SK124099A3 - A method for producing a veterinary product - Google Patents
A method for producing a veterinary product Download PDFInfo
- Publication number
- SK124099A3 SK124099A3 SK1240-99A SK124099A SK124099A3 SK 124099 A3 SK124099 A3 SK 124099A3 SK 124099 A SK124099 A SK 124099A SK 124099 A3 SK124099 A3 SK 124099A3
- Authority
- SK
- Slovakia
- Prior art keywords
- antimicrobial
- flunixin
- veterinary product
- oxytetracycline
- long
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 76
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 43
- 239000002260 anti-inflammatory agent Substances 0.000 claims abstract description 41
- 229940121363 anti-inflammatory agent Drugs 0.000 claims abstract description 30
- 238000009472 formulation Methods 0.000 claims abstract description 29
- 238000007911 parenteral administration Methods 0.000 claims abstract description 6
- 238000011282 treatment Methods 0.000 claims description 45
- 239000004599 antimicrobial Substances 0.000 claims description 43
- 239000004100 Oxytetracycline Substances 0.000 claims description 30
- 229960000625 oxytetracycline Drugs 0.000 claims description 30
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims description 30
- 235000019366 oxytetracycline Nutrition 0.000 claims description 30
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims description 30
- 229960000588 flunixin Drugs 0.000 claims description 25
- NOOCSNJCXJYGPE-UHFFFAOYSA-N flunixin Chemical compound C1=CC=C(C(F)(F)F)C(C)=C1NC1=NC=CC=C1C(O)=O NOOCSNJCXJYGPE-UHFFFAOYSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 13
- 229940124599 anti-inflammatory drug Drugs 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 11
- 229960000469 flunixin meglumine Drugs 0.000 claims description 11
- MGCCHNLNRBULBU-WZTVWXICSA-N flunixin meglumine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C1=CC=C(C(F)(F)F)C(C)=C1NC1=NC=CC=C1C(O)=O MGCCHNLNRBULBU-WZTVWXICSA-N 0.000 claims description 11
- 230000007794 irritation Effects 0.000 claims description 11
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 10
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 10
- -1 aspirin Chemical compound 0.000 claims description 10
- 244000309466 calf Species 0.000 claims description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- 238000002347 injection Methods 0.000 claims description 9
- 239000007924 injection Substances 0.000 claims description 9
- 229960002895 phenylbutazone Drugs 0.000 claims description 9
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 claims description 9
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 8
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 6
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 6
- 229930182555 Penicillin Natural products 0.000 claims description 5
- 239000004098 Tetracycline Substances 0.000 claims description 5
- 239000004182 Tylosin Substances 0.000 claims description 5
- 229930194936 Tylosin Natural products 0.000 claims description 5
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 5
- 229960000723 ampicillin Drugs 0.000 claims description 5
- 235000019364 tetracycline Nutrition 0.000 claims description 5
- 150000003522 tetracyclines Chemical class 0.000 claims description 5
- 229960004059 tylosin Drugs 0.000 claims description 5
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 claims description 5
- 235000019375 tylosin Nutrition 0.000 claims description 5
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 4
- 229930186147 Cephalosporin Natural products 0.000 claims description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 229960003022 amoxicillin Drugs 0.000 claims description 4
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 4
- 229940124587 cephalosporin Drugs 0.000 claims description 4
- 150000001780 cephalosporins Chemical class 0.000 claims description 4
- 229960003276 erythromycin Drugs 0.000 claims description 4
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 4
- 229960000991 ketoprofen Drugs 0.000 claims description 4
- 239000003120 macrolide antibiotic agent Substances 0.000 claims description 4
- HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 claims description 4
- 229960000965 nimesulide Drugs 0.000 claims description 4
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 4
- 229940056360 penicillin g Drugs 0.000 claims description 4
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims description 4
- 229960002702 piroxicam Drugs 0.000 claims description 4
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical compound NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 claims description 4
