SI3147292T1 - Labelled nucleotides - Google Patents

Labelled nucleotides

Info

Publication number
SI3147292T1
SI3147292T1 SI200332583T SI200332583T SI3147292T1 SI 3147292 T1 SI3147292 T1 SI 3147292T1 SI 200332583 T SI200332583 T SI 200332583T SI 200332583 T SI200332583 T SI 200332583T SI 3147292 T1 SI3147292 T1 SI 3147292T1
Authority
SI
Slovenia
Prior art keywords
labelled nucleotides
labelled
nucleotides
nucleoside
linker
Prior art date
Application number
SI200332583T
Other languages
Slovenian (sl)
Inventor
John Milton
Silke Ruediger
Xiaohai Liu
Original Assignee
Illumina Cambridge Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31946334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3147292(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/227,131 external-priority patent/US7057026B2/en
Application filed by Illumina Cambridge Limited filed Critical Illumina Cambridge Limited
Publication of SI3147292T1 publication Critical patent/SI3147292T1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention provides a nucleotide or nucleoside having a 3'-azidomethyl group and a base attached to a detectable label via a linker.
SI200332583T 2002-08-23 2003-08-22 Labelled nucleotides SI3147292T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/227,131 US7057026B2 (en) 2001-12-04 2002-08-23 Labelled nucleotides
EP16193088.8A EP3147292B1 (en) 2002-08-23 2003-08-22 Labelled nucleotides

Publications (1)

Publication Number Publication Date
SI3147292T1 true SI3147292T1 (en) 2019-01-31

Family

ID=31946334

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200332500A SI2119722T1 (en) 2002-08-23 2003-08-22 Labelled nucleotides
SI200332618T SI3438116T1 (en) 2002-08-23 2003-08-22 Labelled nucleotides
SI200332583T SI3147292T1 (en) 2002-08-23 2003-08-22 Labelled nucleotides

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI200332500A SI2119722T1 (en) 2002-08-23 2003-08-22 Labelled nucleotides
SI200332618T SI3438116T1 (en) 2002-08-23 2003-08-22 Labelled nucleotides

Country Status (12)

