SK11222001A3 - Proenergetic food supplement based on NADH, Octocosanol and vitamin E - Google Patents

Abstract

A food supplement based on NADH, Octocosanol, is described and vitamin E, which stimulates energy production by the body.

Description

Energy supplement based on NADH, Octocosanol and Vitamin E

Technical field

It is an object of the present invention to provide a nutritional supplement based on NADH, Octocosanol and Vitamin E, which stimulates the body to produce energy.

BACKGROUND OF THE INVENTION

NADH (nicotinamide adenine dinucleotide in reduced form) is a physiological substance found in all living cells, including human cells, and which acts as an activating factor for various enzymes that catalyze oxidation and reduction reactions. In particular, the primary function of NADH is to stimulate the respiratory activity of a cell using oxygen to produce water and three ATP molecules as a high energy substance that is present in all living cells. NADH triggers the generation of energy by generating ATP and acts as a primary activating enzyme capable of controlling the oxidative and reduction mechanisms of cell metabolic processes.

NADH is an extremely complex molecule and an essential element in obtaining energy from foods. Therefore, NADH is the primary electron transporter in the oxidation of molecules to generate energy within the cell. The greater the NADH content in the cell, the more energy is produced.

As the most potent antioxidant present in the body, NADH is able to regenerate other important antioxidants whose role is to protect the body against free radical attack. Not many NADH molecules can have a major impact on the body's antioxidant defense against the free radicals that cause disease.

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A lack of NADH is manifested by a lack of energy at the cellular level and its relative symptom is fatigue. Unfortunately, the level of NADH that is in the human body decreases with age, and the same becomes an NADH-dependent enzyme, especially those designed to produce energy.

NADH is present in all living cells,> animal or plant. As a result, it is also contained in our daily food intake. Meat, poultry and fish contain the highest proportion of NADH. Vegetables, fruits and other vegetarian food have a much lower NADH content than meat. It should be noted that much of the NADH taken with food is destroyed by cooking. This situation would not improve much, even if our diet consisted of raw meat or fish, because most of the NADH of these foods would be destroyed by the gastric juices present in the stomach.

The most important biological functions of NADH are those listed below:

1. as cellular fuel for energy production,

2. as a key component that controls the cell and removes DNA disorders,

3. as a stimulator of the cellular immune system,

4. as an effective arithioxidant,

5. as a dopamine, adrenaline and norepinephrine stimulator. Octocosanol is also present in the dietary supplement of the invention. Octocosanol is a natural food ingredient that is found in small amounts in vegetable oils and waxes, in the leaves of lantern, wheat and other plant embryos.

The mechanism by which Octocosanol exerts a distinct ergogenic effect (generating work or releasing energy) is not fully understood and this is the subject of further studies.

The dietary supplement of the invention also contains vitamin E. Vitamin E is well known to have antioxidant properties that are manifested in a cell where they protect a number of important biologicals from oxidation, such as fatty acids with multiple unsaturated errr bonds, vitamin A, carotenes, etc. . Specifically, it is in legumes and vegetable oils.

SUMMARY OF THE INVENTION

It has been found that when NADH is accompanied by Octocosa'nol, a surprising enhancement of the ergogenic activity of NADH appears and that the addition of vitamin E has a stabilizing effect on NADH, making it less susceptible to degradation. It is therefore an object of the present invention to provide a nutritional supplement based on NADH, Octocosanol and Vitamin E, which can be used to stimulate the body to generate energy under physical fatigue, sports and / or any situation expected to cause energy expenditure .

In particular, NADH is present in the dietary supplement of the invention in a total amount of 1 to 15 wt%, and preferably in a total amount of 3 to 7 wt%.

Octocosanol is present in the dietary supplement of the invention in a total amount of 1 to 15% by weight, and preferably in a total amount of 3 to 7% by weight.

Vitamin E is present in the dietary supplement of the invention in a total amount of 2 to 15% by weight, and preferably in a total amount of 6 to 13% by weight.

The dietary supplement of the invention may also finally contain some amino acids, adenosine in an amount of 15% by weight. and other vitamins such as (3-carotene oxidation inhibitor in an amount of 5 wt.%), and nicotinamide as a precursor of NADH in an amount of 10 wt.

The dietary supplement may also contain some antioxidants and anti-radical agents such as grape extract, powdered crushed red wine, resveratrol, lycopene, citrus fruit bioflavonoids, α-lipoic acid, carotenoids, salen yeast, coenzyme Q10 (enzyme activator Q10) , dried blackberry extract, reduced glutathione, dried Mediterranean pine extract, apple cocot, dried extract rr • e • errf • ef • rer • r Γ • r ^r rc ':

green tea, dried base extract and anthocyanins from red oranges. Said antioxidants and anti-radicals may be present in the dietary supplement in an amount of 20 to 30% by weight, but the yeast is present in an amount of 150 µg (150 mcg).

The association of NADH with Octocosanol has proven to be an important source of active energy, as found in in vitro reactions carried out in the laboratory. The addition of vitamin E has been shown to be important for the antioxidant and stabilizing effects on NADH, as shown in the laboratory tests specified below (see Vitamin E stabilizing effect test on NADH).

The product described above may be administered with the addition of a suitable carrier and in various pharmaceutical forms, such as hard or soft capsules or tablets, preferred pharmaceuticals.