- 229940124530 sulfonamide Drugs 0.000 claims description 4
- 150000003456 sulfonamides Chemical class 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims description 4
- 229960001082 trimethoprim Drugs 0.000 claims description 4
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical class NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 claims description 3
- 229940126575 aminoglycoside Drugs 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 3
- 230000001754 anti-pyretic effect Effects 0.000 claims description 3
- 229940111133 antiinflammatory and antirheumatic drug oxicams Drugs 0.000 claims description 3
- 230000003115 biocidal effect Effects 0.000 claims description 3
- 229960001259 diclofenac Drugs 0.000 claims description 3
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 3
- 150000002476 indolines Chemical class 0.000 claims description 3
- 229960000905 indomethacin Drugs 0.000 claims description 3
- 229940041033 macrolides Drugs 0.000 claims description 3
- 229960005489 paracetamol Drugs 0.000 claims description 3
- 150000002960 penicillins Chemical class 0.000 claims description 3
- 150000004672 propanoic acids Chemical class 0.000 claims description 3
- 235000019260 propionic acid Nutrition 0.000 claims description 3
- 150000003217 pyrazoles Chemical class 0.000 claims description 3
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 150000003873 salicylate salts Chemical class 0.000 claims description 3
- 229940040944 tetracyclines Drugs 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 229960004368 oxytetracycline hydrochloride Drugs 0.000 claims description 2
- 229940049954 penicillin Drugs 0.000 claims description 2
- 239000000902 placebo Substances 0.000 claims description 2
- 229940068196 placebo Drugs 0.000 claims description 2
- YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical class CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 claims description 2
- MWKJTNBSKNUMFN-UHFFFAOYSA-N trifluoromethyltrimethylsilane Chemical compound C[Si](C)(C)C(F)(F)F MWKJTNBSKNUMFN-UHFFFAOYSA-N 0.000 claims description 2
- 241001138504 Mycoplasma bovis Species 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000000047 product Substances 0.000 description 34
- 239000000126 substance Substances 0.000 description 28
- 241001465754 Metazoa Species 0.000 description 26
- 238000012360 testing method Methods 0.000 description 19
- 210000001519 tissue Anatomy 0.000 description 9
- 241000283690 Bos taurus Species 0.000 description 7
- 208000023504 respiratory system disease Diseases 0.000 description 6
- 230000037396 body weight Effects 0.000 description 5
- 238000001990 intravenous administration Methods 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 208000037656 Respiratory Sounds Diseases 0.000 description 4
- 230000036760 body temperature Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 238000007918 intramuscular administration Methods 0.000 description 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 4
- 230000000451 tissue damage Effects 0.000 description 4
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 3
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 208000022362 bacterial infectious disease Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 231100000827 tissue damage Toxicity 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 239000013066 combination product Substances 0.000 description 2
- 229940127555 combination product Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000000122 hyperventilation Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000009021 pre-vaccination Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 230000036387 respiratory rate Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229960002180 tetracycline Drugs 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 238000011870 unpaired t-test Methods 0.000 description 2
- 208000030090 Acute Disease Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001293418 Mannheimia haemolytica Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 238000011203 antimicrobial therapy Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960002537 betamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 229960003469 flumetasone Drugs 0.000 description 1
- WXURHACBFYSXBI-GQKYHHCASA-N flumethasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]2(C)C[C@@H]1O WXURHACBFYSXBI-GQKYHHCASA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229960003194 meglumine Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000031990 negative regulation of inflammatory response Effects 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB1997/001222 WO1998050045A1 (en) | 1997-05-06 | 1997-05-06 | Improvements in or relating to long-acting antimicrobials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK124099A3 true SK124099A3 (en) | 2000-12-11 |
