²⁵ or are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, one of R ⁶ , R ⁷ , R ⁸ , R ⁹ and R ¹⁰ represents a group

-co-n = c (nh ₂ ) ₂ , the other substituents R ⁸ and R ¹⁸ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, fluorine atom, chlorine atom, -OR ¹³² , -NR ¹³³ R ¹³⁴ or trifluoromethyl,

R ( ¹³²⁾ , R ( ¹³³⁾ and R ( ¹³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, the other substituents R ( ⁷⁾ and R ( ⁹⁾ independently of one another are hydrogen, fluorine or chlorine, bromine, iodine, hydroxy, cyano, trifluoromethyl, -CO-NC (NH ₂ ) ₂ , alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl a group containing 2, 3, 4, 5, 6, 7 or 8 carbon atoms or - (CH ₂ ) _mm R ¹¹⁴ , mm being 0, 1 or 2,

R ¹¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹¹⁵ R ¹¹⁶ .

R ¹¹⁵ and R ¹¹⁸ are hydrogen or methyl or the other substituents R ⁷ and R ⁹ independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted 1-4 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, cyano, C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl,

123 ifg-> ^ny RB-yl group ', trifluoromethyl, methyl and methoxy, or substitution present oscatné R ⁷ and R ⁹ represent the group -SO 2 R ²² group, R ¹²³ R ¹² N-CO-, R ¹²⁸ -CO- or the group r ¹²⁹ r ¹³⁰ n-so2,

R ¹²² and R ¹²⁸ independently of one another are methyl or trifluoromethyl,

R ( ¹²³⁾ , R ( ¹²⁴⁾ , R ( ¹² ) and R ( ^38), independently of one another, are hydrogen or methyl or the other substituents R ( ⁷⁾ and R ( ⁹⁾ independently of one another are -OR ¹³⁵ or -NR ¹³⁵ R ¹³⁸ ,

R ( ¹⁸⁾ and R ( ¹³⁸⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or

· R ³⁵ and R ³⁸ together are 4-7 methylene groups, of which one _CH2 group can be replaced by oxygen, S, -NH-, -NCH ₃ or -N-benzyl, the last qi ης R represents a hydrogen atom, a group -SR, a group -OR ¹²⁵ , a group -NR ¹²⁵ R ^128, or a group

-cr ' ¹²⁵ r ^12S r ¹²⁷

R ¹²⁵ represents a hydrogen atom, an alkyl group having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl a group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group; or

R ¹²⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, methylamino - and dimethylamino, R ¹²⁸ and R ^127, independently of one another, are as defined for R ¹²⁵ or are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms,

124

A is absent or is -NR 1 -CO-, -NR ¹² -CO-NR ¹³ -, -NR ¹⁷ -CO-NR ¹⁸ -SO ₂ -, NR ¹⁹ -SO ₂ -, -SO ₂ -NR ¹⁹ -SO 2, -SO 2 -NR ¹⁹ -CO-, -O-CO-NR ¹⁹ -SO 2 - or -CR ²⁰ = CR ²¹ -,

R ( ¹¹⁾ , R ( ¹²⁾ , R ( ¹³⁾ , R ( ¹⁷⁾ , R ( ¹⁸⁾ , R ( ¹⁹⁾ , R ( ²⁰⁾ and R ( ²⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 (u) a substituted thiophenylalkenylcarboxylguanidide of the formula I (HOE 96 / F 026);

wherein at least one of R ¹ , R ² and R ³ is -Op- (CH 2) g -CgF 2 q + 1, R ⁴⁰ CO-, or R ³¹ -SO 3 -, p is 0 or 1, s is 0 , 1, 2, 3 or 4, g is 1, 2, 3, 4, 5, 6, 7 or 8, k is 0, 1 or 2,

R ⁴⁰ represents an alkyl group containing 1, 2, 3, 4, 5,

6, 7 or 8 carbon atoms, a perfluoroalkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine , trifluoromethyl, methyl and methoxy,

R ³¹ represents an alkyl group containing 1, 2, 3, 4, 5,

6, 7 or 8 carbon atoms, a perfluoroalkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms,

125 cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, mecyl or methoxy or

R ³¹ represents NR ⁴¹ R ⁴² ,

R ( ⁴¹⁾ and R ( ⁴²⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, perfluoroalkyl having 1, 2, 3 or 4 carbon atoms or

R ( ⁴¹⁾ and R ( ⁴²⁾ together are 4 or 5 methylene groups, one of which is a G1 group; ₂ can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, and the other substituents R ^1, R ² and R ³ independently of one another represent H, F, Cl, bromine, iodine, cyano, a group -0-C ^ _to ^ and _{K, and} Og Malebo group C _r H _{2 R a} R ^10, or Q is 1, m is 0, 1, 2, 3, 4, 5, 6 , 7 or 8, ga is 0 or 1, and r is 0, 1, 2, 3, or 4,

^R10 is cycloalkyl having 3, 4, 5, 6, or 8 carbon atoms or phenyl, where phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl and methoxy, -group,

R ⁴ and R ⁵ independently of one another are hydrogen, fluorine, chlorine, bromine, iodine, cyano, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, perfluoroalkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3,4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom,

126 trifluoromethyl, methyl, methoxy and NR ¹⁴ R ^15,

R ( ¹⁴⁾ and R ( ¹⁵⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms as well as their pharmaceutically acceptable salts; -substituted benzoylguanidine of general formula I (HOE 96 / F 032)

in which

R ² and R ³ independently of one another, H, Cl, Br, alkyl having 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or a radical -OR ^5,

R ⁵ represents an alkyl group having 1 to 8 carbon atoms or a ^{cd H} 2d -cycloalkyl group in which the cycloalkyl radical contains 3 to 8 carbon atoms, d represents 0, 1 or 2, each of R ² and R ³ represents a hydrogen atom, but simultaneously both R ² and R ³ do not represent a hydrogen atom as well as its pharmaceutically acceptable salts, and x) benzoylguanidine of the general formula I (HOE 96 / F 042)

127

in which

R ¹ represents H, F, Cl, Br, I, cyano, nitro, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkoxy containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms, a cycloalkoxy group containing 3, 4, 5, 6, 7 or 8 carbon atoms or X _and - (CH ₂ ) _b - (CF ₂ ) _c -CF ₃ ,

X is O, S or NR ^5, and a is 0 or 1, b is 0, 1 or 2, c is 0, 1, 2 or 3,

R ⁵ represents a hydrogen atom, an alkyl group containing 1, 2, 3 or 4 carbon atoms or a -C 1 H 4 -R ^{6 group} , d represents 0, 1, 2, 3 or 4,

R ^{6 is} cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms, phenyl, biphenylyl or naphthyl, said aromatic comprising phenyl, biphenylyl or naphthyl being unsubstituted or substituted by 1 to 3 substituents selected from; a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an NR R group,

R ⁷ and R ⁸ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or

R ^{1 is} -SR ¹⁰ , -OR ^10, or -ΟΗ ¹ R ¹¹ ; ¹² ,

R ¹⁰ represents ^-c fH ₂ f -cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms in the cycloalkyl

Wherein the phenyl group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group, methyl group, hydroxy group, amino group, methylamino group and dimethylamino group -group, f is 0, 1 or 2,

R ¹¹ and R ¹² independently of one another are as defined for R ¹⁰ or are hydrogen or alkyl having 1, 2, 3 alebc 4 carbon atoms or

R ¹ represents a phenyl group, a naphthyl group, a biphenyl group or a heteroaryl group having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, the latter being bonded via a carbon atom or a ring nitrogen atom; said groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, methylamino group and dimethylamino group, or

R ¹ is -SR ¹³ , -OR ¹³ , -NKR ¹³ , -NR ¹³ R ¹⁴ , -CHR ¹³ R ¹⁵ , C- (R ¹⁵ R ¹⁶ OH), -CaCR ¹⁸ , - C (R ¹⁹ ) = CHR ¹⁸ , -C (R ²⁰ R ²¹ ) k - (CO) - / CR ²² R ²³ /1-R ²⁴ , k is 0, 1, 2, 3 or 4 is Q, 1, 2, 3 or 4

R ¹³ and R ¹⁴ , which are the same or different, represent - (CH 2) a - (CHOH) h- (CH 2) -CHOH) jR ¹⁷ or - (CH 2) _g -O- (CH ₂ -CH ₂ O) _h -R ²⁴ ,

R ¹⁷ represents a hydrogen atom or a methyl group, g, h and i, which are the same or different, represent 0, 1,

2, 3 or 4, j is 1, 2, 3 or 4,

R ¹⁵ and R ¹⁶ , which are the same or different, represent a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5 or carbon atoms or together with the carbon atom to which they are attached a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms,

129

R ¹⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ^{2 S} group R ²⁶ ,

R ²⁵ and R ²⁶ represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or R ¹⁸ represents a heteroaryl group containing 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon acoms which is unsubstituted or substituted as phenyl, or R ¹⁸ represents an alkyl group containing 1, 2, 3, 4, 5 or 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxyl groups or R ¹⁸ represents a cycloalkyl group containing 3, 4, 5 , 6, 7 or 8 carbon atoms,

R ¹⁹ , R ²⁰ , R ²¹ , R ²² and R ²³ , which are the same or different, represent a hydrogen atom or a methyl group,

R ²⁴ is H, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms, -C _H2m-R ^18, m is 1, 2, 3 or 4,

R ² and R ³ are defined as R ^1,

R ⁴ represents an alkyl group containing 1, 2, 3 or 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, and y) an ortho-substituted benzoylguanidine of the formula I (HOE 96 / F 043)

R '(D

RO NH ₂

130 in which

R ¹ represents H, F, Cl, Br, I, cyano, nitro, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkoxy containing 1, 2, 3, 4, 5, S, 7 or 8 carbon atoms, a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms or x - (CH ₂ ) _b - (CF ₂ ) _c -CF ₃ ,

X is O, S or NR ^5, and a is 0 or 1, b is 0, 1 or 2, c is 0, 1, 2 or 3,

R ⁵ is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or -C _d H _2d R ⁶ , d is 0, 1, 2, 3 or 4,

R ⁸ represents a cycloalkyl group having 3, 4, 5, 6, or 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups comprising a phenyl group, a biphenylyl group and a naphthyl group being unsubstituted or substituted by 1 to 3 substituents selected a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an NR ⁷ R ^{8 group} ,

R and R are, independently of one another, a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or

R ¹ is -SR ¹⁰ , -OR ^10, or a group

-r ¹⁰ r ¹³ -r ¹²

R ¹⁰ is -C (H ₂₎ 6 -cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms in the cycloalkyl ring or phenyl, wherein the phenyl is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, f is 0, 1 or 2,

131

R ¹¹ and R ¹² independently of one another are as defined for R ¹⁰ or are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or

R 'is phenyl, naphthyl, biphenylyl or heteroaryl containing 1, 2, 3,

4, 5, 6, 7, 8 or 9 carbon atoms, the latter being bonded via a carbon atom or a ring nitrogen atom and said groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl a group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group; or

R ¹ is -SR ³ R ³ , -OR ³ , -NHR ³ R ³ , -NR ¹³ R ¹⁴ , -CHR ¹³ R ¹⁵ , -C (R ¹⁵ R ¹⁶ OH), -C »CR ¹⁸ , -C (R ¹⁹ ) = CHR ¹⁸ , -C (R ²⁰ R ²¹ ) k - (CO) - / CR ²² R ²³ /1-R ²⁴ , k is 0, 1, 2, 3 or 4 , is 0, 1, 2, 3, or 4,

R ¹³ and R ¹⁴ , which are the same or different, represent - (CH 2) g - (CHOH) h - (CH ₂ ) _g - R ¹⁷ or - (CH 2) _g -O- (CH ₂ -CH ₂ O) ) _h -R ²⁴

R ¹⁷ represents a hydrogen atom or a methyl group, g, h and i, which are the same or different, represent 0, 1,

2, 3 or 4, j is 1, 2, 3 or 4,

R ¹⁵ and R ¹⁶ , which are the same or different, represent a hydrogen atom, an alkyl group containing 1, 2, 3,4,5 or carbon atoms or together with the carbon atom to which they are attached, represent a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms,

R ¹⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ^{2 S} group R ²⁶ ,

R ²⁵ and R ²⁶ represent a hydrogen atom or an alkyl group

132 having 1, 2, 3 or 4 carbon atoms or R ¹⁸ represents a heteroaryl group having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms which is unsubstituted or substituted as phenyl or R ¹⁸ represents an alkyl group containing 1, 2, 3, 4, 5 or 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups, or

R ¹⁸ represents a cycloalkyl group containing 3, 4, 5, 6, or 8 carbon atoms,

R ¹⁹ , R ²⁰ , R ²¹ , R ²² and R ²³ , which are the same or different, represent a hydrogen atom or a methyl group,

R ²⁴ represents a hydrogen atom, an alkyl group having 1, 2, 3, 4, 5 or 6 carbon atoms, a cycloalkyl group having 3, 4, 5, 6, 7 or 8 carbon atoms or a -C _m H _2m -R ^{18 group} , m is 1, 2, 3 or 4, one of R ² and R ³ is hydroxy and the other R ² and R ³ have the meanings defined for R ¹ , R ⁴ is an alkyl group containing 1, 2, 3 or 4 carbon atoms, an alkoxy group containing 1, 2, 3 or 4 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom or a - (CH ₂ ) _n - (CF ₂ ) _O -CF _{3 group} , n being 0 or 1, o is 0 or 1, as well as pharmaceutically acceptable salts thereof.

II) Also suitable are compounds of the general formula (DE 195 02 895, DE 44 30 212, EP 667 341, DE 44 04 183,

8 708 088, EP 723 963, EP 0 694 537, DE 44 21 495,

EP 699 660, EP 699 663, EP 699 666, DE 43 37 611, EP 0719 766, WO 94/26709, WO 96 04 241, EP 726 254, US 4,251,545,

DE 35 02 629; WO 84/00875; Kumamoto et al., Pharm. Bull. (1966), 7-13; US 3,780,027, JP 8225513)

133

in which

W, Y and Z are nitrogen or carbon substituted with R ² or R ³ or R ⁴ ,

R ¹ is hydrogen, A, halogen, trifluoromethyl, -CH ₂ , -CH ₂ F, -CH ₂ CF ₃ , -C ₂ F ₅ , cyano, nitro, ethynyl or X-R ',

A represents an alkyl group having 1 to 6 carbon atoms, a halogen atom means a fluorine atom, a chlorine atom, a bromine atom or an iodine atom,

X represents an oxygen atom, a sulfur atom or an NR '' group,

R ' ¹ represents a hydrogen atom, A or a cyclic methylene chain containing 3 to 7 carbon atoms,

R * represents a hydrogen atom, A, HO-A, HOOC-A-, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 6 to 8 carbon atoms, trifluoromethyl, CH ₂ F, CH ₂ -CF ₃ , Ph, -CH ₂ -Ph or Het,

Ph represents an unsubstituted, one, two or three times substituted phenyl, naphthyl or biphenylyl group, the substituents being selected from the group consisting of A, OA, NR * R * ¹ , Hal and trifluoromethyl,

Het means a mono- or di-core, saturated or unsaturated or aromatic group containing 1 to 4 heteroatoms selected from the group consisting of nitrogen, oxygen and / or sulfur, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, trifluoromethyl, A,

134 is hydroxy, OA, -X-R ', cyano, nitro and CO-O, wherein Het is bonded via a nitrogen atom or an alkylene chain wherein m is 0, 1, 2, 3, 4 , 5 and 6 or

R ¹ and R ¹¹ together represent an alkylene group containing 4 or 5 carbon atoms, one of which CH ₂ may be replaced by oxygen, sulfur, NH, NA, N-Ph or N-CH ₂ -Ph .

2

R and R independently of one another are hydrogen, halogen, A, HO-A, XR *, -C (= N-OH) -A, AO-CO-alkyl, wherein the alkyl moiety contains 1 up to 4 carbon atoms, cyano, nitro, carboxy, substituted with A, in particular trifluoromethyl, CH ₂ F, CHF ₂ , C ₂ F ₅ , CH ₂ CF ₃ or SiO ¹¹ ;

R ¹¹ is A, Ph or -Het, n is 0, 1 or 2 or

R and R independently of one another are SO ₂ NR ^{I 1,} Ph, -O-Ph, _-O-CH2 -Ph, -CO-A, -CHO, -COO, a - CSNR'R ' ¹ , CONR'R ¹ ', CH = CH-COOH, -CH = CH-COOA, indenyl, indanyl, decahydronaphthyl, cyclopentenyl, dihydrothenyl, dihydrofuryl, heterobicyclyl, alkylthienyl a halothienyl group, a haloalkylthenyl group, an acylthienyl group, a halofuryl group, a haloalkylfuryl group, or a pyrrolyl group, or

R ² and R ³ independently of one another are R ^a -O-,

R ⁵ represents a hydrogen atom, A, an alkenyl group having 1 to 6 carbon atoms or a cycloalkyl group having 3 to 7 carbon atoms,

R ⁴ represents Ph, Het, -Ο-Het, trifluoromethyl, S (O) _n R ''', -SO ₂ NR'R'', Alk or a group of the formula

135

or two of R ¹ to R ⁴ together represent -O-CR ⁶ R ⁷ -CO-NR ⁸ or a group of the formula

or a group of formula (R) 0-4 where

R ² has the abovementioned meaning,

R ⁶ , R ⁷ , R ⁸ and R ⁹ independently of one another are hydrogen or A or

R ⁸ is C 5 -C 7 cycloalkyl or R ⁹ is cyano,

Alk represents a straight or branched alkyl group having 1 to 8 carbon atoms or a cycloalkyl group having 3 to 8 carbon atoms which is unsubstituted or substituted one, two or three times with substituent A, or

136

Alk represents an ethenyl group or an ethynyl group substituted with substituents selected from the group consisting of hydrogen, A, Ph or Het,

III) compounds of the general formula (DE 41 27 026, DE 4337609, JP 07025768, Edward J. Cragoe, Jr.,

Diuretics [Chemistry, Pharmacology and Medicine], J. Wiley 3 &amp; Sons (1983), 303-341];

in which

X represents a hydrogen atom, Hal, (Hal) ₃ C-, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, a substituted phenyl group, an alkyl-S- group in which the alkyl radical contains 1 to 5 or an alkyl-SO ₂ - group in which the alkyl moiety contains 1 to 5 carbon atoms,

Y represents an amino group or a substituted amino group, or

X and Z together are a - (CH _{2) 4} or 1,3-butadienylene chain or

Z represents a hydrogen atom, a halogen atom, a hydroxy group, a HS group, an alkyl group containing 1 to 5 carbon atoms, a cycloalkyl group containing 3 to 6 carbon atoms, a substituted phenyl group or

Z is amino or -NR ¹ R ² ,

R ¹ represents a hydrogen atom or a straight or branched and optionally substituted alkyl group having 1 to 8 carbon atoms, which may be interrupted by an oxygen atom, or

137

R ¹ is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, C 3 -C 7 cycloalkyl, hydroxy substituted phenyl, phenylalkyl in which the alkyl radical contains 1 to 4 carbon atoms and which is substituted with a hydroxy group or a cycloalkyl group containing 3 to 7 carbon atoms and substituted with up to 7 carbon atoms,

R represents a 1-morpholino group, a hydrogen atom or a straight or branched alkyl group having 1 to 8 carbon atoms which may be interrupted by an oxygen atom, an amino group, wherein the straight or branched alkyl group having 1 to 8 carbon atoms is unsubstituted or substituted substituted or unsubstituted mono- or polynuclear heterocycle containing as the heteroatoms a nitrogen atom, an oxygen atom or a sulfur atom, or said alkyl group being substituted by a phenyl group, optionally mono- or poly-substituted by an alkoxy group containing 1 to carbon atoms and optionally substituted by a hydroxy group , alkylamino, alkyl or phenyl, or said alkyl substituted by aminocarbonyl or hydroxy or alkoxy having 1 to 4 carbon atoms, or

R ² is phenyl, which is unsubstituted or substituted alkyl group, an alkoxy group which bears as substituents a hydrogen atom, either one or more of the core heterocycle comprising heteroatoms such as N, O or S and which is unsubstituted or substituted by a hydrogen atom, a halogen atom or an alkyl group, or a phenyl radical which is unsubstituted or substituted by substituents selected from the group consisting of alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, halogen and hydroxy, or

138

Ο

R represents a 1-piperidino group which is unsubstituted or substituted in the 4-position by an acyl radical of an aliphatic, alicyclic, aromatic or heteroaromatic carboxylic acid, an alkyl group having 1 to 8 carbon atoms which may be substituted by a hydroxy group or an alkoxy group having 1 to 4 carbon atoms or a phenyl radical substituted with an alkoxy group; or

^R2 is amidino group, which is unsubstituted or substituted by phenyl, which is unsubstituted or substituted by halogen or alkyl, or

R ² is an acyl radical of an aliphatic, alicyclic, aromatic or heteroaromatic carboxylic acid, or

R ² is alkyl of 1 to 8 carbon atoms which may be substituted by hydroxy, alkoxy or phenyl bearing alkyl radicals, or

R ¹ and R ² together with the nitrogen atom to which they are attached denote a piperazine ring which is unsubstituted or carries, through a C 1 -C 6 methylene chain, a one or more nuclear heterocyclic group containing a nitrogen atom as heteroatoms, oxygen or sulfur (DE 41 27 026 and DE 43 37 609), and Hal represents a fluorine atom, a chlorine atom, a bromine atom or an iodine atom.

IV) An indoylguanidine derivative of the general formula (EP 708 091, EP 622 356, JP 5-125085) is also suitable.

139 in which n

R represents a hydrogen atom, an unsubstituted or substituted alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, a hydroxy group, an alkyl-O- group in which the alkyl radical contains 1 to 6 carbon atoms, an aromatic group or -CH ₂ -R ²⁰

R ²⁰ represents a C 2 -C 6 alkenyl group or a C 2 -C 6 alkynyl group,

R ¹ represents 1 to 5 identical or different substituents which are hydrogen, unsubstituted or substituted C 1 -C 8 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 cycloalkyl up to 7 carbon atoms, halogen, nitro, alkanoyl of 2 to 8 carbon atoms, arylalkanoyl of up to 10 carbon atoms, aroyl of up to 11 carbon atoms, carboxyl, alkoxycarbonyl of 2 to 6 carbon atoms, aromatic a group and any of the following groups: -OR ³ , -NR ® R ^7, or -S (O) _n R ⁴⁰ ,

R ³ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a substituted alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, an aromatic group, a -CH ₂ R ^{30 group} ,

R ( ³⁰⁾ is alkenyl or alkynyl, R ( ⁷⁾ and R ( ⁷⁾ independently of one another are hydrogen, unsubstituted or substituted alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, alkanoyl of 2 to 8 carbon atoms atoms, an arylalkanoyl group containing up to 10 carbon atoms, an aroyl group containing up to 11 carbon atoms, an aromatic group or a -CH ₂ -R ® ° - group,

140

R ⁶⁰ represents an alkenyl group having 2 to 6 carbon atoms or an alkynyl group having 2 to 6 carbon atoms or gy

R and R 'together with the nitrogen atom represent a 5- to 7-membered cyclic amine group which may contain further heteroatoms in the ring, n being 0, 1 or 2,

R ⁴⁸ represents unsubstituted or substituted C 1 -C 8 alkyl or an aromatic group or -A-CH

NR '

A is O, -S (O) _n - or -NR ⁵⁸ -,

R ⁵⁸ represents a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms,

R 'represents a hydrogen atom, an unsubstituted or substituted alkyl group having 1 to 8 carbon atoms, which represents a saturated 3- to 8-membered heterocyclic group having one nitrogen atom, and said substituted alkyl group bears one or more groups selected from a halogen atom , hydroxy, C 1 -C 6 alkoxy, cyano, carboxyl, C 2 -C 6 alkoxycarbonyl, C 2 -C 8 alkanoyl, arylalkanoyl C max of up to 10 carbon atoms, aroyl containing not more than 11 carbon atoms, an aromatic group or a -CONR ⁴ R ^{5 group} ,

R ⁴ and R ⁵ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms,

141

R ⁴ and R ⁸ together represent a 5- to 7-membered cyclic amine group which may contain further heteroatoms in the ring, or said substituted alkyl group carries a -A-CH group

E — R in which

E represents a nitrogen atom or a CH group,

R ' ¹ represents a hydrogen atom, an unsubstituted or hydroxy-substituted alkyl group having 1 to 8 carbon atoms or a substituted alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a cyano group, a carboxyl group, an alkoxycarbonyl group 2 to 6 carbon atoms, alkanoyl of 2 to 8 carbon atoms, aralkanoyl of up to 10 carbon atoms, aroyl of up to 11 carbon atoms, aromatic group, -NR ⁸ R ⁷ , -CONR ⁴ R ⁸ ,

R ⁴ and R ⁵ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms, wherein the cyclic system -A-CH represents a 3- to 8-membered saturated aliphatic or heterocyclic ring system with a nitrogen atom and said aromatic groups represent aryl of up to 10 carbon atoms, 5- or 6-membered heteroaryl of 1 to 4 nitrogen atoms, 5 or 6-membered heteroaryl of 1 or 2 nitrogen atoms and one heteroatom selected from the group consisting of:

142 comprising an oxygen and sulfur atom or a furyl group, and said aryl groups are unsubstituted or substituted by an unsubstituted alkyl group containing 1 to 8 carbon atoms or a substituted alkyl group containing 1 to 8 carbon atoms, a halogen atom, a nitro group, an alkoxycarbonyl group, a carboxyl group a group, -OR ³ , NR ⁶ R ⁷ , -CONR ⁴ R ⁵ , -SO ² NR ⁶ R ^7, or S (O) n R ⁴⁰ , wherein R ¹ and the guanidinocarbonyl radical may be at any point 5- or A 6-membered ring of the indole system as well as pharmaceutically acceptable salts thereof. It is also suitable

V) heterocyclic guanidine derivative of the general formula (WO 95 04052)

in which

X is O, S, -NH-, -N (alkyl) - in which the alkyl radical contains 1 to 4 carbon atoms, or -N (phenyl) -,

R ¹ , R ² and R ³ are hydrogen, halogen, C 1 -C 4 alkyl, alkyl-O- in which the alkyl radical contains 1 to 4 carbon atoms, phenyl, benzyl or two of the substituents R ¹ , R ² and R ³ together with the side of the benzene system denote a 4- and 6-membered carbocyclic ring,

R ⁴ and R ⁵ independently of one another represent a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a benzhydryl group, an aralkyl group which is unsubstituted or substituted by one or more

143 substituents selected from the group consisting of halogen, alkyl of 1 to 4 carbon atoms, an alkyl-Ο- in which the alkyl portion contains 1 to 4 carbon atoms, a trifluoromethyl group or a group- _{(CH2) m-CH2-T} , m is 0 to 3

T is -CO-OT ¹ ,

T ¹ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

Cy represents a benzo-fused unsaturated or dihydro-5-membered heterocycle of formula

a pyrazole or imidazole ring of formula or formula

naphthyl or dihydro- or tetrahydronaphthyl

A 2-, 3- or 4-pyridyl group of the formula

R '

144

Z is N or CH, thienyl of formula

R ⁶ represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group containing 1 to 10 carbon atoms, an alkyl-O group in which the alkyl radical contains 1 to 10 carbon atoms, a phenoxy group, an alkyloxymethyloxy group in which the alkyl radical contains 1 to 10 carbon atoms or - (O) _n SR ⁹ ,

R ⁹ represents an alkyl group having 1 to 10 carbon atoms, a thienyl group, a pyridyl group, a thiazolyl group, a thiadiazolyl group, an imidazolyl group, a pyrazolyl group or a phenyl group which are unsubstituted or substituted once or twice with a halogen atom; carbon atoms or an alkyl-Ο- group in which the alkyl radical contains 1 to 4 carbon atoms,

R ⁷ and R ⁸ represent a hydrogen atom, a halogen atom, a hydroxy group, an alkyl group containing 1 to 10 carbon atoms, an alkyl-Ο- group in which the alkyl radical contains 1 to 10 carbon atoms, a phenyl group, a phenoxy group or an alkoxymethyloxy group in which the alkoxy radical is 1 to 10 carbon atoms;

Cy represents a phenyl group which is unsubstituted or substituted once or twice by a halogen atom, an alkyl group containing 1 to 4 carbon atoms or an alkyl-Ο- group in which the alkyl radical contains 1 to 4 carbon atoms, or

Cy is -Gr-Am,

Gr is -R ¹³ -R ¹² (CH ² ) g C / W / yw ¹ - (CH 2) g, R ¹³ R ¹⁴ - or -R ¹⁵ -,

R ¹² represents a single bond, an oxygen atom, - (O) _n S-, -CO- or -CONH-,

145

R ¹³ represents a single bond, a phenyl group, a thienyl group, a pyridyl group, a thiazolyl group, a thiadiazolyl group, an imidazolyl group or a pyrazolyl group,

R ¹⁴ represents a single bond or a SO ₂ - group,

R ¹⁵ represents a C 2 -C 10 alkenyl or C 2 -C 10 alkynyl group,

W and W ¹ independently of one another, H or alkyl having 1 to 4 carbon atoms, or

W and W ¹ , which are cyclically bonded to each other, are a hydrocarbon ring containing 3 to 8 carbon atoms, g and g are 0 or 1 to 9,

Am is -NR 4 R ¹¹ ,

R ¹⁰ is H, alkyl of 1 to 4 carbon atoms or benzyl,

R ¹¹ is C 1-4 alkyl, phenyl or benzyl, or R ¹⁰ and R ¹¹ together represent C 3 -C 10 alkylene which is unsubstituted or substituted by carboxyl, alkoxycarbonyl, in which the alkyl moiety contains 1 to 5 carbon atoms, a hydroxyalkylene group containing 2 to 4 carbon atoms or a benzyl group, or Am represents a pyrrolyl group, a pyridyl group, a pyrazolyl group, a morpholinyl group, a dihydropyridyl group, a tetrahydropyridyl group, a quinuclidinyl group, an imidazolyl group, /3.2.1/ an octyl group which is unsubstituted or substituted by an alkyl group containing 1 to 4 carbon atoms, or

Am represents an azabicyclo [3.2.2] nonyl group, or Am represents a piperazine group of the general formula

146

R ¹⁶ represents a hydrogen atom, a C 1 -C 4 alkyl group, a C 3 -C 6 cycloalkyl group, a phenyl group, a tolyl group, a methoxyphenyl group, a halophenyl group, a diphenylmethylene group, a benzyl group or a pyridyl group or

Am is an azido group - (O) _t - (CH ₂ ) g C / W / ZW ¹ / - (CH ₂ ) g -N _{3 (} , t is 0 or 1, wherein W and W ¹ have the meanings given above, such as as well as its optical enantiomers and pharmacologically acceptable salts thereof.

Preferably, Na ⁺ / H ⁺ subtype 3 exchange inhibitors are used:

r) benzene-fused 5-membered heterocycle of formula I (HOE 93 / F 223 K-EP 639573, NZ 264130)

in which

X represents a nitrogen atom or a CR ⁸ group,

Y is O, S or NR ^7,

A, B together represent a bond or

A, B are both hydrogen when both X is CR ⁸ and Y is NR ⁷ , one of R ¹ to R ⁸ is -CO-N = C- (NH ₂ ) ₂ and the other R is ¹ to R ⁸ represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom or an alkyl group containing 1 to 6 carbon atoms, at most two other substituents R ¹ to R ⁸ represent

147 cyano, nitro, N ₃ , C 1 -C 4 alkyloxy or trifluoromethyl, at most one of the other substituents being a group

R-C _{n 2n} -Z-, n is 0 or 1 to 10, wherein the alkylene group C _n H _2n is a straight or branched carbon atom can be replaced by oxygen, sulfur or nitrogen atom,

R ⁸ represents a hydrogen atom, a C 2 -C 6 alkenyl group or a C 3 -C 10 cycloalkyl group which is unsubstituted or substituted by 1 to 4 methylene groups or a hydroxy group, or which may contain an ethylene group CH = CH, one methylene group the group may be replaced by an oxygen atom or a sulfur atom or a nitrogen atom, or

R ⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, trifluoromethylene group, CH ₃ -S (O) _g - or R ⁹ -Wy -, s stands for 0, 1 or 2,

R ⁹ represents a hydrogen atom, a methyl group or an ethyl group,

W represents an oxygen atom or an NR ¹⁰ group,

R ¹⁰ represents a hydrogen atom or a methyl group; y represents 0 or 1;

R ⁸ represents a group C _{R 1} ^F 2 m + 1 m represents 1 to 3 or

R ⁸ is 1- or 2-naphthyl, pyridyl, quinolyl or isoquinolyl,

Z is -CO-, -CH ₂ - or - (CR ¹¹⁾ (OH) / g-, g is 1, 2 or 3,

R ¹¹ represents a hydrogen atom or a methyl group, or

148

Z is oxygen or -NR ¹² -,

R ¹² represents a hydrogen atom or a methyl group, or

Z is -S (O) _g -, s is 0, 1 or 2, or Z is -SO ₂ -NR ¹³ R ¹³ is hydrogen or C 1 -C 4 alkyl,

R ⁷ is H, alkyl of 1 to 10 carbon atoms, alkenyl of 2 to 10 carbon atoms or a radical R ⁸ -C _{n 2n} -, and its pharmaceutically-acceptable salt thereof,

v) acylguanidine of the formula I

in which

X represents a carbonyl group or a sulfonyl group,

R ¹ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms which is unsubstituted or substituted by a hydroxy group, a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino or dimethylamino, o

R represents a hydrogen atom, an alkyl group containing 1 to 4 carbon atoms,

149 as well as its pharmaceutically acceptable salts,

w) phenyl substituted alkylcarboxylguanidide bearing perfluoroalkyl groups of the general formula I (HOE 94 / F 014 K-EP-OS 666252, NZ 270 370)

in which

R ^A is H, F, Cl, Br, I, cyano, OR ^6, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, O _r (CH ₂ ) _a ^c b ^F 2b + 1 a ^or b is NR ⁷ R ⁸ , r is 0 or 1, a is 0, 1, 2, 3 or 4, b is 1, 2, 3, 4, 5, 6, 7 or 8,

R ⁶ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group or a benzyl group, said aromatic groups being substituted or unsubstituted; when substituted, they are substituted with 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ⁹ R ¹⁰ ,

R ⁹ and R ¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ⁷ and R ⁸ independently of one another have the meanings given for R ⁶ ,

R ^b independently has the meanings given for R ^A ,

X is 1, 2 or 3,

150

R ¹ is H, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, _t -0 (CH ₂₎ d ^C e ^F 2e + ^l of ^m ^ F, Cl, Br, iodine or cyano, t is 0 or 1, d is 0, 1, 2, 3 or 4, e is 1, 2, 3, 4, 5, 6, 7 or 8,

R ^2, R ^3, R ⁴ and R ⁵ independently of one another are as defined for R ^1, with the proviso that at least one of R ^1, R ^2, R ^3, R ^4, R ^8, R and R ^b is -O _t (CH ₂ ) _d C _e F _{2e + 1} , or O _r (CH ₂ ) _a C _b F _{2b + 1} , and pharmaceutically acceptable salts thereof,

(y) a bicyclic heteroarylguanidine of the formula I (HOE 94 / F 123-EP-OS 682017, NZ 272058)

in which

T, U, V, W, X, Y and Z independently of one another are nitrogen or carbon, but with the proviso that

X and Z do not simultaneously represent a nitrogen atom that

T, U, V, W, X, Y and Z bear no substituents when they are nitrogen, and that no more than four of them simultaneously are nitrogen,

R ¹ and R ² independently of one another represent H, F, Cl, Br, I, alkyl having 1 to 3 carbon atoms, perfluoro fluoroalkyl of 1 to 3 carbon atoms, OR ^8, NR ⁸ R ⁹ or C (= O) N = C (NH ₂ ) ₂ ,

151

R ( ⁸⁾ and R ( ⁹⁾ independently of one another are hydrogen or alkyl having 1 to 3 carbon atoms, or

R ⁸ and R ⁹ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group,

R ³ , R ⁴ , R ³ , R ³ and R ^7, independently of one another, represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a group X 1 - (CH ₂ ) p - ₊₁ ) · group

R ^10a -SOfam, R ^10b R ^10c N-CO, R ¹¹ -CO- or R ¹² R ¹³ N-SO 2 -, wherein the perfluoroalkyl group is straight or branched,

X is O, S or NR ^14, R ¹⁴ is H or alkyl of 1 to 3 carbon atoms, bm = 0, 1, or 2, p is 0, 1 or 2, k is 0 or 1, g is 1, 2, 3, 4, 5 or 6, _R 10, _R L0B _R II independently, an _ar 12 _than of one another are alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, -C _n H _2n -R ¹³ or a perfluoroalkyl group containing 1 to 8 carbon atoms, n being 0, 1, 2, 3 or 4,

R ¹³ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹³ R ^{17 group} ,

R ¹³ and R ¹⁷ are hydrogen or C 1 -C 4 alkyl or R ¹² is hydrogen,

R ( ^10c) and R ( ¹³⁾ independently of one another are hydrogen or (C1-C4) -alkyl or

152

R ^10b and R ^10c as well as R ¹² and R ¹³ together represent 4 or 5 methylene groups, one of which may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group or

R ^3, R ^4, R ^5, R ⁸ and R ⁷ independently of one another are alkyl having 1 to 8 carbon atoms, ^C al ^H 2al ^{RL8 a} l ^e ^ ° alkenyl group containing 3 to 8 carbon atoms, Al represents 0, 1, or 2

R ¹⁸ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy - group and group NR ^19a R ^19b ,

R ( ^19a) and R ( ¹⁹ * ⁵⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or

R ³ , R ⁴ , R ⁵ , R ⁸ and R ⁷ independently of one another represent a heteroaryl group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of comprising a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group or a dimethylamino group, or

R ³ , R ⁴ , R ⁵ , R ⁸ and R ⁷ independently of one another represent a group

-Y // v

(C) 4 - (CHOH) y - (CH 2) - (CHOH) 4 -R or -Y

(C) ^ (OH) - (CH ^ R ^ CHO

153 or a group

O-ICTE-ÍCHOHJs-CC ^ R ^ H OH ²⁵

Y-

Y represents an oxygen atom, a sulfur atom or the group -NR ²² h, ad, and h independently of one another represent 0 or 1, i, j, k, ae, af, ag, ao, ap and if independently of one another represent 0, 1, 2, 3 or 4, where h, although not simultaneously 0, ad, ae and g do not simultaneously mean 0 and ah, and o and if not simultaneously 0,

R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁵⁾ and R ( ^22), independently of one another, represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, or

R ³ , R ⁴ , R ⁸ , R ⁸ and R ⁷ independently of one another represent SR ²⁹ , -OR ³⁰ , -NR ³¹ R ³² or

R ^29, R ^30, R ³¹ and R ³³ independently of one another are -C _a H _2a -heteroaryl radical, wherein the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, and is 0, 1 or 2

R ( ³²⁾ , R ( ³⁴⁾ and R ( ³⁸⁾ independently of one another have the meanings defined for R ( ²⁹⁾ or are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or

R ³ , R ⁴ , R ⁸ , R ⁸ and R ⁷ independently of one another represent a group

154 or a group or group

R ( ⁹⁶⁾ , R ( ⁹⁷⁾ and R ( ⁹⁸⁾ independently of one another are a heteroaryl group containing 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine , trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino, dimethylamino or benzyl,

W represents an oxygen atom, a sulfur atom or a group NR ³⁶ -, R ³⁶ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or

R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a group R ⁴⁶ X 6 -,

X ¹ represents an oxygen atom, a sulfur atom, a group NR ⁴⁷ , a (D = O) A- group or a group NR ⁴⁸ C = MN * R ⁴⁹ -,

M represents an oxygen atom or a sulfur atom,

A is O or NR ⁵⁸ ,

D represents a carbon atom or an SO group,

R ⁴⁶ is alkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms, a group = ^CH 2 R b ^C d ^F 2d + l or the radical ^C x ^H 2x ^{R 51} 'b is 0 or 1, d is 1 , 2, 3, 4, 5, 6, or 7, x is 0, 1, 2, 3, or 4,

R ⁵¹ represents a cycloalkyl group containing 3 to 8 carbon atoms, a phenyl group, a biphenylyl group

155 or naphthyl, the aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁸² R ^{83 group} ,

R ( ⁵²⁾ and R ( ⁵³⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ( ⁴⁷⁾ , R ( ⁴⁸⁾ and R ( ⁸⁰⁾ independently of one another are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ⁴⁹ is as defined for R ⁴⁶ ,

R ⁴⁶ and R ^47, or R ⁴⁶ and R ⁴⁸ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, A and N * are attached to the phenyl core of the basic heteroaroylguanidine skeleton or

R ³ , R ⁴ , R ⁸ , R ⁶ and R ⁷ independently of one another represent -SR ⁶⁴ , -OR ⁶⁸ , -NHR ⁶⁶ , -NR ⁶⁷ R ⁶⁸ , -CHR ⁶⁹ R ⁷⁰ or -CR ⁸⁴ R ⁸⁸ OH, -C «CR ⁸⁶ , -CR ⁸⁸ = CR ⁸⁷ or - / CR ⁸⁹ R ⁶⁰ / U-CO- / CR ⁶¹ R ⁶² / VR ⁶³ ,

R ⁶⁴ , R ⁶⁸ , R ⁶⁶ , R ⁶⁷ and R ⁶⁹ , which are the same or different, represent a group

- (CH _{2) y} - (CHOH) _z - (CH _{2) aa} - (CHOH) _t -R ⁷¹ or a group

- (CH ₂ ) _ab -O- (CH ₂ -CH ₂ O) _and -R ⁷² ,

R ⁷¹ and R ⁷² independently of one another represent a hydrogen atom or a methyl group, u represents 1, 2, 3 or 4, v represents 0, 1, 2, 3 or 4, y, z, aa which are the same or different, are 0, 1, 2, 3 or 4, t is 1, 2, 3 or 4,

R ⁶⁸ , R ⁷⁰ , R ⁵⁴ and R ⁸⁸ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or

R ⁶⁹ and R ⁷⁰ or R ⁸⁴ and R ⁶⁸ together represent, together with the carbon-15 atom to which they are attached, a cycloalkyl group containing 3 to 8 carbon atoms,

R ⁶³ is hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl or -C _e H _2e -R e is 0, 1, 2, 3 or 4,

R ⁵⁶ , R ⁵⁷ and R ^73, independently of one another, represent a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁷⁴ R ^{78 group} .