Country Link
EP (5) EP2119722B1 (en)
AT (1) ATE431354T1 (en)
AU (1) AU2003259352A1 (en)
CY (3) CY1118471T1 (en)
DE (1) DE60327649D1 (en)
DK (4) DK2119722T3 (en)
ES (4) ES2694651T3 (en)
GB (1) GB2395953A (en)
HU (2) HUE032483T2 (en)
PT (3) PT3438116T (en)
SI (3) SI2119722T1 (en)
WO (1) WO2004018493A1 (en)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE356222T1 (en) 2000-10-06 2007-03-15 Univ Columbia MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
EP3002289B1 (en) 2002-08-23 2018-02-28 Illumina Cambridge Limited Modified nucleotides for polynucleotide sequencing
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
EP2119722B1 (en) 2002-08-23 2016-10-26 Illumina Cambridge Limited Labelled nucleotides
EP1725572B1 (en) 2003-11-05 2017-05-31 AGCT GmbH Macromolecular nucleotide compounds and methods for using the same
US7622279B2 (en) 2004-03-03 2009-11-24 The Trustees Of Columbia University In The City Of New York Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry
GB0427236D0 (en) * 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
WO2006064199A1 (en) * 2004-12-13 2006-06-22 Solexa Limited Improved method of nucleotide detection
GB0509508D0 (en) * 2005-05-10 2005-06-15 Solexa Ltd Improved polymerases
WO2007002204A2 (en) 2005-06-21 2007-01-04 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compostions
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0517097D0 (en) * 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
WO2007053702A2 (en) 2005-10-31 2007-05-10 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods
US8796432B2 (en) 2005-10-31 2014-08-05 The Trustees Of Columbia University In The City Of New York Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods
US8241573B2 (en) 2006-03-31 2012-08-14 Illumina, Inc. Systems and devices for sequence by synthesis analysis
ES2645661T3 (en) 2006-04-04 2017-12-07 Keygene N.V. High performance detection of molecular markers based on restriction fragments
WO2007135368A2 (en) * 2006-05-18 2007-11-29 Solexa Limited Dye compounds and the use of their labelled conjugates
US8921073B2 (en) 2006-06-23 2014-12-30 Illumina, Inc. Devices and systems for creation of DNA cluster arrays
EP2038425B1 (en) 2006-07-12 2010-09-15 Keygene N.V. High throughput physical mapping using aflp
US8399188B2 (en) 2006-09-28 2013-03-19 Illumina, Inc. Compositions and methods for nucleotide sequencing
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
EP2076609A1 (en) 2006-10-10 2009-07-08 Illumina Inc. Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization
WO2008069973A2 (en) 2006-12-01 2008-06-12 The Trustees Of Columbia University In The City Of New York Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
MX2009005936A (en) 2006-12-05 2010-01-15 Lasergen Inc Photocleavable labeled nucleotides and nucleosides and labeled nucleotides and nucleosides and methods for their use in dna sequencing.
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US7678894B2 (en) * 2007-05-18 2010-03-16 Helicos Biosciences Corporation Nucleotide analogs
US9163053B2 (en) 2007-05-18 2015-10-20 Fluidigm Corporation Nucleotide analogs
EP2725107B1 (en) 2007-10-19 2018-08-29 The Trustees of Columbia University in the City of New York DNA sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified ddNTPs and nucleic acid comprising inosine with reversible terminators
EP2207900B1 (en) 2007-10-19 2015-04-29 The Trustees of Columbia University in the City of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
ES2528971T3 (en) 2008-03-17 2015-02-13 Stichting Genetwister Ip Discoveries of genes linked to expression
EP2279194A1 (en) 2008-04-29 2011-02-02 Life Technologies Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use
NZ594812A (en) 2008-06-11 2012-12-21 Lasergen Inc Nucleotides and nucleosides and methods for their use in dna sequencing
ES2403312T3 (en) 2009-01-13 2013-05-17 Keygene N.V. New strategies for genome sequencing
EP2494073B1 (en) 2009-10-26 2017-11-29 AGCT GmbH Nucleotide conjugates and methods of uses thereof
WO2012034007A2 (en) 2010-09-10 2012-03-15 Bio-Rad Laboratories, Inc. Size selection of dna for chromatin analysis
WO2012106081A2 (en) 2011-01-31 2012-08-09 Illumina, Inc. Methods for reducing nucleic acid damage
US9994894B2 (en) 2011-04-27 2018-06-12 Agct Gmbh Method and components for detecting nucleic acid chains
DE102012008759A1 (en) 2011-05-04 2012-11-08 Genovoxx Gmbh Nucleoside-triphosphate conjugates and methods for their use
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
WO2013009175A1 (en) 2011-07-08 2013-01-17 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
KR102048274B1 (en) 2011-09-13 2019-11-25 애질런트 테크놀로지스, 인크. 5-methoxy, 3'-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
RS62530B1 (en) 2011-09-23 2021-11-30 Illumina Inc Compositions for nucleic acid sequencing
DK2964612T3 (en) 2013-03-08 2017-04-03 Illumina Cambridge Ltd POLYMETHIN COMPOUNDS AND USE THEREOF AS FLUORESCING LABELS
US8754244B1 (en) 2013-03-08 2014-06-17 Illumina Cambridge Limited Rhodamine compounds and their use as fluorescent labels
CN105263918B (en) 2013-03-08 2018-05-18 伊鲁米纳剑桥有限公司 Rhodamine compound and its purposes as fluorescent marker
WO2014135669A1 (en) 2013-03-08 2014-09-12 Roche Diagnostics Gmbh Egfr mutation blood testing
