SI3331881T1 - Nova kristalna oblika in adukti palbocikliba in matanojske kisline - Google Patents

Nova kristalna oblika in adukti palbocikliba in matanojske kisline

Info

Publication number
SI3331881T1
SI3331881T1 SI201630261T SI201630261T SI3331881T1 SI 3331881 T1 SI3331881 T1 SI 3331881T1 SI 201630261 T SI201630261 T SI 201630261T SI 201630261 T SI201630261 T SI 201630261T SI 3331881 T1 SI3331881 T1 SI 3331881T1
Authority
SI
Slovenia
Prior art keywords
palbociclib
acetic acid
crystalline form
new crystalline
acid adducts
Prior art date
Application number
SI201630261T
Other languages
English (en)
Inventor
Jens Geier
Wolfgang Albrecht
Ludovic Coutable
Manfred Erdmann
Original Assignee
Ratiopharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm Gmbh filed Critical Ratiopharm Gmbh
Publication of SI3331881T1 publication Critical patent/SI3331881T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI201630261T 2015-08-05 2016-07-12 Nova kristalna oblika in adukti palbocikliba in matanojske kisline SI3331881T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15179779 2015-08-05
EP15185891 2015-09-18
EP16164123 2016-04-06
EP16739090.5A EP3331881B1 (en) 2015-08-05 2016-07-12 New crystalline form and acetic acid adducts of palbociclib
PCT/EP2016/066557 WO2017021111A1 (en) 2015-08-05 2016-07-12 New crystalline form and acetic acid adducts of palbociclib

Publications (1)

Publication Number Publication Date
SI3331881T1 true SI3331881T1 (sl) 2019-08-30

Family

ID=56413650

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201630261T SI3331881T1 (sl) 2015-08-05 2016-07-12 Nova kristalna oblika in adukti palbocikliba in matanojske kisline

Country Status (6)

Country Link
US (1) US10526326B2 (sl)
EP (2) EP3543235A1 (sl)
ES (1) ES2741958T3 (sl)
IL (1) IL257223A (sl)
SI (1) SI3331881T1 (sl)
WO (1) WO2017021111A1 (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017145054A1 (en) 2016-02-24 2017-08-31 Lupin Limited Modified particles of crystalline palbociclib free base and process for the preparation thereof
CN109078006B (zh) * 2016-03-29 2021-04-20 深圳市药欣生物科技有限公司 一种帕布昔利布的药物制剂及其制备方法
WO2018073574A1 (en) * 2016-10-20 2018-04-26 Cipla Limited Polymorphic forms of palbociclib
CN108864078B (zh) * 2017-05-10 2021-10-15 江苏豪森药业集团有限公司 帕博西尼晶型b的制备方法
CN114149426B (zh) * 2021-12-13 2023-06-02 江苏海洋大学 帕博西尼药物共晶及其制备方法
CN115667260B (zh) * 2022-08-26 2024-04-23 成都硕德药业有限公司 一种哌柏西利糖精盐晶型及其制备方法
WO2024040668A1 (zh) * 2022-08-26 2024-02-29 成都苑东生物制药股份有限公司 一种哌柏西利糖精盐晶型及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20063909B (en) 2002-01-22 2006-08-25 Warner Lambert Co 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES
SI1648889T1 (sl) 2003-07-11 2009-02-28 Warner Lambert Co Izetionatna sol selektivnega CDK4 inhibitorja
KR20090052385A (ko) 2006-09-08 2009-05-25 화이자 프로덕츠 인크. 2-（피리딘-2-일아미노）-피리도［2,3-ｄ］피리미딘-7-온의합성
EP2687511A1 (de) 2012-07-17 2014-01-22 Zedira GmbH Pyridinonderivate als Gewebetransglutaminaseinhibitoren
PT3431475T (pt) 2013-02-21 2021-05-13 Pfizer Formas sólidas de um inibidor de cdk4/6 seletivo
WO2016024249A1 (en) * 2014-08-14 2016-02-18 Sun Pharmaceutical Industries Limited Crystalline forms of palbociclib
CN104447739B (zh) * 2014-11-07 2016-02-17 郑州泰基鸿诺药物科技有限公司 一种氘代Palbociclib衍生物、制备方法及应用
WO2016092442A1 (en) * 2014-12-08 2016-06-16 Sun Pharmaceutical Industries Limited Processes for the preparation of crystalline forms of palbociclib acetate
WO2016156070A1 (en) 2015-04-02 2016-10-06 Sandoz Ag Modified particles of palbociclib
CN106632311B (zh) 2015-11-02 2021-05-18 上海科胜药物研发有限公司 一种帕博西尼晶型a和晶型b的制备方法
WO2017145054A1 (en) 2016-02-24 2017-08-31 Lupin Limited Modified particles of crystalline palbociclib free base and process for the preparation thereof
WO2018007927A1 (en) 2016-07-04 2018-01-11 Dr. Reddy's Laboratories Limited Process for preparation of palbociclib
WO2018073574A1 (en) 2016-10-20 2018-04-26 Cipla Limited Polymorphic forms of palbociclib

Also Published As

Publication number Publication date
US20180222903A1 (en) 2018-08-09
US10526326B2 (en) 2020-01-07
WO2017021111A1 (en) 2017-02-09
ES2741958T3 (es) 2020-02-12
EP3331881B1 (en) 2019-05-15
IL257223A (en) 2018-03-29
EP3543235A1 (en) 2019-09-25
EP3331881A1 (en) 2018-06-13

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