R ( ⁷⁴⁾ and R ( ⁷⁸⁾ are hydrogen or (C1-C4) -alkyl or

R ⁸⁶ , R ⁸⁷ and R ^73, independently of one another, are a heteroaryl group which is unsubstituted or substituted as a phenyl group,

R ⁸⁸ , R ⁸⁹ , R ⁶⁰ , R ⁶¹ and R ⁶² are hydrogen or methyl;

R ³ , R ⁴ , R ⁸ , R ⁶ and R ⁷ independently of one another represent the group r ⁷⁶ -nh-s ₂ -, R ⁷⁶ , R ⁷⁷ R ⁷⁸ N- (C = Y ') -,

Y 'is O, S, or NR ⁷⁹ , R ⁷⁷ and R ⁷⁸ , which are the same or different, are hydrogen, C 1 -C 8 alkyl, C 3 -C 6 alkenyl or -Cf H ₂ f R ⁸⁰ , f is 0, 1, 2, 3 or 4, gn

R represents a cycloalyl or phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group and alkyl group having 1 to 4 carbon atoms, or

R ⁷⁷ and R ⁷⁸ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl;

R ⁷⁹ is as R ⁷⁷ or is an amidino group;

157

R ³ , R ⁴ , R ⁵ , R ⁸ and R ⁷ independently of one another are NR ^84a R ⁸⁵ , OR ^84b , SR ^84c or

-CH = e84d '-n ^H 2n ^x · n means 0, 1, 2, 3 or 4,

R ^84d represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁶ R ^{17 group} ,

R ( ¹⁸⁾ and R ( ¹⁷⁾ are hydrogen or (C1-C4) -alkyl,

R ^84a, R ⁸⁴ b, R ^84c, and R ⁸⁵ independently of one another are H, alkyl having 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms or a (CH ₂₎ -R ⁸⁴ _{and x} 3, and x means 0, 1, 2, 3 or 4,

R ^84g represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ^84u group R ^84v ,

R ( ^84u) and R ( ^84v) are hydrogen or (C1-C4) -alkyl or

R ^84a and R ⁸⁵ together represent 4 or 5 methylene groups of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, and pharmaceutically acceptable salts thereof; ) phenyl substituted alkenylcarboxylguanidide which carries perfluoroalkyl groups of formula I (HOE 94 / F 168-EP-OS 690048, NZ 272373)

158

in which

R ^A represents a hydrogen atom, a fluorine atom, a bromine atom, an iodine atom, a cyano group, a hydroxy group, an OR ⁸ group, an alkyl group containing 1 to 8 carbon atoms, a 0 _r (CH ₂ ) group _{and a} ^c b ^F 2b + 1 cycloalkyl NR ⁷ R ⁸ , r is 0 or 1, and is 0, 1, 2, 3 or 4, b is 1, 2, 3, 4, 5, 6, 7 or 8,

R ⁸ is C 1 -C 8 alkyl, C 1 -C 4 perfluoroalkyl, C 3 -C 8 alkenyl, C 3 -C 8 cycloalkyl, phenyl or benzyl, said aromatic groups being: unsubstituted or substituted by 1 to 3 carbon atoms selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, 1-pin methoxy group and NR R group,

R ⁹ and R ¹⁰ represent a hydrogen atom, a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group;

R and R independently of one another have the meanings given for R ⁸ or R ⁸

R ⁷ and R ⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH 8 group or an N-benzyl group,

159

R ® independently has the meanings given for r \

X is 0, 1 or 2,

Y is 0, 1 or 2,

R ^c is hydrogen, fluorine, chlorine, bromine, iodine, cyano, OR ^12, alkyl of 1 to 8 carbon atoms, O _{p (CH2)} fC _{g of} F _{2 g-i,} or cycloalkyl having 3 to 8 carbon atoms, p is 0 or 1, f is 0, 1, 2, 3 or 4, g is 1, 2, 3, 4, 5, 6, 7 or 8,

R ¹² is C 1 -C 8 alkyl, C 1 -C 4 perfluoroalkyl, C 3 -C 8 alkenyl, C 3 -C 8 cycloalkyl, phenyl or benzyl, wherein said aromatic groups include phenyl or benzyl are unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy and NR ¹³ R ^14,

R ¹³ and R ^14, independently of one another, are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl,

R ^D independently has the meanings given for R ^c ,

R ¹ represents a hydrogen atom, a C 1 -C 8 alkyl group, -O _t (CH ₂ ) d ^c e ^F 2e + 1 C 3 -C 8 cycloalkyl, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom or cyano, t is 0 or 1, d is 0, 1, 2, 3 or 4, e is 1, 2, 3, 4, 5, 6, 7 or 8,

R ² , R ³ , R ⁴ and R ⁵ independently of one another have the meanings given for R ¹ as well as pharmaceutically acceptable salts thereof,

160 provided, however, that at least one of R ¹ , R ^1, ^ ⁰ ^ ¹³ ^ ¹ ^ ² ^ ^4, or R ⁵ represents the group ° r ^ ^CH 2 ^ and ^c b ^F 2b + 1 'the group Op (CH ₂ ) _f C _g F ₂ g ₊₁ - or O _t (CH ₂ ) d ^c e ^F 2e + 1 - ^and _r ^{3 is} not 0 _t (CH ₂ ) d ^c e ^F 2e + 1 'ah) benzoylguanidine of formula I ( HOE 95 / F 007K-EP 723956, NZ 280 887)

wherein one of the three substituents R ¹ , R ² and R ³ represents a group R ⁶ -ABD,

R ⁸ represents a basic protonatable radical, i.e. the amino group -NR ⁷ R ⁸ , the amidino group R ⁷ R ⁸ NC (= NR ⁹ ) or the guanidino group of the general formula

R ⁷ , R ⁸ , R ⁹ and R ¹⁰ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or

R ⁷ and R ⁸ together represent C _and H _2a , and are 4, 5, 6 or 7, and if a, 5, 6 or 7, then one methylene group of C _and H _2a may be replaced by an oxygen atom, SO _m or NR ¹¹ ; or

R ⁸ and R ⁹ or R ⁹ and R ¹⁰ or R ⁷ and R ¹⁰ represent a group ^c and ^H 2a 'and represent 2, 3, 4 or 5,

161 wherein, if a = 3, 4 or 5, it may be a methylene group of the group C _a H _2a replaced by O, S0 _m or NR ^11, m is 0, 1 or 2,

R ¹¹ represents a hydrogen atom or a methyl group, or R ⁸ represents a basic heteroaromatic ring system containing 1 to 9 carbon atoms,

A is C ^ H ^, b is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, wherein the group C ₀ H _{2] 3} may be one or two methylene groups replaced with a group selected from the group consisting of O, -CO-, -CH / OR ²⁰ / -, -SoM- group, -NR ²⁰ -CO-, -NR ²⁰ -CO-NH-SO 2, group of the formula (O) aa

-r ²⁰ nS- [NR'j bb and -SO _aa / NR ¹⁹ , and in the group one methylene group may be replaced by -CH-R ⁹⁹ , where R ⁹⁹ together with R ⁷ forms a pyrrolidine or piperidine ring, and aa represents 1 or 2, bb stands for 0 or 1, aa + bb = 2,

R ( ¹⁹⁾ is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms,

R ²⁰ represents a hydrogen atom or a methyl group,

B represents a phenylene or naphthylene radical of the formulas

162

R ¹² and R ¹³ independently of one another represent a hydrogen atom, a methyl group, a fluorine atom, a chlorine atom, an iodine atom, a bromine atom, a trifluoromethyl group or a group -SO _W -R ¹⁴ ,

R ¹⁴ is methyl or NR ¹⁵ R ¹⁶ ,

R ( ¹⁵⁾ and R ( ¹⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, w is 0, 1 or 2,

D is -C _d H _2d -Xf-, d is 0, 1, 2, 3 or 4,

X represents O, -CO-, -CH / OR ²¹ / -, a group of -S0 _m - or -NR ^21, f is 0 or 1,

R ²¹ is a hydrogen atom or a methyl group, m is 0, 1 or 2, and the other substituents R ¹ , R ² and R ³ independently of one another are hydrogen, fluorine, bromine, iodine, cyano, alkyl C 1 -C 8, C 2 -C 8 alkenyl, -NR ³⁵ R ³⁶ or g is 0, 1, 2, 3 or 4, h is 0 or 1,

R ( ³⁵⁾ and R ( ³⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, or

R ³⁵ and R ³⁶ together are 4-7 methylene groups, of which one _CH2 group can be replaced by oxygen, S, -NH-, -NCH ₃ or -N-benzyl;

Z is -O-, -CO-, -SO _{H -,} -NR ^18, -NR ¹⁸ -CO-NH- or -NR ¹⁸ -SO ₂ -,

Q

R represents a hydrogen atom or a methyl group, v represents 0, 1 or 2-,

R ¹⁷ represents a hydrogen atom, a cycloalkyl group containing 3, 5 or 6 carbon atoms or a C group _to F _{2k + 1} -,

163 k is 1, 2 or 3, or

R ¹⁷ represents a pyrrol-1-yl group, a pyrrol-2-yl group or a pyrrol-3-yl group which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, cyano - a group having from 2 to 8 carbon atoms, an alkoxycarbonyl group having from 2 to 8 carbon atoms, a formyl group, a carboxy group, a trifluoromethyl group, a methyl group and a methoxy group, or

R ¹⁷ represents a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 carbon atoms from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group, - NR ³⁷ R ³⁸ , CH ₃ SO ₂ and H ₂ NO ₂ S-,

R ³⁷ and R ³⁸ represent a hydrogen atom or a methyl group,

R ⁴ and R ⁵ independently of one another are H, alkyl having 1, 2, 3 or 4 carbon atoms, F, Cl, -OR ^32, -NR ³³ R ³⁴ or -C _r F _{2r +1}

R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 carbon atoms, r is 1, 2, 3 or 4, and their pharmacologically acceptable salts, and (i) indenoylguanidine of the formula I (HOE 95 / F 072-EP 738712, NZ 286 380)

(I)

164 in which

R ^{@ 1} and R @ ² independently of one another represent a hydrogen atom, an alkyl group containing from 1 to 10 carbon atoms, a cycloalkyl group containing from 3 to 6 carbon atoms, an O-alkyl group containing from 1 to 4 carbon atoms, a O-C group. alkyl in which the alkyl portion contains 1 to 4 carbon atoms, or ^{C H2m -NR L R} ^ 2 ^ ^of ^ ^{and R 1} independently of one another are hydrogen or alkyl having 1 to 4 carbon atoms and m represents 0 , 2, 3 or 4, NH-C (= O) -NH ₂ , C (% O) -O-C 1-4 alkyl, C (= O) -NH ₂ , C (= O) -NH-alkyl in which the alkyl moiety contains 1 to 4 carbon atoms, a C (0O) -N- (alkyl) ₂ moiety in which each alkyl moiety contains 1 to 4 carbon atoms, an alkenyl group containing C 1 -C 10 alkynyl, C 2 -C 10 alkynyl, alkylaryl wherein the alkyl moiety contains 1 to 4 carbon atoms, an alkenylaryl moiety wherein the alkenyl moiety contains 2 to 10 carbon atoms, an alkynylaryl moiety wherein the alkynyl moiety contains 2 to 10 carbon atoms, an aryl group substituted with an alkyl moiety of 1 to 4 carbon atoms atoms, an alkylheteroaryl group in which the alkyl radical contains 1 to 4 carbon atoms, an alkenylheteroaryl group in which the alkenyl radical contains 1 to 4 carbon atoms, an aminoalkylaryl group in which the alkyl radical contains 1 to 4 carbon atoms, a substituted aryl group, a heteroaryl group, and substituted heteroaryl,

R ³ , R ⁴ , R ⁵ and R ⁶ independently of one another represent a hydrogen atom, an alkyl group containing 1 to 10 carbon atoms, an O-alkyl group containing 1 to 10 carbon atoms, a halogen atom such as a fluorine atom, a chlorine atom, an atom bromine and iodine, hydroxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, O- (lower alkyl),

165

O-aryl. O- (lower alkyl) aryl, O-substituted aryl, O- (lower alkyl) -substituted aryl, O-C (R) -alkylaryl in which the alkyl moiety contains 1 to 4 carbon atoms, O- C (= O) -NH-alkyl in which the alkyl radical contains 1 to 4 carbon atoms, O-C (O) -N- (alkyl) ₂ , nitro, cyano, trifluoromethyl, amino, NH-C (= O) -NH ₂ , carboxyl,

C (= O) -O-alkyl in which the alkyl radical contains 1 to 4 carbon atoms, C (= O) -NH ₂ , C (= O) -NH-alkyl in which the alkyl radical contains 1 to 4 carbon atoms 4 carbon atoms, a C (= O) -N- (alkyl) ₂ group in which each alkyl radical contains 1 to 4 carbon atoms, an alkyl-COOH group in which the alkyl radical contains 1 to 4 carbon atoms, an alkyl-C (= O) -O-alkyl in which each alkyl radical contains 1 to 4 carbon atoms, SO ₃ H, SO ₂ -alkyl, SO ₂ -alkylaryl, SO ₂ -N- (alkyl) ₂ , SO ₂ -N (alkyl (aryl) alkyl, a C-OJ-R ^11, alkyl-C (= 0) -R ^11, in which the alkyl portion has 1 to 10 carbon atoms, alkenyl-C ( -O) -R ¹¹ in which the alkenyl radical contains 2 to 10 carbon atoms, an alkynyl-C (= O) -R ¹¹ radical in which the alkynyl radical contains 2 to 10 carbon atoms, a NH-C (= O) - alkyl-C (= O) -R ¹¹ , wherein a an alkyl radical containing from 1 to 10 carbon atoms, an O-alkyl-C (-O) -R ^{11 group} in which the alkyl radical contains from 1 to 11 carbon atoms,

R ¹¹ is alkyl of 1 to 4 carbon atoms, alkynyl of 1 to 4 carbon atoms, aryl, substituted aryl, amino, NH-alkyl having 1 to 4 carbon atoms, N- (alkyl) ₂ - in which each alkyl radical contains 1 to 4 carbon atoms, SO ₃ H, SO ₂ -alkyl, SO ₂ -alkylaryl, SO ₂ -N- (alkyl) ₂ , SO ₂ -N- ( alkyl) -alkylaryl, means an oxygen atom, a sulfur atom or an NH group,

166

R ⁷ , R ⁸ , R ⁹ and R ¹⁰ independently of one another are hydrogen, alkyl, cycloalkyl, aryl, alkylaryl or

R ⁸ and R ⁹ together are part of a 5-, 6- or 7-membered heterocyclic ring,

A is absent or is a non-toxic organic or mineral acid if a) benzyloxycarbonylguanidine of formula I (HOE 95 / F 109-EP 748795, NZ 286583)

in which

R ^{@ 1} , R ^{@ 2} and R @ ³ independently of one another represent --Y-- (4 - R @ ^{8 -} phenyl), --Y-- (3 - R @ ^{8 -} phenyl) or --Y-- (2 - R @ ^{8 -} phenyl) wherein the phenyl radical is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group and -NR ⁹⁶ R ^{97 group} ,

R ( ⁹⁶⁾ and R ( ^97), independently of one another, are hydrogen or methyl,

Y represents a bond, a CH ₂ group, an oxygen atom, a sulfur atom or an -NR ⁹ group,

R ⁹ represents a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms,

R ⁸ is a group of SOA / ⁹⁸ NR /] ONR ⁹⁹ R ^18, a is 1 or 2, b is 0 or 1, a + b = 2,

R ^98, R ⁹⁹ and R ¹⁰ independently of one another are H, alkyl having 1 to 8 carbon atoms, benzyl group, -alkylene-NR ¹¹ R ^12,

167 wherein the alkylene moiety contains 2 to 8 carbon atoms, the alkylene-NR ¹³ -alkylene-NR ³⁷ R ^{28 group} , wherein each alkylene moiety contains 2 to 8 carbon atoms, or the alkylene-CR ³⁹ R ⁴⁰ -CR ⁴¹ R group ⁴² -alkylene-NR ⁴³ R ⁴⁴ , wherein each alkylene residue contains 2 to 8 carbon atoms,

R ( ¹¹⁾ , R ( ¹²⁾ , R ( ¹³⁾ , R ( ³⁷⁾ , R ( ³⁸⁾ , R ( ⁴³⁾ and R ( ^44), independently of one another, represent a hydrogen atom, an alkyl group containing 1 to 8 carbon atoms or a benzyl group,

R ( ³⁹⁾ , R ( ⁴⁰⁾ , R ( ⁴¹⁾ and R ( ^42), independently of one another, represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkylenephenyl group in which the alkylene radical contains 2 or 3 carbon atoms, the phenyl radical being unsubstituted or substituted; up to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl and methoxy; or

R ⁹⁹ and R ¹⁰ together are 4-6 methylene groups, of which one _CH2 group can be replaced by O, NH, S, _-N-CH3 or -N-benzyl; or

R ⁸ is SOa (NR ⁹⁸ bNR ⁹⁵ -C) = NR ⁹⁴ / -NR ⁹³ R ⁹² ,

R ( ⁹²⁾ , R ( ⁹³⁾ , R ( ⁹⁴⁾ and R ( ⁹⁸⁾ independently of one another are hydrogen or (C1-C4) -alkyl or

R ¹ , R ² and R ³ independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a 2-8 carbon atom alkanoyl group, a 2-8 carbon atom alkoxycarbonyl group, a formyl group, a carboxy group, a trifluoromethyl group, a methyl group and a methoxy group;

T 2 2

R, R and R are, independently of one another, a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms or a group - (CH ₂ ) _m R ¹⁴ ,

168 m is 0, 1 or 2,

R ¹⁴ represents a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy- and -NR ¹⁸ R ¹⁸ ,

R ¹⁵ and R ¹⁶ represent a hydrogen atom or a methyl group;

R ¹ , R ² and R ^3, independently of one another, are -Q-4 / (CH 2) f -C -CHR ¹⁷ - (C 10) R ²⁰ / -phenyl or -Q-3 / (CH 2) _k -CHR ¹⁷ - (C = 0) ^R20 / phenyl group or -Q-2 / (CH _{2) a} -CHR ¹⁷ - (C = O) R ²⁰ / phenyl, where the phenyl radical is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group and -NR ³⁸ R ^{38 group} ,

R ( ³⁸⁾ and R ( ^38), independently of one another, are hydrogen or methyl,

Q is a bond, O, S or NR ^18,

R ¹⁸ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

R ¹⁷ is -OR ²¹ or -NR ²¹ R ²² ,

R ²¹ and R ²² independently of one another are hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkanoyl, alkoxycarbonyl in which the C 1 -C 8 alkoxy radical, benzyl, benzyloxycarbonyl or

R ²¹ represents a trityl group,

R ²⁰ is -OR ²³ or -NR ²³ R ²⁴ ,

R ²³ and R ^24, independently of one another, are hydrogen, C 1 -C 8 alkyl or benzyl, k is 0, 1, 2, 3 or 4, or

R ¹ , R ² and R ³ independently of one another are heteroaryl

A C 1 -C 9 group bonded through a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy- a group, an amino group, a methylamino group, and a dimethylamino group; or

R ¹ , R ² and R ³ are -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁶ ,

-CR ²⁵ R ²⁶ R ²⁷

R ²⁵ represents a -CfH ₂ f-heteroaryl group in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy- a hydroxy group, an amino group, a methylamino group and a dimethylamino group, f is 0, 1 or 2,

R ²⁶ and R ²⁷ independently of one another have the meanings given for R ²⁵ or are hydrogen or C 1 -C 4 alkyl or

R ¹ , R ² and R ³ independently of one another denote a heteroaryl-N-oxide group in which the heteroaryl radical contains 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group, or

R ^1, R ² and R ³ independently of one another are -SR ^28, -OR ^28, -NR ²⁸ R ²⁹ or -CR ²⁸ R ²⁹ R ^30, R ²⁸ is a group -CgH _{2 g} -heteroaryl-N an oxide in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group or dimethylamino group,

170 g means 0, 1 or 2,

R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are as defined for R ( ²⁸⁾ or are hydrogen or (C1-C4) -alkyl or

R ^1, R ² and R ³ independently of one another are hydrogen, chlorine, fluorine, bromine, iodine, cyano, ^C ^ T i ^F 2i + l ^ ' ^ R ³¹ SO, R @ ³² R ³³ N-CO-, R ³⁴ -CO- or R ⁴⁵ R ⁴⁸ N-SO ₂ , wherein the perfluoroalkyl group is straight or branched,

T represents a bond, an oxygen atom, a sulfur atom or a group -NR ⁴⁷ , represents 0, 1 or 2, h represents 0, 1 or 2, i represents 1, 2, 3, 4, 5 or 6,

R ( ³¹⁾ , R ( ³²⁾ , R ( ³⁴⁾ and R ( ⁴⁵⁾ independently of one another are C 1 -C 8 alkyl, C 3 -C 6 alkenyl, (CH ₂ ) _n R ⁴⁸ or trifluoromethyl, n being 0, 1, 2, 3 or 4

R ⁴⁷ represents a hydrogen atom or an alkyl group containing 1, 2 or 3 carbon atoms,

R ⁴⁸ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ⁴⁹ R ⁵⁰ .

R ( ⁴⁹⁾ and R ( ⁵⁰⁾ are hydrogen or (C1-C4) -alkyl or R ( ³²⁾ , R ( ³⁴⁾ and R ( ⁴⁵⁾ are hydrogen,

R ( ³³⁾ and R ( ⁴⁸⁾ independently of one another are hydrogen or (C1-C4) -alkyl or

R ³² and R ³³ as well as R ⁴⁵ and R ⁴⁸ together represent 5 or 6 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH 4 group or an -N- benzyl, or

171

R ¹ , R ² and R ³ independently of one another are a group

R ⁵¹ -AGD-,

R ⁵¹ represents a basic protonatable radical, i.e. amino group -NR ⁵² R ⁵³ , amidino group R ⁵² R ⁵³ NC (= NR ⁵⁴ ) or guanidino group R ⁵² R ⁵³ NC / = NR ⁵⁴ / -NR ⁵⁵ -,

R ( ⁵²⁾ , R ( ⁵³⁾ , R ( ⁵⁴⁾ and R ( ⁵⁵⁾ independently of one another are hydrogen or (C1-C4) -alkyl or

R ⁵² and R ⁵³ represent a group C 6 _and H _2a if _a , alpha denotes 4, 5, 6 or 7, and if alpha represents 5, 6 or 7, then one carbon atom of the group C _and if _and H _2a if _and ^can be replaced by O, S0 _d or NR ⁵⁸ or

R ⁵³ and R ⁵⁴ or R ⁵⁴ and R ⁵⁵ or R ⁵² and R ⁵⁵ represent a group CyH _2y , y represents 2, 3, 4 or 5, provided that if y = 3,4 or 5, one carbon atom of the group CyH _2y . ^{is m} ° ^ ^e replaced by O, S0 _d or NR ^58, d is 0, 1 or 2,

R ⁵⁸ represents a hydrogen atom or a methyl group or R ⁵¹ represents a basic heteroaromatic ring group containing 1 to 9 carbon atoms,

A is H, C _{@ 2 e,} e is 0 or 1 to 10, wherein the group C _e H _2e may be one carbon replaced by O, -C0-, -CH / OR ⁵⁷ / -, a group -SO , -NR ⁵⁷ -, -NR ⁵⁷ -CO-, -NR ⁵⁷ -CO-NH, -NR ⁵⁷ -CO-NH-SO ₂ - or -nr ⁵⁷ -so ₂ -, r is 0, 1 or 2,

G is phenyl

172 R ⁵⁸ and R ⁵⁹ independently of one another are hydrogen, methyl, methoxy, fluoro, chloro, bromo, iodo, trifluoromethyl or a group -SO _g R ^60,

R ⁸⁰ is methyl or NR ⁸¹ R ⁸² ,

R ( ⁸¹⁾ and R ( ⁸²⁾ independently of one another are hydrogen or (C1-C4) -alkyl,

D is -C _in H _{2 in} -E _w , v is 0, 1, 2, 3 or 4,

E represents an oxygen atom, a -CO- group, a group

-CH (OR ⁸³ ), -SO _aa - or -NR ⁸³ -, w is 0 or 1, and a is 0, 1 or 2,

R ⁸³ represents a hydrogen atom or a methyl group, or

R ^1, R ² and R ³ independently of one another are-CF2R ^84, -CF / R ⁶⁵ // R ⁶⁶ /, -CF / (CF 2) _q -CF ₃ R // ⁸⁵ /.

-C (CF ₂ ) p-CF ₃ / CR ⁶⁵ R ⁶⁶ ,

R ⁸⁴ is C 1 -C 4 alkyl or C 3 -C 7 cycloalkyl,

R ( ⁸⁵⁾ and R ( ⁸⁸⁾ independently of one another are hydrogen or (C1-C4) -alkyl, q is 0, 1 or 2, p is 0, 1 or 2, or

R ^1, R ² and R ³ independently of one another, are -OR ⁸⁷ or -NR ⁸⁷ R ^88,

R ⁸⁷ and R ⁸⁸ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or

R ⁸⁷ and R ⁸⁸ together represent 4, 5, 6 or 7 methylene groups of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, -SO ₂ -, -NH-, -NCH ₃ or - N-benzyl,

R ⁴ and R ^5, independently of one another, are hydrogen, C 1 -C 4 alkyl, fluoro, chloro, -OR ⁸⁹ , -NR ⁷⁰ R ^71, or -C ₂ F _{2 Z + 1} ,

R &lt; ⁸⁹ &gt;, R &lt; ⁷⁸ &gt; and R &lt; ⁷ &gt; independently represent a hydrogen atom or an alkyl group containing from 1 to 3 carbon atoms, z is 1, 2, 3 or 4,

R ³ and R ⁷ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms,

X is O or NR ⁷² ,

R ⁷² represents a hydrogen atom or a C 1 -C 4 alkyl group, as well as pharmaceutically acceptable salts thereof, and a) alkenylcarboxylguanidine which carries fluorophenyl groups of the general formula I (HOE 95 / F 115-EP 744397, NZ 286622)

in which

R ³ represents a hydrogen atom, a C 1 -C 8 alkyl group, a C 3 -C 8 cycloalkyl group or a phenyl group, wherein the phenyl group is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl , methyl, methoxy and NR ⁹ R ¹⁰ ,

R ⁹ and R ¹⁰ represent a hydrogen atom, a (C 1 -C 4) alkyl group or a perfluoroalkyl group,

R ⁷ independently of one another have the meanings as R ³ ,

R ^1, R ^2, R ^3, R ⁴ and R ⁹ independently of one another are hydrogen or F, wherein at least one of R ^1, R ^2, R ^3, R ⁴ and R ⁵ has is F, as and pharmaceutically acceptable salts thereof,

And (n) a substituted cinnamic acid guanidide of formula I

wherein at least one of R ¹ , R ² , R ³ , R ⁴ and R ⁵ is - ^x and ^Y b - ^L n - ^U '

X is ^CR-LD · R ^J, O, S or NR ^18,

R ( ¹⁶⁾ , R ( ¹⁷⁾ and R ( ¹⁸⁾ independently of one another are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, and are 0 or 1,

Y represents an alkylene group having 1 to 8 carbon atoms, an alkylene-T group having an alkylene radical having 1 to 8 carbon atoms, a Τ, až-alkylene having 1 to 8 carbon atoms in the alkylene radical,

T is NR ²⁰ , oxygen, sulfur or phenylene, wherein the phenylene group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ²¹ R ²² ,

R ( ²⁰⁾ , R ( ²¹⁾ and R ( ²²⁾ independently of one another are hydrogen, (C1-C4) -alkyl or (C1-C4) -fluoroalkyl, b = 0 or 1,

L is O, S, NR ²³ , or

175 C 1 _c H 2 k 'k is 1, 2, 3, 4, 5, 6, 7 or 8, n is 0 or 1,

U is NR ²⁴ R ²⁵ or an N-containing heterocycle containing 1 to 9 carbon atoms,

R ²⁴ and R ^25, independently of one another, are hydrogen, C 1 -C 8 alkyl or C 1 -C 8 perfluoroalkyl; or

R ²⁴ and R ²⁵ together represent 4 or 5 methylene groups, one of which may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, the N-containing heterocycle being linked via a nitrogen atom or a carbon atom and is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an NR R group,

R ( ²³⁾ , R ( ²⁷⁾ and R ( ^28), independently of one another, are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, and the other substituents R ( ¹⁾ , R ( ²⁾ , R ( ³⁾ , R ( ⁴⁾ and R (1) ^5, independently of one another, represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a -O _n -C _m H _{2 m + 1} group, an -Op- (CH ₂ ) _s -C _q F group _{2q + 1} or n is 0 or 1, m is 0, 1, 2, 3, 4, 5, 6, 7 or 8, p is 0 or 1, g is 1, 2, 3, 4, 5, 6 , 7 or 8, s is 0, 1, 2, 3 or 4, r is 0, 1, 2, 3 or 4,

R ¹⁰ is C 3 -C 8 cycloalkyl or phenyl wherein the phenyl is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ¹¹ R ¹² ,

176

R ( ¹¹⁾ and R ( ¹²⁾ independently of one another are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl,

R ⁶ and R ^7, independently of one another, are hydrogen, fluorine, bromine, chlorine, iodine, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 cycloalkyl atoms or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁴ R ^{15 group} ,

R ( ¹⁴⁾ and R ( ^15), independently of one another, are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, and pharmaceutically acceptable salts thereof, (a) benzene dicarboxyldiguanidide of the formula I (HOE 95 / F 269) K)

wherein one of R ¹ , R ² , R ³ and R ⁴ is -CO-N = C (NH ₂ ) ₂ , and the other R ¹ , R ² , R ^3, and R ⁴ have the following meanings.

R ¹ represents a hydrogen atom, a (C 1 -C 4) alkyl group, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, -OR ³² , -NR ³³ R ^34, or trifluoromethyl,

R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or (C1-C4) -alkyl,

R ² and R ⁴ independently of one another are hydrogen, fluorine, chlorine, bromine, iodine, hydroxy, cyano, trifluoromethyl, -CO-N = C (NH ₂ ) 2 / alkyl (C 1 -C 8), (C 2 -C 8) alkenyl, or - (CH ₂ ) _m R ¹⁴ , m being 0, 1 or 2,

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁵ R ¹⁸ .

R ¹⁵ and R ^3-8 represent a hydrogen atom or a methyl group;

R ² and R ^4, independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of F, Cl, a bromine atom, an iodine atom, a cyano group, a C 2 -C 8 alkanoyl group, a C 2 -C 8 alkoxycarbonyl group, a formyl group, a carboxy group, a trifluoromethyl group, a methyl group, a methoxy group or

R ² and R ⁴ independently of one another are R ²² -SO 2 -, R ²³ R ²⁴ N-CO-, R ²⁸ -CO- or R ²⁹ R ³⁰ N-SO 2 -, R ²² and R ²⁸ independently second, methyl or trifluoromethyl,

R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl; or

R ² and R ⁴ independently of one another, are -OR ³⁵ or -NR ³⁵ R ^38,

R ( ³⁵⁾ and R ( ^38), independently of one another, are hydrogen or (C1-C6) -alkyl;

R ³⁵ and R ³⁶ together are 4-7 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, a group -NCH ₃ or -N-benzyl;

R ³ represents a hydrogen atom, -SR ²⁵ , -OR ²⁵ , -NR ² R ²⁶ , -CR ²⁵ R ²⁶ R ²⁷ ,

R ²⁵ represents a hydrogen atom, a C 1 -C 8 alkyl group or a phenyl group which is unsubstituted or substituted by 1 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom , trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino and dimethylamino, or

R ²⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group - the group and the dimethylamino group, R ²⁶ and R ^27, independently of one another, have the meanings given for R ²⁵ or represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms,

R ⁵ represents an alkyl group having 1 to 4 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an X- (CH ₂ ) y-CF ₃ group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an -NR ⁶ R ^{7 group} ,

R ⁶ and R ⁷ independently of one another represent a hydrogen atom or a methyl group,

X is a bond or an oxygen atom, y is 0, 1 or 2, as well as pharmaceutically acceptable salts thereof,

179 as) benzenedicarboxyldiguanidide of formula I (HOE 95 / F 269 BK)

wherein one of R ¹ , R ² , R ³ and R ⁵ is -CO-N = C (CH ₂ ) ₂ and the other of R ¹ , R ² , R ^3, and R ⁵ have the following meanings:

R ( ¹⁾ and R ( ⁵⁾ independently of one another are hydrogen, alkyl having 1 to 4 carbon atoms, fluorine, chlorine, -NR ³³ R ³⁴ or trifluoromethyl,

R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or (C1-C4) -alkyl,

R ² represents H, F, Cl, Br, I, hydroxy, cyano, trifluoromethyl, -CO-N-C _{(NH2) 2,} alkyl having 1 to 8 carbon atoms, , (C 1 -C 8) alkenyl or m is 0, 1 or 2,

R ¹⁴ represents a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and -NR ^{1 S} R ¹⁸ .

R ( ¹⁵⁾ and R ( ^18), independently of one another, are hydrogen or methyl;

R ² is R ²² -SO ₂ , R ²³ R ²⁴ N-CO-, R ²⁸ -CO- or

180 group R ²⁹ R ³⁰ N-SO ₂ ,

R ²² and R ^28, independently of one another, are methyl or trifluoromethyl,

R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl; or

R ² is -OR ³⁸ or -NR ³⁸ R ^36,

R ³⁸ and R ³⁶ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or

R ³⁸ and R ³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH ₃ group or an -N-benzyl group,

R ³ represents a hydrogen atom, -SR ²⁸ , -OR ²⁸ , -NR ²⁸ R ²⁶ , -CR ²⁸ R ²⁶ R ²⁷ ,

R ²⁸ represents a hydrogen atom, a C 1 -C 8 alkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group , amino, methylamino, and dimethylamino, or

R ²⁸ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, methylamino - a group and a dimethylamino group, R ²⁶ and R ²⁷ independently of one another have the meanings given for R ²⁸ or are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms,

R ⁴ is trifluoromethyl, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 3 -C 8 cycloalkyl or - (CB ₂ ) _m R ¹⁴ , m is 1 or 2,

181

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁵ R ¹⁶ .

