SI3672968T1 - Trdna oblika ribociklib sukcinata - Google Patents
Trdna oblika ribociklib sukcinataInfo
- Publication number
- SI3672968T1 SI3672968T1 SI201831040T SI201831040T SI3672968T1 SI 3672968 T1 SI3672968 T1 SI 3672968T1 SI 201831040 T SI201831040 T SI 201831040T SI 201831040 T SI201831040 T SI 201831040T SI 3672968 T1 SI3672968 T1 SI 3672968T1
- Authority
- SI
- Slovenia
- Prior art keywords
- solid state
- state form
- ribociclib succinate
- ribociclib
- succinate
- Prior art date
Links
- NHANOMFABJQAAH-UHFFFAOYSA-N butanedioic acid;7-cyclopentyl-n,n-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide Chemical compound OC(=O)CCC(O)=O.N1=C2N(C3CCCC3)C(C(=O)N(C)C)=CC2=CN=C1NC(N=C1)=CC=C1N1CCNCC1 NHANOMFABJQAAH-UHFFFAOYSA-N 0.000 title 1
- 229950010518 ribociclib succinate Drugs 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762550208P | 2017-08-25 | 2017-08-25 | |
| US201762555170P | 2017-09-07 | 2017-09-07 | |
| US201762577446P | 2017-10-26 | 2017-10-26 | |
| US201762593319P | 2017-12-01 | 2017-12-01 | |
| EP18762743.5A EP3672968B1 (en) | 2017-08-25 | 2018-08-22 | Solid state form of ribociclib succinate |
| PCT/US2018/047434 WO2019040567A1 (en) | 2017-08-25 | 2018-08-22 | RIBOCICLIB SALTS AND SOLID STATE FORMS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3672968T1 true SI3672968T1 (sl) | 2024-03-29 |
Family
ID=63449728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201831040T SI3672968T1 (sl) | 2017-08-25 | 2018-08-22 | Trdna oblika ribociklib sukcinata |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11155545B2 (sl) |
| EP (2) | EP4327880A3 (sl) |
| KR (1) | KR102715956B1 (sl) |
| CA (1) | CA3073936A1 (sl) |
| ES (1) | ES2968174T3 (sl) |
| HR (1) | HRP20240026T1 (sl) |
| IL (1) | IL272859A (sl) |
| MX (1) | MX2020002123A (sl) |
| SI (1) | SI3672968T1 (sl) |
| WO (1) | WO2019040567A1 (sl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9994579B2 (en) | 2014-12-12 | 2018-06-12 | Crystal Pharmatech Co., Ltd. | Salt of pyrrolo[2,3-D]pyrimidine compound and novel polymorph of salt |
| CA3048036A1 (en) | 2018-07-02 | 2020-01-02 | Apotex Inc | Novel crystalline form of ribociclib succinate |
| WO2020225827A1 (en) * | 2019-05-08 | 2020-11-12 | Mylan Laboratories Limited | Novel polymorphs of ribociclib succinate |
| CN112010857B (zh) * | 2019-05-30 | 2021-11-05 | 常州制药厂有限公司 | 一种瑞博西尼单丁二酸盐的晶型 |
| CN112375081B (zh) * | 2020-11-23 | 2022-04-12 | 中国医学科学院医药生物技术研究所 | 具有抑制CDK4、6或9活性的吡咯[2,3-d]嘧啶衍生物及其制备方法和应用 |
| WO2022207788A2 (en) | 2021-04-01 | 2022-10-06 | Krka, D.D., Novo Mesto | Process for the preparation of ribociclib and pharmaceutically acceptable salts thereof |
| WO2024115680A1 (en) | 2022-12-01 | 2024-06-06 | Krka, D.D., Novo Mesto | Ribociclib salts and formulations thereof |
