SI8811698A8 - Process for obtaining bipartited solid gelatine capsules - Google Patents

Description

Technical problem

These capsules are made by immersing the molded column in hot gelatin solution and removing the column from solution to make gelatin by drying into shells, which remove the satire from the columns · During the drying process, water is lost, which gives the shell gelatin hard from the water contents which is held at around 13 - 16 · $ ·

I remove further amounts of water from the shell from the walls to the psyllium and then, after filling and closing to the psyche, the contents of the capsules may be lost due to damage that occurs during mechanical handling during packaging, or due to the pressure of the wall of the capsules when removing from the shell. packaging ·

Water loss and brittleness can be caused by a number of causes. Thus, capsules can be stored © or transported before or after filling and coupling in conditions that lead to the loss of water from the capsule walls into the atmosphere · And very often in the pharmaceutical industry it is necessary to encapsulate hygroscopically or soluble satoriums to initiate moisture absorption and atmosphere, which at night does not dissipate decomposition ©. If this capsule is used, then hygroscopes or soluble sateria can deprive water of gelatin capsules, which causes chrtoate and can lead to damage of the sole and to the loss or spoilage of contents. * The oxygen of the pate is particularly high when removing capsules and blisters. , because of the usual stress on the shell, "Of course, two-part gelatin capsules containing hygroscopic or soluble aatorium and found in blister blisters" may become brittle during the period from the dawn to the end of use, which may break even after use. «To contents, at nspreeing, which capsule suffers while removing blister pack»

c) State of the art

Attempts have been made to reduce the brittleness of hard gelatin capsules - if an attempt was made to add plaetifics, such as glycerin, sorbitol, or expensive pills, to the gelatin solution and to which the capsules were formed. used in the manufacture of mono-shocks Already "Latin capsules" A succinct attempt was to soak up any aa thorium, such as diethyl phthalate or triacetins, which used salt as plasticizers in film-coated tablets.

one of the attempts, umd.jenfe to work, sows the bottom of a fruit-hard hard capsule capsule, which can store it with hygroscopic and soluble contents without becoming brittle solutions or lead to a weakening of the capsule, or decoupling it further. , due to the incompatibility of the polymer.

d) Onia solutions technically ^ problem

We have found a procedure for obtaining hard Selatine caps from two valleys, the walls of which do not become brittle or cleave upon accretion, and which contain hygroscopic or soluble substances

The invention provides for a two-part hard shell capsule consisting of a gelatin and fibrous aater «larss two-part capsule shell that the capsule consists of cylindrically shaped® body and is coincident and both have an iodine etvew and iodine sowing end, and the body is too narrow as the lid can dissolve the "open kayaking" of the body into the lid "Fibrous material is preferably hydrophilic" and swell when absorbing water "Fiber authors * alpha gelatin is present as added to such crazy and additive, as in the center of gravity hejjo * sr <? d ~ things with crochet, preservsnsiaa and others added.

The amount of fibrous aatorium added to α Gelatin is not critical, it is present in an α amount of up to about $ 10. It is advisable that it be present in quantities up to about 2 and better than about $ 0.5 to about 2, oM «The optimum amount depends on the fat 1 of the properties of the selected Fiber Batteries and Training and it is easy to determine«

The fiber material is used in powder form, the fiber length should be below 1000 microns, preferably about 300 alkrons, for example from about 50 to about microns.

An example of this aateric croscaraellos crosslinked * sodium carboxyethylcolulose form, used as + Ac2iScl * ί by ao for tablets with separation to dissolve and dissolve · It is a fibrous material * containing fiber 50 * 300 microns in size, as follows oso * binate a) swelling when in contact with water «and b) containing ab * sorted water ·

Isaacs of various fibrous materials, which have the same advantages in use, may be enhanced by aichrocrystalline ole * bad 1 high-density polyethylene fibers "However, it is desirable that the fibrous" atherium is bidrophilic, with a pronounced "water content" *

The aforementioned aaterials are only examples, each ecclesiastical monk may choose other "aterials, on the basis of the aforementioned Mourners" When used orally, the fibrous material must also be pharaoic or veterinary acceptable.

Pressing capsules of the invention for the manufacture of technological processes "which are adhered aorally" The required amount of fibrous material is added to the "slurry before, during" 111 after dissolution, with the form of a water suspension, from which the "real shells of the capsule are filled"

The good effects of the invention are clearly explained by the following examples.

a ^ sas

Cartridge capsules br * δ produced au gelatin to which 1 "and 2-8 croscellose were added as suspension, count as weight / s & preoin" Determines the number of standard capsules and capsules containing fibers filled, each oa 150 ag caral yew. which is a very hygroscopic crystalline solid of supsteuoa. Specimens of each earle capsule were examined visuolao in iatorvalis of 5 "ia, seeking naps or capsule whispering" of theperiospinal capsule revealed a great improvement in the pre-emptive capsule. the "Capsules made of" © letin containing $ 1 croekaraeloae did not attempt to limp, and those made of gelatin containing 2.8 kroekaroelases showed a very salient tendency to limp into extraanalysis compared to the standard "capsules," which became mole and tart. between 10 sons and 2 Sas.

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Adv / FREE VUKOVIC

APPLICATION 2A PSIVKSBKD gPOTKSBU FINDING

The pharmaceutical industry of linen is looking for a solution to the problem of icrtoates of hard two-part Selatias capsules. Each manufacturer has tried to solve this problem on its own, so that plasticizers have been added to the gelatin solution, which is used in the manufacture of single-layer some gelatin capsules, or used in the production of tablets to overcome tablets. Cva solutions did not produce satisfactory results. The process of obtaining hard two-part gelatin capsules, the walls of which do not become brittle, consists in the addition of up to a maximum of 10M of fibrous material, which is before the invention of sodium "carboxymethylcellulose, into a solution of gelatin from which hard capsules are formed" There are other fibrous materials which can use the invention, it is important that they be hydrophilic and have a pronounced water retention property.

Hard two-part gelatin capsules made in this way have no solid walls and are not cleaved when stored, transported, or removed from the package, thus no loss or deterioration of the contents of the capsules.

Claims (7)

1 · Procedure aa obtain two-part hard gelatin capsules, characterized in that the capsule is made up of a mixture of gelatin and fibrous material » 2. A process for the preparation of two-part hard shellatin capsules according to claim 1, wherein the shell is up to 1C; fibrous material · 3. A process for the preparation of two-part hard shellatin capsules according to claim 1 or claim 2, characterized in that the fibrous material is hydrophilic. The method of producing two-part hard shellatin capsules according to claim 3, characterized in that the fiber mafzerial is cross-sectioned sodium carboxymethylcellulose. A method for producing two-part hard shellatin capsules according to claim 4, wherein the fibers in the fibrous material have a length of up to 1CCC microns. 5. A process for producing two-part hard shellatin capsules according to claim 5, characterized in that the 3Θ length of the fibers is in the range of 50 to 300 microns. 7, A process for producing two-piece hard scholatine capsules according to any one of claims 1 to 6, characterized in that the fibrous material is present in an amount of 0.5 '· to 2 · ο *. 8. A process for the preparation of two-piece hard shellatin capsules containing hygroscopic or soluble filling, wherein the shell is a capsule according to any one of claims 1 to 7.