R ( ¹⁵⁾ and R ( ^16), independently of one another, are hydrogen or methyl;

R ⁴ represents a phenyl group which is substituted with 2 to 5 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an -NR ¹⁵ R ^{16 group} ,

R ¹⁵ and R ^16, independently of one another, represent a hydrogen atom or a methyl group, as well as their pharmaceutically acceptable salts, etc. (a) diaryldicarboxyldiguanidide of the general formula I (HOE 96 / F 013)

wherein one of R ¹ , R ² , R ³ , R ⁴ and R ⁵ represents a group

-co-n-c (nh ₂ ) ₂ , the other substituents R ¹ and R ⁵ independently of one another represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a fluorine atom, a chlorine atom, a -OR ³² group, an -NR group ³³ R ³⁴ or trifluoromethyl,

R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or (C1-C4) -alkyl, the other substituents R ( ²⁾ and R ( ^4), independently of one another, are hydrogen, fluorine, chlorine, bromine , iodine, hydroxy, cyano, trifluoromethyl, -CO-N-C (NH4) 2 ', C 1 to C 8 alkenyl, C 2 to C 8 alkenyl, or m is 0, 1, or 2

R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methoxy group and an -NR ^{1 S} R ^{16 group} ,

R ¹⁵ and R ¹⁶ are hydrogen or methyl or the other substituents R ² and R ⁴ independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted 1-4 substituents selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl a group, a methyl group, a methoxy group or the other substituents R ² and R ⁴ represent a group R ²² -SO 2 -, a group R ²³ R ²⁴ N-CO-f a group R ²⁸ -CO- or a group r 29r ³ ° n_so ₂ ,

R ²² and R ^28, independently of one another, are methyl or trifluoromethyl,

R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl or the other substituents R ( ²⁾ and R ( ⁴⁾ independently of one another are -OR ³³ or -NR ³³ R ³³ ,

3FI

R and R are, independently of one another, a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or

R ³⁵ and R ³⁶ together represent 4 to 7 methylene groups,

183 of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH ₃ group, or an -N-benzyl group, the other R ³ being a hydrogen atom, -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁶ , -CR ²⁵ R ²⁶ R ²⁷ ,

R ²⁵ represents a hydrogen atom, a C 1 -C 8 alkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group , amino, methylamino, and dimethylamino, or

R ²⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, a methylamino group and dimethylamino -group,

R ²⁶ and R ²⁷ independently of one another represent the meanings given for R ²⁵ or represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms, one of R ⁶ , R ⁷ , R ⁸ , R ⁹ and R ¹⁰ represents a group

-co-n = c (nh ₂ ) ₂ , the other substituents R ⁸ and R ¹⁸ independently of one another represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a fluorine atom, a chlorine atom, a -OR ¹³² group, an -NR group ¹³³ R ¹³⁴ or trifluoromethyl,

R ( ¹³²⁾ , R ( ¹³³⁾ and R ( ¹³⁴⁾ independently of one another are hydrogen or (C1 -C4) -alkyl, the other substituents R ( ⁷⁾ and R ( ⁹⁾ independently of one another are hydrogen, fluorine, chlorine, bromine, atom iodo, hydroxy, cyano, trifluoromethyl, -CO-N-C _{(NH2) 2,} alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms or a radical mm is 0, 1 or 2,

184

R ¹¹⁴ is C 3 -C 8 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹¹⁸ R ¹¹⁶ .

R ¹¹⁵ and R ¹¹⁶ are hydrogen or methyl or the other substituents R ⁷ and R ⁹ independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted 1-4 substituents selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl a group, a methyl group and a methoxy group or the other substituents R ⁷ and R ⁹ are R ¹²² -SO 2 -, R ¹²³ R ¹²⁴ N-CO-, R ¹²⁸ -CO- or R ¹²⁹ R ¹³⁰ N-SO 2,

R ¹²² and R ¹²⁸ independently of one another are methyl or trifluoromethyl,

R ¹²³ , R ¹²⁴ , R ¹²⁹ and R ¹³⁸ independently of one another are hydrogen or methyl or the other substituents R ⁷ and R ⁹ independently of one another are -OR ¹³⁸ or -NR ¹³⁸ R ¹³⁶ ,

R ( ¹³⁵⁾ and R ( ¹³⁶⁾ independently of one another are hydrogen or (C1-C6) -alkyl or

R ¹³⁵ and R ¹³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH 8 group or an -N-benzyl group, another R ⁸ being a hydrogen atom , -SR ¹²⁸ , -OR ¹²⁸ , -NR ¹²⁵ R ^126, or -cr ¹²⁸ r ¹²⁶ r ¹²⁷ ,

R ¹²⁸ represents a hydrogen atom, an alkyl group containing 1

185 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino or

R ¹²⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, amino group, methylamino group and dimethylamino,

R ¹²⁶ and R ¹²⁷ independently of one another represent the meanings given for R ¹²⁵ or represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms,

A is absent or is -NR ^1: -CO-, -NR ¹² -CO-NR ¹³ -, -NR ¹⁷ -CO-NR ¹⁸ -SO ₂ -, NR ¹⁹ -SO ₂ -, -SO ₂ -NR ¹⁹ -SO 2 -, -SO 2 -NR ¹⁹ -CO-, -O-CO-NR ¹⁹ -SO 2 - or -CR ²⁰ = CR ²¹ ,

R ( ¹¹⁾ , R ( ¹²⁾ , R ( ¹³⁾ , R ( ¹⁷⁾ , R ( ¹⁸⁾ , R ( ¹⁹⁾ , R ( ²⁰⁾ and R ( ²¹⁾ independently of one another are hydrogen or alkyl having 1 to 8 carbon atoms and pharmaceutically acceptable salts thereof; thiophenylalkenylcarboxylguanidide of the general formula I (HOE 96 / F 026) in which at least one

186

-Op- (CH ₂ ) _s -CqF ₂ q ₊₁ , R ⁴⁰ CO- or R ³¹ SO _k -, p is 0 or 1, s is 0, 1, 2, 3 or 4, q is 1, 2, 3, 4, 5, 6, 7 or 8, k is 0, 1 or 2,

R ⁴⁰ represents an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl and methoxy,

R ³¹ represents an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chloro, trifluoromethyl, methyl or methoxy; or

R ³¹ represents NR ⁴¹ R ⁴² ,

R ( ⁴¹⁾ and R ( ^42), independently of one another, are hydrogen, (C1-C4) alkyl, (C1-C4) perfluoroalkyl; or

R ⁴¹ and R ⁴² together are 4 or 5 methylene groups, of which one _CH2 group is O, S, -NH, _N-CH3 or N-benzyl and the other substituents R ^1, R ^2, and R ^3, independently of one another represent H, F, Cl, Br, I, cyano, a group of the ° ^'c m' + l 2 mA ^H or -O _ga C _ra H _{2 R} R ^10, is 0 or 1, and m is 0, 1, 2, 3, 4, 5, 6, 7 or 8, and g is 0 or 1, and r is 0, 1, 2, 3, or 4,

R ¹⁰ represents a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group, the phenyl group being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group and a methoxy group,

R ⁴ and R ^5, independently of one another, are hydrogen, fluorine, bromine, iodine, cyano, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 cycloalkyl or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and a group

NR ¹⁴ R ¹⁵

R ¹⁴ and R ¹⁵ independently of one another are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, as well as pharmaceutically acceptable salts thereof.

Numerous medical applications have already been described for the Na ⁺ / H ⁺ exchange inhibitors described above, for example, their use in the treatment of diseases that result from poor chronic or acute blood supply to the organs, particularly the heart (ischemia). These inhibitors are therefore suitable, for example, for the treatment of ischemic-induced arrhythmias, various forms of cardiac angina (angina pectoris), further for use in cardiac transplantation, in cardiac surgery and in angioplastic surgery. Other reported indications for Na ⁺ / H ⁺ exchange inhibitors are stroke, brain swelling and pro-differentiated induced diseases including atherosclerosis, late diabetic complications, fibrosis diseases, and organ hypertrophy.

It has now surprisingly been found that inhibitors of Na ⁺ / H ⁺ exchangers favorably affect serum lipoproteins. It is generally recognized that for arteriosclerotic vascular changes, in particular

188 blood coronary heart disease, a so-called hyperlipoproteinaemia, is an important risk factor for blood coronary heart disease. Thus, reducing the elevated serum lipoprotein levels is of particular importance for the prophylaxis and regression of atherosclerotic changes. In addition to lowering total serum cholesterol, it is of particular importance to reduce the proportion of specific atherogenic lipid fractions of this total cholesterol, particularly low density liporoteins (LDLs) and very low density lipoproteins (VLDLs), since these lipid fractions represent atherogenic risk factor. On the other hand, high density lipoproteins (HDL) are attributed a protective function against coronary heart disease. Accordingly, hypolipidemics should be able to reduce not only total cholesterol but especially VLDL- and LDLfraction of serum cholesterol, it has now surprisingly been found that Na ⁺ / H ⁺ exchanger inhibitors exhibit valuable therapeutically useful properties in influencing serum lipid levels. Thus, these agents substantially reduce elevated serum LDL and VLDL concentrations, such as seen with increased dietary intake of a cholesterol-rich and lipid-rich diet, or pathological changes in metabolism, such as genetic-related hyperlipidemia. Thus, they can be used for the prophylaxis and regression of atherosclerotic changes, eliminating the causal risk factor. These include, for example, not only primary hyperlipidemia, but also some secondary hyperlipidemia, such as occur, for example, in diabetes. In addition, Na ⁺ / H ⁺ exchanger inhibitors lead to a significant reduction in infarcts induced by metabolic anomalies and in particular to significantly reduce the size and severity of the induced infarct. Furthermore, Na ⁺ / H ⁺ exchanger inhibitors effectively protect against endothelial damage induced by metabolic anomalies. As a result of this vascular protection against endothelial dysfunction syndrome, Na ⁺ / H ⁺ exchanger inhibitors are valuable drugs for the prevention and treatment of coronary vascular spasms, atherogenesis and

189 ischemic lesions and postischemic reperfusion lesions induced by hypercholesterolemia and endothelial dysfunction, for the manufacture of a medicament for the prevention and treatment of cardiac hypertrophies and cardiomyopathies induced by hypercholesterolemia and endothelial dysfunction, for the manufacture of a medicament for the prevention and treatment of myocardial infarction and for the manufacture of a medicament for the treatment of the aforementioned diseases in combination with blood pressure lowering agents, preferably angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor antagonists, or in combination with a Na ⁺ / H * exchange inhibitor with a blood fat lowering agent, preferably with an HMG-CoA reductase inhibitor, for example lovastatin or pravastatin, the latter having a hypolipidemic action and thereby increasing the hypolipidemic properties of the Na ⁺ / H ⁺ exchange, and this combination thus proves to be a suitable combination with an enhanced effect and a reduced amount of active substances used.

Accordingly, administration of Na ⁺ / H ⁺ exchange inhibitors, as well as a combination of Na ⁺ / H ⁺ inhibitors with blood pressure lowering drugs and / or hypolipidemic drugs, is a new treatment for lowering increased blood fat levels (i.e., blood fat levels) .

189 Ä

The results:

Total cholesterol values as well as VLDL, LDL and HDL subfraction from rabbit serum: (Mmol / 1) cholesterol VLDL LDL HDL normal food 0.65 + 0.08 0.05 + 0.01 0.12 + 0.02 0.48 + 0.06 normal food + Hoe 642 0.69 + 0.1 0.05 + 0.02 0.23 + 0.04 0.41 + 0.17 cholesterol food 17.85 + 3.71 5.68 + 1.38 9.31 + 1.88 2.86 + 0.73 cholesterol food + Hoe 642 7.95 + 0.89 * 4.6 + 0.6 2.1 ± 0.2 1.8 ± 0.2

Values are given as mean + SEM (standard deviation; mean error of mean).

Significance: * p <0.05 when comparing a Hoe 642 containing cholesterol diet with a cholesterol diet. There are no significant differences between the two groups fed normal food. Both groups fed a normal diet differ significantly from both groups fed a cholesterol diet.

Thus, the compounds used according to the invention are preferably used for the manufacture of a medicament for the treatment of hypercholesterolemia, for the manufacture of a medicament for the prevention of atherogenesis, for the manufacture of a medicament for the prevention and treatment of atherosclerosis treatment of diseases caused by endothelial dysfunction, for the manufacture of a medicament for the prevention and treatment of atherosclerosis-induced hypertonia, for the manufacture of a medicament for the prevention and treatment of atherosclerosis-induced thromboses, for the manufacture of a medicament for the prevention and treatment

Atherosclerosis, left ventricular hypertrophy and dilated cardiomyopathy and thrombotic diseases.

DETAILED DESCRIPTION OF THE INVENTION

This antihyperlipidemic action is for one of the Na ⁺ / H ⁺ exchanger inhibitors, 4-isopropyl-3-methylsulfonylbenzoylguanidine methanesulfonate (Hoe 642) listed in the table below, using New Zealand white rabbits 28 to weigh 3 to 4 kg. , randomly divided into four groups of 7 animals each given the following diet: 1) standard rabbit feed (®Altromin 2834), 2) atherogenic diet containing 0.25% cholesterol and 3% coconut oil, 3 ) standard rabbit feed + Hoe 642 (0.1%), 4) atherogenic feed + Hoe 642 (0.1%).

Blood samples were taken once after 30 days of feeding using the ear artery puncture. Serum was obtained from blood. Total serum cholesterol was measured using the cholesterol oxidase method CHOD-PAP (Merckotest, Merck Diagnostics, E. Merck, 64271 Darmstadt, Germany). Lipoprotein separation was also performed from serum, using the FPLC (Fast Liquid Chromatography of Proteins) method (März et al., 1993, Clin. Chem. 39/11: 2276-2281).

Claims (13)