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
CN105377869B (en) 2013-03-15 2018-07-10 伊鲁米纳剑桥有限公司 The nucleosides or nucleotide of modification
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
WO2014144883A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
JP6151360B2 (en) 2013-07-31 2017-06-21 株式会社日立ハイテクノロジーズ Nucleic acid analysis flow cell and nucleic acid analyzer
CN103667469A (en) * 2013-11-29 2014-03-26 武汉科技大学 DNA sequencing method based on universal bases
WO2015103225A1 (en) 2013-12-31 2015-07-09 Illumina, Inc. Addressable flow cell using patterned electrodes
GB201408077D0 (en) 2014-05-07 2014-06-18 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
WO2016065248A1 (en) 2014-10-23 2016-04-28 Complete Genomics, Inc. Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing
GB201508858D0 (en) 2015-05-22 2015-07-01 Illumina Cambridge Ltd Polymethine compounds with long stokes shifts and their use as fluorescent labels
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
US10465232B1 (en) 2015-10-08 2019-11-05 Trace Genomics, Inc. Methods for quantifying efficiency of nucleic acid extraction and detection
US10894981B2 (en) 2015-10-13 2021-01-19 Japan Agency For Marine-Earth Science And Technology Method for fragmenting double-stranded RNA and use of the same
WO2017185026A1 (en) * 2016-04-22 2017-10-26 Complete Genomics, Inc. Reversibly blocked nucleoside analogues and their use
US10385214B2 (en) 2016-09-30 2019-08-20 Illumina Cambridge Limited Fluorescent dyes and their uses as biomarkers
EP3559004B1 (en) 2016-12-22 2023-07-05 Illumina Cambridge Limited Coumarin compounds and their uses as fluorescent labels
GB2567124A (en) 2017-05-08 2019-04-10 Vysoka Akola Chemicko Tech V Praze Imaging agents and methods
WO2018215803A1 (en) 2017-05-26 2018-11-29 Nuclera Nucleics Ltd Use of terminal transferase enzyme in nucleic acid synthesis
PT3663407T (en) 2017-08-01 2023-03-27 Complete Genomics Inc Nucleic acid sequencing method
GB201716931D0 (en) 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
MX2020013416A (en) 2019-03-01 2021-04-28 Illumina Cambridge Ltd Tertiary amine substituted coumarin compounds and their uses as fluorescent labels.
WO2020178231A1 (en) 2019-03-01 2020-09-10 Illumina, Inc. Multiplexed fluorescent detection of analytes
MX2020013384A (en) 2019-03-01 2021-04-28 Illumina Cambridge Ltd Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels.
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
BR112022010248A2 (en) 2019-11-27 2022-09-06 Illumina Cambridge Ltd COLORINGS AND COMPOSITIONS CONTAINING CYCLO-OCTATETRAENE
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
CA3177293A1 (en) 2020-06-22 2021-12-30 Illumina Cambridge Limited Nucleosides and nucleotides with 3' acetal blocking group
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
GB2617481A (en) 2020-10-30 2023-10-11 Element Biosciences Inc Reagents for massively parallel nucleic acid sequencing
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
EP4334327A1 (en) 2021-05-05 2024-03-13 Illumina Cambridge Limited Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing
BR112023024130A2 (en) 2021-05-20 2024-01-30 Illumina Cambridge Ltd COMPOSITIONS AND METHODS FOR SEQUENCING BY SYNTHESIS
WO2023278608A1 (en) 2021-06-29 2023-01-05 Illumina, Inc. Self-learned base caller, trained using oligo sequences
EP4374343A1 (en) 2021-07-19 2024-05-29 Illumina, Inc. Intensity extraction with interpolation and adaptation for base calling
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
EP4377960A1 (en) 2021-07-28 2024-06-05 Illumina, Inc. Quality score calibration of basecalling systems
JP2024529843A (en) 2021-08-03 2024-08-14 イルミナ インコーポレイテッド Base calling using multiple base call models
US12077789B2 (en) 2021-08-14 2024-09-03 Illumina, Inc. Polymerases, compositions, and methods of use
WO2023186815A1 (en) 2022-03-28 2023-10-05 Illumina Cambridge Limited Labeled avidin and methods for sequencing
WO2023192163A1 (en) 2022-03-29 2023-10-05 Illumina Cambridge Limited Systems and methods of sequencing polynucleotides
WO2023186982A1 (en) 2022-03-31 2023-10-05 Illumina, Inc. Compositions and methods for improving sequencing signals
US20230332197A1 (en) 2022-03-31 2023-10-19 Illumina Singapore Pte. Ltd. Nucleosides and nucleotides with 3' vinyl blocking group
WO2023232829A1 (en) 2022-05-31 2023-12-07 Illumina, Inc Compositions and methods for nucleic acid sequencing
US20230416279A1 (en) 2022-06-28 2023-12-28 Illumina Cambridge Limited Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
US20240177807A1 (en) 2022-09-16 2024-05-30 Illumina, Inc. Cluster segmentation and conditional base calling
US20240140939A1 (en) 2022-09-30 2024-05-02 Illumina Cambridge Limited Compositions and methods for reducing photo damage during sequencing
WO2024123866A1 (en) 2022-12-09 2024-06-13 Illumina, Inc. Nucleosides and nucleotides with 3´ blocking groups and cleavable linkers
WO2024137886A1 (en) 2022-12-21 2024-06-27 Illumina, Inc. Context-dependent base calling
US20240229131A1 (en) 2022-12-22 2024-07-11 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
US20240247311A1 (en) 2022-12-22 2024-07-25 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
WO2024145154A1 (en) 2022-12-27 2024-07-04 Illumina, Inc. Methods of sequencing using 3´ allyl blocked nucleotides

