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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Claims (2)
1 Patentna zahtevka 1. N-substituirani derivati 3-azabiciklo[3.2.0]heptana s formulo R1 R2N-substituted 3-azabicyclo [3.2.0] heptane derivatives of formula R1 R2N—(CH2)N— (CH2)I, v kateri R1 pomeni v danem primeru z atomi halogena, Cj-C^alkilnimi, tri- fluorometilnimi, hidroksi, Cj-Cj-alkoksi, amino, monometilamino, dimetilamino, ciano ali nitro skupinami mono- ali disubstituirano fenilno, piridilno, tienilno ali pirolno skupino, R2 je atom vodika ali v danem primeru s halogenom, metoksi, hidroksi ali amino sub-stituirana fenilna skupina, n pomeni število 0,1,2, 3 ali 4, R3 je atom vodika, hidroksi, Cj-C4-alkilna ali Cj-C^-alkoksi skupina, ali pomeni skupaj s sosednjim atomom ogljika skupino C=0 ali C=S, X in Y pomenita atome ogljika, skupine CH, CH^ NH ali Cj-C^alkil-N- ali atome dušika, Z predstavlja direktno vez, skupino CO, skupino CS ali skupino CH oz. CH2, v katerih je lahko en atom vodika zamenjan s hidroksi, amino ali Cj-C4-alkoksi skupino ali atomom halogena, in A pomeni atom vodika, hidroksi, amino, merkapto, Cj-C4-alkilamino, di-Cj-C4-alkilamino, Cj-C^alkiltio ali Cj-C^alkoksi skupino ali skupaj s sosednjim atomom ogljika skupino C=0, ali A pomeni z Y povezano C3-C4-alkilensko skupino, ki lahko vsebuje eno ali dve nekumulirani dvojni vezi in v kateri je lahko ena skupina CH ali CH^ nadomeščena z atomom dušika ali žvepla ali skupino NH ali N-CH3 in pri - 2 - čemer je lahko obroč bodisi monosubstituiran z atomom fluora ali klora ali z metilno, metoksi, nitro ali amino skupino ali je lahko v primeru benzenovega obroča le-ta mono, di- ali trisubstituiran z atomi fluora ali klora ali metilnimi, trifluorometilnimi, nitro, hidroksi, metoksi, amino, monometil- ali dimetilamino skupinami, in v kateri lahko nosi obroč v desnem delu formule I na atomu dušika št. 1 C-C.- 1 4 alkilno, alkilno ali benzilno skupino in lahko vsebuje 1 do 3 nekumulirane dvojne vezi, in njihove soli s fiziološko prenesljivimi kislinami.I in which R 1 represents optionally with halogen atoms, C 1 -C 4 alkyl, trifluoromethyl, hydroxy, C 1 -C 1 -alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups mono- or disubstituted phenyl, pyridyl, thienyl or a pyrrole group, R 2 is a hydrogen atom or optionally a halogen, methoxy, hydroxy or amino substituted phenyl group, n is 0,1, 2, 3 or 4, R 3 is a hydrogen atom, hydroxy, C 1 -C 4 - alkyl or C 1 -C 4 -alkoxy group, or together with an adjacent carbon atom means a group C = O or C = S, X and Y represent carbon atoms, groups CH, CH 2 NH or C 1 -C 4 alkyl-N- or atoms nitrogen, Z represents a direct bond, a CO group, a CS group or a CH group or CH2 in which one hydrogen atom may be replaced by a hydroxy, amino or C1-C4-alkoxy group or a halogen atom, and A represents a hydrogen atom, hydroxy, amino, mercapto, C1-C4-alkylamino, di-C1-C4-alkylamino , A C 1 -C 4 alkylthio or C 1 -C 4 alkoxy group or together with an adjacent carbon atom a C = O group, or A represents a C 3 -C 4 -alkylene group attached to Y, which may contain one or two uncumulated double bonds and in which one group CH or CH 2 may be replaced by a nitrogen or sulfur atom or an NH or N-CH 3 group and at - 2 - the ring may be either monosubstituted by a fluorine or chlorine atom or by a methyl, methoxy, nitro or amino group or may be in In the case of a benzene ring, it is mono, di- or trisubstituted with fluorine or chlorine atoms or methyl, trifluoromethyl, nitro, hydroxy, methoxy, amino, monomethyl or dimethylamino groups, and in which it can carry the ring in the right part of formula I on the nitrogen atom no. 1 C-C- 1 4 alkyl, alkyl or benzyl group and may contain 1 to 3 non-accumulated double bonds, and their salts with physiologically tolerable acids.2. Uporaba spojin s formulo I po zahtevku 1 za pripravo zdravil z nevroleptičnim, antidepresivnim, sedativnim, hipnotičnim, protektivnim učinkom na centralno živčevje in mišično relaksantnim učinkom.Use of compounds of formula I according to claim 1 for the preparation of medicaments with neuroleptic, antidepressant, sedative, hypnotic, protective effect on the central nervous system and muscle relaxant effect.
SI9300625A1993-12-021993-12-02N-substituted azabicycloheptane derivatives, their preparation and use
SI9300625B
(en)
Process compounds for the preparation of the same pharmaceutical compositions use of a compound and process for the treatment of a mammal that includes humans