| WO2024201299A1 (en) | 2023-03-27 | 2024-10-03 | Novartis Ag | Method of treating early breast cancer with ribociclib in combination with an aromatase inhibitor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8685980B2 (en) | 2008-08-22 | 2014-04-01 | Novartis Ag | Pyrrolopyrimidine compounds and their uses |
| AR083797A1 (es) | 2010-11-10 | 2013-03-20 | Novartis Ag | Succinato de dimetil-amida del acido 7-ciclopentil-2-(5-piperazin-1-il-piridin-2-il-amino)-7h-pirrolo-[2,3-d]pirimidin-6-carboxilico, proceso para prepararla, intermediarios de dicha sintesis y proceso de preparacion de los mismos |
| CN105111215B (zh) * | 2014-12-12 | 2019-06-18 | 苏州晶云药物科技股份有限公司 | 一种周期蛋白依赖性激酶抑制剂的晶型及其制备方法 |
| US9994579B2 (en) | 2014-12-12 | 2018-06-12 | Crystal Pharmatech Co., Ltd. | Salt of pyrrolo[2,3-D]pyrimidine compound and novel polymorph of salt |
| EP3156406A1 (en) | 2015-10-14 | 2017-04-19 | ratiopharm GmbH | Crystalline forms of ribociclib free base |
| WO2019150181A1 (en) * | 2018-02-05 | 2019-08-08 | Biophore India Pharmaceuticals Pvt Ltd | Improved process for the preparation of 7-cyclopentyl-n, n-dimethyl-2-(5-(piperazin-1-yl) pyridin-2-ylaminuteso)-7h-pyrrolo[2,3-d] pyrimidine-6-carboxamide succinate (ribociclib succinate) and its crystalline forms thereof |
| TWI675662B (zh) * | 2018-05-17 | 2019-11-01 | 中化合成生技股份有限公司 | 瑞博西尼琥珀酸鹽（Ｒｉｂｏｃｉｃｌｉｂ ｓｕｃｃｉｎａｔｅ ｓａｌｔ）晶型Ｂ、Ｃ及Ｄ與其衍生物，以及其等之製造方法與藥物組合物 |
| US20230042479A1 (en) | 2019-01-23 | 2023-02-09 | Novartis Ag | New crystalline forms of a succinate salt of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine -6-carboxylic acid dimethylamide |
-
2018
- 2018-08-22 CA CA3073936A patent/CA3073936A1/en active Pending
- 2018-08-22 MX MX2020002123A patent/MX2020002123A/es unknown
- 2018-08-22 SI SI201831040T patent/SI3672968T1/sl unknown
- 2018-08-22 WO PCT/US2018/047434 patent/WO2019040567A1/en unknown
- 2018-08-22 EP EP23205642.4A patent/EP4327880A3/en active Pending
- 2018-08-22 HR HRP20240026TT patent/HRP20240026T1/hr unknown
- 2018-08-22 US US16/641,390 patent/US11155545B2/en active Active
- 2018-08-22 ES ES18762743T patent/ES2968174T3/es active Active
- 2018-08-22 KR KR1020207008143A patent/KR102715956B1/ko active IP Right Grant
- 2018-08-22 EP EP18762743.5A patent/EP3672968B1/en active Active
-
2020
- 2020-02-23 IL IL272859A patent/IL272859A/en unknown
-
2021
- 2021-10-25 US US17/509,140 patent/US20220041598A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200074942A (ko) | 2020-06-25 |
| EP4327880A3 (en) | 2024-05-22 |
| WO2019040567A1 (en) | 2019-02-28 |
| KR102715956B1 (ko) | 2024-10-10 |
| US11155545B2 (en) | 2021-10-26 |
| HRP20240026T1 (hr) | 2024-03-29 |
| EP4327880A2 (en) | 2024-02-28 |
| US20220041598A1 (en) | 2022-02-10 |
| US20200190084A1 (en) | 2020-06-18 |
| ES2968174T3 (es) | 2024-05-08 |
| EP3672968B1 (en) | 2023-11-01 |
| MX2020002123A (es) | 2020-09-18 |
| CA3073936A1 (en) | 2019-02-28 |
| IL272859A (en) | 2020-04-30 |
| EP3672968A1 (en) | 2020-07-01 |
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