Use of a Na / H 'exchange inhibitor for the manufacture of a medicament for the treatment of increased blood fat levels. Use according to claim 1, characterized in that as the Na ^- / H 'exchange inhibitor: Z a) from benzcylguanidín the formula wherein one of the radicals R or R 'is R - S (0) _r R @ alebc ⁷ R ⁸ NO ₂ S- and nrur.v of the radicals R or R ² represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, a (C1-C4) alkyl group, a (C1-C4) alkoxy group or a phenoxy group which is unsubstituted or substituted by Z to 3 substituents selected from fluorine, a chlorine atom, a methyl group and a methoxy group, or the other of the substituents R ^{@ 1} or R ^{@ 2} is R ^{@ 6} --S (O) _n or R @ ⁷ R @ ⁸ N- wherein n is 0, 1 or 2, 191 R ⁸ represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, a cyclopentylmethyl group, a cyclohexylmethyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine , methyl and methoxy, R ⁷ and R ⁸ are the same or different, are hydrogen or alkyl having 1 to 6 carbon atoms and * 7 R 1 represents a phenyl- (CH ₂ ) _{m group} , wherein m represents 1 to 4, or R represents a phenyl group which is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group, or R and R ° together represent a straight or branched chain of 4 to 7 carbon atoms, which chain may in addition be interrupted by an oxygen atom, a sulfur atom or a group R ⁹ where Q R represents a hydrogen atom or a methyl group, or R ⁷ and R ⁸ together with the nitrogen atom to which they are attached represent a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system, R, R ^-, and R ^p, independently of one another are hydrogen or alkyl having 1 or 2 carbon atoms, or R ^J and R ⁴ together are an alkylene chain of 2 to 4 carbon atoms, or R ⁴ and R ⁵ together represent an alkylene chain containing 4 to 7 carbon atoms, as well as pharmaceutically acceptable salts thereof, b) a benzoylguanidine of the formula I 192 in which R ¹ is a group R ⁴ -SO 2 or a group R ⁵ R ⁸ N-SO 2 -, wherein m is 0, 1 or 2, R ⁴ and R ⁵ are C 1 -C 8 alkyl, C 3 -C 6 alkenyl or -C _n H _{2 n} -R ⁷ , where n is 0, 1, 2, 3 or 4, R ⁷ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, CF ₃ group, methyl group, methoxy group and NR ⁸ R ^{9 group} , where R ⁸ and R ⁹ represent a hydrogen atom or a C 1 -C 4 alkyl group, or R ⁵ represents a hydrogen atom, R ⁶ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or R ⁵ and R ⁶ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH _{3 group} or an N-benzyl group, o R is H, F, Br, alkyl having 1 to 4 carbon atoms, a group -O- (CH _{2) m} CpF ₂ p _{+ 1,} or a group -XR ¹⁰ in which m is 0 or 1, p is 1, 2 or 3, X is O, S or NR ^11, R ¹⁰ is H, alkyl of 1 to 193 6 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, cyclohexylmethyl, cyclopentylmethyl or -C _n H _2n -R ^12, n is 0, 1, 2, 3 or 4, R ¹² represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a CF ₃ group, a methyl group, a methoxy group and an NRR group wherein R ⁸ and R ⁹ represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms; or R ¹⁰ and R ¹¹ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; R ³ is as R ¹ or is C 1 -C 6 alkyl, nitro, cyano, trifluoromethyl, fluoro, chloro, bromo, iodo, or -XR ¹⁰ , wherein: X is O, S or NR ^11, R ¹⁰ is H, alkyl having 1 to 6 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, cyclohexylmethyl, cyclopentylmethyl group or a group _"CnH2n-R ¹² n is 0 to 4, R ¹² represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a CF ₃ group, a methyl group, a methoxy group and an NR ⁸ R ⁹ group wherein R ⁸ and R ⁹ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, R ¹¹ represents an alkyl group having 1 to 3 carbon atoms, or R ¹⁰ and R ¹¹ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; 194 as well as its pharmaceutically acceptable salts, c) an ortho-substituted benzoylguanidine of the formula I in which R ¹ represents a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an alkyl group having 1 to 6 carbon atoms or a -XR ⁶ group, wherein: X is O, S, NR ⁷ or Y-ZO, Y is O or NR ^7, Z represents a carbon atom or a SO group, R ⁶ is H, alkyl of 1 to 6 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, cyclohexylmethyl, cyclopentylmethyl, - (CH2) mCpF2p + 1 or a group ^_ CnH _{2 n} -R ^8, m = 0 or 1, p is 1 to 3, n is 0 to 4, R ⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a CF ₃ group, a methyl group, a methoxy group and an NR ⁹ R ¹⁰ group wherein R ⁹ and R ¹⁰ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms; R represents a hydrogen atom or an alkyl group containing 195 to 1 to 3 carbon atoms, or R ⁶ and R ⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, R ³ represents a hydrogen atom or a group -XR ⁶ where X is O, S, NR, or Y-ZO, m R represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, Y is O or NR ^7, wherein Y is bonded to the phenyl radical of the formula I, Z represents a carbon atom or a SO group, R ⁶ is H, alkyl of 1 to 6 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, cyclohexylmethyl, cyclopentylmethyl, - ^(CH 2 ^ m ^C p ^F 2p + l ^but ^ ° _n -C H _2n -R ⁸ , m is 0 or 1, p is 1 to 3, n is 0 to 4, Q R represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a CF ₃ group, a methyl group, a methoxy group and an NR ⁹ R ¹⁰ group wherein R ⁹ and R ¹⁰ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or g 7 R and R together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; O> 1 R and R, which are the same or different, represent a group R ^{1: L} -SOq- or a group R ¹² R ¹³ N-SO ₂ -, q represents 0 to 2, R ¹¹ represents an alkyl group having 1 to 4 carbon atoms which is unsubstituted or which bears as a substituent a phenyl group which is unsubstituted 196 or substituted with 1 to 3 substituents selected from the group consisting of fluorine, chlorine, CF ₃ , methyl, methoxy and NR ⁹ R ¹⁰ , wherein: R ⁹ and R ¹⁰ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, R ¹² and R ¹³ have the meanings as R ⁶ and R ⁷ , or one of the two radicals R ² or R ⁴ is hydrogen or has the meaning of R ¹ and R ⁸ represents a hydrogen atom, a methyl group, a fluorine atom, a chlorine atom or a methoxy group, as well as pharmaceutically acceptable salts thereof, d) a benzoylguanidine of the formula I in which: R ¹ or R ² represents an amino group -NR ³ R ⁴ wherein R ³ and R ⁴ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a cycloalkyl group having 3 to 7 carbon atoms, or R ³ is phenyl- (CH ₂ ) p -, wherein p is 0, 1, 2, 3 or 4 or R ³ represents a phenyl group which is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group, or R ³ and R ^{4 taken} together are straight or branched 197 methylene chain containing 4 to 7 carbon atoms, where one member of the -CH ₂ -methylene chain may be replaced by an oxygen atom, a sulfur atom or an NR ⁵ group where R ⁵ is a hydrogen atom or a lower alkyl group, and the other of R ¹ or R ² is a hydrogen atom, a fluorine atom, a chlorine atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a CF group ₃ , a C _m F _{2 m + 1} -CH ₂ -, benzyl or phenoxy group, wherein the phenyl residue is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of methyl, methoxy, fluoro and chloro, m means 1, 2 or 3, as well as pharmaceutically acceptable salts thereof, e) a benzoylguanidine of the general formula I in which: R ¹ is a group R ⁴ -SO 2 or a group R ⁵ R ⁶ N-SO 2 wherein m is 0, 1 or 2, R ⁴ and R ⁵ are C 1 -C 8 alkyl, C 3 -C 6 alkenyl or -C _n H _{2 n} -R ⁷ , where n is 0, 1, 2, 3 or 4, R ⁷ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a CF ₃ group, a methyl group, a methoxy group and a group 198 NR ⁸ R ⁹ where R ⁸ and R ⁹ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms or R ⁵ represents a hydrogen atom, R ⁶ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms; or R ⁵ and R ⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, n R represents a hydrogen atom, a straight- or branched-chain alkyl group containing 5 to 8 carbon atoms, a group -CR ¹³ 'CHR ¹² or a group -C'CR ¹² , R ³ * ² represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a CF ₃ group, a methyl group, a methoxy group and an NR ¹⁴ -R ¹⁵ group wherein R ( ¹⁴⁾ and R ( ¹⁵⁾ are hydrogen or (C1-C4) -alkyl; R is a C 1 -C 9 heteroaryl group which is unsubstituted or substituted as a phenyl group, or R ¹² represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups, or R represents a cycloalkyl group containing 3 to 8 carbon atoms, R ¹³ represents a hydrogen atom or a methyl group or R ¹² represents a cycloalkyl group containing 3 to 8 carbon atoms, a cycloalkylalkyl group in which the cycloalkyl radical contains 3 to 8 carbon atoms and the alkyl radical contains 1 to 4 carbon atoms, a phenyl group, C 8 H 8 -alkyl a group in which the alkyl radical contains 1 to 4 carbon atoms, a naphthyl group, a biphenylyl group, a 1,1-diphenylalkyl group in which the alkyl radical contains 1 to 4 carbon atoms, a cyclopentadienyl group, a pyridyl group, a pyrrolyl group, a furanyl group, thienyl, thiazolyl, oxazolyl, indenyl, quinolyl, indolyl, indolyl, benzofuranyl, benzothienyl, benzothiazolyl, benzoxazolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, scrazolyl, scrazolyl, scrazolyl, tetrazolyl, upin, pyrazinyl, pyrimidinyl, pyridazinyl, indazolyl, isoquinolyl, phthalazinyl, quinoxalinyl, quinazolinyl, or cinolinyl, R ³ is as R ² , wherein the aromatic substituents R ² and R ³ are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, CF ₃ , alkyl of 1 to 4 carbon atoms, alkoxy- a group containing 1 to 4 carbon atoms or a group NR ¹ ^ ¹¹ in which R ¹⁸ and R ¹¹ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, f) a benzoylguanidine of the formula I About which R ¹ or R ² is R ³ S (O) _n or a group ^R \ N — O2S— ⁵ / R ² and the other of R ¹ or R ² are hydrogen, hydroxy, fluorine, chlorine, iodine, C 1-4 alkyl, C 1-4 alkoxy, benzyloxy a group or phenoxy group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group, a methoxy group, a hydroxy group or a benzyloxy group, a group R ³ -S (O) _n , -NR ⁴ R ⁵ or 3,4-dehydropiperidine, wherein R ³ represents an alkyl group containing 1 to 6 carbon atoms. atoms, a C 5 -C 7 cycloalkyl group, a cyclopentylmethyl group, a cyclonexylmethyl group or a phenyl group which is unsubstituted or substituted by one to three substituents selected from the group consisting of fluorine atom, chlorine atom, methyl group and methoxy group, R ⁴ and R ⁵ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or R ⁴ represents a phenyl- (CH ₂ ) _{m group} , wherein m represents 1, 2, 3 or 4, or R ⁴ represents a phenyl group which is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group; or R ⁴ and R ⁵ together represent a straight or branched chain containing 4 to 7 carbon atoms, which chain may be additionally interrupted by an oxygen atom, a sulfur atom or an NR ⁶ group, where R ⁶ represents a hydrogen atom or a methyl group, or R ⁴ and R ⁵ together with the nitrogen atom to which they are attached represent a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system, n represents 0, 1 or 2, and pharmaceutically acceptable salts thereof, g) isoquinoline of the formula I 201 X (I) in which R ¹ represents a hydrogen atom, an alkyl group, a cycloalkyl group, an arylalkyl group, an alkenyl group, a substituted aminoalkyl group or an aryl or heteroaryl ring, said rings being unsubstituted or substituted by 1 to 3 groups selected from halogen, nitro, amino a group, a mono (lower alkyl) amino group, a di (lower alkyl) amino group, a lower alkyl group, a benzyloxy group, a phenoxy group, a hydroxy group, a trifluoromethyl group, R ² represents a hydrogen atom, a halogen atom, an alkyl group or an aryl group which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of halogen, nitro, amino, mono (lower alkyl) amino, di ( lower alkyl) amino, lower alkyl, lower alkoxy, benzyloxy, phenoxy, hydroxy, G is a group of formula VII (VII) X ^2, X ³ and X ⁴ independently of one another are hydrogen, halogen, nitro, amino, alkyl, sulfonamide, mono (lower alkyl) amino-ami202, di (lower alkyl) amino a lower alkyl group, a benzyloxy group, a hydroxy group, X ¹ is hydrogen, oxygen, sulfur or NR ⁷ where R 'represents a hydrogen atom, an alkyl group, a cycloalkyl group, an arylalkyl group, an alkenyl group, a substituted aminoalkyl group or an aryl or heteroaryl ring, said rings being unsubstituted or substituted by 1 to 3 substituents selected from halogen, nitro, amino a group, a mono (lower alkyl) amino group, a di (lower alkyl) amino group, a lower alkyl group, a lower alkoxy group, a benzyloxy group, a phenoxy group, a hydroxy group and a trifluoromethyl group, each alkyl chain in said substituents or alkenyl can be interrupted by O, S or NR ^8, R ⁸ represents a hydrogen atom, an alkyl group, a cycloalkyl group, an arylalkyl group, an alkenyl group, a substituted aminoalkyl group or an aryl or heteroaryl ring, said rings being unsubstituted or substituted by 1 to 3 substituents selected from halogen, nitro, amino a group, a mono (lower alkyl) amino group, a di (lower alkyl) amino group, a lower alkyl group, a lower alkoxy group, a benzyloxy group, a phenoxy group, a hydroxy group and a trifluoromethyl group, and pharmaceutically acceptable salts thereof . (h) compounds of formula I (I) 203 in which R ¹ represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an -NO 2 group, a cyano group, a trifluoromethyl group, an R ⁴ -SO 2 group or a R ³ R ³ N-SO ₂ - group; , 1 or 2 R ⁴ and R ⁵ are C 1 -C 8 alkyl, C 3 -C 6 alkenyl, -C _n H _{2 n} -R ⁷ or trifluoromethyl, n is 0, 1, 2, 3 or 4, R ⁷ represents a C 3 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ® R ⁹ group, where R ⁸ and R ⁹ represent a hydrogen atom or a C 1 -C 4 alkyl group, or R ³ represents a hydrogen atom, R ³ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms; or R ³ and R ³ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH _{3 group} or an N-benzyl group, R ² is -SR ^10, -OR ^10, -NHR ^10, -NR ¹⁰ R ^11, -CHR ¹⁰ R ^12, a group - / CR ¹² R ¹³ OR ¹³ '/, a - / C / CH 2 -OR ¹³ '(R ¹² R ¹³ ) or - (CR ¹⁸ R ¹⁷ ) p-CO- (CR ¹⁹ R ²⁰ ) g ¹⁴ , wherein R ¹⁰ and R ¹¹ , which are the same or different, are - CHR ¹³ / g- (CH 2) _p - (CHOH) _q - (CH ₂ ) _r - (CHOH) _t -R ²¹ or - (CH ₂ ) p O- (CH ₂ ^-CH 2 ^O ^ q ^_ R ²¹ ') R ²¹ represents a hydrogen atom or a methyl group, p, g, r, which are the same or different, represent 0, 1, 2, 3 or 4, s is 0 or 1, t is 1, 2, 3 or 4, 204 R ¹² and R ¹³ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or together with the carbon atom to which they are attached a cycloalkyl group having 3 to 8 carbon atoms, R ¹³ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, R ¹⁴ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or a group -C _and H _2a -R ¹⁵ , and is 0, 1, 2, 3 or 4, R ¹⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an NR ⁸ R ⁹ group wherein R ⁸ and R ⁹ represent a hydrogen atom or a (C 1 -C 4) alkyl group; R ¹⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group, R ¹⁵ represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups, R ¹⁶ , R ¹⁷ , R ¹⁸ , R ¹⁹ and R ²⁰ represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, R ³ is as R ¹ or R ³ represents an alkyl group having 1 to 6 carbon atoms or a group -XR ²² where X represents an oxygen atom, a sulfur atom or an NR ¹⁶ group, wherein R ¹⁶ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms; or R and R ^A together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, R ²² is as R ¹⁴ , 205 as well as their pharmaceutically acceptable salts, i) a benzoylguanidine of the general formula I in which: R ¹ represents a hydrogen atom, a fluorine atom, a bromine atom, an iodine atom, a nitro group, a cyano group, a group R ¹⁸ -CpH ² p -Og, a group R ⁴ -SOm or a group R ³ R ⁸ N-SO ₂ where m represents 0, 1 or 2, p is 0 or 1, q is 0, 1, 2 or 3, R ¹⁶ represents a group C _r F _{2r +} 1, r represents 1, 2 or 3, R ⁴ and R ⁵ are alkyl of 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, -C _n H _2n -R ¹⁷ or trifluoromethyl, n is 0, 1, 2, 3 or 4, R ⁷ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁸ R ^{9 group} , where R ⁸ and R ⁹ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms or R ⁵ represents a hydrogen atom, R ⁸ represents a hydrogen atom or a (C 1 -C 4) alkyl group; or R ⁵ and R ⁸ together represent 4 or 5 methylene groups, 206 of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, R is a C 1 -C 9 heteroaryl group which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methoxy, hydroxy, amine a methylamino group and a dimethylamino group; or R ² is -SR ^10, -OR ^10, -NR ¹⁰ R ^{i: l,} -CR ¹⁰ R ¹¹ R ^12, wherein R ¹⁰ represents a -C _and H _2a -heteroaryl group in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group, hydroxy group a group, an amino group, a methylamino group and a dimethylamino group, and is 0, 1 or 2, R ¹¹ and R ¹² independently of one another have the meaning of R ¹⁰ or represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, R is as R ^x or is C 1 -C 6 alkyl or -X R ¹³ , X represents an oxygen atom, a sulfur atom or an NR ¹⁴ group, R ¹⁴ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, R ¹⁸ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or a group - C _b H _2b -R ¹⁵ , b being 0, 1, 2, 3 or 4 or R ¹³ and R ¹⁴ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; R ¹⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected 207 from the series consisting of F, Cl, trifluoromethyl, methyl, methoxy and NR ⁸ R ^9, R ⁸ and R ⁹ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, k) a benzoylguanidine of the formula I in which one of R ¹ , R ² , R ³ or R ⁴ represents an amino group of the formula c "h, -R" R ⁵ is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, n is 0, 1, 2, 3 or 4, R ⁶ represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, one CH ₂ group being replaced by one sulfur atom or NR ⁷ group, R ⁷ represents a hydrogen atom, a methyl group or an ethyl group, or R ⁶ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a bromine atom, a methyl group, a methoxy group, a group 208 -NR ⁸ R ⁹ R ⁸ and R ⁹ represent a hydrogen atom, a methyl group or an ethyl group; R ⁵ and R ⁶ together with the nitrogen atom represent 5-, 6- or A 7-membered ring in which one carbon atom can be replaced by a sulfur atom, an oxygen atom or an NR ¹⁰ group, R ¹⁰ represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a benzyl group, and another of the substituents R ¹ , R ² , R ³ or R ⁴ represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine, cyano -group, trifluoromethyl, nitro, a group CF ^ -O-, ^C m ^F 2 m + l '° ^{CH2 "and} l ^ ^e ° group, m is 1, 2 or 3, g is 0, 1, 2 , 3 or 4, p is 0 or 1, X represents an oxygen atom or an NR ¹² group, R represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, R ¹¹ is H, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or phenyl, which is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, methyl , methoxy and NR ¹³ R ^14, R ¹³ and R ¹⁴ represent a hydrogen atom, a methyl group or an ethyl group, as well as pharmaceutically acceptable salts thereof, 1) a benzoylguanidine of the formula I (I) 209 in which R ¹ represents a group R ⁴ R ⁵ NC (X) -, X is O, S or NR ^6, R ⁴ and R ⁵ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 6 carbon atoms or a group ^- C _n H _2n -R ⁷ , n being 0, 1, 2, 3 or 4 R is C 5 -C 7 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methoxy and alkyl of 1 to 4 carbon atoms, or R ⁴ and R ⁵ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, R is as R or is an amidine group, o R represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an alkyl group containing 1 to 8 carbon atoms, a 1-alkenyl or 1-alkynyl group, a cycloalkyl group containing 3 to 8 carbon atoms, a cycloalkylalkyl group the radical contains 3 to 8 carbon atoms and the alkyl radical contains 1 to 4 carbon atoms, a phenyl group, a C 8 H 8 -alkyl group in which the alkyl radical contains 1 to 4 carbon atoms, a naphthyl group, a biphenylyl group, a 1,1-diphenylalkyl group, wherein the alkyl radical contains 1 to 4 carbon atoms, cyclopentadienyl, pyridyl, thiopyridyl, pyrrolyl, furanyl, thienyl, thiazolyl, oxazolyl, indenyl, quinolyl, indolyl, indolyl, benzofuranyl, benzofuranyl, benzofuranyl, benzofuranyl, benzofuranyl, benzofuranyl, benzofuranyl, benzofuranyl, benzofuranyl a benzoxazolyl group; o -WR ⁸ group, 210 W represents an oxygen atom, a sulfur atom or an NR ⁹ group, R ⁸ is H, alkyl having 1 to 6 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, cyclohexylmethyl, cyclopentylmethyl, - (CH2) m ^C p ^F 2p + l ^alelao group -C q H 2q -R ^10, , m is 0 or 1, p is 1, 2 or 3, g is 0, 1, 2, 3 or 4, R ¹⁰ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an NR ¹¹ R ^{12 group} , R ( ¹¹⁾ and R ( ¹²⁾ are hydrogen or (C1-C4) -alkyl, R ⁹ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms; or R ⁸ and R ⁹ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, R is H, F, Cl, Br, I, alkyl having 1 to 6 carbon atoms, or a group -WR ^8, which is as defined for R ^2, and a pharmaceutically-acceptable salt thereof, (m) benzoylguanidine of the formula I (I) 211 in which R ¹ , R ² , R ³ are hydrogen, fluorine, chlorine, bromine, iodine or C 1 -C 12 alkyl, one of R ¹ , R ² or R ³ is N ₃ , cyano, a hydroxy group or an alkyloxy group having 1 to 10 carbon atoms, when at least one of the remaining substituents R ¹ , R ² or R ³ is a sufficiently lipophilic alkyl radical having 3 to 12 carbon atoms or one of the substituents R ¹ , R ² or R ³ represents a group ^{R 4 -c} n ^H 2 n ° m 'm represents 0 or 1, n represents 0, 1, 2 or 3, R ⁴ is CpF ₂ p + 1 p is 1, 2 or 3 when n is 0 or 1 or R ⁴ represents a cycloalkyl group having 3 to 12 carbon atoms, a phenyl group, a pyridyl group, a quinolyl group or an isoquinolyl group, said aromatic and heteroaromatic ring systems being unsubstituted or substituted by one substituent selected from the group consisting of fluorine, chlorine, trifluoromethyl methyl, methoxy and NR ⁵ R ^e , C g R and R are hydrogen or alkyl having 1 to 4 carbon atoms or one of R ^1, R ² or R ³ is a group -CaCR ⁵ or-C / R ⁶ / -CR ⁵ R ⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group and a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group; or 212 R ⁵ represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups, or R ⁵ represents a cycloalkyl group having 3 to 8 carbon atoms, R ⁶ represents a hydrogen atom or a methyl group, as well as pharmacologically acceptable salts thereof, o) benzoylguanidine of the general formula I in which n 1x m o P and R are hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano, X _o - (CH ₂ ) p - (CF ₂ ) g-CF ₃ , R ⁵ - SO 2, R ⁶ -CO or R ° R ⁷ N-SO 2 -, represents an oxygen atom, a sulfur atom or an NR ¹⁴ group, represents 0, 1 or 2, represents 0 or 1, represents 0, 1 or 2, represents 0, 1, 2, 3, 4, 5 or 6, are alkyl of 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, -C _n H _2n -R ⁸ or a trifluoromethyl group, n is 0, 1, 2, 3 or 4 R ⁸ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group 213 and NR ⁹ R ¹⁰ , R ⁹ and R ¹⁰ are hydrogen or C 1 -C 4 alkyl or R ⁵ is hydrogen, R ⁷ represents a hydrogen atom or a C 1 -C 4 alkyl group; R ⁶ and R ⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, R ² is the group Y or a group (C) _h - (CHOH) - (CH2) i- (CHOH) _r R ¹¹ Y- Y represents an oxygen atom, a sulfur atom or an -NR ¹² - group, R ¹¹ and R ¹² represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, h is 0 or 1, i, independently of one another being 0, 1, 2, 3 or 4, but h while not simultaneously 0 . R ³ is as R ¹ or is an alkyl group containing 214 C 1-6 carbon atoms or -XR ¹³ ; X represents an oxygen atom, a sulfur atom or an NR ¹⁴ group, R ¹⁴ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, R ¹³ represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a -C _b H ₂ j group _: R ¹⁵ , b represents 0, 1, 2, 3 or 4 or R ¹³ and R ¹⁴ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; R ¹⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ¹⁰ , and 10 R @ 1 and R @ 2 are hydrogen or (C1 -C4) alkyl, R ⁴ represents a hydrogen atom, -OR ¹⁶ or -NR ¹⁶ R ¹⁷ ig 17 R and R ^{x #} independently of one another represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, as well as pharmaceutically acceptable salts thereof, p) benzoylguanidine of formula I (I) 215 in which R ¹ is R ⁶ -CO or R ⁷ R ⁸ N-CO, R ⁶ is C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl or C _n H _2n -R ⁹ , n is 0, 1, 2, 3 or 4 . R ⁹ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, the aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy- and NR ¹⁸ R ¹¹ , R ¹⁰ and R ¹¹ represent hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R ⁷ is H, alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms or -C _n H _2n -R ^12, n is 0, 1, 2 , 3 or 4 R ¹² represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ¹³ R ^14, R ¹³ and R ¹⁴ represent a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group, Q R represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a perfluoroalkyl group having 1 to 4 carbon atoms, or R and R together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, N-CHG sku216 Pina or N-benzyl; R ² is as R ¹ or is hydrogen, fluoro, chloro, bromo, iodo, cyano, nitro, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, an alkenyl group having 3 to 8 carbon atoms or -C _n H _{2 n} R ^18, n is 0, 1, 2, 3, 4, R ¹⁵ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ¹⁶ R ^17, R ( ¹⁶⁾ and R ( ¹⁷⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; R represents a C 1 -C 9 heteroaryl group which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group, hydroxy group, amino group a group, a methylamino group and a dimethylamino group; or R ² is SR ^18, -OR ^18, -NR ¹⁸ R ^19, -CR ¹⁸ R ¹⁹ R ^20, R ¹⁸ represents a -C _and H _2a -heteroaryl group in which the heteroaryl radical contains 1 to 9 carbon atoms, which radical is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy, hydroxy, amino, methylamino and dimethylamino, and is 0, 1 or 2, R ¹⁹ and R ²⁰ independently of one another are as R ¹⁸ or are hydrogen, C 1-4 alkyl or C 1-4 perfluoroalkyl having 1 to 4 carbon atoms, or R ² is R ²¹ -SO ² or R ^{2 22} R ^{23 is} N-SO 2 -, m is 1 or 2, R ²¹ is alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, an alkenyl radical containing 3 to 8 carbon atoms, -C _n H _2n -R ^24, n is 0, 1, 2, 3 or 4. R ²⁴ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ²⁷ R ²⁸ , R ²⁷ and R ²⁸ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R is H, alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, an alkenyl radical containing 3 to 8 carbon atoms, ~ CnH _{2 n} R ^29, n is 0, 1, 2, 3 or 4. R ²⁹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy -group and NR ³⁸ R ³¹ , R ³⁸ and R ³³ * represent a hydrogen atom, a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group, R represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a perfluoroalkyl group having 1 to 4 carbon atoms, or R ²² and R ²³ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by kys218 £ l ms, by S, NH, _N-CH3 or N-benzyl, R ² is R ³³ -X-, X represents an oxygen atom, a sulfur atom, a group NR ³⁴ , a group (D = O) A-, a group NR ³⁴ C = MN 4, R ³⁵ M means an oxygen atom or a sulfur atom, A represents an oxygen atom or a group NR ³⁴ , D represents a carbon atom or an SO group, R ³³ is alkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms, (CH2 ^ b ^c d ^F 2d + L ^ ^{of the} PI ^{did not} -C _{n 2n} -R ^36, n is 0 or 1, d is 1, 2, 3, 4, 5, 6 or 7, n is 0, 1, 2, 3 or 4, R ³⁶ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy and NR ³⁷ R ³⁸ , R ( ³⁷⁾ and R ( ³⁸⁾ are hydrogen, (C1-C4) -alkyl or (C1-C4) perfluoroalkyl, R ³⁴ represents a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group, R ³⁵ is as R ³³ or R ³³ and R ³⁴ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, where A and N ^ * ^ are bonded to the phenyl core of the benzoylguanidine backbone; or R ² is -SR ^40, -OR ^40, -NHR ^40, the group - NR ⁴ ° R ^41, -CHR ⁴⁰ R ^42, -C / R ⁴² R ⁴³ OH /, -C »CR ⁴⁵ , - / CR ⁴⁷ R ⁴⁸ / U - (CO) - / CR ⁴⁹ R ⁵⁰ / in R ⁴⁴ , R ⁴⁰ and R ⁴¹ , which are the same or different, is - (CH ₂ ) _p - (CHOH) _q - (CH ₂ ) _r - (CHOH) _t -R ⁵¹ or a group 219 - (CH ₂ ) _p -O- (CH ₂ -CH ₂ O) _q -R ⁵¹ , R ⁵¹ represents a hydrogen atom or a methyl group, u represents 1, 2, 3 or 4, v represents 0, 1, 2, 3 or 4, p, q, r, which are the same or different, represent 0, 1, 2, 3 or 4, t is 1, 2, 3 or 4, R ⁴² and R ⁴³ , which are the same or different, represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or R ( ⁴²⁾ and R ( ⁴³⁾ together are the carbon atom to which they are attached a cycloalkyl group containing 3 to 8 carbon atoms, R ⁴⁴ is H, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or -C _e H _2e -R ^45, e is 0, 1, 2, 3 or 4, R ⁴⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁵² group R ⁵³ , R @ ⁵² and R @ ⁵³ are each hydrogen, C1 -C4 alkyl or R ⁴⁵ represents a C 1 -C 9 heteroaryl group which is unsubstituted or substituted as a phenyl group, or R ⁴⁵ represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups, R ⁴⁶ , R ⁴⁷ , R ⁴⁸ , R ⁴⁹ and R ⁵⁰ represent a hydrogen atom or a methyl group, or R ² is R ⁵⁵ -NH-SO ₂ -, R ⁵⁵ is R ⁵⁶ R ⁵⁷ N- (C = Y) -, Y represents an oxygen atom, a sulfur atom or NR ⁵⁸ , eg e * 7 R and R, which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 6 carbon atoms 220 cg atoms or -CfH ₂ fR, f is 0, 1, 2, 3 or 4, R ⁵⁹ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethoxy group and an alkyl group of 1 to 4 carbon atoms, or R and R together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, as R is as R or is an amidino group, R ³ , R ⁴ and R ⁵ independently of one another have the meanings as R ¹ or R ^2, and a pharmaceutically-acceptable salt thereof, g) a benzoylguanidine of the general formula I in which: R ¹ represents a hydrogen atom, a fluorine atom, a bromine atom, an iodine atom, a nitro group, a cyano group, a -Χθ- (CH ₂ ) _q -CF ₃ group, a R ⁵ -SOm- group, a R ⁶ -CO- group, R ⁶ R ⁷ -CO- or R ⁶ R ⁷ N-SO 2 - X is O, S or NR ^14, m is 0, 1 or 2, o is 0 or 1, p is 0, 1 or 2, g is 0, 1, 2, 3, 4, 5 or 6, 221 R ⁵ and R ⁶ are C 1 -C 8 alkyl, C 3 -C 6 alkenyl, -C _n H _{2 n} -R ⁸ or trifluoromethyl, n is 0, 1, 2, 3 or 4, R ⁸ represents a C 3 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ^{18 group} , R ⁹ and R ¹⁸ are hydrogen or C 1 -C 4 alkyl or R ⁶ is hydrogen, R is hydrogen or C 1 -C 4 alkyl; or R ⁶ and R ⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group; R is a group or group or group R ¹¹ represents a heteroaryl group having 1 to 9 carbon atoms which is bonded via a carbon atom; 222 is a nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group, dimethylamino group and benzyl group group Y represents an oxygen atom, a sulfur atom or an NR group, R ¹² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R ³ is as R ¹ or R ³ represents an alkyl group having 1 to 6 carbon atoms or -XR ¹³ ; X represents an oxygen atom, a sulfur atom or an NR ¹⁴ group, R ¹⁴ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, R ¹³ is hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl or -C _b H _2b -R ¹⁵ , b is 0, 1, 2, 3 or 4, or R ¹³ and R ¹⁴ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; R ¹⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ^{10 group} , R ⁹ and R ¹⁰ represent an alkyl group having 1 to 4 carbon atoms, R ⁴ is H, -OR ^16, -NR ^{1 S} R ¹⁷ or C _r F _{2r + 1,} T6 17 R and R are, independently of one another, a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, r is 1, 2, 3 or 4, as well as pharmaceutically acceptable salts thereof. 223 r) a 5-membered fused benzene ring heterocycle of formula (I) wherein: X represents a nitrogen atom or a CR ⁶ group, Y is O, S or NR, A, B together represent a bond or A, B are both hydrogen when X is CR ⁶ and Y is NR ⁷ at the same time, one of R ¹ to R ⁶ is -CO-N = C (NH ₂ ) ₂ , the other R ¹ to R ⁶ are a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom or an alkyl group containing 1 to 6 carbon atoms, at most two of the other substituents R ¹ to R ^{6 being} cyano, nitro, N ₃ , alkoxy containing 1 to 4 carbon atoms or trifluoromethyl, not more than one of the other substituents ^{R 8} is the group - ^C n ^H 2n · n is ^from 0 to about 10, wherein the alkylene chain -C _n H _2n is a straight or branched carbon atom is optionally replaced by oxygen, sulfur or nitrogen, R ⁸ represents a hydrogen atom, a C 2 -C 6 alkenyl group or a C 3 -C 10 cycloalkyl group which is unsubstituted or substituted by 1 to 4 methylene groups or a hydroxy group, or may contain an ethylene group CH = CH, wherein the methylene group the group may be replaced by an oxygen or sulfur atom or a nitrogen atom, I 224 which is unsubstituted by substituents selected from or R ⁸ is phenyl, or substituted with 1 to 3 of fluoro, chloro, bromo, iodo, trifluoromethyl, CHS (O) _s, or R ⁹ -W _y -, is 0, 1, or 2 . R 1 represents a hydrogen atom, a group, a methyl group or an ethyl group represents an oxygen atom or a NR ¹⁰ group, represents a hydrogen atom or a methyl group, represents 0 or 1, or represents a C _m group ^F 2m + 1 is 1-3 or 1 or 2 - naphthyl, pyridyl, quinolyl or isoquinolyl, 10 Y R ⁸ m «8 Z is -CO-, -CH ₂ - or - / CR ¹¹ (OH) / g, q is 1, 2 or 3, R ¹¹ represents a hydrogen atom or a methyl group or Z represents an oxygen atom or a group -NR ¹² -, R is hydrogen or methyl, or Z is -S (O) _s -, s is 0, 1 or 2, or Z is -SO ₂ -NR ¹³ -, R ¹³ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, R represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 10 carbon atoms, or an R ^C CH H H group, as well as pharmaceutically acceptable salts thereof. s) benzoylguanidine of the formula I 225 in which R ¹ , R ³ or R ⁴ is -NR ⁸ C = X NR ⁷ R ⁸ , X represents an oxygen atom or a sulfur atom, R ⁸ is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl or -C _n H _{2 n} -R ⁹ , n is 0, 1, 2 , 3 or 4 R ⁹ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ^ Or ¹¹ , R ¹⁰ and R ¹¹ represent hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R ⁷ is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl or -c _o h ₂₀ -r ¹² , o is 0, 1, 2 , 3 or 4 R ¹² represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ¹³ R ^14, 226 R ¹³ and R ¹⁴ represent a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group, R ⁸ is as R ⁷ or R ⁷ and R ⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, the remaining R ² , R ³ , R ⁴ , R ⁵ or R ¹ , R ² , R ⁴ , R ⁵ or R ¹ , R ² , R ³ , R ⁵ independently of one another represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a group -Ota-alkyl in which the alkyl portion contains 1 to 8 carbon atoms, -0-alkenyl, wherein the alkenyl group contains 3 to 8 carbon atoms, -0tc (CH2) bCdF2d + L P ^inu -0tjCpH ^Item ₂ -R ¹⁸ , or more than two CN, N0 ₂ »NR ¹⁸ R ^17, b is 0 or 1, d is 1, 2, 3, 4, 5, 6 or 7, that is 0 or 1, tb is 0 or 1, tc is 0 or 1, td is 0 or 1, p is 0, 1, 2, 3 or 4, R ¹⁸ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ¹⁹ R ²⁰ , R ( ¹⁹⁾ and R ( ²⁰⁾ are hydrogen or (C1-C4) alkyl or (C1-C4) perfluoroalkyl, R ¹⁸ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms or a C 8 H ₂ qR · g group being 0, 1, 2, 3 or 4, R ²¹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy or NR ²² R ²³ , R ( ²²⁾ and R ( ²³⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, R ¹⁷ is H, alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms or the group C _r H _2r -R ^24, r is 0, 1, 2, 3 or 4, R ²⁴ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, chlorine atom, trifluoromethyl, methyl, ï methoxy and NR R, R ( ²⁵⁾ and R ( ²⁶⁾ are hydrogen, (C1-C4) -alkyl or (C1-C4) perfluoroalkyl; or R ¹⁶ and R ¹⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, and pharmaceutically acceptable salts thereof, t) diacyl-substituted guanidines of the formula I xi NH NHX About NH O (I) 228 in which T 2 X ¹ * and X represent a group of the general formula in which T1 is 0, 1, 2, 3 or 4 R ^A and R ^A independently of one another represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, an OR ¹⁸⁸ group, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a group O _exp (¾) zl ^C zm ^F 2ZM + L ^phen Y ^fishing or benzyl, wherein the aromatics are unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy and NR ¹⁸⁹ R ¹¹⁸ , R ¹⁰⁹ and R ¹¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, Z 1 is 0, 1, 2, 3 or 4, Z is 0 or 1, Z is 1, 2 , 3, 4, 5, 6, 7, or 8, R ¹⁸⁸ represents hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl, C 3 -C 8 cycloalkyl, phenyl or benzyl; the aromatic groups are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ^13,1 R ^{112 group} , 229 R ( ¹¹¹⁾ and R ( ¹¹²⁾ are hydrogen, (C1-C4) -alkyl or perfluoroalkyl; R ¹⁰⁷ and R ¹⁰ ® independently of one another have the meaning of R ¹⁰⁶ or R ¹⁰⁷ and R ¹⁰⁸ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, or X ¹ and X ² represent a group of the general formula in which T 2A and T 2b independently of one another represent 0, 1 or 2, wherein the double bond may be of the (E) or (Z) configuration, or X ¹ and X ² represent a group of the general formula in which T3 is 0, 1 or 2, U, YY and Z independently represent a carbon atom 230 or nitrogen, wherein U, YY, Z may carry the following number of substituents: υ, γγ or Z Bound in a double bond Number of possible substituents C Yes 1 C not 2 N Yes 0 N not 1 R ^d represents a hydrogen atom, an alkyl group containing 1 to 8 carbon atoms or a perfluoroalkyl group containing 1 to 8 carbon atoms, R ^U1, R ^U2, R ^Y1, R ^Y2, R ^Z1, R ^Z2, independently of one another are hydrogen, F, Cl, Br, I, cyano, OR · * · ¹⁴ alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, ° LA ^(CH2) zla ^C zma ^F 2zma 'NR ^{11 S} R ^116, phenyl or benzyl, wherein the aromatics are unsubstituted or substituted 1 up to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, NR ¹¹⁷ R ¹¹⁸ , R @ ¹ and R @ ^{1 = O} are hydrogen, C1 -C4 alkyl or C1 -C4 perfluoroalkyl, z is 0 or 1, z is 0, 1, 2, 3 or 4, grains are 1, 2, 3, 4, 5, 6, 7, or 8, R ¹¹⁴ is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl, C 3 -C 8 cycloalkyl, phenyl or benzyl; aromatic groups are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, 231 trifluoromethyl, methyl, methoxy and ^NR19 R ¹²⁰ , R ¹¹⁹ and R ¹²⁰ represent a hydrogen atom, a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group, R ¹¹⁵ and R ¹¹⁶ independently of one another have the meanings as R ¹¹⁴ or R ¹¹⁴ ; R ¹¹⁵ and R ¹¹⁶ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, the constitution being excluded a nitrogen atom, YY is a nitrogen atom, and Z is a carbon atom, R ^101, R ^102, R ^103, R ¹⁰⁴ and R ¹⁰⁵ independently of one another are hydrogen, fluoro, bromo, iodo, cyano X _Zoa - ^{(σι 2}} ZPA ^"(c zqa ^F 2zqa + l ⁾ 'is a group R ¹¹⁰ R110a_gOzbmŕ ^ R ^{110c of} the N-CO