Family
ID=10806366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1240-99A SK124099A3 (en) | 1997-05-06 | 1997-05-06 | A method for producing a veterinary product |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6479473B1 (de) |
| EP (1) | EP0980248B1 (de) |
| AT (1) | ATE207751T1 (de) |
| AU (1) | AU731799B2 (de) |
| CA (1) | CA2285052C (de) |
| DE (1) | DE69707927T2 (de) |
| DK (1) | DK0980248T3 (de) |
| ES (1) | ES2163147T3 (de) |
| HU (1) | HUP0002125A3 (de) |
| IL (2) | IL132676A0 (de) |
| SK (1) | SK124099A3 (de) |
| TR (1) | TR199902748T2 (de) |
| WO (1) | WO1998050045A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020035107A1 (en) * | 2000-06-20 | 2002-03-21 | Stefan Henke | Highly concentrated stable meloxicam solutions |
| US6787568B1 (en) * | 2000-11-27 | 2004-09-07 | Phoenix Scientific, Inc. | Antibiotic/analgesic formulation and a method of making this formulation |
| AU2002335077B2 (en) * | 2001-10-19 | 2006-09-07 | Idexx Laboratories, Inc. | Injectable compositions for the controlled delivery of pharmacologically active compound |
| US6790867B2 (en) | 2002-05-20 | 2004-09-14 | Schering-Plough Animal Health Corporation | Compositions and method for treating infection in cattle and swine |
| DE10227938B4 (de) | 2002-06-21 | 2006-07-20 | Heraeus Kulzer Gmbh | Pharmazeutische Zubereitung, Verfahren zu ihrer Herstellung sowie deren Verwendung |
| US6918561B2 (en) * | 2002-10-31 | 2005-07-19 | Yon So Chong | Shell assembly for winding tire cord strip or belt cord strip |
| AR044437A1 (es) | 2003-05-29 | 2005-09-14 | Schering Plough Ltd | Composiciones y metodo para el tratamiento de infecciones en ganado vacuno y porcino |
| WO2005044254A1 (en) * | 2003-10-29 | 2005-05-19 | Idexx Laboratories, Inc. | Salts of pharmacologically active compounds |
| EP1568369A1 (de) | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von Meloxicam zur Behandlung von Atemwegserkrankungen bei Schweinen |
| AU2005311892B2 (en) * | 2004-11-30 | 2010-04-22 | Mwi Veterinary Supply Co. | Determining respiratory or circulatory health condition in animals for improved management |
| CN101600686A (zh) | 2006-12-13 | 2009-12-09 | 先灵-普劳有限公司 | 氯霉素、甲砜霉素及其类似物的水溶性前药 |
| JP2011529895A (ja) | 2008-07-30 | 2011-12-15 | インターベツト・インターナシヨナル・ベー・ベー | フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法 |
| RU2563826C1 (ru) * | 2014-08-21 | 2015-09-20 | Общество с ограниченной ответственностью "Научно-внедренческий центр Агроветзащита" | Инъекционная антибактериальная фармацевтическая композиция |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9413873D0 (en) * | 1994-07-09 | 1994-08-31 | Norbrook Lab Ltd | Long-acting oxytetracycline composition |
-
1997
- 1997-05-06 DE DE69707927T patent/DE69707927T2/de not_active Expired - Lifetime
- 1997-05-06 IL IL13267697A patent/IL132676A0/xx active IP Right Grant
- 1997-05-06 HU HU0002125A patent/HUP0002125A3/hu unknown
- 1997-05-06 US US09/381,069 patent/US6479473B1/en not_active Expired - Lifetime
- 1997-05-06 AU AU27061/97A patent/AU731799B2/en not_active Expired
- 1997-05-06 ES ES97920830T patent/ES2163147T3/es not_active Expired - Lifetime
- 1997-05-06 TR TR1999/02748T patent/TR199902748T2/xx unknown
- 1997-05-06 EP EP97920830A patent/EP0980248B1/de not_active Expired - Lifetime
- 1997-05-06 DK DK97920830T patent/DK0980248T3/da active
- 1997-05-06 WO PCT/GB1997/001222 patent/WO1998050045A1/en active IP Right Grant
- 1997-05-06 CA CA002285052A patent/CA2285052C/en not_active Expired - Lifetime
- 1997-05-06 AT AT97920830T patent/ATE207751T1/de not_active IP Right Cessation
- 1997-05-06 SK SK1240-99A patent/SK124099A3/sk unknown
-
1999
- 1999-11-01 IL IL132676A patent/IL132676A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0980248B1 (de) | 2001-10-31 |
| AU731799B2 (en) | 2001-04-05 |
| AU2706197A (en) | 1998-11-27 |
| IL132676A (en) | 2006-12-10 |
| TR199902748T2 (xx) | 2000-05-22 |
| CA2285052C (en) | 2004-06-29 |
| DK0980248T3 (da) | 2001-11-19 |
| CA2285052A1 (en) | 1998-11-12 |
| IL132676A0 (en) | 2001-03-19 |
| WO1998050045A1 (en) | 1998-11-12 |
| HUP0002125A2 (hu) | 2000-12-28 |
| DE69707927D1 (de) | 2001-12-06 |
| ES2163147T3 (es) | 2002-01-16 |
| DE69707927T2 (de) | 2002-04-11 |
| HUP0002125A3 (en) | 2001-01-29 |
| EP0980248A1 (de) | 2000-02-23 |
| ATE207751T1 (de) | 2001-11-15 |
| US6479473B1 (en) | 2002-11-12 |
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