Due to the high instability of NADH, the tablet is coated with a gastrointestinal barrier to be able to withstand stomach acidity and to be absorbed only in the intestine. For example, to form this gastrointestinal barrier, it is possible to use an acidic copolymer that does not contain isopropanol and methacrylates that are used to coat the tablet with a suitable device known as a rotary conditioner. The rotary conditioner causes cascading movement of the tablets to be coated, during which it is moistened with a liquid that keeps the coating material in solution. The tablets are then allowed to dry in a stream of air. This results in the formation of a first weak protective layer, whereby the entire protective process is completed by alternating the soaking and drying phases. Alternatively, a wax-free, bleached and purified natural shellac resin polymer (Dewaxed Orange Shellac, Shellac, E 904) is used for gastrointestinal coating.

The shellac resin is spray coated with one or more non-sticking agents (talc, silica / colloidal silica, lactose) in amounts of 2 and 8% by weight. and, if necessary, one or more colored or light-impermeable agents in the aqueous solution, the solution still containing one or more plastic coating agents> r r

r. C (glycerin, lauric acid, oleic acid, polyvinylpyrrolidone) in amounts of 0.5 and 4 wt.

The amount of shellac resin used to protect the tablets in the stomach is 2 to 8 wt. increase relative to the weight of the original tablet. The repeating of the coating process is carried out by means of a rotary conditioner (as described above) or by means of a granulated-fluidized bed coating device in which the applied solution is dried by a stream of air from one or more nozzles directed to the tablets which are kept in the basket (or granulator plates), which also gradually dries the tablets themselves.

After the gastrointestinal protective coating has been formed, the product is sampled and 10 tablets are immersed in an acidic solution (at pH 4) at a constant temperature of 32 ° C. The tablets must remain intact for at least 90 minutes, otherwise protection is insufficient and an additional coating step is required. If the tablets exceed 90 minutes, recheck by immersing 10 tablets in a basic solution (at pH 7) at a constant temperature of 32 ° C. The tablets must be reconstituted within 15 to 20 minutes.

Below is a test to evaluate the stabilizing effect of vitamin E on NADH.

Vitamin E stabilizing effect test on NADH

Two tubes containing 50 g of water having a pH of 4 and a constant temperature of 32 ° C are prepared. 10 mg of NADH is 'dissolved in the first tube and' mixed. The acidity inactivates NADH, which cleaves to NAD + H. Within 20 minutes, 9.5 mg of NADH is cleaved, while 0.5 mg remains unchanged.

In a second tube, 10 mg of NADH and 5 mg of vitamin E are dissolved. Acidity deactivates NADH, which is cleaved to NAD + H. Within 20 minutes, 7.5 mg of NADH is cleaved, while 2.5 mg of NADH remains unchanged. The pH of 4 and the temperature of 32 ° C for 20 minutes were chosen because the use of the food supplement 'is expected in the morning, on an empty stomach, 30 minutes before breakfast. it

leads to the fact that the tablets readily penetrate the physiological gastric barrier within 20 minutes, so that they reach the first part of the intestine where they can be absorbed and enter the bloodstream.

The following are non-limiting examples of formulations of the present invention. ·.

DETAILED DESCRIPTION OF THE INVENTION

Example 1

Example of formulation 1 for tablets having a total weight of 80 mg per tablet

NADH 2.5 mg Octocosanol 2.5 mg Vitamin E 5 mg Magnesium stearate from plants 3 mg Microcrystalline cellulose 41 mg Sipernat (hydrated silica) 1 mg Calcium hydrogen phosphate 25 mg Example 2 Example of Formulation 2 for Tablets with Total one pill weight 80 mg NADH 5 mg Octocosanol 5 mg Vitamin E 10 mg Magnesium stearate from plants 3 mg Microcrystalline cellulose 3.1 mg

Sipernat (hydrated silica) 1 mg

Calcium hydrogen phosphate 25 mg

Example 3

Example of formulation 3 for tablets having a total weight of 80 mg per tablet

NADH 5 mg

Octocosanol 2.5 mg

Enzyme Activator Q10 20 mg

Magnesium stearate from plants 2.4 mg

Microcrystalline cellulose 37 mg

Sipernat (hydrated silica) 2.6 mg

Calcium hydrogen phosphate 10.5 mg

Example 4

Example of formulation 4 for tablets having a total weight of 80 mg per tablet

NADH 5 mg

Vitamin E 10 mg

Magnesium stearate from plants 2.4 mg

Microcrystalline cellulose 49.5 mg

Sipernat (hydrated silica) 2.6 mg

Calcium hydrogen phosphate 10.5 mg

Claims (5)

PATENT CLAIMS A dietary supplement comprising NADH, Octocosanol and Vitamin E. . Food supplement according to claim 1, characterized in that it contains 1 to 15 wt. % NADH, 1 to 15 wt. Octocosanol and 2 to 15 wt. vitamin E from the total amount of the dietary supplement. A food supplement according to claim 1, characterized in that it comprises 3 to 7 wt. % NADH, 3 to 7 wt. % Of Octocosanol and 6 to 13 wt. vitamin E from the total amount of supplement. A food supplement as claimed in any one of claims 1 to 3, characterized in that it also contains other vitamins such as β-carotene antioxidants, nicotinamide, amino acid adenosine and some antioxidants and anti-radicals such as grape extract, powdered red wine, resveratrol, lycopene, citric fruit bioflavonoids, α-lipoic acid, carotenoids, selenium yeast, coenzyme Q10 (Q10 enzyme activator), dried blackberry extract, reduced glutathione, dried Mediterranean pine extract ,, apple vinegar, dried green tea extract, dried base extract and anthocyanins from red oranges. Food supplement according to any one of claims 1 to 4, characterized in that it is in the form of a tablet coated with a gastrointestinal protective film.