group, R ,, R @ ^IIIa -COalebo ^112a R ^113a N-SO 2, wherein the perfluoroalkyl group is straight or branched, X represents an oxygen atom, a sulfur atom or a NR ^114a group, R ^114a represents a hydrogen atom or an alkyl group containing from 1 to 3 carbon atoms, za represents 0 or 1, b and m represents 0, 1 or 2, and p represents 0, 1, 2, 3 or 4, zqa represents 1, 2, 3, 4 , 5, 6, 7, or 8, R ^110a, R ^110b, R ^112a and R @ ^IIIa, independently of one another are alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 8 carbon atoms, - ^{C H} 2zn- ^Rll5a marks or perfluoroalkyl of 1 to 8 carbon atoms, n is 0, 1, 2, 3 or 4, Rll5a _{A is} cycloalkyl having 3 to 8 carbon atoms, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, 232 methoxy and NR ^116a R ^117a , R ^116a and R ^117a represent a hydrogen atom, a C 1 -C 4 perfluoroalkyl group or a C 1 -C 4 alkyl group or RllOb, IIIa _{R and R means} Wow H 2a H, _{and R} rIIOc independently, an H 3a _than of one another are H, alkyl or perfluoroalkyl of 1 to 4 carbon atoms, or RllOb _and £ ± 10ο _as R.H2a _{and j, and R} p _is H 3a _S] _ _u is 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, N-CH ₃ or N-benzyl; R ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ¹⁰⁵ independently of one another denote an alkyl group having 1 to 8 carbon atoms, a "C _zal H 2 _zal R ^118a" or an alkenyl group zal means 0, 1, 2, 3 or 4. R 18a represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group or a group NR R ^{119a 11 913,} _{R (} 19a) _{and R (} 9b) are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or R ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ¹⁰⁵ independently of one another denote a heteroaryl group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of including fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group, or R ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ^105, independently of one another, are -CaC-R ¹⁹³ , 193 R represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected 233 from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group or NR ¹⁹⁴ R ^{195 group} , R ¹⁹⁴ and R ¹⁹⁵ represent a hydrogen atom or a methyl group, or R ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ¹⁰⁵ independently of one another represent a group -Y-para- _Cg H ₄ - (CO) _z - - (CHOH) _z - (CH ₂ ) _z - (CHOH) _z -R ¹²³ or a group -Y-meta-C 8 H ₄ - (CO) _back - (CHOH) _2ae - (CH ₂ ) _2af - (CHOH) _Zag -R ¹²⁴ or a group -Y-ortho-C ₆ H ₄ - (CO) _2ah - (CHOH) _2ao - (CH ₂ ) _2ap - (CHOH) _Zak -R ¹²⁵ , Y represents an oxygen atom, a sulfur atom or the group -NR ^122d -, zh, back, and independently of one another are 0 or 1, zi, zz, zk, zae, zaf, zag, zao, zap and zak independently of one another 0, 1, 2, 3 or 4, where zh, zi and zk do not simultaneously mean 0, back, zae and zag do not simultaneously mean 0 and za, zao and zak do not mean 0, R ( ¹²³⁾ , R ( ¹²⁴⁾ , R ( ¹²⁵⁾ and R ( ¹²² ) independently of one another represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, or t ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ¹⁰⁵ independently of one another; ¹²⁹ , -OR ¹³⁰ , -NR ¹³¹ R ^132, or SR -CR ¹³³ R ¹³⁴ R ¹³⁵ , R ¹²⁹ , R ¹³⁰ , R ¹³¹ and R ^133, independently of one another, represent a _-Cb H 2 _zab -heteroaryl group in which the aryl radical contains 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, a group, a methyl group, a hydroxy group, an amino group, a trifluoromethyl methoxy group, a methyl amino group and a dimethylamino group, b and n are 0, 1 or 2, R ¹³² , R ¹³⁴ and R ¹³⁵ independently of one another have the meaning 234 as R ¹²⁹ or is hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, or R ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ⁸⁴ , R ^185, independently of one another, are -W-para- (C 8 H ₄ ) -R ¹⁹⁶ , -W-meta- (C 8 H 4) -R ^197, or - N-ortho (C 8 H 6) - R ¹⁹⁸ , R ¹⁹⁶ , R ¹⁹⁷ and R ¹⁹⁸ independently of one another denote a heteroaryl group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom , trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino, dimethylamino and benzyl, W represents an oxygen atom, a sulfur atom or an NR ¹³⁶ i * ag group R represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or R ¹⁸¹ , R ¹⁸² , R ¹⁸³ , R ¹⁸⁴ , R ¹⁸⁵ independently of one another are R ¹⁴⁶ X ^1a -, X ^1a represents an oxygen atom, a sulfur atom, a group NR ¹⁴⁷ , a group (D = O) A-, a group NR ¹⁴⁸ C · MN * R ¹⁴⁹ -, M represents an oxygen atom or a sulfur atom, A is O or NR ¹⁵⁸ , D represents a carbon atom or an SO group, R ¹⁴⁶ is alkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms, (CH ₂₎ b of _the ^C zdz 2zdz ^{F-I or} a group f * h ⁿ _ol51 ZXA 2zxa ^C · ZBZ is 0 or 1, the DTC is 1, 2, 3, 4, 5, 6 or 7, ZXA is 0, 1, 2, 3 or 4, R ¹⁵¹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ¹⁵² -R ¹⁵³ , 235 R ( ¹⁵²⁾ and R ( ¹⁵³⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, R ( ¹⁴⁷⁾ , R ( ¹⁴⁸⁾ and R ( ^150), independently of one another, are hydrogen, (C1-C4) -alkyl, (C1-C4) -fluoroalkyl, R ¹⁴⁹ is as R ¹⁴⁶ or R ¹⁴⁶ and R ¹⁴⁷ and R ¹⁴⁶ and R ¹⁴⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH 8 group or an N-benzyl group, and N * are attached to the phenyl core of the alkanoyl backbone, or R ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ¹⁰⁵ independently of one another are -SR ¹⁶⁴ , -OR ¹⁶⁵ , -NHR ¹⁶⁶ , -NR ¹⁶⁷ R ¹⁶⁸ , -CHR ¹⁶⁹ R ¹⁷⁰ , -CR ¹⁵⁴ R ¹⁵⁵ OH, -C = CR ¹⁸⁶ , -CR ¹⁸⁸ = CR ¹⁸⁷ or - (cr ¹⁵⁹ r ¹⁶⁰ ) z- (C = 0) ) - / cr ¹⁶¹ r ¹⁶² / zv-r ¹⁶³ , R ¹⁶⁴ , R ¹⁶⁵ , R ¹⁶⁶ , R ¹⁶⁷ , R ¹⁶⁹ , which are the same or different, represent a group - (CH _{2) Z} y (CHOH) _zz - _{(CH2) zaa} - (CHOH) _Zt-R ¹⁷¹ or a group - (CH ₂ ) zab-° - (CS ₂ -CH ₂ O) _Zac -R ¹⁷² , R ¹⁷¹ and R ¹⁷² are hydrogen or methyl, zu is 1, 2, 3 or 4, z is 0, 1, 2, 3 or 4, zy, zz, z, z, z, z, z are the same or different, are 0, 1, 2, 3 or 4, t is 1, 2, 3 or 4, R ¹⁶⁸ , R ¹⁷⁰ , R ¹⁵⁴ , R ¹⁵⁵ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or R ¹⁶⁹ and R ¹⁷⁰ and R ¹⁵⁴ and R ¹⁵⁵ together with the carbon atom to which they are attached represent a cycloalkyl group containing 3 to 8 carbon atoms, R represents a hydrogen atom, an alkyl group containing from 1 to 6 carbon atoms, a cycloalkyl group containing from 3 to 8 carbon atoms, or a group _-Czeb H 2 from _-eb ¹⁷³ , 236 zeb means 0, 1, 2, 3 or 4, R @ ¹⁵⁶ , R @ ¹⁵⁷ and R @ ¹⁷³ independently of one another represent a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁷⁴ group R ¹⁷⁵ . R ( ¹⁷⁴⁾ and R ( ¹⁷⁵⁾ are hydrogen or (C1-C4) -alkyl or R ^{@ 156} , R ^{@ 1 = 7} and R @ ¹⁵⁸ independently of one another are a heteroaryl group containing 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group, R ¹⁵⁸ , R ¹⁵⁹ , R ¹⁶⁰ , R ¹⁶¹ and R ¹⁶² are hydrogen or methyl; R ¹⁰¹ , R ¹⁰² , R ¹⁰³ , R ¹⁰⁴ , R ¹⁰⁵ independently of one another are R ¹⁷⁶ -NH-SO ₂ -, R ¹⁷⁶ is R ¹⁷⁷ R ¹⁷⁸ N- (C = Y '), Y 'is O, S, or NR ¹⁷⁹ R ¹⁷⁷ and R ¹⁷⁸ , which are the same or different, are hydrogen, C 1 -C 8 alkyl, C 3 -C 6 alkenyl or -C 2 _{R 6;} H 2 _zfa -R ¹⁸⁰ , zfa means 0, 1, 2, 3 or 4, R is C 5 -C 7 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from fluoro, chloro, trifluoromethyl, methoxy or (C 1 -C 4) alkyl, or R ¹⁷⁷ and R ¹⁷⁸ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; R ¹⁷ is as R ¹⁷⁷ or is an amidino group, or R ¹ ® ¹ »R ^102, R ^103, R ^104, R ^105, independently of one another are NR ¹⁸⁵ R ^{184a, 184b} OR, SR or-C ^184c _ZnX H _2znx R ^184d, 237 znx means Ο, 1, 2, 3 or 4, R ^184d _{A is} cycloalkyl having 3 to 7 carbon atoms or phenyl, which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy and NR ¹¹⁶ ^ R ¹¹⁷ ^, _R ^ _{j, and} 116k H7k Ju _means H or alkyl of 1 to 4 carbon atoms, R ^184a , R ^184b , R ^184c , R ^185, independently of one another, are hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl or (CH ₂ ) _{z o} -R ¹⁸⁴ R, o o means 0, 1, 2, 3 or 4, ^r1884 represents a cycloalkyl group containing 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group , methoxy and NR ^184u R ^184v , R ^184u and R ^184v are hydrogen or (C 1 -C 4) -alkyl or R ^184a and R ¹⁸⁵ together are 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, N-CH ₃ or N-benzyl, and pharmaceutically acceptable salts thereof, (u) a benzoylguanidine of the formula I R - nh ₂ nh ₂ (D 238 in which R ³ * represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a nitro group, a C 1 -C 8 alkyl group, a C 3 -C 8 cycloalkyl group or X _and - ( CH ₂ ) _b - (CF ₂ ) _c -CF ₃ , X is O, S or NR ^5, and a is 0 or 1, b is 0, 1 or 2, c is 0, 1, 2 or 3, R ⁵ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a -C 1 H 4 R ^{8 group} , d represents 0, 1, 2, 3 or 4, R ⁸ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ⁷ R ⁸ , R ⁷ and R ⁸ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or R ¹ is -SR ^10, -OR ^10, or -CR ¹⁰ R ¹¹ R ^12, R ¹⁰ represents -CfH ₂ f -cycloalkyl wherein the cycloalkyl radical contains 3 to 8 carbon atoms, heteroaryl containing 1 to 9 carbon atoms, or phenyl, said aromatic systems being unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methylene group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, f represents 0, 1 or 2, R ¹¹ and R ¹² independently of one another have the meaning of R ¹⁰ or are hydrogen or C 1-4 alkyl having 1 to 4 carbon atoms, or R ¹ represents a phenyl group, a naphthyl group, a biphenylyl group or a heteroaryl group having 1 to 9 carbon atoms, the latter being bonded via a carbon atom or a nitrogen atom and said groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino and dimethylamino, or R ¹ is -SR ¹³ , -OR ¹³ , -NHR ¹³ , -NR ¹³ R ¹⁴ , -CHR ¹³ R ¹⁸ , -C / R ¹⁸ R ¹⁶ OH, -CeCR ¹⁸ , -C (R ¹⁹ ) = CR ¹⁸ , - / CR ²⁰ R ²¹ / k - (CO) - / CR ²² R ²³ R ^24/1 , R ¹³ and R ¹⁴ , which are the same or different, represent - (CH 2) - (CHOH) h - (R 2) 5, - (CHOH) j R ¹⁷ , wherein R is hydrogen or methyl, or - (CH 2) g O- (CH ₂ -CH ₂ O) _h -R ²⁴ , wherein g, h, i, which are the same or different, are 0, 1, 2, 3 or 4, j is 1, 2, 3 or 4, R ¹⁸ and R ¹⁶ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or, together with the carbon atom to which they are attached, a cycloalkyl group having 3 to 8 carbon atoms, R ¹⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ²⁸ R ^{26 group} , R ²⁸ and R ²⁶ represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R ¹⁸ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group, or R ¹⁸ is C 1 -C 6 alkyl which is unsubstituted or substituted by 1 to 3 hydroxy groups, or R ¹⁸ represents a cycloalkyl group having 3 to 8 carbon atoms, R ¹⁹ , R ²⁰ , R ²¹ , R ²² and R ²³ represent a hydrogen atom or a methyl group, k is 0, 1, 2, 3 or 4, 1 is 0, 1, 2, 3 or 4, R ²⁴ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a -C _m H _2m -R ^{18 group} , m being 1, 2, 3 or 4, R ² and R ³ independently of one another are defined as R ¹ R ⁴ represents an alkyl group having 1 to 3 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group or a - (CH ₂ ) _n - (CF ₂ ) _Q -CF _{3 group} , n being 0 or 1 , o is 0, 1 or 2, as well as pharmaceutically acceptable salts thereof, v) acylguanidine of the general formula I in which: X represents a carbonyl group or a sulfonyl group, R ¹ represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms which is unsubstituted or substituted by a hydroxy group, a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 8 carbon atoms 241 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, amino group, methylamino group or dimethylamino group, R ² is H or alkyl of 1 to 4 carbon atoms, and the pharmaceutically acceptable salts thereof, w) phenyl-substituted alkylcarboxylguanidide which carries perfluoroalkyl groups of the general formula I in which: R ^A is H, F, Cl, Br, I, cyano, OR ^6, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, 0 _R (CH ₂ ) a C 10 ^R 2b + 1 ^allele NR ⁷ R ⁸ , r is 0 or 1, and is 0, 1, 2, 3 or 4, b is 1, 2, 3, 4, 5, 6, 7 or 8 , g R represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group or a benzyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ^{18 group} , 242 R ⁹ and R ¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R ⁷ and R ⁸ independently of one another have the meaning as R ⁶ , R ^B is independently as R ^A , X is 1, 2 or 3, R ¹ is H, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, _t -0 (CH ₂₎ d ^C e ^F 2e + I ^{'m at} ° F, CI, Br, iodine or cyano, t is 0 or 1, d is 0, 1, 2, 3 or 4, e is 1, 2, 3, 4, 5, 6, 7 or 8, R ^2, R ^3, R ⁴ and R ⁵ independently of one another are as defined for R ^1, with the proviso that at least one of R ^1, R ^2, R ^3, R ^4, R ^5, and R ⁸ is group -O _t (CH ₂ ) _d C _e F _{2e + 1} or the group O _r (CH ₂ ) _a C _b F _{2b + 1} as well as its pharmaceutically acceptable salts, x) a heteroaroylguanidine of the formula I wherein: HA is SO _m , oxygen or NR ⁵ , m is 0, 1 or 2, R ⁵ is H, alkyl of 1 to 8 carbon atoms or -C _{AM 2am} H R ^81, 243 am means 0, 1 or 2, R ⁸¹ is C 3 -C 8 cycloalkyl or phenyl substituted with 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and Nr 82r 83 and unsubstituted, R ⁸² and R ⁸³ represent a hydrogen atom or a methyl group, or R ⁸¹ represents a heteroaryl group having 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group , hydroxy, amino, methylamino and dimethylamino, one of R ¹ and R ² being -CO-N = C- (NH ₂ ) ₂ and the other of hydrogen, F, Cl, Br, I, alkyl having 1 to 3 carbon atoms, -OR ^{3, C} r ^F 2r + L is -CO-N »C (NH _{2) 2,} or -NR ⁶ R ⁷ , R ³ and R ⁷ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, r represents 1, 2, 3 or 4, R ³ and R ⁴ independently of one another represent H, F, Cl, Br, I, CN, X- (CH2) p- (Cq-F2q + 1), R @ ⁸ -SObm, group R ⁹ R ¹⁰ N-CO, R 6 -CO- or R ¹² R ¹³ N-SO ₂ -, wherein the perfluoroalkyl group is straight or branched, X is O, S or NR ^14, R ¹⁴ is H or alkyl of 1 to 3 carbon atoms, bm = 0, 1, or 2, p is 0, 1 or 2, g is 0, 1, 2 , 3, 4, 5 or 6 R ^8, R ^9, R ¹¹ and R ¹² independently of one another are al244 alkyl group of 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, -C _n H _2n -R ¹⁵ or trifluoromethyl, n is 0, 1, 2, 3 or 4 R ¹⁵ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group or NR ¹⁶ R ^{17 group} , R ¹⁶ and R ¹⁷ are hydrogen or C 1 -C 4 alkyl or R ⁹ , R ¹¹ and R ¹² are hydrogen, R ( ¹⁰⁾ and R ( ¹³⁾ independently of one another are hydrogen or (C1-C4) -alkyl or R ⁹ and R ¹⁰ as well as R ¹² and R ¹³ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, or R ³ and R ⁴ independently of one another are alkyl having 1 to 8 carbon atoms or -C _al H _2al R ^18, al is 0 or 1 or 2, R ¹⁸ is C 3 -C 8 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁹ R ^{20 group} , R ¹⁹ and R ²⁰ represent a hydrogen atom or a methyl group, or R ³ and R ⁴ independently of one another represent a heteroaryl group which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy- a hydroxy group, an amino group, 245, 23 methylamino and dimethylamino, or R ³ and R ⁴ independently of one another denote a (C) - (CHOH) - (CH ₂ ) - (CHOH) group or a (C 2 CH ₃ ) -CH ₂ CHOHY- group; R or the group ff (C 1 - (CHOH) - (CH ₂ ) - (CHOH) -RY - represents -NR ²² -, an oxygen atom, a sulfur atom or a group h, ad, and h independently of one another represent 0 or 1, i, j, k, ae, af, ag, ao, ap and if independently of one another represent 0, 1, 2, 3, 4, where h, however, do not simultaneously mean 0, ad, ae and g do not mean 0 and ah, and o and if they do not mean simultaneously 0, R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁸⁾ and R ( ²²⁾ independently of one another are alkyl having 1 to 3 carbon atoms, or and R ( ⁴⁾ independently of one another are hydrogen, fluorine, chlorine, bromine, iodine, cyano , (C 1 -C 8) alkyl, (C 1 -C 8) perfluoroalkyl, (C 3 -C 8) alkenyl, or -C 8 H 8 R ²⁸ , g is 0, 1, 2, 3, or 4, R ²⁸ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic compounds being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy and NR ²⁷ R ²⁸ , R ( ²⁷⁾ and R ( ²⁸⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or R ³ and R ^4, independently of one another, are SR ²⁹ , -OR ³⁰ , -NR ³¹ R ^32, or -CR ³³ R ³⁴ R ³⁵ , R ²⁹ , R ³⁰ , R ³¹ and R ^{33 are} independently of one another -C _and H 2 _and -heteroaryl in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group a group, an amino group, a methylamino group and a dimethylamino group, and is 0, 1 or 2, R ( ³²⁾ , R ( ³⁴⁾ and R ( ³⁵⁾ independently of one another have the meanings defined for R ²⁹ or are C, C 1-4 alkyl or C 1-4 perfluoroalkyl, or R ³ and R ⁴ independently of one another represent a group or a group or a group W- 247 R ( ⁹⁶⁾ , R ( ⁹⁷⁾ and R ( ⁹⁸⁾ independently of one another are a heteroaryl group containing 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine , trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino, dimethylamino or benzyl, W represents an oxygen atom, a sulfur atom or an NR - group, R ³⁶ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or R ³ and R ⁴ independently of one another are R ³⁷ -SOcm or R ³⁸ R ³⁹ N-SO 2 -, cm is 1 or 2, R ³⁷ is alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, an alkenyl radical containing 3 to 8 carbon atoms or -C _g H _{2 g} R ^40, s is 0, 1, 2, 3 or 4 . R ⁴⁰ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ⁴¹ R ⁴² , R ( ⁴¹⁾ and R ( ⁴²⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, R is H, alkyl of 1-8 carbon atoms, perfluoroalkyl having 1-8 carbon atoms, alkenyl having 3 to 8 carbon atoms or-C _w H _{2 watts} -R ^43, w is 0, 1, 2, 3 or 4, R ⁴³ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, wherein said aromatic assays are unsubstituted or substituted with 1 to 3 substituents selected from fluoro, chloro, trifluoromethyl, methyl, methoxy and NR ⁴⁴ R ⁴⁵ , R ( ⁴⁴⁾ and R ( ⁴⁵⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, R ³⁹ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a perfluoroalkyl group having 1 to 4 carbon atoms, or R ³³ and R ³⁹ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, or R ³ and R ⁴ independently of one another represent a group R ⁴⁶ X ¹ -, X ¹ is O, S, NR ⁴⁷ , (D = O) A-, NR ⁴⁸ C = MN * R ⁴⁹ , M represents an oxygen atom or a sulfur atom, A is O or NR ⁵⁸ , D represents a carbon atom or an SO group, R ⁴⁶ is C 1 -C 8 alkyl, C 3 -C 8 alkenyl, (CH ₂ ) _b C _d F _{2 d + 1} or c _x h _2x -r ⁵¹ , b is 0 or 1, d is 1, 2, 3, 4, 5, 6 or 7, x is 0, 1, 2, 3 or 4, R ⁵¹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy -group and NR ⁵² R ⁵³ , R and R are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R ⁴⁷ , R ⁴⁸ and R ⁵⁸ independently of one another are an atom 249 hydrogen, a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group, R ⁴⁹ is as R ⁴⁶ or R ⁴⁶ and R ^47, or R ⁴⁶ and R ⁴⁸ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, N-CH-J or N-benzyl; wherein A and N * are bound to the phenyl core of the benzoylguanidine backbone, or R ³ and R ^4, independently of one another are -SR ^64, -OR ^65, -NHR ^66, NR ⁶⁷ R ^68, -CHR ⁶⁹ R ^70, -C (OH) R ⁵⁴ R ⁵⁵ group, -CaCR ⁵⁶ , -CR ⁵⁸ = CHR ⁵⁷ , - / CR ⁵⁹ R ⁶⁰ / u- (CO) - / CR ⁶¹ R ⁶² / in R ⁶³ , R ⁶⁴ , R ⁶⁵ , R ⁶⁶ , R ⁶⁷ and R ⁶⁹ , which are the same or different, represent a group - (CH ₂ ) _y - (CHOH) _z - (CH ₂ ) _aa - (CH ₂ OH) _t -R ⁷¹ or - <CH ₂ > ab- ° - <= H ₂ -CH ₂ °> ac-E ⁷² . R ⁷¹ and R ⁷² are hydrogen or methyl, u is 1, 2, 3 or 4, v is 0, 1, 2, 3 or 4, y, z, and a, which are the same or different, are 0, 1 , 2, 3 or 4, t is 1, 2, 3 or 4, R ⁶⁸ , R ⁷⁰ , R ⁵⁴ and R ⁵⁵ , which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or R ⁶⁹ and R ⁷⁰ , or R ⁵⁴ and R ⁵⁵ together with the carbon atom to which they are attached, represent a cycloalkyl group containing 3 to 8 carbon atoms, R ⁶³ is hydrogen, C 3 -C 8 alkyl or -C _e H _2e -R ⁷³ , e is 0, 1, 2, 3 or 4, R ⁵⁶ , R ⁵⁷ and R ^73, independently of one another, represent a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl 250 group, methoxy group and NR ⁷⁴ R group ⁷⁵ , R ( ⁷⁴⁾ and R ( ⁷⁸⁾ are hydrogen or (C1-C4) -alkyl, or R ⁸⁸ , R ⁸⁷ and R ^73, independently of one another, represent a heteroaryl group containing 1 to 9 carbon acoms which is unsubstituted or substituted as a phenyl group, R ⁵⁸ , R ⁵⁹ , R ⁸⁰ , R ⁸¹ and R ⁸² are hydrogen or methyl; R ³ and R ⁴ independently of one another represent the group r ⁷⁶ -nh-s ₂ -, R ⁷⁸ is R ⁷⁷ R ⁷⁸ N- (C = Y ') -, Y * is O, S or NR ⁷⁹ , R and R are the same or different, are H, alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms or CFH ₂ fR ^80, f is 0, 1, 2, 3 or 4 . R is C 5 -C 7 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methoxy and alkyl of 1 to 4 carbon atoms, or R ⁷⁷ and R ⁷⁸ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; R ⁷⁹ is as R ⁷⁷ or is an amidine group, or R ³ and R ⁴ independently of one another are NR ⁸⁴ R ⁸⁵ , O / flC R and R independently of one another represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N- group CH ₃ or N-benzyl, or of which one or two CH ₂ groups may be replaced by ^{CH c} dm ^H 2dm + 1 ' 251 as well as its pharmaceutically acceptable salts, y) a bicyclic heteroaroylguanidine of the general formula I wherein T, U, V, W, X, Y, and Z independently of one another are nitrogen or oxygen, provided that X and Z together are not nitrogen, and that T, U, V, W, X, Y, and Z bear no substituents when they are nitrogen, and that no more than four of them together are nitrogen, R ¹ and R ² independently of one another represent H, F, Cl, Br, I, alkyl having 1 to 3 carbon atoms, perfluoroalkyl of 1 to 3 carbon atoms, OR ^8, NR ⁸ R ⁹ or C (= O) N = C (NH ₂ ) ₂ , R ⁸ and R ⁹ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, or R ⁸ and R ⁹ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, R ³ , R ⁴ , R ⁵ , R ⁶ and R ^7, independently of one another, are hydrogen, fluorine, chlorine, bromine, iodine, cyano, Xk- (CH 2) p - (CqF 2 g + 1) ), a group R ¹⁰ _SObm group, R ^10b, R ^10c, the N-CO group, R ¹¹ -CO- or a group R ¹² R ¹³ N-SO _2, wherein the perfluoroalkyl group is straight or branched, 252 X is O, S or NR ^14, R ¹⁴ is H or alkyl of 1 to 3 carbon atoms, bm = 0, 1, or 2, p is 0, 1 or 2, k is 0 or 1, q is 1, 2, 3, 4, 5, 6 alebc _R 10a, _R 10b, _R 11 _{and R} 12 independently, an _than of one another are alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, -C _n H _2n -R ¹⁵ or a perfluoroalkyl group containing 1 to 8 carbon atoms, n is Q, 1, 2, 3 or 4, R ¹⁵ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁶ R ^{17 group} , R ¹⁶ and R ¹⁷ represent a hydrogen atom or a (C 1 -C 4) alkyl group or R ¹⁰ * ⁵ , R ¹¹ and R ¹² represent a hydrogen atom, R ( ^10c) and R ( ¹³⁾ independently of one another are hydrogen or (C1-C4) -alkyl or ¹⁰ R * ³ and R ^10c, and R ¹² and R ¹³ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _NCH3 or the group N benzyl or R ³ , R ⁴ , R ⁵ , R ⁶ and R ^7, independently of one another, represent an alkyl group containing 1 to 8 carbon atoms, a ^-C 1 ^H 2al ^{R 18 group, but a} 4 ° alkenyl group containing 3 to 8 carbon atoms, and a is 0 , 1 or 2 R ¹⁸ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy and NR ¹⁹ R ¹⁹ ^. R ^19a and R ^19b are H, alkyl having 1 to 4 carbon atoms or perfluoroalkyl of 1 to 4 carbon atoms, or R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a heteroaryl group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of including a fluorine atom, a chlorine atom, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group or a dimethylamino group; or R ^3, R ^4, R ^5, R ⁶ and R ⁷ independently of one another are -Y or an dX "(NAV-ÍCHOHJ ^ CH ^ H OH R Y ²⁵ Y represents an oxygen atom, a sulfur atom or the group -NR ²² h, ad, and h independently of one another represent 0 or 1, i, j, k, aa, af, ag, ao, ap and if independently of one another represent 0, 1, 2, 3 or 4, wherein h, however, does not simultaneously mean 0, ad, ae and g do not mean simultaneously 0, and 254 ah, ao and if they do not simultaneously mean 0,, 23, 24 R ²⁵ and R ²² independently of one another represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, or R ⁴ , R ⁵ , R ⁸ and R ⁷ independently of one another are SR ²⁹ , -OR ³⁰ , -NR ³¹ R ³² or -CR ³³ R ³⁴ R ³⁵ , R ²⁹ , R ³⁰ , R ³¹ and R ³³ independently of one another denote a -C _and H _2a -heteroaryl group in which the heteroaryl radical contains 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluoro, chloro, trifluoromethyl, methoxy, hydroxy, amino, methylamino and dimethylamino, and is 0, 1 or 2, R ( ³²⁾ , R ( ³⁴⁾ and R ( ³⁵⁾ independently of one another are as defined for R ( ²⁹⁾ or are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or R ⁴ , R ⁵ , R ⁸ and R ⁷ independently of one another represent a group or a group or group O) - ^Ri w— 255 R ( ⁹⁶⁾ , R ( ⁹⁷⁾ and R ( ⁹⁸⁾ independently of one another are a heteroaryl group containing 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine , trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino, dimethylamino or benzyl, W represents an oxygen atom, a sulfur atom or a group NR ³⁶ -, R ³⁶ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a group R ⁴⁶ X ¹ -, X ¹ represents an oxygen atom, a sulfur atom, a group NR ⁴⁷ , a (D = O) A- group or a group NR ⁴⁸ C = MN * R ⁴⁹ -, M represents an oxygen atom or a sulfur atom, A is O or NR ^50, D represents a carbon atom or an SO group, R ⁴⁶ is alkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms, ^(CH 2 R b ^C d ^F 2d + l or-C -R ^51, b is 0 or 1, d is 1, 2, 3, 4, 5, 6 or 7, x being 0, 1, 2, 3 or 4, R ⁵¹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy -group and NR ⁵² R ⁵³ , R and R ^J are hydrogen, alkyl having 1 to 4 carbon atoms or perfluoroalkyl of 1 to 4 carbon atoms, R ( ⁴⁷⁾ , R ( ⁴⁸⁾ and R ( ⁵⁰⁾ independently of one another are hydrogen, (C1-C4) -alkyl; 256 or a perfluoroalkyl group containing 1 to 4 carbon atoms, R ⁴⁹ is as R ⁴⁶ , or R ⁴⁶ and R ^47, or R ⁴⁶ and R ⁴⁸ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _NCH3 or N-benzyl, where A and N ^x are attached to the phenyl core of the basic heteroaroylguanidine skeleton, or R ³ , R ⁴ , R ⁵ , R ⁶ and R ^{7 are} each independently -SR ⁶⁴ , -OR ⁶⁵ , -NR ⁶⁷ R ⁶⁸ , -CHR ⁶⁹ R ^70, or -CR ⁵⁴ R ⁵⁵ OH , -C = CR ⁵⁶ , -CR ⁵⁸ , CR ^57, or - / CR ^{5 9} R ⁶⁰ / u-CO- / CR ⁶¹ R ⁶² / vR ⁶³ R ⁶⁴ , R ⁶⁵ , R ⁶⁶ , R ⁶⁷ and R ⁶⁹ , which are the same or different, represent a group - (CH ₂ ) _y - (CHOH) ₂ - (CH ₂ ) _aa - (CHOH) _t -R ⁷¹ or - (CH ₂ > ab- ° - (CH ₂ -CH ₂ O> _ac -R ⁷²⁾ , R ⁷¹ and R ⁷² independently of one another represent a hydrogen atom or a methyl group, u represents 1, 2, 3 or 4, v represents 0, 1, 2, 3 or 4, y, z, aa which are the same or different, are 0, 1, 2, 3 or 4, t is 1, 2, 3 or 4, R ⁶⁸ , R ⁷⁰ , R ⁵⁴ and R ⁵⁵ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or R ⁶⁹ and R ⁷⁰ , or R ⁵⁴ and R ⁵⁵ together with the carbon atom to which they are attached, represent a cycloalkyl group containing 3 to 8 carbon atoms, R ⁶³ is hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl or -C _e H _2e -R ⁷³ , e is 0, 1, 2, 3 or 4, R ⁵⁶ , R ⁵⁷ and R ^73, independently of one another, represent a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of 257 is fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ⁷⁴ R ⁷⁵ , R ( ⁷⁴⁾ and R ( ⁷⁵⁾ are hydrogen or (C1-C4) -alkyl or R ⁵⁶ , R ⁵⁷ and R ^73, independently of one another, represent a heteroaryl group containing 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group, R ⁵⁸ , R ⁵⁹ , R ⁸⁸ , R ⁸¹ and R ⁸² are hydrogen or methyl; R ³ , R ⁴ , R ⁵ , R ⁸ and R ⁷ independently of one another are R ⁷⁶ -NH-SO ₂ - or R ⁷⁸ R ⁷⁷ R ⁷⁸ N- (C = Y ') -, Y 'is O, S or NR, R ⁷⁷ and R ⁷⁸ are the same or different, are H, alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms or -C _f H _2f -R ⁸⁸ , f represents 0, 1, 2, 3 or 4, Q Λ R is C 5 -C 7 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methoxy and alkyl of 1 to 4 carbon atoms, or R and R together represent 4 or 5 methylene groups, one of which may be replaced by an oxygen atom, a sulfur atom, an NH group, an NCH ₃ group or an N-benzyl group, R ⁷⁹ is as R ⁷⁷ or is an amidino group; R ^3, R ^4, R ^5, R ⁸ and R ⁷ independently of one another are NR ^84a R ^85, OR ⁸⁴ * ^5, SR ^84c, or the group _ / i W _p84d ^the n2n ^R n is 0, 1, 2, 3 or 4 R ( ⁸⁴ ) is a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, 258 trifluoromethyl, methyl, methoxy and NR ¹⁶ R ^17, R ¹⁶ and R ¹⁷ represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, R ^84a, R ⁸⁴ b, R ^84c, and R ⁸⁵ independently of one another are H, alkyl having 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms or a (CH ₂₎ -R ⁸⁴ _{and x} ^ and x means 0, 1, 2, 3 or 4, R ^84g represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ^84u group R ^84v , R ( ^84u) and R ( ^84v) are hydrogen or (C1-C4) -alkyl or R ^84a and R ⁸⁵ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, as well as pharmaceutically acceptable salts thereof, z) a benzoylguanidine of the formula I in which: R ¹ is R ⁶ -SQ _m , m is 0, 1 or 2, 259 R ⁶ represents a perfluoroalkyl group having 1, 2, 3, 4, 5 or 6 carbon atoms which is straight or branched, R ² and R ³ independently of one another represent H, F, Cl, Br, I, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms or a phenoxy group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group; or R and R independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom , iodine, cyano, alkanoyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkoxycarbonyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, formyl, carboxy , trifluoromethyl, methyl and methoxy, R ⁴ and R ⁵ independently of one another are hydrogen, alkyl having 1, 2 or 3 carbon atoms, fluorine, chlorine, bromine, cyano, OR ⁷ , NR ⁸ R ⁹ or - ( CH ₂ ) _n - (CF ₂ ) _O -CF ₃ , R ⁷ / R ⁸ and R ⁹ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, n represents 0 or 1, o is 0, 1 or 2, as well as its pharmacologically acceptable salts, and b) a phenyl-substituted alkenylcarboxylguanidide which carries perfluoroalkyl groups of formula I 260 (I) in which R ^a represents a hydrogen atom, a fluorine atom, a bromine atom, an iodine atom, a cyano group, a hydroxy group, an OR ⁶ group, an alkyl group containing 1 to 8 carbon atoms, an Or (C ^H 2) _and C _b ^F ₂ b _{+ 1} , cycloalkyl having 3 to 8 carbon atoms or NR ⁷ R ⁸ , r is 0 or 1, and is 0, 1, 2, 3 or 4, b is 1, 2, 3, 4, 5, 6, 7 or 8, R ⁶ represents an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group or a benzyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁹ R ^{10 group} , R ⁹ and R ¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R ⁷ and R ⁸ independently of one another are as defined for R ⁶ or R ⁷ R ⁷ and R ⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or a benzyl group, 261 R ^b independently is defined as R ^f, X is 0, 1 or 2, Y is 0, 1 or 2, RC is H, fluoro, bromo, iodo, cyano, OR ^12, alkyl of 1 to 8 carbon atoms, Op _(CH2) f ^C g ^F 2G + l ^but ^ ^c cycloalkyl having 3 to 8 carbon atoms, p is 0 or 1, f is 0, 1, 2, 3 or 4, g is 1, 2, 3, 4, 5, 6, 7 or 8, R ¹² is C 1 -C 8 alkyl, C 1 -C 4 perfluoroalkyl, C 3 -C 8 alkenyl, C 3 -C 8 cycloalkyl, phenyl or benzyl, said aromatic groups being: unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹³ R ^{14 group} , R ¹³ and R ^14, independently of one another, are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R is independently as R, R ¹ represents a hydrogen atom, a C 1 -C 8 alkyl group, -O _t (CH ₂ ) d ^c e ^F 2e + 1 C 3 -C 8 cycloalkyl, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom or cyano, t is 0 or 1, d is 0, 1, 2, 3 or 4, e is 1, 2, 3, 4, 5, 6, 7 or 8, R ² , R ³ , R ⁴ and R ⁵ independently of one another are as defined for R ¹ , provided that at least one of R 6, R 6, R ^c , R ¹ , R ² , R ⁴ or R ⁵ is O _r (CH ₂ ) _and C _b F _{2b + 17} 262 O _p (CH ₂ ) _d C _e F _{2g + 1} - or 0 _t (CH ₂ ) d ^c e ^F 2e + 1 and that R ^{3 is} not 0 _t (CH ₂ ) _d C _e F _{2e + 1} - and pharmaceutically acceptable salts thereof; and c) an ortho-amino-substituted benzoylguanidine of formula I wherein: R ¹ represents a group NR ^SO R ⁶ , R ⁵⁰ and R ⁶ independently of one another are hydrogen, C 1 -C 8 alkyl or C 1 -C 8 perfluoroalkyl, R ^2, R ^3, R ⁴ and R ⁵ independently of one another are R ¹⁰ ~ -SOa, an R ^ R ^ N-CO-, R ¹³ -CO- or a group R ¹⁴ R ¹⁵ N-SO 2, a is 0, 1 or 2, R ( ¹⁰⁾ , R ( ¹¹⁾ , R ( ¹²⁾ , R ( ¹³⁾ , R ( ¹⁴⁾ and R ( ¹⁵⁾ independently of one another denote an alkyl group containing 1 to 8 carbon atoms, a perfluoroalkyl group containing 1 to 8 carbon atoms, an alkenyl group containing 3 to 6 carbon atoms or a group -C _b H _2b -R ^16, b is 0, 1, 2, 3 or 4, R ¹⁶ represents a cycloalkylene having 3 to 7 carbon atoms, phenyl which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy or NR ¹⁷ R ¹⁸ 263 R ( ¹⁷⁾ and R ( ¹⁸⁾ independently of one another are hydrogen, trifluoromethyl or (C1 -C4) -alkyl or R ( ¹¹⁾ , R ( ¹²⁾ and R ( ¹⁴⁾ and R ( ¹⁵⁾ together are 4 or 5 methylene groups, of which one may be replaced by oxygen, sulfur, NH, N-CH2 or N-benzyl, or R ^11, R ^12, R ¹⁴ and R ¹⁵ independently of one another are hydrogen or R ² , R ³ , R ⁴ and R ⁵ independently of one another represent a group SR ²¹ , -OR ²² , -NR ²³ R ^24, or -CR ²⁵ R ²⁶ R ²⁷ , R ²¹ , R ²² , R ²³ and R ^{25 are} independently of one another -C 1-6 -heteroaryl in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group a group, an amino group, a methylamino group and a dimethylamino group, b represents 0, 1 or 2, R ( ²⁴⁾ , R ( ²⁸⁾ and R ( ²⁷⁾ independently of one another are hydrogen, (C1-C4) -alkyl or (C1-C4) perfluoroalkyl; or R ^2, R ^3, R ⁴ and R ⁵ independently of one another represent H, F, Cl, I, a cyano group, a group - (X) _o -C _da H _{2da + 1,} a group - (Xb) (CH ₂ ) _{d 3} -C _{de Fede + 1} , C 3 -C 8 alkenyl or -C _{d f} H 2 _dt R ³⁰ , (Xa) represents oxygen, sulfur or NR ³³ , R ³³ is hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, dg is 0 or 1, (Xb) is oxygen, sulfur or NR ³⁴ , R ³⁴ is hydrogen , a (1-4C) alkyl group or a (1-4C) perfluoroalkyl group. dh means 0 or 1, will give means 0 1 2 3 4 5 6 7 8 db means 0 1 2 3 4 de means 0 1 2 3 4 5 6 7 df means 0 1 2 3 4 R ³⁰ means cycloalkyl containing a phenyl, biphenylyl or naphthyl group, said aromatic groups comprising a phenyl, biphenylyl or naphthyl group being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methyl group, and NR ³¹ R ³² , R ( ³¹⁾ and R ( ³²⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or R ^2, R ^3, R ⁴ and R ³ independently of one another are NR ⁴⁰ R ⁴¹ or - (Xe) - _{(CH2) eb} R ^45, R ( ⁴⁰⁾ and R ( ^41), independently of one another, are hydrogen, (C 1 -C 8) alkyl, (C 1 -C 8) perfluoroalkyl or (CH ₂ ) _e -R ⁴² , e is 0, 1, 2, 3 or 4, R is C 3 -C 7 cycloalkyl, phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁴³ R ^{44 group} , R ( ⁴³⁾ and R ( ^44), independently of one another, are hydrogen, trifluoromethyl or (C1 -C4) -alkyl or R ⁴⁰ and R ⁴¹ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, (Xe) is oxygen, sulfur or NR ⁴⁷ , 265 R ⁴⁷ represents a hydrogen atom, a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group, or eb is 0, 1, 2, 3 or 4, R ⁴⁵ represents a cycloalkyl group having 3 to 7 carbon atoms, a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, NR ⁵⁰ R ⁵¹ and is - (Xfa) - _{(CH2) ed} - (XFB) R ^46, Xfa is CH ₂ , oxygen, sulfur or NR ⁴⁸ , X fb represents an oxygen atom, a sulfur atom or an NR ⁴⁹ group, and ed represents 1, 2, 3 or 4, R ⁴⁶ represents a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group, R ⁴⁸ , R ⁴⁹ , R ⁵⁰ and R ⁵¹ independently of one another represent a hydrogen atom or a C 1 -C 4 alkyl group or a C 1 -C 4 perfluoroalkyl group, where R ³ and R ⁴ do not represent a hydrogen atom or its pharmaceutically acceptable salts, and d) benzoylguanidine of the formula I wherein one of the three substituents R ¹ , R ² and R ³ represents a heteroaryl-N-oxide group in which the heteroaryl radical contains 1 to 9 carbon atoms, which is bound via a carbon atom or a nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group or one of three R ¹ , R ² and R ³ are -SR ¹⁰ , -OR ¹⁰ , -NR ¹⁰ R ¹¹ or -CR ¹⁰ R ¹¹ R ¹² R ¹⁰ is ^-c and ^H 2 and a -heteroaryl-N-oxide group in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group a group, an amino group, a methylamino group and a dimethylamino group, and is 0, 1 or 2, R ¹¹ and R ¹² independently of one another are as defined for R ¹⁰ or are hydrogen or alkyl having 1 to 4 carbon atoms, and the other substituents R ^1, R ² and R ³ independently of one another C8 C8 represent an alkyl group having 1 atoms, alkenyl of 2 atoms or -C _m H 2 _and ¹⁴ R / m = 0, 1 or 2, R ¹⁴ represents cycloalkyl having 3 to 8 carbon atoms or phenyl, which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy and NR ^{1 S} R ^16, R ¹⁵ and R ¹⁶ represent a hydrogen atom or a methyl group; R ² and the other substituents R ¹ represent a hydrogen atom, a cyano group, a group R ²² -SO. R ^J independently of one another is fluorine, bromine, ^{x {ca} 2 ^} p- ⁽ cg ^F 2q + 1 ⁾ u, R ²³ R ²⁴ N-CO, R ² -CO or r ²⁶ r ²⁷ n-so2-, wherein the perfluoroalkyl group is straight or branched at 276, X is a bond, oxygen, sulfur or NR ²⁸ , u is 0, 1 or 2, p is 0, 1 or 2, g is 0, 1, 2, 3, 4, 5 or 6, R ^22, R ^23, R ²⁵ and R ²⁶ independently of one another are alkyl having 1 to 8 carbon atoms, alkenyl of 2 to 6 carbon atoms, -C _n H _2n -R ²⁹ or trifluoromethyl, n is 0 , 1, 2, 3, or 4, R ²⁸ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, R ²⁹ represents a cycloalkyl group having 3 to 7 carbon atoms, a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ³⁰ R ^{31 group} , R ( ³⁰⁾ and R ( ³¹⁾ are hydrogen or (C1-C4) -alkyl or R ( ²³⁾ , R ( ²⁵⁾ and R ( ²⁶⁾ are also hydrogen, R and R ^f independently of one another are alkyl having 1 to 4 carbon atoms, or R ²³ and R ^24, and R ²⁸ and R ²⁷ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by O, , by S, NH, _N-CH3 or N-benzyl, and the other substituents R ^1, R ² and R ³ independently of one another are oR ³⁵ or NR ³⁸ R ^36, R ³⁵ and R ³⁶ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or R and R together are 4-7 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; R ⁴ and R ^8, independently of one another, are hydrogen, A (C 1 -C 4) alkyl group, a fluorine atom, a chlorine atom, a -OR ³² group, an -NR ³³ R ³⁴ group, or a C _r F _{2r + 1 group} , R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1 to 3 carbon atoms, r is 1, 2, 3 or 4, and pharmaceutically acceptable salts thereof, and (d) benzoylguanidine of the formula I R ¹ is H, fluoro, bromo, iodo, cyano, nitro, hydroxyl, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or an 0 _and - ( CH ₂ )] ₃ - (CF ₂ ) _c -CF ₃ , a is 0 or 1, b is 0, 1 or 2, c is 0, 1 or 3, or R ¹ is R ⁵ -SO 2 or R ⁸ R ⁷ N-SO 2 -, m is 0, 1 or 2, R ⁵ and R ⁸ independently of one another denote an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 6 carbon atoms, a trifluoromethyl group Q is a group or a ~ C _n H _2n -R, n is 0, 1, 2, 3 or 4, R ⁷ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, R 8 represents a cycloalkyl group containing 3 to 7 269 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and a NR ⁹ R ^{10 group} , R ( ⁹⁾ and R ( ¹⁰⁾ independently of one another are hydrogen or (C1-C4) -alkyl or R ⁸ is hydrogen or R ⁸ and R ⁷ together represent 4 or 5 methylene groups of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, or R ¹ is -SR ^11, -OR ^11, or -CR ¹¹ R ¹² R ^{13, R11} is -CpH ₂ p-cycloalkyl group in which the cycloalkyl portion contains 3 to 8 carbon atoms, heteroaryl of 1 to 9 carbon atoms or phenyl, where the aromatics are unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, R ¹² and R ¹³ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, p represents 0, 1 or 2, or R ¹ represents a phenyl group, a naphthyl group, a biphenylyl group or a heteroaryl group having 1 to 9 carbon atoms, the latter group being bonded via a carbon or hydrogen atom and said groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine , chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino and dimethylamino, R ² is a group -CF2R ^14, -CF / R ¹⁵ // R ¹⁸ / group -CF / (CH 2) _q -CF ₃ // ¹⁵ R /, -C / (CF _{2) y} -CF ₃ / = CR ¹⁵ R ^16, 270 R ¹⁴ is C 1 -C 4 alkyl or C 3 -C 6 cycloalkyl, R ( ¹⁵⁾ and R ( ¹⁶⁾ independently of one another are hydrogen or (C1-C4) -alkyl, q is 0, 1 or 2, r is 0, 1 or 2, R ³ is as defined for R ^1, R ⁴ represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a - (CH ₂ ) _s - (CF ₂ ) _t -CF _{3 group} ; F) benzoylguanidine of the formula I in which one of the three substituents R ¹ , R ² and R ³ represents a group -Y-4 - / (CH 2) k-CHR ⁷ - (OO) R ⁸ / -phenyl or -Y-3 - / (CH 2) _k -CHR ⁷ - (C = O) R ⁸ / -phenyl or -Y-2 - / (CH ₂₎ ) _of -CHR ⁷ - (CO) R ⁸ / phenyl, wherein the methyl group is a phenyl radical unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, hydroxy , methoxy or -NR ³⁷ R ³⁸ , R ³⁷ and R ³⁸ independently of one another represent a hydrogen atom 271 or methyl, Y represents a bond, an oxygen atom, a sulfur atom or an -NR ⁹ group, Q R ³ is H or alkyl of 1 to 4 carbon atoms, R ⁷ is -OR ^10, or -NR ¹ ^ ^11, R ¹⁰ and R ¹¹ independently of one another are hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkanoyl, alkoxycarbonyl in which the alkoxy radical contains 1 to 8 carbon atoms, benzyl or benzyloxycarbonyl or R ⁸ is -OR ¹² or -NR ¹² R ¹³ , R ¹² and R ³ * ^3, independently of one another are H, alkyl having 1 to 8 carbon atoms or benzyl, a is 0, 1, 2, 3 or 4, and the other substituents R ^1, R ² and R ³ independently of one another are C 1 -C 8 alkyl, C 2 -C 8 alkenyl or - (CH ₂ ) _m R ¹⁴ , m is 0, 1 or 2, R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ^{1 S} R ¹⁶ R ¹⁵ and R ¹⁶ represent a hydrogen atom or a methyl group or the other substituents R ¹ , R ² and R ^3, independently of one another, represent a group R ¹⁸ R ¹⁹ N- (C = Y ') -NH-SO ₂ , Y * represents an oxygen atom, a sulfur atom or the group -NR ²⁰ R and R ^x, independently of one another, represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group or a - (CH ₂ ) _t -R ^{21 group} ; Q, 1, 2, 3, or 4 R ²¹ represents a cycloalkyl group containing 5 to 7 272 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methoxy group and an alkyl group having 1 to 4 carbon atoms, or R ¹⁸ and R ¹⁹ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; R ²⁸ is as R ¹⁸ or is an amidine group or the other substituents R ¹ , R ² and R ³ independently of one another are hydrogen, fluorine, chlorine, bromine, iodine, cyano, X- ( CH 2) p- (CqF 2 g + 1), R ²² -SO 2, R ²³ R ²⁴ N-CO-, R ²⁵ -CO- or R ²⁶ R ²⁷ N-SO ₂ -, wherein the perfluoroalkyl group is direct or branched X is a bond, oxygen, sulfur or -NR ²⁸ , u is 0, 1 or 2, p is 0, 1 or 2, q is 1, 2, 3, 4, 5 or 6, R ^22, R ^23, R ²⁵ and R ²⁶ independently of one another are alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, - (CH _{2) n} R ²⁹ or trifluoromethyl, n is 0, 1, 2, 3 or 4 R ²⁸ represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, R ²⁹ is cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and -NR ³⁸ R ³¹ , R ( ³⁸⁾ and R ( ³¹⁾ are hydrogen or (C1-C4) -alkyl or R ( ²³⁾ , R ( ²⁵⁾ and R ( ²⁶⁾ are hydrogen, R ²⁴ and R ²⁷ independently of one another are hydrogen Or an alkyl group containing 1 to 4 carbon atoms; or R ²³ and R ²⁴ as well as R ²⁸ and R ²⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -N-CH ₃ group or a - N-benzyl, or the other substituents R ¹ , R ² and R ³ independently of one another are -OR ³⁵ or -NR ³⁵ R ³⁶ , R ( ³⁵⁾ and R ( ³⁸⁾ independently of one another are hydrogen or (C1-C6) -alkyl or R ³⁸ and R ³⁸ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, a -ΝΉ- group, an -N-CH ₃ group or an -N-benzyl group, R ⁴ and R ⁸ independently of one another are H, alkyl having 1 to 4 carbon atoms, F, Cl, -OR ^32, NR ³³ R ³⁴ or -C _r F _{2r + 1,} R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1 to 3 carbon atoms, r is 1, 2, 3 or 4, and pharmaceutically acceptable salts thereof, and (g) benzoylguanidine of the formula I R ¹ is R ⁸ -CO or R ⁷ R ⁸ -N-CO, 274 R ⁸ is C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl or -C _n H _2n -R ⁹ , n is 0, 1, 2, 3 or 4. Q R is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy- and NR @ ¹¹ R @ ¹¹ , and R @ ¹¹ are hydrogen, (C1 -C4) alkyl or (C1 -C4) perfluoroalkyl, R represents a hydrogen atom, an alkyl group containing 1 to 8 carbon atoms, a perfluoroalkyl group containing 1 to 8 carbon atoms, an alkenyl group containing 3 to 8 carbon atoms, or a -C _n H _2n -R ^{12 group} , n being 0, 1, 2, 3 or 4, R is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic group being unsubstituted or substituted by 1 to 3 substituents selected from fluoro, chloro, trifluoromethyl, methyl, methoxy- and NR ¹³ R ¹⁴ , R ¹³ and R ¹⁴ represent a hydrogen atom, a (C 1 -C 4) alkyl group or a (C 1 -C 4) perfluoroalkyl group, Q R represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a perfluoroalkyl group having 1 to 4 carbon atoms, or R 1 and R 0 together represent 4 or 5 methyl groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, R is as R ^{@ 1} · or is hydrogen, hydroxy, fluorine, chlorine, bromine, iodine, cyano, nitro, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl 8 carbon atoms, an alkenyl radical containing 3 to 8 carbon atoms or -C _n H _2LL R ^15, n is 0, 1, 2, 3 or 4, R ¹⁵ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ^{1 S} R ^17, R ¹⁶ and R ¹⁷ represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a perfluoroalkyl group having 1 to 4 carbon atoms, or R ² is a heteroaryl group having 1 to 9 carbon atoms which is linked via carbon or nitrogen and which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methoxy, hydroxy a group, an amino group, a methylamino group, and a dimethylamino group; or R ² is SR ^18, -OR ^18, -NR ¹⁸ R ¹⁹ or -CR ¹⁸ R ¹⁹ R ^20, R represents -C _and H _2a -heteroaryl in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group , hydroxy, amino, methylamino and dimethylamino, and is 0, 1 or 2, R @ 1 and R @ 2 independently of one another are as defined for R @ ¹⁸ or are hydrogen, C1 -C4 alkyl or C1 -C4 perfluoroalkyl, or 276 R ² is R ²¹ -SO 2 or R ²² R ²³ N-SO 2, m is 1 or 2, R ²¹ is alkyl of l to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, an alkenyl radical containing 3 to 8 carbon atoms or ^- C _n H _2n -R ^24, n is 0, 1, 2, 3 or 4. R ²⁴ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ²⁷ R ²⁸ , R ²⁷ and R ²⁸ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 alkenyl or C _n H _2n R ²⁹ , n is 0, 1, 2, 3 or 4. R is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic group being unsubstituted or substituted by 1 to 3 substituents selected from fluoro, chloro, trifluoromethyl, methyl, methoxy- and NR ³⁰ R ³¹ , R ( ³⁰⁾ and R ( ³¹⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, R represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a perfluoroalkyl group having 1 to 4 carbon atoms, or R ²² and R ²³ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-sku277 Pina benzyl, or R ² is R ³³ -X-, X is O, S, NR ³⁴ , (D = O) A- or NR ³⁴ C = MN * R ³⁵ -, M represents an oxygen atom or a sulfur atom, A represents an oxygen atom or a group NR ³⁴ , D represents a carbon atom or an SO group, R is alkyl of 1 to 8 carbon atoms, alkenyl having 3 to 8 carbon atoms, (CH ₂₎ b ^C d ^F 2d + l or an -CrAn- ^»36; b is 0 or 1, d is 1, 2, 3, 4, 5, 6 or 7, n is 0, 1, 2, 3 or 4, R is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy- and NR ³⁷ R ³⁸ , R and R are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R ³⁵ is as R ³³ , or R ³³ and R ³⁴ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, N-Chg or N-benzyl, where A and N * are bonded to the phenyl a core of the benzoylguanidine backbone; or R ² is -SR ^40, -OR ^40, -NHR ^40, -NR ⁴⁰ R ^41, CHR ⁴⁰ R ^42, -CR ⁴² R ⁴³ OH, C »CR ⁴⁵ -CR ⁴⁶ -CR ⁴⁵ or - / cr ⁴⁷ r ⁴⁸ / u-co- (CR ⁴⁹ R ⁵⁰ / v R ⁴⁴⁾ , R ⁴⁸ and R ⁴¹ independently of one another denote the group "^ ^CH 2 ^ p (CHOH) q" (0 ') r "(CHOH) tR ^{51 and} - (CH 2) _p -O- (CH ₂ -CH ₂₎ 0) qR ⁵¹ 278 R ⁵¹ represents a hydrogen atom or a methyl group, u represents 1, 2, 3 or 4, v represents 0, 1, 2, 3 or 4, p, σ and r independently from each other represent 0, 1, 2, 3 or 4, t is 1, 2, 3 or 4, R ( ⁴²⁾ and R ( ⁴³⁾ independently of one another are hydrogen or (C1-C6) -alkyl or R ⁴² and R ⁴³ together with the carbon atom to which they are attached represent a C 3 -C 8 cycloalkyl group, R ⁴⁴ is H, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or -C _e H _2e -R ^45, e is 0, 1, 2, 3 or 4, R ⁴⁵ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁵² group R ⁵³ , R ( ⁵²⁾ and R ( ⁵³⁾ are hydrogen or (C1-C4) -alkyl or R ⁵⁴ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted as a phenyl group, or R ⁴⁵ represents an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups, R ( ⁴⁶⁾ , R ( ⁴⁷⁾ , R ( ⁴⁸⁾ , R ( ⁴⁹⁾ and R ( ^50), independently of one another, are hydrogen or methyl; or R ² is R ⁵⁵ -NH-SO ₂ -, R ⁵⁵ represents a group R ⁵⁶ R ⁵⁷ N- (C = Y, -, Y is O, S or NR ⁵⁸ , R ⁵⁶ and R ⁵⁷ independently of one another are hydrogen, C 1 -C 8 alkyl, C 3 -C 6 alkenyl or -C (H ₂ F ₎ ⁵⁹ 279 f is 0, 1, 2, 3 or 4, R ⁵⁹ represents a C 5 -C 7 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group and C 1 -C 4 alkyl group, or R ⁵⁶ and R ⁵⁷ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, R is as R or is an amidino group, R ³ , R ⁴ and R ⁵ are independently of one another as R ¹ or R ^2, wherein at least one of R ^2, R ^3, R ⁴ and R ⁵ has is a hydroxyl group, and a pharmaceutically-acceptable salt thereof, and h) a benzoylguanidine of the formula I, wherein one of the three substituents R ^1, R ^2, and R ³ represents a group R ⁶ -ABD, R ⁶ represents a basic protonatable radical, ie amino-group-NR ⁷ R ®, an amidino group R ⁷ R ⁸ NC (= NR ⁹ ) or a guanidino group of the general formula 280, 10 r ^ ⁿ R ⁷ , R ⁸ , R ⁹ and R ¹⁰ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or R ⁷ and R ⁸ together represent C _and H _2a , and are 4, 5, 6 or 7, and when a = 5, 6 or 7, one methylene group of C _and H _{2a may} be replaced by an oxygen atom, SO _m or NR ¹¹ ; R ⁸ and R ⁹ or R ⁹ and R ¹⁰ or R ⁷ and R ¹⁰ is ^C a ^H 2a 'a is 2, 3, 4 or 5, wherein, if a = 3, 4, or 5, can be, replace the methylene group of groups C _and H _2a with an oxygen atom, SO _m or NR ¹¹ , m being 0, 1 or 2, R ¹¹ represents a hydrogen atom or a methyl group or R ⁶ represents a basic heteroaromatic ring system containing 1 to 9 carbon atoms, A is C _b H _2b , b is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, and in the% H _2b group one or two methylene groups may be replaced by an oxygen atom group -C0-, -CH / OR ²⁰ / -, -SoM- group, -NR ²⁰ -, -NR ²⁰ CO-, -NR ²⁰ -CO-NH-, -NR ²⁰ -CO- NH-SO 2 -, a group of formula (O) _M aa -20 I-R NS- [NR ¹⁹ ] bb 281 and SO _aa (NR ¹⁹ ), wherein one further methylene group can be replaced by -CH-R ⁹⁹ and R ⁹⁹ together with R ^{7 form a} pyrrolidine or piperidine ring, aa is 1 or 2, bb is 0 or 1, aa + bb - 2 R ( ¹⁹⁾ is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, R ²⁸ represents a hydrogen atom or a methyl group, B represents a phenylene or naphthylene radical of the formulas R ¹² and R ¹³ independently of one another represent a hydrogen atom, a methyl group, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a trifluoromethyl group or a group -SO _W -R ¹⁴ , R ¹⁴ is methyl or NR ^{1 S} R ^16, R ( ¹⁵⁾ and R ( ¹⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, w is 0, 1 or 2, D is - ^C d ^H 2d - ^X fd is 0, X represents an oxygen atom, a -CO- group, a group -CH (OR ²¹ ) -, -SO ₂ - or -NR ²¹ -, f is 0 or 1, R is H or methyl, m is 0, 1 or 2, and the other substituents R ^1, R ² and R ³ independently of one another 282 represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an -NR ³⁵ R ³⁸ group or R ^17- CGH ₂ g _{of n} -, g is 0, 1, 2, 3 or 4, h is 0 or 1, R ( ³⁵⁾ and R ( ³⁸⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or R ³⁵ and R ³⁸ together are 4-7 methylene groups, of which one _CH2 group can be replaced by lic acid, by S, NH, _N-CH3 or -N-benzyl; Z is -O-, -CO-, -SO _{H -,} -NR ¹⁸ -, -NR ¹⁸ CO-, -NR ¹⁸ -CO-NR ¹⁸ NHalebo radical -SO ₂ -, R represents a hydrogen atom or a methyl group, v represents 0, 1 or 2, R represents a hydrogen atom, a cycloalkyl group containing 3, 5 or 6 carbon atoms or a group _{C1c F2k + 1} , k represents 1, 2 or 3, or T7 R represents a pyrrol-1-yl group, a pyrrol-2-yl group or a pyrrol-3-yl group which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, cyano- C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl, methyl and methoxy; or R represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group, -NR ³⁷ group R ³⁸ , CH ₃ SO ₂ and H ₂ NO ₂ S-, 283 R ³⁷ and R ³⁸ represent a hydrogen atom or a methyl group, R ⁴ and R ⁵ independently of one another are H, alkyl having 1, 2, 3 or 4 carbon atoms, F, Cl, -OR ^32, -NR ³³ R ³⁴ or C _r F _{2r + 1} , R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2 or 3 carbon atoms, r is 1, 2, 3 or 4 as well as pharmacologically acceptable salts thereof, and (ii) indenoylguanidine of the formula I in which R ¹ and R ² independently of one another are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms, O-alkyl having 1, 2, 3 or 4 carbon atoms, 0-0 (= O) - alkyl in which the alkyl moiety contains 1, 2, 3 or 4 carbon atoms, or a C _m H _{2 m} -NR ¹² R ^{13 group} , R ( ¹²⁾ and R ( ¹³⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, m is 0, 2, 3 or 4, NH-C (O) -NH ₂ , C ( = O) -O-alkyl in which the alkyl radical contains 1, 2, 3 or 4 carbon atoms, C (= O) -NH ₂ , C (= O) -NH-alkyl in which the alkyl radical contains 1, 2, 3 or 4 carbon atoms, A C (= O) -N (alkyl) ₂ group in which each alkyl radical contains 1, 2, 3 or 4 carbon atoms, an alkenyl group containing 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon284 carbon atoms, an alkynyl group containing 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, an alkylaryl group in which the alkyl moiety contains 1, 2, 3 or 4 carbon atoms, an alkenylaryl group in which an alkenyl radical containing 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, an alkynylaryl group in which the alkynyl radical contains 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms , aryl substituted with 1 to 4 carbon atoms, alkylheteroaryl in which the alkyl moiety contains 1 to 4 carbon atoms, alkenylheteroaryl in which the alkenyl moiety contains 2 to 4 carbon atoms, an aminoalkylaryl group in which the alkyl moiety contains 1 , 2, 3 or 4 carbon atoms, substit an aryl, heteroaryl, and substituted heteroaryl group, R ³ , R ⁴ , R ⁵ and R ^6, independently of one another, are hydrogen, alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, O-alkyl having 1 , 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, halogen atom such as fluorine atom, chlorine atom, bromine atom and iodine atom, aryl group, substituted aryl group, heteroaryl group, substituted heteroaryl group , O- (lower alkyl), O-aryl, O- (lower alkyl) -aryl, O-substituted aryl, O- (lower alkyl) -substituted aryl, O-C (= O) -alkylaryl in which the alkyl radical contains 1 to 4 carbon atoms, the O-C (= O) -NH-alkyl group in which the alkyl radical contains 1 to 4 carbon atoms, O-C (= O) -N (alkyl) ₂ , nitro, cyano, trifluoromethyl, NH-C (= O) -alkyl in which the alkyl moiety contains 1 to 4 carbon atoms, NH-C (= O) -NH ₂ , carboxylic acid C (= O) -NH-alkyl in which the alkyl moiety contains 1 to 4 carbon atoms, C (= O) -NH ₂ , C (= O) -NH-alkyl in which the alkyl moiety contains 1-4 carbon atoms, C (= O) -N (alkyl) ₂ , wherein each alkyl moiety contains 1-4 carbon atoms, alkyl-COOH, wherein the alkyl285 moiety contains 1-4 carbon atoms, alkyl -C (= O) -O-alkyl in which each alkyl radical contains 1 to 4 carbon atoms, SO 3 H, SO ₂ -alkyl, SO ₂ -alkylaryl, SO ₂ -N- (alkyl) ₂ , SO ₂ -N (alkyl) (aryl) alkyl, a C-OJ-R ^11, alkyl-C (= 0) -R ^11, in which the alkyl portion has 1 to 10 carbon atoms, alkenyl-C (= O) -R ¹¹ in which the alkenyl radical contains 2 to 10 carbon atoms, an alkynyl-C (= O) -R ¹¹ radical in which the alkynyl radical contains 2 to 10 carbon atoms, a NH-C (= O) -alkyl group -C (= O) -R ¹¹ , wherein the alkyl moiety the radical contains from 1 to 10 carbon atoms, the O-alkyl-C (= O) -R ^{11 group} in which the alkyl radical contains from 1 to 11 carbon atoms, R ¹¹ is alkyl of 1 to 4 carbon atoms, alkynyl of 1 to 4 carbon atoms, aryl, substituted aryl, NH _2, an alkyl group ΝΗ-containing 1 to 4 carbon atoms, N- (alkyl) ₂ »Wherein each alkyl radical contains 1 to 4 carbon atoms, SO ₃ H, SO ₂ -alkyl, SO ₂ -alkylaryl, SO ₂ -N- (alkyl) ₂ and SO ₂ -N- (alkyl) (alkylaryl), X represents an oxygen atom, a sulfur atom or an NH group, R ⁷ , R ⁸ , R ⁹ and R ¹⁰ independently of one another are hydrogen, alkyl, cycloalkyl, aryl, alkylaryl or R ⁸ and R ⁹ together form a 5, 6 or 7-membered heterocyclic ring, A is absent or is a non-toxic organic or mineral acid if: a) benzyloxycarbonylguanidine of formula I (I) 286 in which R ^{@ 1} , R ^{@ 2} and R @ ³ independently of one another represent --Y-- (4 - R @ ^{8 -} phenyl), --Y-- (3 - R @ ^{8 -} phenyl) or --Y-- (2 - R @ ^{8 -} phenyl) wherein the phenyl group is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group and -NR ⁹⁸ R ^{97 group} , R ( ⁹⁶⁾ and R ( ^97), independently of one another, are hydrogen or methyl; Y represents a bond, a CH ₂ group, an oxygen atom, a sulfur atom or an -NR ⁹ group, R ⁹ represents a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, R ⁸ is SO _and / NR ⁹⁸ / bNR ⁹⁹ R ¹⁰ , a is 1 or 2, b is 0 or 1, a + b = 2, R, R and R ^x independently of one another represent a hydrogen atom, an alkyl group containing 1 to 8 carbon atoms, a benzyl group, an -alkylene-NR ¹¹ R ^{12 group} in which the alkylene residue contains 2 to 8 carbon atoms, an alkylene-NR group ^13- alkylene-NR ³⁷ R ³⁸ wherein each alkylene radical contains 2 to 8 carbon atoms, or an alkylene-CR ³⁹ R ⁴⁰ -CR ⁴¹ R ⁴² -alkylene-NR ⁴³ R ⁴⁴ radical wherein each alkylene radical contains 2 to 8 carbon atoms; 8 carbon atoms, R ^{11 »1} R ^, R ^ ^1, R ^37, R ^38, R ⁴³ and R ⁴⁴ independently are H, alkyl having 1 to 8 carbon atoms or benzyl, R ( ³⁹⁾ , R ( ⁴⁰⁾ , R ( ⁴¹⁾ and R ( ^42), independently of one another, represent a hydrogen atom, an alkyl group containing 1 to 8 carbon atoms or an alkylenephenyl group in which the alkylene radical contains 2 or 3 carbon atoms, the phenyl being unsubstituted or substituted up to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group and methoxy group; or 287 .10 .99 4 to 6 methylene groups to be replaced by -NH-, _-N-CH3 ALERT ", and ^AU R together are one group of which oxygen, S, will -N-benzyl, or CH ₂ can R ⁸ is SOa / NR ⁹⁸ / bNR ⁹⁵ -C / -NR ⁹⁴ / -NR ⁹³ R ⁹² R ( ⁹²⁾ , R ( ⁹³⁾ , R ( ⁹⁴⁾ and R ( ⁹⁵⁾ independently represent a hydrogen atom or an alkyl group or, on the other, a radical containing from 1 to 4 carbon atoms R ¹ , R ² and R ³ pyrrol-1-yl pyrrol-3-yl substituted 1 independently one on the other represents a group, a pyrrol-2-yl group or a group which is unsubstituted or up to 4 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, cyano group, alkanoyl group containing 2 to 8 carbon atoms , C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl, methyl, methoxy or R, R, and ^Rj independently of one another are H, alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms or - (CH _{2) m} R ^14, m is 0, 1 or 2, R 4 represents a cycloalkyl group or a phenyl group ¹⁴ nu, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and -NR ¹⁵ R ¹⁶ , R ¹⁵ a R ¹⁶ represents a hydrogen atom or a methyl group; R, R and R independently of one another are -Q-4 - / _{(CH2) k} -CHR ¹⁷ - (C = O) R ²⁰ / phenyl group or a -Q-3 - / (CH2) k-CHR ¹⁷ - (C = O) R ^2Q / phenyl or -Q-2- / (CH 2) _k -CHR ¹⁷ - (CO) R ²⁰ / phenyl, wherein the phenyl group is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, hydroxy, methoxy, and -NR ³⁵ R ³⁶ , R ³⁵ and R ³⁶ independently of one another are hydrogen or methyl, Q is a bond, O, S or NR ^18, R ¹⁸ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, R ¹⁷ is -OR ²¹ or -NR ²¹ R ²² , R ²¹ and R ²² independently of one another are hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkanoyl, alkoxycarbonyl in which the alkyl radical contains 1 to 8 carbon atoms, benzyl, benzyloxycarbonyl or R ²¹ represents a trityl group, R ²⁸ is -OR ²³ or -NR ²³ R ²⁴ , R ²³ and R ^24, independently of one another, are hydrogen, C 1 -C 8 alkyl or benzyl, k is Q, 1, 2, 3 or 4 or R, R and R independently of one another are heteroaryl containing 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino a group, a methylamino group and a dimethylamino group; or R ¹ , R ² and R ³ are -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁶ , -CR ²⁵ R ²⁶ R ²⁷ , R represents a CFH _{2 f} -heteroaryl group wherein the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy, hydroxy a group, amino group, methylamino group and dimethylamino group, f represents 0, 1 or 2, 289 R ( ²⁶⁾ and R ( ²⁷⁾ independently of one another are as defined for R ( ²⁵⁾ or are hydrogen or (C1-C4) -alkyl, or R ¹ , R ² and R ^3, independently of one another, represent a heteroaryl-N-oxide group having 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino and dimethylamino; or R, R, and ^RJ independently of one another are -SR, -OR ²⁸ , -NR ²⁸ R ^29, or -CR ²⁸ R ²⁹ R ³⁰ , -C ₉ H ₂ -heteroaryl-N-oxide, wherein: the heteroaryl radical contains 1 to 9 carbon atoms and is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimeyl amino, g is 0, 1 or 2, R ³ and R ^USB independently of one another are as defined for R ²⁸ or are hydrogen or alkyl having 1 to 4 carbon atoms, or R ¹ , R ² and R ^3, independently of one another, are hydrogen, fluorine, bromine, iodine, cyano, R ³¹ SO 3 -, R ³² R ³³ N-CO-, R ³⁴ -CO- or R ⁴⁵ R ⁴⁶ N-SO ₂ , the perfluoroalkyl group being straight or branched, T represents a bond, an oxygen atom, a sulfur atom or an -NR ⁴⁷ group, 1 is 0, 1 or 2, h is 0, 1 or 2, i is 1, 2, 3, 4, 5 or 6, R ( ^31), R ( ^32), R ( ³⁴⁾ and R ( ^45), independently of one another, denote alkyl having 1 to 8 carbon atoms, alkenyl having 3 to 6 carbon atoms, 290 (CH _{2) n} R ⁴⁸ or trifluoromethyl, n is 0, 1, 2, 3 or 4, R ⁴⁷ represents a hydrogen atom or an alkyl group containing 1, 2 or 3 carbon atoms, R ⁴⁸ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ⁴⁹ R ⁵⁸ . R ( ⁴⁹⁾ and R ( ⁵⁸⁾ are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or R ( ³²⁾ , R ( ³⁴⁾ and R ( ⁴⁵⁾ are hydrogen, R ( ³³⁾ and R ( ⁴⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or R ³² and R ³³ as well as R ⁴⁵ and R ⁴⁶ together represent 5 or 6 methyl groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH ₃ group or an -N- group benzyl or R, R and R independently of one another are R ⁵¹ -AGD, R ⁵¹ represents a basic protonatable radical, i.e. amino group -NR ⁵² R ⁵³ , amidino group R ⁵² R ⁵³ -NC (= NR ⁵⁴ ) or guanidino group R ⁵² R ⁵³ NC / = NR ⁵⁴ / -NR ⁵⁵ -, R ⁵² , R ⁵³ , R ⁵⁴ and R ⁵⁵ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or 52 51 R and R is ^C alpha ^H 2.alpha. 'alpha' is 4, 5, 6 or 7, prions when the alpha '5, 6 and 7, it can be the date the carbon atom of C _and LFA ^H 2.alpha. ^refunds ený heterocyclic group selected from the group consisting of oxygen, SO ^ or NR ⁵⁶ or R ⁵³ and R ⁵⁴ or R ⁵⁴ and R ⁵⁵ or R ⁵² and R ⁵⁵ are CyH _2y , y is 2, 3, 4 or 5, wherein in the case of that y = 3, 4 or 5, then may be 291 day carbon atom of the group CyH _2y . replaced by a hetero group selected from O, SO 2 or NR ⁸⁸ , d is 0, 1 or 2, R ⁸⁸ represents a hydrogen atom or a methyl group or R ⁵¹ represents a basic heteroaromatic ring system containing 1 to 9 carbon atoms, A is C _e H _2e , e is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, wherein in C _e H _2e one carbon atom can be replaced by an oxygen atom, - CO-, -CH (OR ⁵⁷ ) -, -SO 2, -NR ⁸⁷ -CO-, -NR ⁵⁷ -CO-NH-, -NR ⁸⁷ -CO-NH-SO 2 -, or -NR ⁸⁷ -SO ₂ -, r is 0, 1 or 2, G is a phenyl radical of formula CQ CQ R and R ³ independently of one another are hydrogen, methyl, methoxy, fluoro, chloro, bromo, iodo, trifluoromethyl or a group -SO _p -R ^80, R ⁸⁰ represents methyl or NR ⁶¹ R ⁶² , R ⁸¹ and R ⁸² independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, D is -C _in H _{2 in} -E _w , v is 0, 1, 2, 3 or 4, E represents an oxygen atom, a -CO- group, a group -CH (OR ⁸³ ) -, -SO _aa - or -NR ⁸³ -, w is 0 or 1, and a is 0, 1 or 2, R ⁸³ represents a hydrogen atom or a methyl group, or R ¹ , R ² and R ³ independently of one another represent a group -CF ₂ R ⁶⁴ , -CF (R ^{65) (} R ⁶⁶ ), 292 -CF ((CF ₂ ) _q -CF ₃ ) (R ⁵ ), -C ((CF ₂ ) _p -CF ₃ ) = CR ⁶⁵ R ⁶⁶ , R ⁶⁴ represents an alkyl group having 1, 2,3 or 4 carbon atoms or a cycloalkyl group having 3, 4, 5, 6 or 7 carbon atoms, R ⁶⁵ and R ⁶⁶ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, g is 0, 1 or 2, p is 0, 1 or 2, or R, R * and ^RJ independently of one another represent -OR ° or -NR ⁶⁷ R ⁶⁸ , r ⁶⁷ and R ⁶⁸ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3, 4, 5 or Or 6 carbon atoms R ⁶⁷ and R ⁶⁸ together represent 4, 5, 6 or 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an SO ₂ group, an -NH- group, an -NCH ₃ group or an -N- benzyl, R ⁴ and R ^5, independently of one another, are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, fluorine, chlorine, -OR ⁶⁹ , -NR ⁷⁰ R ⁷¹ or C _of F _{2z + 1} , R ⁶⁹ , R ⁷⁰ and R ^71, independently of one another, are hydrogen or alkyl having 1, 2 or 3 carbon atoms, z is 1, 2, 3 or 4; R and R are, independently of one another, a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, X is O or NR ⁷² , R represents a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, and a) alkenylcarboxylguanidine bearing fluorophenyl groups of the general formula I 293 in which R ⁶ represents a hydrogen atom, a C 1 -C 8 alkyl group, a C 3 -C 8 cycloalkyl group or a phenyl group wherein the phenyl group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group , methyl, methoxy and NR ⁹ R ¹⁰ , R ⁹ and R ¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R ⁷ is each independently defined as R ^6, R ^1, R ^2, R ^3, R ⁴ and R ⁵ independently of one another are hydrogen or F, wherein at least one of R ^1, R ^2, R ^3, R ⁴ and R ⁵ has is F, as and the pharmaceutically acceptable salts thereof, and m) a benzoylguanidine of the formula I wherein R ¹ is R ⁴ -SO _m or R ⁵ R ⁶ N-SO 2 m is 1 or 2, R ⁴ and R ^5, independently of one another, represent an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, an alkenyl group containing 3, 4, 5 or 6 carbon atoms, trifluoromethyl or - ^c n ^H 2n- ^{R 7} · n means 0, 1, 2, 3 or 4, R ⁸ represents a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, R ⁷ represents a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁸ R ^{9 group} , R ⁸ and R ⁹ are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, or R ^{5 is} also hydrogen or R ⁵ and R ⁸ together represent 4 or 5 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an NH group, an N-CH ₃ group or an N-benzyl group, or R ¹ is -O _p - (CH ₂ ) g - (CF ₂ ) _r -CF ₃ , p is 0 or 1, g is 0, 1 or 2, r is 0, 1, 2 or 3, or R ¹ is -SR ^10, -OR ^10, or -CR ¹⁰ R ¹² R ^1X, R ^10, R ¹¹ and R ¹² independently of one another are H, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, -C _g H _{2 grams} -cycloalkyl, wherein the cycloalkyl moiety contains 3 to 8 carbon atoms, or an aromatic system selected from the group consisting of pyridyl, pyrrolyl, quinolyl, isoquinolyl, imidazolyl or phenyl, s being 0, 1 or 2, wherein said aromatic systems are selected from pyridyl, pyrrolyl, quinolyl, isoquinolyl, imidazolyl and phenyl are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methoxy, hydroxy, amino, methylamino- a dimethylamino group, R ² is - _{(CH2) u} - (CF _{2) t} -CF _3, t is 0, 1, 2 or 3, u is 0 or 1, R ³ represents a hydrogen atom or independently has the meaning defined for R ¹ as well as its pharmaceutically acceptable salts, and an) a substituted guanidide of the formula I wherein at least one of R ¹ , R ² , R ³ , R ⁴ and R ⁵ represents a group ^-x a ~ ^Y b ^L n ^_u ' X is CR ¹⁸ R ¹⁷ , O, S or NR ¹⁸ , R ( ¹⁸⁾ , R ( ¹⁷⁾ and R ( ¹⁸⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms, and is 0 or 1, Y represents an alkylene group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, an alkylene-T group in which the alkylene residue contains 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, a T, T-alkylene group in which the alkylene radical contains 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, T represents an NR ²⁰ group, an oxygen atom, a sulfur atom or a phenylene group, wherein the phenylene group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom. 296 trifluoromethyl, methoxy and NR ²¹ R ²² , R ( ²⁰⁾ , R ( ²¹⁾ and R ( ²²⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms, b being 0 or 1, L is O, S, NR ²³ or C] _C H ₂ of the K is 1, 2, 3, 4, 5, 6, 7, 8, n is 0 or 1, U is NR ²⁴ R ²⁵ or an N-containing heterocyclic group containing 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, R ²⁴ and R ²⁵ independently of one another represent a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, a perfluoroalkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, or R ²⁴ and R ²⁵ together are 4 or 5 methylene groups, of which one CH ₂ may be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, N-containing heterocyclic group is bonded through nitrogen or carbon and is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ²⁷ R ²⁸ , R ( ²³⁾ , R ( ²⁷⁾ and R ( ²⁸⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms, and the other substituents R ^1, R ^2, R ^3, R ⁴ and R ⁵ independently of one another are hydrogen, F, Cl, cyano group, ° n ^C m ^H 2 m + 1 - the group -Op- (CH ₂ ) _g -CgF ₂ q _{+ 1} or n is 0 or 1, m is 0, 1, 2, 3, 4, 5, 6, 7 or 8, p is 0 or 1, 297 g stands for 1, 2, 3, 4, 5, 6, 7 or 8, s stands for 0, 1, 2, 3 or 4, r stands for 0, 1, 2, 3 or 4, R ¹⁸ represents a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group, wherein the phenyl group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR R group, R ¹¹ and R ¹² independently of one another are H, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms, 7 g of R, and R ^z independently of one another are hydrogen, F, Cl, Br, cyano, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, perfluoroalkyl having 1 2 3 4 5, 6, 7 or 8 carbon atoms, a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl methyl, methoxy, and NR ¹⁴ R ¹⁵ , R ( ¹⁴⁾ and R ( ¹⁵⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, and o) benzoylguanidine in general of formula I (I) 298 wherein at least one of R ¹ , R ^2, and R ³ is R ⁶ -C (OH) ₂ -, R ⁶ represents a perfluoroalkyl group containing 1, 2 or 3 carbon atoms which is straight or branched and the other substituents R ¹ , R ² and R ^3, independently of one another, represent a hydrogen atom, a hydroxy group, a fluorine atom, a chlorine atom, an atom bromine, iodine, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms or phenoxy - a group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a methyl group and a methoxy group or the other substituents R ¹ , R ² and R ^3, independently of one another, represent an alkyl-SO _{x group} , -CR ⁷ = CR ⁸ R ⁹ or -C aCR ⁹ , x being 0, 1 or 2, R ⁷ represents a hydrogen atom or a methyl group, R ⁸ and R ⁹ independently of one another represent a hydrogen atom, an alkyl group containing 1, 2, 3 or 4 carbon atoms, a cycloalkyl group containing 3, 4, 5, 6, 7 or Or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group and a methoxy group or other substituents R ¹ , R ² and R ³ independently of one another means phenyl, C _g H ₅ alkyl group in which the alkyl portion contains 1 to 4 carbon atoms, naphthyl, biphenylyl, quinolinyl, isoquinolinyl or imidazolyl, wherein the quinolinyl, isoquinolinyl or imidazolyl are bonded via carbon or a nitrogen atom and a phenyl group, a C _{g of} Hg-alkyl, naphthyl, biphenylyl, quinolinyl, isoquinolinyl and imidazolyl, The 299 group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group or other substituents R ¹ , R ² and R ³ independently of one another are SR ¹⁰ , -OR ¹⁰ , -CR ¹⁰ R ¹¹ R ¹² , R ¹⁰ is -CfH ₂ f -cycloalkyl wherein the cycloalkyl radical contains 3 to 8 carbon atoms, quinolinyl, isoquinolinyl, pyridinyl, imidazolyl or phenyl, said aromatic systems including quinolinyl, isoquinolinyl, pyridinyl imidazolyl and phenyl are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino and dimethylamino , f is 0, 1 or 2, R and R independently of one another have the meanings defined for R ¹⁰ or are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, R ⁴ and R ^5, independently of one another, are hydrogen, alkyl having 1, 2 or 3 carbon atoms, fluorine, chlorine, bromine, iodine, cyano, OR ¹³ , NR ¹⁴ R ¹⁵ , - (ch ₂ ) _n - (cf ₂ ) _o -cf ₃ R ¹³ , R ¹⁴ and R ^15, independently of one another, are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, n is 0 or 1, o is 0, 1 or 2, as well as pharmacologically acceptable salts thereof, and p) a sulfonamide of formula I 300 (I) N ' = O-R I 4 / N. Wherein at least one of the three substituents R ¹ , R ² and R ³ represents a benzoylguanidine group of the formula which is unsubstituted or substituted by 1 to 4 substituents on the phenyl moiety selected from the group consisting of 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, an alkenyl group containing 2, 3, 4, 5, 6, 7 or 8 carbon atoms, a - (CH ₂ ) _m -R ^{14 group} , a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, cyano, trifluoromethyl, R ²² SO 2 -, R ²³ R ²⁴ N-CO-, R ²⁸ -CO-, R ²⁶ R ²⁷ N-SO 2, -OR ³⁵ , -SR ^35, or -NR ³⁵ R ³⁶ , m is 0, 1 or 2, R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁵ R ¹⁶ R and R are, independently of one another, a hydrogen atom or a methyl group, 301 R ( ²²⁾ , R ( ²³⁾ , R ( ²⁵⁾ and R ( ²⁶⁾ independently of one another denote alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, (CH ₂ ) _n R ²⁹ or trifluoromethyl, n represents 0, 1, 2, 3 or 4, R ²⁹ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ³⁰ R ³¹ . R ( ³⁰⁾ and R ( ³¹⁾ are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or R ( ²³⁾ , R ( ²⁵⁾ and R ( ²⁶⁾ are hydrogen, R ²⁴ and R ²⁷ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or R ²³ and R ²⁴ as well as R ²⁶ and R ²⁷ together represent 5 or 6 methylene groups, one of which may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH ₃ group or an -N-benzyl group, R and R independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or R ³⁸ and R ³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, -CH ₃ group or -N-benzyl group or R ³⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, SO ² R ⁸ group, SO ² NR ⁶ R ⁷ group and -NR ³² R group ³³ , R ⁸ represents an alkyl group having 1, 2, 3, 4, 5 or 6 carbon atoms, R and R are, independently of one another, a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, R ( ³²⁾ and R ( ³³⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or R ³⁵ represents a heteroaryl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group and the other substituents R ¹ , R ² and R ³ independently of one another represent an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a (CH ₂₎ p R ¹⁰ p is 0, 1, 2, 3 or 4, R ¹⁰ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, -SO 2 NR ¹⁷ R ¹⁸ and -SO ² R ⁹ , R ( ¹⁷⁾ and R ( ¹⁸⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, Q R represents an alkyl group containing 1, 2, 3 or 4 carbon atoms or other substituents R ¹ and R ³ represent a hydrogen atom, R ⁴ is H or alkyl having 1, 2, 3 or 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, and g) benzoylguanidine of formula I II i O = S - R (D 303 in which R ¹ represents an alkyl group containing 1, 2, 3, 4, 5, 6, 7 7 fl or 8 carbon atoms or NR R, R ( ⁷⁾ and R ( ⁸⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, R ² is H, alkyl having 1, 2, 3, 4.5, 6, 7 or 8 carbon atoms or a -SO ₂ R ^9, R ⁹ is independently as defined for R ^1, R ³ represents a hydrogen atom, -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁸ or -CR ²⁵ R ²⁶ R ²⁷ , R ²⁵ represents a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethoxy a group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, or R ²⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, R ( ²⁸⁾ and R ( ^27), independently of one another, are as defined for R ( ²⁵⁾ or are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, R ⁴ is H, fluoro, chloro, bromo, iodo, hydroxy, cyano, trifluoromethyl, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms or - (CH _{2) m} R ^14, m is 0, 1 or 2, R ¹⁴ is C 3 -C 8 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from fluoro, chloro, trifluoromethyl, methyl, methoxy and -NR ¹⁵ R ¹⁶ , R ( ¹⁵⁾ and R ( ^18), independently of one another, are hydrogen or methyl, R ⁵ and R ⁸ independently of one another are H, alkyl having 1, 2, 3 or 4 carbon atoms, F, Cl, -OR ^32, -NR ³³ R ³⁴ or trifluoromethyl, R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, and pharmaceutically acceptable salts thereof, and (b) benzenedicarboxyldiguanidide of the formula I in which one of R ¹ , R ^2, R ³ and R ⁴ is a group -CO-N = C (NH ₂ ) ₂ and the other substituents R ¹ , R ² , R ³ and R ⁴ represent: R ¹ represents a hydrogen atom, an alkyl group containing 1, 2, 3 or 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, -OR ³² , -NR ³³ R ³⁴ or trifluoromethyl group, R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, R ² and R ⁴ independently of one another represent H, F, Cl, Br, I, 305 hydroxy, cyano, trifluoromethyl, -CO-N-C _{(NH2) 2,} alkyl having l, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl of 2, 3, 4, 5, 6, 7 or 8 carbon atoms or - (CH ₂ ) _n R ¹⁴ , m being 0, 1 or 2, R ¹⁴ is C 3 -C 8 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from fluoro, chloro, trifluoromethyl, methyl, methoxy and -NR ^{1 S} R ¹⁶ . R ¹⁵ and R ¹⁶ represent a hydrogen atom or a methyl group; R ² and R ^4, independently of one another are pyrrol-l-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of F, Cl, a bromine atom, an iodine atom, a cyano group, a C 2 -C 8 alkanoyl group, a C 2 -C 8 alkoxycarbonyl group, a formyl group, a carboxy group, a trifluoromethyl group, a methyl group and a methoxy group; or R ² and R ⁴ independently of one another are R ²² -SO ₂ -, R ²³ R ²⁴ N-CO-, R ²⁸ -CO- or R ²⁹ R ³⁰ N-SO ₂ 22 28 R and R independently of one another are methyl or trifluoromethyl, R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl; or R ² and R ⁴ independently of one another, are -OR ³⁵ or -NR ³⁵ R ^36, R and R ^JO independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, or R ³⁵ and R ³⁶ together form 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, -CH ₃ group or 306 N-benzyl, R ³ represents a hydrogen atom, -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁶ , -CR ²⁵ R ^{25 S} R ²⁷ , R ²⁵ represents a hydrogen atom, an alkyl group having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl a group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group; or R represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino- group a group and a dimethylamino group, R ²⁶ and R ²⁷ independently of one another have the meanings defined for R ²⁵ or are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, R ⁵ represents an alkyl group containing 1, 2, 3 or 4 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an X- (CH ₂ ) y-CF ₃ group or a phenyl group which is unsubstituted or substituted 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ⁸ R ^{7 group} , R ⁶ and R ⁷ independently of one another represent a hydrogen atom or a methyl group, X represents a bond or an oxygen atom, y represents 0, 1 or 2 as well as pharmaceutically acceptable salts thereof, and (a) a benzenedicarboxyldiguanidide of the formula I 307 wherein one of R ¹ , R ² , R ³ and R ⁵ is -CO-N = C (NH ₂ ) _2, and the other R ¹ , R ² , R ^3, and R ⁵ are: R ¹ and R ^5, independently of one another, are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, fluorine, chlorine, -OR ³² , -NR ³³ R ^34, or trifluoromethyl, R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, R ² represents H, F, Cl, Br, I, hydroxy, cyano, trifluoromethyl, -CO-N-C _{(NH2) 2,} alkyl having 1, 2, 3 , 4, 5, 6, 7 or 8 carbon atoms, an alkenyl group containing 2, 3, 4, 5, 6, 7 or 8 carbon atoms or - (CH ₂ ) _m R ¹⁴ , m being 0, 1 or 2, R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁵ R ¹⁶ . R ( ¹⁵⁾ and R ( ^16), independently of one another, are hydrogen or methyl; R ² is R ²² -SO ² -, R ²³ R ²⁴ N-CO-, R ²⁸ -CO or R ²⁹ R ³⁰ N-SO 2. R ²² and R ²⁸ independently of one another are methyl 308 or trifluoromethyl, R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl; or R ² is -OR ³⁸ or -NR ³⁸ R ³⁸ R ( ³⁸⁾ and R ( ³⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or R ³⁸ and R ³⁸ together represent 4 to 7 methylene groups, of which one CK ₂ group may be replaced by oxygen, sulfur, -NH-, -NCH ₃ or -N-benzyl, R ³ is H, -SR ^28, -OR ^28, -NR ²⁵ R ^26, -CR ²⁸ R ²⁸ R ^27, R ²⁸ represents a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl a group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group; or R represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by X to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino- group a group and a dimethylamino group, R ²⁸ and R ²⁷ independently of one another represent the meanings defined for R ²⁸ or represent a hydrogen atom or an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, R ⁴ is trifluoromethyl, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3 up to 8 carbon atoms or - (CH ₂ ) _m R ¹⁴ , m being 1 or 2, R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ^{1 S} R group ¹⁶ , R ( ¹⁵⁾ and R ( ^16), independently of one another, are hydrogen or methyl; R ⁴ represents a phenyl group which is unsubstituted or substituted by 2, 3, 4 or 5 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁵ R ¹⁶ R ¹⁵ and R ¹⁶ independently of one another represent a hydrogen atom or a methyl group, as well as pharmaceutically acceptable salts thereof, and (a) a diaryldicarboxyldiguanidide of the formula I wherein one of R ¹ , R ² , R ³ , R ⁴ and R ⁵ represents a group -co-n = c (nh ₂ ) ₂ , the other substituents R ¹ and R ⁵ independently of one another represent a hydrogen atom, an alkyl group containing 1,2, 3 or 4 carbon atoms, fluorine atom, chlorine atom, -OR ³² , -NR ³³ R ³⁴ or trifluoromethyl, R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, or 4 carbon atoms, 310 the other substituents R ² and R ⁴ independently of one another are hydrogen, fluoro, bromo, iodo, hydroxy, cyano, trifluoromethyl, -CO-N »C _(NH2) 2 <alkyl 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, 2, 3, 4, 5, 6, 7 or 8 carbon alkenyl or - (CH ₂ ) _m R ¹⁴ , m means 0, 1 or 2, R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁹ R ¹⁶ . R ¹⁵ and R ¹⁶ are hydrogen or methyl or the other substituents R ² and R ⁴ independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted 1-4 substituents selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl a group, a methyl group, a methoxy group or the other substituents R ² and R ⁴ represent a group R ²² -SO 2 -, a group R ²³ R ²⁴ N-CO, a group R ²⁸ -CO- or a group r ²⁹ r ³⁰ n -so 2, R and R independently of one another are methyl or trifluoromethyl, R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl or the other substituents R ( ²⁾ and R ( ⁴⁾ independently of one another are -OR ³⁹ or -NR ³⁹ R ³⁸ , R and R independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or 311 R ³⁵ and R ³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH 4 group or an -N-benzyl group, the last R ³ being an atom hydrogen, -OR ²⁵ , -SR ²⁵ , -NR ²⁵ R ²³ , -CR ²⁵ R ²³ R ²⁷ , R ²⁵ represents a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl R ²⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a radical, a methoxy group, a methyl group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group; a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, R ²⁶ and R ²⁷ independently of one another have the meanings defined for R ²⁵ or hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, one of R ³ , R ⁷ , R ⁸ , R ⁹ and R ¹⁰ represent a group -co-n = c (nh ₂ ) ₂ , the other substituents R ³ and R ¹⁰ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, fluorine atom, chlorine atom, -OR ¹³² , -NR ¹³³ R ¹³⁴ or trifluoromethyl, R ¹²² , R ¹³³ and R ¹³⁴ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, the other substituents R ⁷ and R ⁹ independently of one another represent a hydrogen atom, a fluorine atom, a chlorine atom, bromine, iodine, hydroxy, cyano, trifluoromethyl, -CO-N = C (NH ₂ ) ₂ , alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms , an alkenyl group containing 2, 3, 4, 5, 6, 7 or 8 312 carbon atoms or - (CH ₂ ) _mm R ¹¹⁴ , mm being 0, 1 or 2, R ¹¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹¹⁵ R ¹¹⁶ . R ¹¹⁵ and R ¹¹⁶ are hydrogen or methyl or the other substituents R ⁷ and R ⁹ independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted 1-4 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, cyano, C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl R ⁷ and R ⁹ are R ¹²² -SO ₂ -, R ¹²³ R ¹²⁴ N-CO-, R ¹²⁸ -CO- or _R 129 _R 130 _{N- S} Q _2r 122 128 R and R independently of one another are methyl or trifluoromethyl, R ¹²³ , R ¹²⁴ , R ¹²⁹ and R ¹³⁰ independently of one another are hydrogen or methyl or the other substituents R ⁷ and R ⁹ independently of one another are -OR ¹³⁵ or -NR ¹³⁵ R ¹³⁶ , R ( ¹³⁵⁾ and R ( ¹³⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms or R ¹³⁵ and R ¹³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen, sulfur, -NH-, -NCH ₃ or -N-benzyl group, the last R ⁸ being an atom hydrogen, -SR ¹²⁵ , -OR ¹²⁵ , -NR ¹²⁵ R ¹²⁶ or 313 -CR ¹²⁵ R ¹²⁶ R ¹²⁷ R ¹²⁵ represents a hydrogen atom, an alkyl group having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl a group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group; or R ¹²⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group - a group and a dimethylamino group, R and R ^A 'independently of one another represent the meanings defined for R ¹²⁵ or represent a hydrogen atom or an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, A is absent or is -NR ¹¹ -CO-, -NR ¹² -CO-NR ¹³ -, -NR ¹⁷ -CO-NR ¹⁸ -SO ₂ -, NR ¹⁹ -SO ₂ -, -SO ₂ -NR ¹⁹ -SO 2, -SO 2 -NR ¹⁹ -CO-, -O-CO-NR ¹⁹ -SO 2 - or -CR ²⁰ = CR ²¹ -, R ^11, R ^12, R ^13, R ^17, R ^18, R ^19, R ²⁰ and R ²¹ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, as well as pharmaceutically acceptable salts thereof, and (au) a substituted thiophenylalkenylcarboxylguanidide of formula I (I) 314 wherein at least one of R ^1, R ² and R ³ is a group -0p- (CH2) p-CgF2q + i, an R ⁴⁰ CO- group or R ³¹ -SOk-, p is 0 or 1, p is Q, 1, 2, 3, or 4, q is 1, 2, 3, 4, 5, 6, 7, or 8, k is 0, 1, or 2, R ⁴⁰ represents an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, a perfluoroalkyl group containing 1, 2, 3, 4, 5, S, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine , trifluoromethyl, methyl and methoxy, R ³¹ represents an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, perfluoroalkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which: is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group or methoxy group; or R ³¹ represents NR ⁴¹ R ⁴² , R ( ⁴¹⁾ and R ( ⁴²⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, perfluoroalkyl having 1, 2, 3 or 4 carbon atoms or R ⁴¹ and R ⁴² together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, and the other substituents R ^1, R ² and R ^3, independently of one another represent H, F, Cl, Br, I, cyano, -O ^ Cmax ^ l + m or the group g ° ^C RAH R _{2 R} ^10, or represents 0 1 315 m and is 0, 1, 2, 3, 4, 5, 6, 7 or 8, and g is 0 or 1, and r is 0, 1, 2, 3, or 4, R ¹⁰ represents a cycloalkyl group having 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group, the phenyl group being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group and methoxy, R ⁴ and R ⁵ independently of one another are hydrogen, fluorine, chlorine, bromine, iodine, cyano, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, a perfluoroalkyl group having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, a cycloalkyl group having 3, 4, 5, 6, 7 or 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁴ R ^{15 group} , R ( ¹⁴⁾ and R ( ¹⁵⁾ independently of one another are hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or perfluoroalkyl having 1, 2, 3 or 4 carbon atoms as well as their pharmaceutically acceptable salts; substituted benzoylguanidine of formula I (I) 316 in which R ² and R ³ independently of one another, H, Cl, Br, alkyl having 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms or a radical -OR ^5, R ⁵ represents an alkyl group having 1 to 8 carbon atoms or -O-Η ₂ ^-cycloalkyl group in which the cycloalkyl radical contains 3 to 8 carbon atoms, d represents 0, 1 or 2, each of which R and R are each ^J represents a hydrogen atom, but simultaneously both R ² and R ³ do not represent a hydrogen atom, as well as its pharmaceutically acceptable salts, and x) a benzoylguanidine of the formula I in which: R ¹ represents H, F, Cl, Br, I, cyano, nitro, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkoxy containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms, a cycloalkoxy group containing 3, 4, 5, 6, 7 or 8 carbon atoms or X _and - (CH ₂ ) (CF ₂ ) _c -CF ₃ , X is O, S or NR ^5, and a is 0 or 1, b is 0, 1 or 2, 317c is 0, 1, 2 or 3, R ⁵ is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or -C _d H _2d -R ⁶ , d is 0, 1, 2, 3 or 4, R ^{6 is} cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms, phenyl, biphenylyl or naphthyl, said aromatic comprising phenyl, biphenylyl or naphthyl being unsubstituted or substituted by 1 to 3 substituents selected from; a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an NR R group, R ⁷ and R ⁸ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or R ¹ -SR ^10, -OR ^10, or -CR ¹⁰ R ¹¹ R ^12, R ¹⁰ represents -CfH ₂ f -cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms in the cycloalkyl ring or phenyl group, wherein the phenyl group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, atom chloro, trifluoromethyl, methoxy, methyl, hydroxy, amino, methylamino and dimethylamino, f is 0, 1 or 2, R ¹¹ and R ¹² independently of one another are as defined for R ¹⁰ or are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or R ¹ represents a phenyl group, a naphthyl group, a biphenylyl group or a heteroaryl group having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, the latter being bonded via a carbon or ring nitrogen atom and said groups are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino and dimethylamino; or 318 R ¹ is -SR ¹³ , -OR ¹³ , -NHR ¹³ , -NR ¹³ R ¹⁴ , -CHR ¹³ R ¹⁵ , C / R ¹⁵ R ^{1 S} OH /, -C 'CR ¹⁸ -C / R ¹⁹ /' CHR ¹⁸ -C / R ²⁰ R ²¹ / K (CO) - / CR ²² R ^23/1 -R ²⁴ , k represents 0, 1, 2, 3 or 4, 1 is 0, 1, 2, 3 or 4, R ¹³ and R ¹⁴ , which are the same or different, represent - (CH 2) g - (CHOH) h - (CH 2) 1 - (CHOH) j R ¹⁷ or - (CH 2) _g -O- (CH ₂ -CH) ₂ O) _h -R ²⁴ R ¹⁷ represents a hydrogen atom or a methyl group, g, h and i, which are the same or different, represent 0, 1, 2, 3 or 4, j is 1, 2, 3 or 4, R ¹⁵ and R ¹⁶ , which are the same or different, represent a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5 or 6 carbon atoms or together with the carbon atom to which they are attached represent a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms, T fi R is phenyl which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy and NR ^{2 S} R ^26, R ( ²⁵⁾ and R ( ²⁶⁾ are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or R ( ¹⁸⁾ is heteroaryl having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms which is unsubstituted or substituted as phenyl; or T_8 R is alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxyl groups, or R ¹⁸ is cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms, R ¹⁹ , R ²⁰ , R ²¹ , R ²² and R ²³ , which are the same or different, represent a hydrogen atom or a methyl group, R ( ²⁴⁾ is hydrogen, alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms, 319 is -C (11) -R ( ¹⁸⁾ , m is 1, 2, 3 or 4, R ² and R ³ are defined as R ^1, R ⁴ represents an alkyl group containing 1, 2, 3 or 4 carbon atoms, as well as pharmaceutically acceptable salts thereof, and y) an ortho-substituted benzoylguanidine of the formula I in which: R ¹ represents H, F, Cl, Br, I, cyano, nitro, alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkoxy having 1, 2, 3,4, 5, 6, 7 or 8 carbon atoms, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms or X _a - (-CB) -CCFj _{b) a} -CF ₃ , X is O, S or NR ^5, and a is 0 or 1, b is 0, 1 or 2, c is 0, 1, 2 or 3, R ⁵ represents a hydrogen atom, an alkyl group containing 1, 2, 3 or 4 carbon atoms or a -C 1 H _{2 group (} R ⁶ , d represents 0, 1, 2, 3 or 4, R ⁶ represents a cycloalkyl group having 3, 4, 5, 6, 7 or 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, said aromatic groups comprising a phenyl group, a biphenylyl group and a naphthyl group being unsubstituted or substituted by 1 to 3 substituents selected 320 from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁷ R ^{8 group} , R ⁷ and R ⁸ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or R ¹ is -SR ¹⁰ , -OR ^10, or -CR ¹⁰ R ¹¹ R ¹² R ¹⁰ is -C _f H _2f -cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms in the cycloalkyl ring, or phenyl, where phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of F , a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, f represents 0, 1 or 2, R ¹¹ and R ¹² independently of one another are as defined for R ¹⁰ or are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms or R ¹ represents a phenyl group, a naphthyl group, a biphenylyl group or a heteroaryl group having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, the latter being bonded via a carbon or ring nitrogen atom and said groups are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group, or R ¹ is -SR ¹³ , -OR ¹³ , -NHR ¹³ , -NR ¹³ R ¹⁴ , -CHR ¹³ R ¹⁵ , -C (R ¹⁵ R ¹⁶ OH), -CaCR ¹⁸ , -C (R 1) R ¹⁹ = CHR ¹⁸ , -C (R ²⁰ R ²¹ ) k - (CO) - (CR ²² R ²³ ) -R ²⁴ , k is 0, 1, 2, 3 or 4, 1 is 0, 1, 2, 3 or 4, R ¹³ and R ¹⁴ , which are the same or different, represent 321 nu - (CH ₂ ) g - (CHOH) _h - (CH ₂ ) (CHOH) j -R ¹⁷ or - (CH ₂ ) _g -O- ( CH ₂ CH ₂ O) _h -R ^24th R ¹⁷ represents a hydrogen atom or a methyl group, g, h and i, which are the same or different, represent 0, 1, 2, 3 or 4, j is 1, 2, 3 or 4, R ¹⁵ and r ¹⁵ , which are the same or different, represent a hydrogen atom, an alkyl group containing 1, 2, 3, 4, 5 or 6 carbon atoms or together with the carbon atom to which they are attached represent a cycloalkyl group containing 3, 4, 5, 6, 7 or 8 carbon atoms, R ¹⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ²⁵ R ^{26 group} , R ²⁵ and R ²⁶ represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or R represents a heteroaryl group containing 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms which is unsubstituted or substituted as phenyl or R ¹⁸ represents an alkyl group having 1, 2, 3, 4, 5 or 6 carbon atoms which is unsubstituted or substituted by 1 to 3 hydroxy groups, or R ¹⁸ represents a cycloalkyl group containing 3, 4, 5 , 6, 7 or 8 carbon atoms, R ¹⁹ , R ²⁰ , R ²¹ , R ²² and R ²³ , which are the same or different, represent a hydrogen atom or a methyl group, R ²⁴ represents a hydrogen atom, an alkyl group having 1, 2, 3, 4, 5 or 6 carbon atoms, a cycloalkyl group having 3, 4, 5, 6, 7 or 8 carbon atoms or a -C _m H _2m -R ^{18 group} , m is 1, 2, 3 or 4, one of R ² and R ³ is hydroxy and the other R ² and R ³ have the meanings defined for R ¹ , R ⁴ is an alkyl group containing 1, 2, 3 or 4 carbon atoms, alkoxy group containing 1, 2, 3 or 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, atom 322 iodine or - (CH ₂ ) _n '(CF ₂ ) o ^CF 3' n is 0 or 1, o is 0 or 1, and pharmaceutically acceptable salts thereof, II) compounds of the general formula in which W, Y and Z are nitrogen or carbon substituted with R ² or R ³ or R ⁴ , R ¹ represents a hydrogen atom, A, a halogen atom, a trifluoromethyl group, -CH ₂ , -CH ₂ F, -CH ₂ CF ₃ , -C ₂ F ₅ , cyano, nitro, ethynyl or X-R ' A represents an alkyl group having 1 to 6 carbon atoms, a halogen atom means a fluorine atom, a chlorine atom, a bromine atom or an iodine atom, X represents an oxygen atom, a sulfur atom or a group NR ' ¹ , R * ¹ represents a hydrogen atom, A or a cyclic methylene chain containing 3 to 7 carbon atoms, R 'represents a hydrogen atom, A, HO-A, HOOC-A-, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 6 to 8 carbon atoms, trifluoromethyl, CH ₂ F, CH ₂ - CF ₃ , Ph, -CH ₂ -Ph or Het, Ph represents an unsubstituted, one, two or three times substituted phenyl, naphthyl or biphenylyl group, the substituents being selected 323 from the group consisting of A, OA, NR'R ' ¹ , Hal and trifluoromethyl, Het means a mono- or di-core, saturated or unsaturated or aromatic group containing 1 to 4 heteroatoms selected from the group consisting of nitrogen, oxygen and / or sulfur, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, trifluoromethyl, A, hydroxy, OA, -X-R ', cyano, nitro and CO-O, wherein Het is bonded via a nitrogen atom or an alkylene chain ^c m ^H 2m' wherein m represents 0, 1, 2, 3, 4, 5 and 6 or R 'and R * ¹ together represent an alkylene group containing 4 or 5 carbon atoms, one of which CH ₂ may be replaced by oxygen, sulfur, NH, NA, N-Ph or N-CH ₂ -Ph . R and R independently of one another are hydrogen, halogen, A, HO-A, X-R ', -C (= N-OH) -A, AO-CO-alkyl, in which the alkyl radical it contains 1 to 4 carbon atoms, cyano, nitro, carboxy, substituted with A, in particular trifluoromethyl, CH ₂ F, CHF ₂ , C ₂ F ₅ , CH ₂ CF ₃ or SiO 4); ¹ ', R ' ¹ ' is A, Ph or -Het, n is 0, 1 or 2 or 2 5 R and R independently of one another are SO ₂ NR'R '', Ph, O-Ph, _O-CH2 -Ph, -CO-A, -CHO, -COO, a - CSNR'R ' ¹ , CONR'R' ¹ , CH-CH-COOH, -CH = CH-COOA, indenyl, indanyl, decahydronaphthyl, cyclopentenyl, dihydrothenyl, dihydrofuryl, heterobicyclyl, alkylthienyl a halothienyl group, a haloalkylthienyl group, an acylthienyl group, a halofuryl group, a haloalkyl furyl group or a pyrrolyl group; or R a. R independently of one another represents a group R ^with -O-, R ⁵ represents a hydrogen atom, A, an alkenyl group having from 344 to 1 to 6 carbon atoms or a cycloalkyl group having from 3 to 7 carbon atoms, R ⁴ is Ph, Het, Het--Ο, trifluoromethyl, a group SiO) ^ ''', -Si ^ NR c R ^1, Alk or R = R 1 or two of the substituents R ¹ to R ⁴ together represent -O-CR ⁶ R ⁷ -CO-NR ⁸ or a group of formula or a group of the formula wherein R ² has the abovementioned meaning, R ⁶ , R ⁷ , R ⁸ and R ⁹ independently of one another are hydrogen or A or R ⁸ is C 5 -C 7 cycloalkyl or R ⁹ is cyano, Alk represents a straight or branched alkyl group having 1 to 8 carbon atoms or a cycloalkyl group having 3 to 8 carbon atoms which is unsubstituted or mono-, di- or trisubstituted by the substituent A, or Alk represents ethenyl or ethynyl substituted with substituents selected from the group consisting of hydrogen, A, Ph or Het; III) an indoylguanidine derivative of the general formula wherein: R ² is H, unsubstituted or substituted 328 alkyl having 1 to 8 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, hydroxy, alkyl-O- in which the alkyl moiety contains 1 to 6 carbon atoms, aromatic group or -CH ₂ -R ²⁸ . R ²⁰ represents a C 2 -C 6 alkenyl group or a C 2 -C 6 alkynyl group, R ¹ represents 1 to 5 identical or different substituents which are hydrogen, unsubstituted or substituted alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 up to 7 carbon atoms, halogen, nitro, alkanoyl of 2 to 8 carbon atoms, arylalkanoyl of up to 10 carbon atoms, aroyl of up to 11 carbon atoms, carboxyl, alkoxycarbonyl of 2 to 6 carbon atoms, aromatic a group and any of the following groups: -OR ³ , -NR ⁶ R ⁷ or -S (O) _n R ⁴⁰ , R ³ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a substituted alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, an aromatic group, a -CH ₂ R ^{30 group} , R ³⁸ is alkenyl or alkynyl, R ⁶ and R ⁷ independently of one another are hydrogen, unsubstituted or substituted C 1 -C 8 alkyl, C 3 -C 7 cycloalkyl, C 2 -C 8 alkanoyl atoms, an arylalkanoyl group containing up to 10 carbon atoms, an aroyl group containing up to 11 carbon atoms, an aromatic group or a -CH ₂ -R ⁶⁸ - group, R is C 2 -C 6 alkenyl or C 2 -C 6 alkynyl Or 329 carbon atoms; R ⁶ and R ⁷ together with the nitrogen atom represent a 5- to 7-membered cyclic amine group which may contain further heteroatoms in the ring, n being 0, 1 or 2, R ⁴⁸ represents an unsubstituted or substituted C 1 -C 8 alkyl group or an aromatic group or group A is O, -S (O) _n - or -NR ⁵⁸ -, R ⁵⁸ represents a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms, R 'represents a hydrogen atom, an unsubstituted or substituted alkyl group having 1 to 8 carbon atoms, which represents a saturated 3- to 8-membered heterocyclic group having one nitrogen atom, and said substituted alkyl group bears one or more groups selected from a halogen atom a hydroxy group, an alkoxy group having 1 to 6 carbon atoms, a cyano group, a carboxyl group, an alkoxycarbonyl group having 2 to 6 carbon atoms, an alkanoyl group having 2 to 8 carbon atoms, an arylalkanoyl group having up to 10 carbon atoms, containing not more than 11 carbon atoms, an aromatic group or a -CO ⁴ R ^{5 group} , R ⁴ and R ⁵ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms, R ⁴ and R ⁵ together represent a 5- to 7-membered cyclic amine group which may contain additional hetero330 atoms in the ring, or said substituted alkyl group carries a -A-CH group E — R in which E represents a nitrogen atom or a CH group, R ' ¹ represents a hydrogen atom, an unsubstituted or hydroxy-substituted alkyl group having 1 to 8 carbon atoms or a substituted alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a cyano group, a carboxyl group, an alkoxycarbonyl group 2 to 6 carbon atoms, alkanoyl of 2 to 8 carbon atoms, aralkanoyl of up to 10 carbon atoms, aroyl of up to 11 carbon atoms, aromatic group, -NR ⁶ R ⁷ , -CONR ⁴ R ⁵ , R ⁴ and R ^5, independently of one another, represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms, wherein the cyclic system -A-CH 2 represents a 3- to 8-membered saturated aliphatic or heterocyclic ring system with nitrogen atom and said aromatic groups means an aryl group having at most 10 carbon atoms, a 5- or 6-membered heteroaryl group having 1 to 4 nitrogen atoms, a 5 or 6-membered heteroaryl group having 1 or 2 nitrogen atoms and one heteroatom selected from oxygen and sulfur or a furyl group, and said aryl groups are unsubstituted or substituted with an unsubstituted alkyl group containing 331 C 1 to 8 carbon atoms or substituted alkyl having 1 to 8 carbon atoms, halogen, nitro, alkoxycarbonyl, carboxyl, -OR, NRR, -CONR ⁴ R ⁵ , -SO ² NR ⁶ R ^7, or the S (O) n R ^{40 group} , wherein R ¹ and the guanidinocarbonyl radical may be present at any point in the 5- or 6-membered ring of the indole system, as well as pharmaceutically acceptable salts thereof, IV) a heterocyclic guanidine derivative of the general formula wherein: X is O, S, -NH-, -N (alkyl) - in which the alkyl radical contains 1 to 4 carbon atoms, or -N (phenyl) -, R ¹ , R ² and R ³ are hydrogen, halogen, C 1 -C 4 alkyl, alkyl-Ο- in which the alkyl radical contains 1 to 4 carbon atoms, phenyl, benzyl or two of the substituents R ¹ , R ² and R ³ together with the side of the benzene system denote a 4- and 6-membered carbocyclic ring, R ⁴ and R ⁵ independently of one another represent a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a benzhydryl group, an aralkyl group which is unsubstituted or substituted by one or more substituents selected from the group consisting of a halogen atom, an alkyl group containing 1 to 4 carbon atoms, an alkyl-O- group in which the alkyl radical contains 1 to 4 carbon atoms, a trifluoromethyl group, or 332- (CH ₂ ) _m - CH ₂ -T, m being 0-3 T is -CO-OT ¹ , T ¹ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, Cy represents a benzo-fused unsaturated or dihydro-5-membered heterocycle of formula pyrazole or imidazole ring of formula or formula naphthyl or dihydro- or tetrahydronaphthyl means nitrogen or CH, thienyl group 333 pin formula R ⁶ represents a hydrogen atom, a halogen atom, a hydroxy group, an alkyl group containing 1 to 10 carbon atoms, an alkyl-O group in which the alkyl group contains 1 to 10 carbon atoms, a phenoxy group, an alkyloxymethyloxy group in which the alkyl group contains 1 up to 10 carbon atoms or - (O) _n SR ⁹ , R ⁹ represents an alkyl group having 1 to 10 carbon atoms, a thienyl group, a pyridyl group, a thiazolyl group, a thiadiazolyl group, an imidazolyl group, a pyrazolyl group or a phenyl group which are unsubstituted or mono- or double-substituted by halogen atom; carbon atoms or an alkyl-Ο- group in which the alkyl radical contains 1 to 4 carbon atoms, R and R are hydrogen, halogen, hydroxy, C 1 -C 10 alkyl, C 1 -C 10 alkyl, phenyl, phenoxy or alkoxymethyloxy- a group in which the alkoxy radical is 1 to 10 carbon atoms; or Cy represents a phenyl group which is unsubstituted or substituted once or twice by a halogen atom, an alkyl group containing 1 to 4 carbon atoms or an alkyl-Ο- group in which the alkyl radical contains 1 to 4 carbon atoms, or Cy is -Gr-Am, Gr is -R ¹³ -R ¹² (CH ² ) _g C / W ² / W ¹ - (CH 2) _q , R ¹³ R ¹⁴ - or -R ¹⁵ -, R ¹² represents a single bond, an oxygen atom, - (O) _n S-, -CO- or -CONH-, 334 R ¹³ represents a single bond, a phenyl group, a thienyl group, a pyridyl group, a thiazolyl group, a thiadiazolyl group, an imidazolyl group or a pyrazolyl group, R ¹⁴ represents a single bond or a SO ₂ - group, R ¹⁵ represents a C 2 -C 10 alkenyl or C 2 -C 10 alkynyl group, W and W ¹ independently of one another, H or alkyl having 1 to 4 carbon atoms, or W and W ¹ , which are cyclically bonded to each other, are a hydrocarbon ring of 3 to 8 carbon atoms, q and q * are 0 or 1 to 9, Am is -NR 4 R ¹¹ , R ¹⁰ is H, alkyl of 1 to 4 carbon atoms or benzyl, R ¹¹ is C 1-4 alkyl, phenyl or benzyl, or R ¹⁰ and R ¹¹ together represent C 3 -C 10 alkylene which is unsubstituted or substituted by carboxyl, alkoxycarbonyl, in which the alkyl moiety contains 1 to 5 carbon atoms, a hydroxyalkylene group containing 2 to 4 carbon atoms or a benzyl group, or Am represents a pyrrolyl group, a pyridyl group, a pyrazolyl group, a morpholinyl group, a dihydropyridyl group, a tetrahydropyridyl group, a quinuclidinyl group, an imidazolyl group, /3.2.1/ an octyl group which is unsubstituted or substituted by an alkyl group containing 1 to 4 carbon atoms, or Am represents an azabicyclo [3.2.2] nonyl group, or Am represents a piperazine group of the general formula 335 R ¹⁶ represents a hydrogen atom, a C 1 -C 4 alkyl group, a C 3 -C 6 cycloalkyl group, a phenyl group, a tolyl group, a methoxyphenyl group, a halophenyl group, a diphenylmethylene group, a benzyl group or a pyridyl group or Am represents an azido group - (O) _t - (CH ₂ ) q C / W / yw ¹ - (CH ₂ ) gi-N ₃ , t means 0 or 1, wherein W and W ¹ have the meanings given above, as well as its optical enantiomers and pharmacologically acceptable salts thereof. Use according to claim 1, characterized in that it is used r) a benzene-fused 5-membered heterocycle of formula I wherein: X represents a nitrogen atom or a CR ⁸ group, Y is O, S or NR ^7, A, B together represent a bond or A, B are both hydrogen when both X is CR ⁸ and Y is NR ⁷ , one of R ¹ to R ⁸ is -CO-N = C- (NH ₂ ) ₂ and the other R is ¹ to R ⁸ are hydrogen, fluoro, chloro, bromo, iodo or C 1 -C 6 alkyl, up to two other substituents R ¹ to R ⁸ are cyano, nitro, N ₃ , alkyloxy obsa336 exceeding 1 to 4 carbon atoms or trifluoromethyl, not more than one of the other substituents ^{R 8} is the group - ^C n ^H 2n, n is ^from 0 or 1 to 10, wherein the alkyléncvá group is straight or branched and the carbon is replaced by an oxygen atom, a sulfur atom or a nitrogen atom, R ⁸ represents a hydrogen atom, a C 2 -C 6 alkenyl group or a C 3 -C 10 cycloalkyl group which is unsubstituted or substituted by 1 to 4 methylene groups or a hydroxy group or which may contain an ethylene group CH 2 CK, one methylene group the group may be replaced by an oxygen or sulfur atom or a nitrogen atom, or R ⁸ represents a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, trifluoromethylene group, CH 3 -S (O) s- or R ⁹ -Wy- , s is 0, 1, or 2, R ⁹ represents a hydrogen atom, a methyl group or an ethyl group, W represents an oxygen atom or an NR ¹⁰ group, R ¹⁰ represents a hydrogen atom or a methyl group; y represents 0 or 1; R ⁸ is C _m F 2m + 1 m is 1 to 3 or R ⁸ is 1- or 2-naphthyl, pyridyl, quinolyl or isoquinolyl, Z is -C0-, a group -CH ^ - or - / CR ¹¹ (OH) / _q -, g is 1, 2 or 3, R ¹¹ represents a hydrogen atom or a methyl group, or Z is oxygen or -NR ¹² -, 337 R ¹² represents a hydrogen atom or a methyl group, or Z is -S (O) _g -, s is 0, 1 or 2, or Z is -SO ₂ -NR ¹³ R ¹³ is hydrogen or (C 1 -C 4) -alkyl, R ⁷ is H, alkyl of 1 to 10 carbon atoms, alkenyl of 2 to 10 carbon atoms or a radical R ⁸ -C _{n 2n-f} and a pharmaceutically acceptable salt thereof, v) acylguanidine of the general formula I in which: X represents a carbonyl group or a sulfonyl group, R ¹ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms which is unsubstituted or substituted by a hydroxy group, a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluoro, chloro, trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino or dimethylamino, R represents a hydrogen atom, an alkyl group containing 1 to 4 carbon atoms, and pharmaceutically acceptable salts thereof, 338 w) phenyl-substituted alkylkarboxylguanidid carrying perfluoroalkyl groups of the formula I, in which Ra is hydrogen, fluoro, chloro, bromo, iodo, cyano, OR ^6, alkyl of 1 to 8 carbon atoms, cycloalkyl group having 3 to 8 carbon atoms, 0 _{r (CH2) a} ^C b ^F 2b + l ^but ^ ° NR ⁷ R ^8, r is 0 or 1, a is 0, 1, 2, 3 or 4, b means 1, 2, 3, 4, 5, 6, 7 or 8, R ⁶ represents a hydrogen atom, a C 1 -C 8 alkyl group, a C 3 -C 8 alkenyl group, a C 3 -C 8 cycloalkyl group, a phenyl group or a benzyl group, said aromatic groups being substituted or unsubstituted, wherein: when substituted, they are substituted with 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ⁹ R ¹⁰ , R ⁹ and R ¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R ⁷ and R ⁸ independently of one another have the meanings given for R ⁶ , R ® independently has the meanings given for r \ X is 1, 2 or 3, R ¹ is H, alkyl of 1 to 8 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, _t -0 (CH _{2) d} C _e F _{2e + 1,} ru fluó339 atom, chlorine atom, bromine atom, iodine or cyano, t is 0 or 1, d is 0, 1, 2, 3 or 4, e is 1, 2, 3, 4, 5, 6, 7 or 8, R ² , R ³ , R ⁴ and R ⁵ independently of one another are as defined for R ¹ , but with the proviso that at least one of R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ^a and R -Ofc ^b is (CH2) ^<c j e ^F 2e + L _r ^or O (CH _{2) a} C] ₃ F _{2b + 1,} and a pharmaceutically-acceptable salt thereof, y) a bicyclic heteroarylguanidine of the general formula I wherein T, U, V, W, X, Y and Z independently of one another are nitrogen or carbon, but with the proviso that X and Z do not simultaneously represent a nitrogen atom that T, U, V, W, X, Y and Z bear no substituents when they are nitrogen, and that no more than four of them simultaneously are nitrogen, R ¹ and R ² independently of one another represent H, F, Cl, Br, I, alkyl having 1 to 3 carbon atoms, perfluoroalkyl of 1 to 3 carbon atoms, OR ^8, NR ⁸ R ⁹ or C (= O) N = C (NH ₂ ) ₂ , 8 9 R ⁷ and R ⁷ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, or 340 R® and R ⁹ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl; R ³ , R ⁴ , R ⁵ , R ⁶ and R ^7, independently of one another, represent a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a group Xk- (CH 2) p - (CaFg + 1) )> -SObm radical R ^10, R ^{10 b} R ^{10 c} N-CO group, R ^l CO-or a group R ¹² R ¹³ N-SO ₂ -, wherein the perfluoroalkyl group is straight or branched, X is O, S or NR ^14, R ¹⁴ is H or alkyl of 1 to 3 carbon atoms, bm = 0, 1, or 2, p is 0, I or 2, k is 0 or 1, g is 1, 2, 3, 4, 5 or 6, _R 10 _{and fR} 10b _fR 11 _ar 12 _than independently, an of one another are alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 3 to 6 carbon atoms, - CnH ₂ n - ^{R 15} or a perfluoroalkyl group having 1 to 8 carbon atoms, n being 0, 1, 2, 3 or 4, R ¹⁵ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁶ R ^{17 group} , R ¹⁶ and R ¹⁷ represent a hydrogen atom or a (C 1 -C 4) alkyl group or R (16) R ( ¹¹⁾ and R ( ¹²⁾ are hydrogen, R ( ^10c) and R ( ¹³⁾ independently of one another are hydrogen or (C1-C4) -alkyl or R ^10b and R ^10c, and R ¹² and R ¹³ together are 4 or 5 methylene groups, of which one methylene group can be replaced by oxygen, S, NH, N sku341 _Pina-CH3 or N-benzyl, R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another denote an alkyl group having 1 to 8 carbon atoms, _And C] _H ₂ j R ^18, or an alkenyl radical containing 3 to 8 carbon atoms, al is 0, 1 or 2, R ¹⁸ is C 3 -C 8 cycloalkyl, phenyl, biphenylyl or naphthyl, said aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy -group and NR ¹⁹ R ¹⁹ ^. R ( ^19a) and R ( ¹⁹ * ³⁾ are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a heteroaryl group containing 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of comprising a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group or a dimethylamino group, or R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a group or a (C) - (CHOH) - (CH ₂ ) - (CHOH) -Ŕ group or a group -Y Y- 342 Y represents an oxygen atom, a sulfur atom or the group -NR ²² h, ad, and h independently of one another represent 0 or 1, i, j, k, ae, af, ag, ao, ap and if independently of one another represent 0, 1, 2, 3 or 4, where h, although not simultaneously 0, ad, ae and g do not simultaneously mean 0 and ah, and o and if not simultaneously 0, R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁵⁾ and R ( ^22), independently of one another, represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, or R ³ , R ⁴ , R ⁸ , R ⁶ and R ⁷ independently of one another represent SR ²⁹ , -OR ³⁰ , -NR ³¹ R ³² or -cr ³³ r ³⁴ r ³⁸ , R ^29, R ^30, R ³¹ and R ³³ independently of one another are -C _a H _2a -heteroaryl radical, wherein the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group and a dimethylamino group, and is 0, 1 or 2 R ( ³²⁾ , R ( ³⁴⁾ and R ( ³⁸⁾ independently of one another have the meanings defined for R ( ²⁹⁾ or are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl; or R ³ , R ⁴ , R ⁸ , R ⁶ and R ⁷ independently of one another represent a group -W or a group 343 or a group W- R ( ⁹⁸⁾ , R ( ⁹⁷⁾ and R ( ⁹⁸⁾ independently of one another denote a heteroaryl group containing 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine , trifluoromethyl, methyl, methoxy, hydroxy, amino, methylamino, dimethylamino or benzyl, W represents an oxygen atom, a sulfur atom or an NR ³⁸ - group, R ³⁸ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, or R ³ , R ⁴ , R ⁸ , R ⁸ and R ⁷ independently of one another represent a group R ^{4 8} X ¹ X ¹ represents an oxygen atom, a sulfur atom, a group NR ⁴⁷ , a (D = O) A- group or a group NR ⁴⁸ C = MN * R ⁴⁹ -, M represents an oxygen atom or a sulfur atom, A represents an oxygen atom or a NR ⁸⁰ group, D represents a carbon atom or an SO group, R ⁴⁸ is C 1 -C 8 alkyl, C 3 -C 8 alkenyl, (CH ₂ ) _b C _d F _{2d + 1} or b is 0 or 1, d is 1, 2, 3, 4 , 5, 6 or 7, x is 0, 1, 2, 3 or 4, R ⁸¹ represents a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group, a biphenylyl group or a naphthyl group, the aromatic groups being unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy- sku344 pin and NR ⁵² R ⁵³ R ⁵² and R ⁵³ are H, alkyl having 1 to 4 carbon atoms or perfluoroalkyl of 1 to 4 carbon atoms, R 47 R 48 _N 50 _than independently, an of one another are H, alkyl having 1 to 4 carbon atoms, or a perfluoroalkyl group containing 1 to 4 carbon atoms, R ⁴⁹ is as defined for R ⁴⁶ , R ( ⁴⁶⁾ and R ( ⁴⁷ ) and R ( ⁴⁶⁾ and R ( ⁴⁸⁾ together are 4 or 5 methylene groups, of which one CHg may be replaced by oxygen, sulfur, NH, N-CHg or N-benzyl, where A and N * are bound to the phenyl core of the basic heteroaroylguanidine backbone or R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent -SR ⁶⁴ , -OR ⁶⁵ , -NHR ⁶⁶ , -NR ⁶⁷ R ⁶⁸ , -CHR ⁶⁹ R ⁷⁰ or -CR ⁵⁴ R ⁵⁵ OH, -C «CR ⁵⁶ , -CR ⁵⁸ = CR ⁵⁷ or - / CR ⁵⁹ R ⁶⁰ / U-CO- / CR ⁶¹ R ⁶² / VR ⁶³ , R ⁶⁴ , R ⁶⁵ , R ⁶⁶ , R ⁶⁷ and R ⁶⁹ , which are the same or different, represent a group - _(CH2) y (CHOH) ₂ - (CH _{2) aa} - (CHOH) _t -R ⁷¹ or a group - (CH ₂ ) ab - ° - (CH ₂ -CH ₂ O) _and -R ⁷² , 71 72 R and R independently of one another represent a hydrogen atom or a methyl group, u represents 1, 2, 3 or 4, v represents 0, 1, 2, 3 or 4, y, z, and a which are the same or different represent 0 , 1, 2, 3, or 4, t is 1, 2, 3, or 4, R ⁶⁸ , R ⁷⁰ , R ⁵⁴ and R ⁵⁵ , which are the same or different, represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or R ⁶⁹ and R ⁷⁰ and R ⁵⁴ and R ⁶⁵ together together with the carbon atom to which they are attached represent a cycloalkyl group containing 3 to 8 carbon atoms, R ⁶³ represents a hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, a cycloalkyl group containing 345 C 3 to 8 carbon atoms or -C _e H _2e " ^{R 7} 3 e" denotes 0, 1, 2, 3 or 4, R ⁵⁶ , R ⁵⁷ and R ^73, independently of one another, represent a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ⁷⁴ R ^{75 group} . R ( ⁷⁴⁾ and R ( ⁷⁵⁾ are hydrogen or (C1-C4) -alkyl or R ⁵⁶ , R ⁵⁷ and R ^73, independently of one another, are a heteroaryl group which is unsubstituted or substituted as a phenyl group, R ⁵⁸ , R ⁵⁹ , R ⁶⁰ , R ⁶¹ and R ⁶² are hydrogen or methyl; R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent R ⁷⁶ -NH-SO ₂ -, R ⁷⁶ , R ⁷⁷ R ⁷⁸ N- (C-Y ') Y 'represents an oxygen atom, a sulfur atom or a group NR ⁷⁹ , R ⁷⁷ and R ⁷⁸ which are the same or different, represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 3 to 6 carbon atoms ΟΛ atoms or CFH ₂ £ R, f is 0, 1, 2, 3 or 4, R ⁸⁰ represents a cycloalyl or phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methoxy group and an alkyl group having 1 to 4 carbon atoms, or R ⁷⁷ and R ⁷⁸ together are 4 or 5 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, N-CH3 or N-benzyl; R ⁷⁹ is as R ⁷⁷ or is an amidino group; R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently of one another represent a group NR ^84a R ⁸⁵ , OR ^84b , SR ^84c or u 84d ^c n ^H 2 n ^R n is 0, 1, 2, 3 or 4, 346 R ^84d represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, 17-pin methoxy group and NRR group . R ¹⁶ and R ¹⁷ represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R ( ^84a) , R ( ^84b) , R ( ^84c) and R ( ^85), independently of one another, are hydrogen, alkyl of 1 to 8 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms or (CH ₂ ) _x -R ⁸⁴ R, 0, 1, 2, 3 or 4 R ⁸⁴ S represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and a NR ^{84u group} . R ( ^84u) and R ( ^84v) are hydrogen or (C1-C4) -alkyl or R ^84a and R ⁸⁵ together are 4 or 5 methylene groups, of which one CH ₂ group can be replaced by oxygen, S, NH, _N-CH3 or N-benzyl, and the pharmaceutically acceptable salts thereof, and b phenyl substituted alkenylcarboxylguanidide which carries the perfluoroalkyl groups of formula I 347 in which R ^A represents a hydrogen atom, a fluorine atom, a bromine atom, an iodine atom, a cyano group, a hydroxy group, an OR ⁶ group, a C 1 -C 8 alkyl group, an O _r (CH ₂ ) group _{and a} ^c b ^F 2b + 1 'cycloalkyl NR ⁷ R ⁸ , r is 0 or 1, and is 0, 1, 2, 3 or 4, b is 1, 2, 3, 4, 5, 6, 7 or 8, R ⁶ represents an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group or a benzyl group, said aromatic groups being unsubstituted or substituted by 1 to 3 carbon atoms selected from fluorine, chlorine, trifluoromethyl, methyl, methoxy or 5 methylene, CH ₂ may be replaced by N-CH ₃ or a pin and NR ⁹ R ¹⁰ , R ⁹ and R ¹⁰ are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, R and R independently of one another have the meanings given for R ⁶ or R ⁷ and R ⁸ together represent of which one oxygen, sulfur, NH, N-benzyl, independently of the meanings given for R ^A is 0, 1 or 2, represents 0, 1 or 2, represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, an OR ¹² group, an alkyl group containing 1 to 8 carbon atoms, an O _p (CH ₂ ) group _f C _g F _{2G + 1,} or cycloalkyl having 3 to 8 carbon atoms, p is Q or 1, f is 0, 1, 2, 3 or 4, 348 g means 1, 2, 3, 4, 5, 6, 7 or 8, R ¹² is C 1 -C 8 alkyl, C 1 -C 4 perfluoroalkyl, C 3 -C 8 alkenyl, C 3 -C 8 cycloalkyl, phenyl or benzyl, wherein said aromatic groups include phenyl or benzyl are unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹³ R ^{14 group} , R ¹³ and R ^14, independently of one another, are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, D C R independently has the meanings given for R, R ¹ is H, alkyl of 1 to 8 carbon atoms, _t -0 (CH ₂₎ d ^C e ^F 2e + I 'cycloalkyl having 3 to 8 carbon atoms, F, Cl, Br, I or cyano, t is 0 or 1, d is 0, 1, 2, 3 or 4, e is 1, 2, 3, 4, 5, 6, 7 or 8, O * 3 yi c R, R, R and ^R independently of one another are as defined for R ^1, but with the proviso that at least one of R ^A, R ^B, Η ⁰ ^ ⁰ ^ ¹ ^ ² ^ ⁴ or R ⁵ is the group Or (CH 2) a ^c b ^F 2b + 1 '' Op (CH ₂ ) _f C _g F _{2 g + 1} - or O _t (CH ₂ ) d ^c e ^F 2e + 1 - ^and _r ^{3 is} not 0 _t ( CH ₂ ) _d C _e F _{2 e + 1} - as well as pharmaceutically acceptable salts thereof, (h) benzoylguanidine of the formula I 349 wherein one of the three substituents R ¹ , R ² and R ³ represents a group R ⁶ -ABD, R ⁶ represents a basic proton telephony moiety, i.e. the amino group -NR ⁷ R ⁸ , the amidino group R ⁷ R ⁸ NC (= NR ⁹ ) or the guanidino group of the formula ⁷ by ¹⁰ ff FT R ⁷ , R ⁸ , R ⁹ and R ¹⁰ independently of one another represent a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms or R ⁷ and R ⁸ together represent a group ^c and ^H 2a 'and is 4, 5, 6 or 7, provided that when a = 5, 6 or 7, then one methylene group of groups C _and H _2a may be replaced by an oxygen atom, a SO ₂ group or a group NR ¹¹ , or R ⁸ and R ⁹ or R ⁹ and R ¹⁰ or R ⁷ and R ¹⁰ is ^C a ^H 2a 'a is 2, 3, 4 or 5, wherein, if a = 3, 4 and 5, it can be one methylene group of groups C _and H _2a replaced by oxygen, SO _m or NR ¹¹ , m being 0, 1 or 2, R ¹¹ represents a hydrogen atom or a methyl group or R ⁶ represents a basic heteroaromatic ring system containing 1 to 9 carbon atoms, A is C ^H H ^, 350b is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, and in group C _b H _2b one or two methylene groups may be replaced by a group selected from O, -CO- , -CH / OR ²⁰ / -, -S0m- group, -NR ²⁰ -CO-, -NR ²⁰ -CO-NH-SO 2, a group of formula (L) aa -R NS- (DB ¹⁹ l _bb- ¹⁹ / uu, aa -SO _aa / NR ^x / _bb , in group C _b H _2b one methylene group may be replaced by -CH-R ⁹⁹ , where R ⁹⁹ together with R ⁷ forms a pyrrolidine or piperidine ring, aa means bb means aa + bb = 2, R ¹⁹ means cu 1, 2, 3 and: R ²⁰ means B means NYCHA formulas R ¹² and R ¹³ independently of one another represent a hydrogen atom, a methyl group, a fluorine atom, a chlorine atom, an iodine atom, a bromine atom, a trifluoromethyl group or a group -so _w -r R ¹⁴ is methyl or NR ¹⁵ R ¹⁶ , R ( ¹⁵⁾ and R ( ¹⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms, 351 w means 0, 1 or 2, D is -C 1-6 - Xf-1 d is 0, 1, 2, 3 or 4, X is O, -CO-, -CH (OR ²¹ ) -, -SO _m - or -NR ²¹ , f is 0 or 1, R ²¹ is a hydrogen atom or a methyl group, m is 0, 1 or 2, and the other substituents R ¹ , R ² and R ³ independently of one another are hydrogen, fluorine, bromine, iodine, cyano, alkyl of 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms, -NR ³⁵ R ³⁶ radical or ^RL7 - ^c gH2g- ^of ms is 0, 1, 2, 3 or 4, h is 0 or 1, R ( ³⁵⁾ and R ( ³⁶⁾ independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, or R ³⁵ and R ³⁶ together are 4-7 methylene groups, of which one _CH2 group can be replaced by oxygen, S, -NH-, -NCH ₃ or -N-benzyl; Z is -O-, -CO-, -SO _V, -NR ^18, -NR ¹⁸ -CO-NH- or -NR ¹⁸ -SO ₂ -, A 1 * R represents a hydrogen atom or a methyl group, v represents 0, 1 or 2, R ¹⁷ represents a hydrogen atom, a cycloalkyl group containing 3, 5 or 6 carbon atoms or a C group _to F _{2k + 1} -, k represents 1, 2 or 3, or R ¹⁷ represents a pyrrol-1-yl group, a pyrrol-2-yl group or a pyrrol-3-yl group which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine atom, iodine atom, cyano - a group having from 2 to 8 carbon atoms, a alkoxycarbonyl having from 2 to 8 carbon atoms, a formyl group, 352 carboxy, trifluoromethyl, methyl and methoxy; R ¹⁷ represents a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 carbon atoms from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group, - NR ³⁷ R ³⁸ , CH ₃ SO ₂ and H ₂ NO ₂ S-, R ³⁷ and R ³⁸ represent a hydrogen atom or a methyl group, R ⁴ and R ⁵ independently of one another are H, alkyl having 1, 2, 3 or 4 carbon atoms, F, Cl, -OR ^32, -NR ³³ R ³⁴ or a group ^C ~ r ^F 2r + I ' R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or alkyl having 1, 2, 3 carbon atoms, r is 1, 2, 3 or 4, and their pharmacologically acceptable salts, and (i) indenoylguanidine of the formula I in which η o R and R independently of one another represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an O-alkyl group having 1 to 4 carbon atoms, a group O-C (= O) -alkyl wherein the alkyl moiety contains 1 to 4 carbon atoms, or a ^C m ^H 2m ^{-NR 12} R ¹³ , R ^{12 and} R ^{13 group} independently of one another 353 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and m is 0, 2, 3 or 4, furthermore an NH-C (= O) -NH ₂ group, a C (= O) -O-alkyl group having 1 to 4 carbon atoms 4 carbon atoms, C (= O) -NH ₂ , C (= O) -NH-alkyl in which the alkyl moiety contains 1 to 4 carbon atoms, C (= O) -N- (alkyl) ₂ wherein each alkyl moiety contains 1 to 4 carbon atoms, an alkenyl group containing 1 to 10 carbon atoms, an alkynyl group containing 2 to 10 carbon atoms, an alkylaryl group wherein the alkyl moiety contains 1 to 4 carbon atoms, an alkenylaryl group in which an alkenyl radical having 2 to 10 carbon atoms, an alkynylaryl group in which the alkynyl radical contains 2 to 10 carbon atoms, an aryl group substituted with an alkyl group having 1 to 4 carbon atoms, an alkylheteroaryl group in which the alkyl radical contains 1-4 carbon atoms, alkenyl heteroaryl in which the alkenyl radical contains 1-4 carbon atoms, aminoalkylaryl in which the alkyl radical contains 1-4 carbon atoms, substituted aryl, heteroaryl and substituted heteroaryl, R ³ , R ⁴ , R ⁵ and R ⁶ independently of one another represent a hydrogen atom, an alkyl group containing 1 to 10 carbon atoms, an O-alkyl group containing 1 to 10 carbon atoms, a halogen atom such as a fluorine atom, a chlorine atom, an atom bromo and iodo, hydroxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, O- (lower alkyl), O-aryl, O- (lower alkyl) aryl, O-substituted aryl O- (lower alkyl) -substituted aryl, O-C (1O) -alkylaryl in which the alkyl moiety contains 1 to 4 carbon atoms, O-C (0O) -NH-alkyl in which the alkyl radical contains 1 to 4 carbon atoms, OC (= O) -N- (alkyl) ₂ , nitro, cyano, trifluoromethyl, amino, NH-C (»O) -NH ₂ , a carboxyl group, 354 A C (= O) -O-alkyl group in which the alkyl moiety contains 1 to 4 carbon atoms, a C (= O) -NH _{2 group} , A C (= O) -NH-alkyl group wherein the alkyl moiety contains 1 to 4 carbon atoms, a C (= O) -N- (alkyl) ₂ moiety wherein each alkyl moiety contains 1 to 4 carbon atoms, alkyl-COOH in which the alkyl radical contains 1 to 4 carbon atoms, the alkyl-C (= O) -O-alkyl group in which each alkyl radical contains 1 to 4 carbon atoms, the SO ₃ H, SO ₂ -alkyl group , SO ₂ -alkylaryl, SO ₂ -N- (alkyl) ₂ , SO ₂ -N- (alkyl (alkylaryl), C (= O) -R ¹¹ , alkyl-C (= O) -R ¹¹ in which the alkyl radical contains 1 to 10 carbon atoms, an alkenyl-C (= O) -R ¹¹ radical in which the alkenyl radical contains 2 to 10 carbon atoms, an alkynyl-C (= O) -R ¹¹ radical, wherein the alkynyl radical contains 2 to 10 carbon atoms, the NH-C (= O) -alkyl-C (= O) -R ^{11 group} , wherein the alkyl radical contains 1 to 10 carbon atoms, the O-alkyl-C (= »O) -R ¹¹ wherein the alkyl the residue contains 1 to 11 carbon atoms, R ¹¹ is alkyl of 1 to 4 carbon atoms, alkynyl of 1 to 4 carbon atoms, aryl, substituted aryl, amino, NH-alkyl having 1 to 4 carbon atoms, N- (alkyl) ₂ - wherein each alkyl radical contains 1 to 4 carbon atoms, SO 3 H, SO ₂ -alkyl, SO ₂ -alkylaryl, SO ₂ -N- (alkyl) ₂ , SO ₂ -N- (alkyl) -alkylaryl X represents an oxygen atom, a sulfur atom or an NH group, R ⁷ , R ⁸ , R ⁹ and R ¹⁰ independently of one another are hydrogen, alkyl, cycloalkyl, aryl, alkylaryl or R ⁸ and R ⁹ together are part of a 5-, 6- or 7-membered heterocyclic ring, A is absent or is a non-toxic organic or mineral acid And (ak) a benzyloxycarbonylguanidine of formula I wherein R ^{@ 1} , R ^{@ 2} and R @ ³ independently of one another represent --Y-- (4 - R @ ^{8 -} phenyl), --Y-- (3 - R @ ^{8 -} phenyl) or --Y-- (2 - R @ ^{8 -} phenyl) /, where the phenyl radical is unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, hydroxy, methoxy and -NR R ^JO, R ( ⁹⁶⁾ and R ( ^97), independently of one another, are hydrogen or methyl, Y represents a bond, a CH ₂ group, an oxygen atom, a sulfur atom or an -NR ⁹ group, R ⁹ represents a hydrogen atom or an alkyl group containing 1, 2, 3 or 4 carbon atoms, R ⁸ is SO _and / NR ⁹⁸ / NR ⁹⁹ R ¹⁰ , a is 1 or 2, b is 0 or 1, a + b = 2, R ^98, R ⁹⁹ and R ¹⁰ independently of one another are H, alkyl having 1 to 8 carbon atoms, benzyl group, -alkylene-NR ¹¹ R ^12, in which the alkylene radical contains from 2 to 8 carbon atoms, alkylene -NR ¹³ -alkylene-NR ³⁷ R ³⁸ , wherein each alkylene residue contains 2 to 8 carbon atoms, or an alkylene-CR ³⁹ R ⁴⁰ -CR ⁴¹ R ⁴² -alkylene-NR ⁴³ R ^{44 group} , wherein each alkylene residue contains 2 to 8 carbon atoms, R ( ¹¹⁾ , R ( ¹²⁾ , R ( ¹³⁾ , R ( ³⁷⁾ , R ( ³⁸⁾ , R ( ⁴³⁾ and R ( ^44), independently of one another, represent a hydrogen atom; 356 8 carbon atoms or a benzyl group, R ( ³⁹⁾ , R ( ⁴⁰⁾ , R ( ⁴¹⁾ and R ( ^42), independently of one another, represent a hydrogen atom, an alkyl group containing 1 to 8 carbon atoms or an alkylene phenyl group in which the alkylene radical contains 2 or 3 carbon atoms, the phenyl radical being unsubstituted or substituted 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl and methoxy; or R ⁹⁹ and R ¹⁰ together are 4-6 methylene groups, of which one _CH2 group can be replaced by O, NH, S, _-N-CH3 or -N-benzyl; or R (R) represents a group SO _a / NR ⁹ ® _b NR ⁹⁹ -C / -NR ⁹⁴ / -NR ⁹³ R ⁹² , R ( ⁹²⁾ , R ( ⁹³⁾ , R ( ⁹⁴⁾ and R ( ⁹⁵⁾ independently of one another are hydrogen or (C1-C4) -alkyl or R, R and R independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine, chlorine, a bromine atom, an iodine atom, a cyano group, a C 2 -C 8 alkanoyl group, a C 2 -C 8 alkoxycarbonyl group, a formyl group, a carboxy group, a trifluoromethyl group, a methyl group and a methoxy group; or R, R and R independently of one another are hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl or - (CH ₂ ) _n R ¹⁴ , m is 0, 1 or 2, R ¹⁴ represents a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy- a group -NR ^{1 S} R ^16, 357 R ( ¹⁵⁾ and R ( ¹⁸⁾ are hydrogen or methyl; R ¹ , R ² and R ^3, independently of one another, represent -Q-4 / (CH 2) _k -CHR ¹⁷ - (C 10 O) R ²⁰ / -phenyl or -Q-3 / (CH 2) _k -CHR ^17- (C 10 O) R ²⁰ / -phenyl or the group -Q-2 / (CH ₂ ) _to -CHR ¹⁷ - (C = O) R ²⁰ / -phenyl, wherein the phenyl residue is unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, hydroxy group, methoxy group and -NR ³⁵ R ^{38 group} , R ³⁵ and R ^{38 are,} independently of one another, a hydrogen atom or a methyl group, Q represents a bond, an oxygen atom, a sulfur atom or -NR, R ¹⁸ represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, R ¹⁷ is -OR ²¹ or -NR ²¹ R ²² , R ²¹ and R ²² independently of one another are hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkanoyl, alkoxycarbonyl in which the C 1 -C 8 alkoxy radical, benzyl, benzyloxycarbonyl or R ²¹ represents a trityl group, R ²⁰ is -OR ²³ or -NR ²³ R ²⁴ , R ²³ and R ^24, independently of one another, are hydrogen, C 1 -C 8 alkyl or benzyl, k is 0, 1, 2, 3 or 4, or R, R and R independently of one another represent a heteroaryl group having 1 to 9 carbon atoms which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group , methyl, methoxy, hydroxy, amino, methylamino and dimethylamino, or R ¹ , R ² and R ³ represent a group -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁸ , a group 358 -CR ²⁵ R ²⁸ R ²⁷ R ²⁵ represents a -C ₍ H ₂₎ f-heteroaryl group in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy, hydroxy, amino, methylamino and dimethylamino, f is 0, 1 or 2, R ²⁸ and R ²⁷ independently of one another have the meanings given for R ²⁵ or are hydrogen or C 1 -C 4 alkyl or R ¹ , R ² and R ³ independently of one another denote a heteroaryl-N-oxide group in which the heteroaryl radical contains 1 to 9 carbon atoms, which is bonded via a carbon or nitrogen atom and which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group, or R ^1, R ² and R ³ independently of one another are -SR ^28, -OR ^28, -NR ²⁸ R ²⁹ or -CR ²⁸ R ²⁹ R ^30, R ²⁸ represents a group _G-2 -CgH heteroaryl- N-oxide in which the heteroaryl radical contains 1 to 9 carbon atoms and which is unsubstituted or substituted by a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group, a hydroxy group, an amino group, a methylamino group or dimethylamino group, g is 0, 1 or 2, R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are as defined for R ( ²⁸⁾ or are hydrogen or (C1-C4) -alkyl or R, R and R are, independently of one another, a hydrogen atom, a chlorine atom, a fluorine atom, a bromine atom, an iodine atom, a cyano group, a T- (CH ₂ ) _h - (C ₁ F _{2 + 1} ) group, R ³¹ SO ₁ , R ³² R ³³ N-CO-, R ³⁴ -CO- or 359 R ⁴⁵ R ⁴⁸ N-SO ₂ , wherein the perfluoroalkyl group is straight or branched, T represents a bond, an oxygen atom, a sulfur atom or an -NR ⁴⁷ group, 1 is 0, 1 or 2, h is 0, 1 or 2, i is 1, 2, 3, 4, 5 or 6, R ( ³¹⁾ , R ( ³²⁾ , R ( ³⁴⁾ and R ( ⁴⁵⁾ independently of one another are C 1 -C 8 alkyl, C 3 -C 6 alkenyl, (CH ₂ ) _n R ⁴⁸ or trifluoromethyl, n being 0, 1, 2, 3 or 4 R ⁴⁷ represents a hydrogen atom or an alkyl group containing 1, 2 or 3 carbon atoms, R ⁴⁸ represents a cycloalkyl group having 3 to 7 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ⁴⁹ R ⁸⁰ . R ( ⁴⁹⁾ and R ( ⁵⁰⁾ are hydrogen or (C1-C4) -alkyl or R ( ³²⁾ , R ( ³⁴⁾ and R ( ⁴⁵⁾ are hydrogen, R ( ³³⁾ and R ( ⁴⁸⁾ independently of one another are hydrogen or (C1-C4) -alkyl or R ³² and R ³³ as well as R ⁴⁵ and R ⁴⁸ together represent 5 or 6 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, a -ΝΉ- group, an -NCH ₃ group or an -N- group benzyl, or R ¹ , R ³ and R ³ independently of one another represent a group R ⁵¹ -AGD-, R ⁸¹ is a basic protonatable radical, i.e. amino group -NR ⁵² R ⁵³ , amidino group R ⁵² R ⁵³ NC (= NR ⁵⁴ ) or guanidino group R ⁵² R ⁵³ NC / = NR ⁵⁴ / -NR ⁵⁵ -, R ³ , R ³ , R ³ 'and R ³³ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms or 360 R ⁵² and R ⁵³ is C _alpha H _2Alpha, alpha is 4, 5, 6 or 7, wherein, if the alpha is a 5, 6 or 7, then one of the carbon atoms of C _and if _a H _2a if _a can replaced by O, SO ^, or NR ⁵⁶ or R ⁵³ and R ⁵⁴ or R ⁵⁴ and R ⁵⁵ or R ⁵² and R ⁵⁵ represent a group CyH _2y , y represents 2, 3, 4 or 5, provided that if y = 3,4 or 5, one carbon atom of the group CYH _2y ^m ° ^ Y ^ ^eb replaced by O, SO ^, or NR ^56, d is 0, 1 or 2, R ⁵⁶ represents a hydrogen atom or a methyl group or R ⁵¹ represents a basic heteroaromatic ring group containing 1 to 9 carbon atoms, A represents a group C _e H _2e , e represents 0 or 1 to 10, wherein in the group C _e H _2e one carbon atom can be replaced by an oxygen atom, -CO-, -CH (OR ⁵⁷ ) -, -SOr- , -NR ⁵⁷ -, -NR ⁵⁷ -CO-, -NR ⁵⁷ -CO-NH, -NR ⁵⁷ -CO-NH-SO ₂ - or -nr ⁵⁷ -so ₂ -, r is 0, 1 or 2, G is phenyl R ⁵⁸ and R ⁵⁹ independently of one another are hydrogen, methyl, methoxy, fluoro, chloro, bromo, iodo, trifluoromethyl or a group -SO _g R ^60, R ⁶⁰ is methyl or NR ⁶¹ R ⁶² , R ( ⁶¹⁾ and R ( ⁶²⁾ independently of one another are hydrogen or (C1-C4) -alkyl, D is -C _in H _{2 in} -E _w , 361 v is 0, 1, 2, 3 or 4, E is O, -CO-, -CH (OR ⁶³ ), -SO _aa - or -NR ⁶³ -, w is 0 or 1, and a is 0, 1 or 2, R ⁶³ represents a hydrogen atom or a methyl group, or R ^1, R ² and R ³ independently of one another are-CF2R ^64, -CF / R ⁶⁵ // R ⁶⁶ /, -CF / (CF 2) _q -CF ₃ R // ⁶⁵ /. -C (CF ₂ ) _p -CF ₃ / CR ⁶⁵ R ⁶⁶ , R ⁶⁴ represents an alkyl group having 1 to 4 carbon atoms or a cycloalkyl group having 3 to 7 carbon atoms, R ( ⁶⁵⁾ and R ( ⁶⁶⁾ independently of one another are hydrogen or (C1-C4) -alkyl, g is 0, 1 or 2, p is 0, 1 or 2, or R ^1, R ² and R ³ independently of one another, are -OR ⁶⁷ or -NR ⁶⁷ R ^68, R ⁶⁷ and R ⁶⁸ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or R ⁶⁷ and R ⁶⁸ together represent 4, 5, 6 or 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, a -SO ₂ - group, an -NH- group, an -NCH ₃ group or a group N-benzyl, R and R ³ independently of one another are H, alkyl having 1 to 4 carbon atoms, F, Cl, -OR ^69, -NR ⁷⁰ R ⁷¹ or-C _z F2z + L R ⁶⁹ , R ⁷⁰ and R ⁷¹ independently represent a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, z represents 1, 2, 3 or 4, respectively R and R are, independently of one another, a hydrogen atom or a (C1-C4) alkyl group, X is O or NR ⁷² , R represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms. (362) as well as its pharmaceutically acceptable salts; and (a) alkenylcarboxylguanidine which carries fluorophenyl groups of formula (I) in which: R ⁶ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group, wherein the phenyl group is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl , methyl, methoxy and NR ⁹ R ¹⁰ , q in R and R are hydrogen, C 1-4 alkyl or perfluoroalkyl, R ⁷ independently of one another have the meanings as R ⁶ , R ^1, R ^2, R ^3, R ⁴ and R ⁵ independently of one another are hydrogen or F, wherein at least one of R ^1, R ^2, R ^3, R ⁴ and R ⁵ has is F, as and pharmaceutically acceptable salts thereof; and (n) a substituted cinnamic acid guanidide of formula (I) R '(I) 363 wherein at least one of R ¹ , R ² , R ³ , R ⁴ and R ⁵ is - ^x and ^Y b - ^L n - ^U ' X is CR ¹⁶ R ¹⁷ , O, S or NR ¹⁸ , R ( ¹⁶⁾ , R ( ¹⁷⁾ and R ( ¹⁸⁾ independently of one another are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, and are 0 or 1, Y represents an alkylene group having 1 to 8 carbon atoms, an alkylene-T group having an alkylene radical having 1 to 8 carbon atoms, a Τ, až-alkylene having 1 to 8 carbon atoms in the alkylene radical, T represents NR ²⁸ , oxygen, sulfur or phenylene, wherein the phenylene group is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ²¹ R group ²² , R ( ²⁸⁾ , R ( ²¹⁾ and R ( ²²⁾ independently of one another are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, (b) 0 or 1, L is O, S, NR ²³ , or C _to H _2k , k is 1, 2, 3, 4, 5, 6, 7 or 8, n is 0 or 1, U is NR ²⁴ R ²⁵ or an N-containing heterocycle containing 1 to 9 carbon atoms, R ²⁴ and R ^25, independently of one another, are hydrogen, C 1 -C 8 alkyl or C 1 -C 8 perfluoroalkyl; or R ²⁴ and R ²⁵ together represent 4 or 5 methylene groups, one of which may be replaced by an oxygen atom, 364 by S, NH, _N-CH3 or N-benzyl, N-containing heterocycle is linked via N or C and is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of F, Cl, trifluoromethyl, methyl, methoxy and NRR, R ( ²³⁾ , R ( ²⁷⁾ and R ( ^28), independently of one another, are hydrogen, (C1-C4) alkyl or (C1-C4) perfluoroalkyl, and the other substituents R ( ¹⁾ , R ( ²⁾ , R ( ³⁾ , R ( ⁴⁾ and R (1) ^5, independently of one another, are a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, -O _n -C _m H _{2m + 1} , -Op- (CH ₂ ) g-CqF ₂ q ₊ even or-C _r H _2r R ^10, n m P q with means 0 or 1, means 0, 1, 2, 3, 4, 5, 6, 7 or 8, means 0 or 1, means 1, 2, 3, 4, 5, 6, 7 or 8, means 0, 1, 2, 3 or 4, r means 0, 1, 2, 3 or 4 R ¹⁰ means cycloalkyl containing or phenyl, wherein the phenyl is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine, chlorine, trifluoromethyl, methyl, methoxy and NR ¹² R ¹² , R ( ¹¹⁾ and R ( ^12), independently of one another, are hydrogen, (C1-C4) -alkyl or (C1-C4) perfluoroalkyl; R and R independently of one another are hydrogen, fluorine, bromine, chlorine, iodine, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 cycloalkyl, or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of 365 fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and NR ¹⁴ R ^{15 group} , R ( ¹⁴⁾ and R ( ^15), independently of one another, are hydrogen, (C1-C4) -alkyl or (C1-C4) perfluoroalkyl, and pharmaceutically acceptable salts thereof; and (b) benzenedicarboxyldiguanide of the formula (I) in which one of R is ¹ , R ² , R ³ and R ⁴ are -CO-N = C (NH ₂ ) ₂ , and the other substituents R ¹ , R ² , R ³ and R ⁴ have the following meanings: R ¹ represents a hydrogen atom, a (C 1 -C 4) alkyl group, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, -OR ³² , -NR ³³ R ^34, or trifluoromethyl, R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or (C1-C4) -alkyl, R ² and R ⁴ independently of one another are hydrogen, fluorine, chlorine, bromine, iodine, hydroxy, cyano, trifluoromethyl, -CO-N = C (NH ₂ ) ₂ , alkyl (C 1 -C 8), (C 2 -C 8) alkenyl, or - (CH ₂ ) _m R ¹⁴ , m being 0, 1 or 2, R ¹⁴ represents a cycloalkyl group containing 3 to 8 366 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁵ R ¹⁶ , R ¹⁵ and R ¹⁶ represent a hydrogen atom or a methyl group; R @ 1 and R @ 2 independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted by 1 to 4 substituents selected from the group consisting of fluorine atom, chlorine atom, bromine, iodine, cyano, C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl, methyl, methoxy or n λ λα R and R are, independently of one another, an R group ^of -SO 2 -, R ²³ R ²⁴ N-CO-, R ²⁸ -CO- or R ²⁹ R ³⁰ N-SO 2 -, R ²² and R ^28, independently of one another, are methyl or trifluoromethyl, R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl; or R ² and R ⁴ independently of one another, are -OR ³⁵ or -NR ³⁵ R ^36, R ³⁵ and R ³⁶ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or R ³⁵ and R ³⁶ together are 4-7 methylene groups, of which one _CH2 group can be replaced by oxygen, S, NH, a group -NCHg or -N-benzyl; R ³ represents a hydrogen atom, -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁶ , -CR ²⁵ R ²⁶ R ²⁷ , R ²⁵ represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected 367 from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group and dimethylamino group or R ²⁵ represents a heteroaryl group containing 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group -group and dimethylamino-group, R and R independently of one another have the meanings given for R 25 or are hydrogen or alkyl having 1 to 8 carbon atoms, R ⁵ represents an alkyl group having 1 to 4 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, an X- (CH ₂ ) y-CF ₃ group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and an -NR ⁶ R ^{7 group} , R and R are, independently of one another, a hydrogen atom or a methyl group, X is a bond or an oxygen atom, y is 0, 1 or 2, as well as pharmaceutically acceptable salts thereof, and (a) a benzenedicarboxyldiguanidide of formula I (I) 368 wherein one of R ¹ , R ² , R ³ and R ⁵ is -CO-N = C (CH ₂ ) ₂ and the other of R ¹ , R ² , R ^3, and R ⁵ have the following meanings: R ( ¹⁾ and R ( ⁵⁾ independently of one another are hydrogen, alkyl having 1 to 4 carbon atoms, fluorine, chlorine, -NR ³³ R ³⁴ or trifluoromethyl, R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or (C1-C4) -alkyl, R ² represents H, F, Cl, Br, I, hydroxy, cyano, trifluoromethyl, -CO-N-C _{(NH2) 2,} alkyl having 1 to 8 carbon atoms, , (C 1 -C 8) alkenyl or - (CH 2 '^14' means 0, 1 or 2), R ¹⁴ is C 3 -C 8 cycloalkyl or phenyl which is unsubstituted or substituted by 1 to 3 substituents selected from fluoro, chloro, trifluoromethyl, methyl, methoxy and -NR ^{1 S} R ¹⁶ . R ( ¹⁵⁾ and R ( ^16), independently of one another, are hydrogen or methyl; R ² is R ²² -SO 2, R ²³ R ²⁴ N-CO-, R ²⁸ -CO- or R ²⁹ R ³⁰ N-SO 2, R ²² and R ^28, independently of one another, are methyl or trifluoromethyl, R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl; or R ² is -OR ³⁵ or -NR ³⁵ R ^38, R ³⁵ and R ³⁶ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or R ³⁵ and R ³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an atom 369 oxygen, sulfur, -NH-, -NCH ₃ or -N-benzyl, R ³ represents a hydrogen atom, -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁶ , -CR ²⁵ R ²⁶ R ²⁷ , R ²⁵ represents a hydrogen atom, a C 1 -C 8 alkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group , amino, methylamino, and dimethylamino, or R ²⁵ represents a heteroaryl group containing 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, methylamino group -group and dimethylamino-group, 9 β 77 R and R independently of one another have the meanings given for R ²⁵ or represent a hydrogen atom or an alkyl group containing 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, R ⁴ is trifluoromethyl, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 3 -C 8 cycloalkyl or - (CH ₂ ) _m R ¹⁴ , m is 1 or 2, R ¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹⁵ R ¹⁸ . R ( ¹⁵⁾ and R ( ^18), independently of one another, are hydrogen or methyl; R ⁴ represents a phenyl group which is substituted by 2 to 5 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methyl group, a methoxy group and a group -NR ¹⁵ R ¹⁶ , R ¹⁵ and R ¹⁶ independently of one another represent a hydrogen atom or a methyl group, as well as pharmaceutically acceptable salts thereof; and (a) a diaryldicarboxyldiguanidide of the general formula I wherein one of R ¹ , R ² , R ³ , R ⁴ and R ⁵ represents a group -CO-N = C (NH ₂ ) ₂ , the other substituents R ¹ and R ⁵ independently of one another are hydrogen, C 1-4 alkyl, fluoro, chloro, -OR ³² , -NR ³³ R ³⁴ or trifluoromethyl, R ( ³²⁾ , R ( ³³⁾ and R ( ³⁴⁾ independently of one another are hydrogen or (C1-C4) -alkyl, the other substituents R ( ²⁾ and R ( ⁴⁾ independently of one another are hydrogen, fluorine, chlorine, bromine, atom iodine, hydroxy, cyano, trifluoromethyl, -CO-NC (NH ₂ ) ₂ , (C 1 -C 8) alkyl, (C 2 -C 8) alkenyl, or - (CH ³⁾ P, m means 0, 1, or 2 R ¹⁴ represents a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of a fluorine atom, a chlorine atom, a trifluoromethyl group, a methoxy group and a group 371 -NR ^1S R ¹⁶ R ¹⁵ and R ¹⁶ are hydrogen or methyl or the other substituents R ² and R ⁴ independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted 1-4 substituents selected from the group consisting of fluorine, chlorine, bromine, iodine, cyano, C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl a group, a methyl group, a methoxy group or the other substituents R ² and R ⁴ represent a group R ²² -SO 2 -, a group R ²³ R ²⁴ N-CO-, a group R ²⁸ -CO- or a group r 29r ³⁰ N_SO ₂ , R ²² and R ^28, independently of one another, are methyl or trifluoromethyl, R ( ²³⁾ , R ( ²⁴⁾ , R ( ²⁹⁾ and R ( ³⁰⁾ independently of one another are hydrogen or methyl or the other substituents R ( ²⁾ and R ( ⁴⁾ independently of one another are -OR ³⁵ or -NR ³⁵ R ³⁶ , R ³⁵ and R ³⁶ independently of one another represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, or R ³⁵ and R ³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH ₃ group or an -N-benzyl group, another R ³ being an atom hydrogen, -SR ²⁵ , -OR ²⁵ , -NR ²⁵ R ²⁶ , -CR ²⁵ R ²⁵ R ²⁷ , R represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino, methylamino and dimethylamino; or 372 R ²⁵ represents a heteroaryl group containing 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, methylamino group and dimethylamino group -group, R ²³ and R ²⁷ independently of one another represent the meanings given for R ²⁵ or represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms, one of the substituents R ³ , R ⁷ , R ⁸ , R ⁹ and R ¹⁰ being -CO -N = C (NH ₂ ) ₂ , the other substituents R ³ and R ¹⁰ independently of one another represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a fluorine atom, a chlorine atom, a -OR · ¹ ·· 'group, -NR ¹³³ R ¹³⁴ or trifluoromethyl, R ( ¹³²⁾ , R ( ¹³³⁾ and R ( ¹³⁴⁾ independently of one another are hydrogen or (C1 -C4) -alkyl, the other substituents R ( ⁷⁾ and R ( ⁹⁾ independently of one another are hydrogen, fluorine, chlorine, bromine, atom iodo, hydroxy, cyano, trifluoromethyl, -CO-N-C _{(NH2) 2,} alkyl having 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms or a radical mm is 0, 1 or 2, R ¹¹⁴ represents a C 3 -C 8 cycloalkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group and -NR ¹¹⁵ R ¹¹³ . R ¹¹⁵ and R ¹¹³ are hydrogen or methyl or the other substituents R ⁷ and R ⁹ independently of one another are pyrrol-1-yl, pyrrol-2-yl or pyrrol-3-yl which is unsubstituted or substituted 1 to 4 substituents selected from the group 373 comprising fluorine, chlorine, bromine, iodine, cyano, C 2 -C 8 alkanoyl, C 2 -C 8 alkoxycarbonyl, formyl, carboxy, trifluoromethyl, methyl and methoxy -the group or other substituents R ⁷ and R ⁹ represent R ¹²² -SO ₂ -, R ¹²³ R ¹²⁴ N-CO-, R ¹²⁸ -CO- or _r 129 _R 130 _{n- S} q _2j R ¹²² and R ¹²⁸ independently of one another are methyl or trifluoromethyl, R ¹²³ , R ¹²⁴ , R ¹²⁹ and R ¹³⁰ independently of one another are hydrogen or methyl or the other substituents R ⁷ and R ⁹ independently of one another are -OR ¹³⁵ or -NR ¹³⁵ R ¹³⁶ , R ( ¹³⁵⁾ and R ( ¹³⁶⁾ independently of one another are hydrogen or (C1-C6) -alkyl or R ¹³⁵ and R ¹³⁶ together represent 4 to 7 methylene groups, of which one CH ₂ group may be replaced by an oxygen atom, a sulfur atom, an -NH- group, an -NCH ₃ group or an -N-benzyl group, another R ⁸ being an atom hydrogen, -SR ¹²⁵ , -OR ¹²⁵ , -NR ¹²⁵ R ^126, or -CR ¹²⁵ R 12 ^S R ¹²⁷ , R ¹²⁵ represents a hydrogen atom, a C 1 -C 8 alkyl group or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group , amino, methylamino, and dimethylamino, or R ¹²⁵ represents a heteroaryl group having 1 to 9 carbon atoms which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group, methoxy group, hydroxy group, amino group, amino group, methylamino group and dimethylamino, 374 R ¹²⁶ and R ¹²⁷ independently of one another represent the meanings given for R ¹²⁵ or represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms, A is absent or represents an -NR3 -CO- group -NR ¹² -CO-NR ¹³ -, -NR ¹⁷ -CO-NR ¹⁸ -SO ₂ -, NR ¹⁹ -SO2-, -SO2-NR ¹⁹ -SO 2, a group of -S0 ₂ NR ¹⁹ -C0-, a group -0-C0-NR ¹⁹ -S0 ₂ - or -CR ²⁰ = CR ^21, R ( ¹¹⁾ , R ( ¹²⁾ , R ( ¹³⁾ , R ( ¹⁷⁾ , R ( ¹⁸⁾ , R ( ¹⁹⁾ , R ( ²⁰⁾ and R ( ²¹⁾ independently of one another are hydrogen or alkyl having 1 to 8 carbon atoms and pharmaceutically acceptable salts thereof; a thiophenylalkenylcarboxylguanidide of the formula I in which at least one of R ¹ , R ² and R ³ is -O- (CH 2) 5 -C 8 F 2 g + 1, R ⁴⁰ CO- or R ³¹ SOk -, p is 0 or 1, s is 0, 1, 2, 3 or 4, g is 1, 2, 3, 4, 5, 6, 7 or 8, k is 0, 1 or 2, R ⁴⁰ represents an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chlorine, trifluoromethyl, methyl and methoxy, 375 R ³¹ represents an alkyl group having 1 to 8 carbon atoms, a perfluoroalkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from fluorine, chloro, trifluoromethyl, methyl or methoxy; or R ³¹ represents NR ⁴¹ R ⁴² , R ⁴ and R ^{42 are} each independently hydrogen, C 1 -C 4 alkyl, C 1 -C 4 perfluoroalkyl or R ⁴¹ and R ⁴² together are 4 or 5 methylene groups, of which one _CH2 group is O, S, -NH, N-CH3 or N-benzyl and the other substituents R ^1, R ^2, and R ^3, independently of one another, are a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a cyano group, a -O _to -C _m -H _{2ma + 1} group or an -O _{g and} C _and H _2r R ^{18 group} ; is 0 or 1, and m is 0, 1, 2, 3, 4, 5, 6, 7 or 8, and g is 0 or 1, and r is 0, 1, 2, 3, or 4, R ¹⁸ is C 3 -C 8 cycloalkyl or phenyl, wherein the phenyl is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl group, methyl group and methoxy group, R ⁴ and R ^5, independently of one another, are hydrogen, fluorine, bromine, iodine, cyano, C 1 -C 8 alkyl, C 1 -C 8 perfluoroalkyl, C 3 -C 8 cycloalkyl or a phenyl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of fluorine atom, chlorine atom, trifluoromethyl 376, methyl, methoxy and NR ¹⁴ R ^15, R ¹⁴ and R ¹⁵ independently of one another are hydrogen, C 1 -C 4 alkyl or C 1 -C 4 perfluoroalkyl, as well as pharmaceutically acceptable salts thereof. Use of a Na / H 'exchange inhibitor according to claims 1 to 3 for the manufacture of a medicament for the treatment of cardiovascular diseases caused by hypercholesterolemia. Use of a Na * / H * exchange inhibitor according to claims 1 to 3 for the manufacture of a medicament for the prevention and treatment of endothelial dysfunction syndrome. Use of a Na / H exchange inhibitor according to claims 1 to 3 for the manufacture of a medicament for the prevention and treatment of cardiac hypertrophies and cardiomyopathies. Use of a Na * / H ⁺ exchange inhibitor according to claims 1 to 3 for the manufacture of a medicament for the prevention and treatment of coronary artery spasms and myocardial infarction induced by elevated lipid levels and endothelial dysfunction syndrome. Use of a Na * / H ⁺ exchange inhibitor according to claims 1 to 3 for the manufacture of a medicament for the prevention and treatment of thromboses caused by elevated lipid levels and endothelial dysfunction syndrome. The use of a Na * / H ⁺ exchange inhibitor according to claims 1 to 3 for the manufacture of a medicament for the prevention and treatment of high blood pressure caused by elevated lipid levels and endothelial dysfunction syndrome. Use of a Na ⁺ / H ⁺ exchange inhibitor according to claims 1 to 3 for the manufacture of a medicament for the prevention and treatment of peripheral diseases 3Π of vessels caused by elevated lipid levels and endothelial dysfunction syndrome. 11. Use of an inhibitor exchange Na7H ' on the manufacturing drug according to claims 1 to 10 in combination with drug lowering blood pressure. 12. Use of an inhibitor exchange Na '/ H ⁺ on the manufacturing drug according to claims 1-10; in combination with inhibitor enzyme converting angiotensin. 13. Use of an inhibitor exchange Na ⁺ / H * on the manufacturing drug according to claims 1 to 10 in combination with an angiotensin receptor antagonist. Use of a Na * / H exchange inhibitor for the manufacture of a medicament according to claims 1 to 10 in combination with a blood fat lowering drug. Use of a Na ⁺ / H ⁺ exchange inhibitor for the manufacture of a medicament according to claims 1 to 10 in combination with an HMG-CoA reductase inhibitor. Use of a Na ⁺ / H ⁺ exchange inhibitor for the manufacture of a medicament according to claims 1 to 10 in combination with lovastatin or pravastatin.