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US227131A (en) 1880-05-04 Heney o
DE3906357A1 (en) 1989-03-01 1990-09-06 Boehringer Mannheim Gmbh NEW ACYCLIC NUCLEOSIDE ANALOG, METHOD FOR THE PRODUCTION AND USE OF THESE COMPOUNDS AS ANTIVIRAL MEDICINAL PRODUCTS
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
EP0450060A1 (en) 1989-10-26 1991-10-09 Sri International Dna sequencing
JPH08511002A (en) 1993-04-13 1996-11-19 ナクスコー Non-nucleoside coumarin derivatives as polynucleotide cross-linking agents
WO1996027025A1 (en) 1995-02-27 1996-09-06 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
JP3813818B2 (en) 1998-05-01 2006-08-23 アリゾナ ボード オブ リージェンツ Method for determining the nucleotide sequence of oligonucleotides and DNA molecules
IL141148A0 (en) 1998-07-30 2002-02-10 Solexa Ltd Arrayed biomolecules and their use in sequencing
ATE508200T1 (en) 1999-02-23 2011-05-15 Caliper Life Sciences Inc SEQUENCING THROUGH INCORPORATION
ES2310514T3 (en) 1999-03-10 2009-01-16 Asm Scientific, Inc. A METHOD FOR DIRECT SEQUENCING OF NUCLEIC ACID.
US6309836B1 (en) 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
GB0013276D0 (en) 2000-06-01 2000-07-26 Amersham Pharm Biotech Uk Ltd Nucleotide analogues
ATE356222T1 (en) * 2000-10-06 2007-03-15 Univ Columbia MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA
DE10120797B4 (en) 2001-04-27 2005-12-22 Genovoxx Gmbh Method for analyzing nucleic acid chains
US6753449B2 (en) 2001-10-09 2004-06-22 Arqule, Inc. Cleavable linker for solid phase synthesis
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
EP2119722B1 (en) 2002-08-23 2016-10-26 Illumina Cambridge Limited Labelled nucleotides
EP3002289B1 (en) 2002-08-23 2018-02-28 Illumina Cambridge Limited Modified nucleotides for polynucleotide sequencing
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays

Also Published As

Publication number Publication date
EP2119722A1 (en) 2009-11-18
DK1560838T3 (en) 2009-09-07
GB2395953A (en) 2004-06-09
CY1123971T1 (en) 2022-05-27
AU2003259352A1 (en) 2004-03-11
CY1120882T1 (en) 2019-12-11
DK2119722T3 (en) 2016-12-12
DK3438116T3 (en) 2021-03-22
CY1118471T1 (en) 2017-07-12
HUE055068T2 (en) 2021-10-28
HUE032483T2 (en) 2017-09-28
EP3848380A1 (en) 2021-07-14
ES2326077T3 (en) 2009-09-30
DE60327649D1 (en) 2009-06-25
SI3438116T1 (en) 2021-07-30
EP1560838A1 (en) 2005-08-10
EP3438116A1 (en) 2019-02-06
PT2119722T (en) 2016-12-12
PT3438116T (en) 2021-03-23
SI2119722T1 (en) 2017-03-31
EP2119722B1 (en) 2016-10-26
GB0405882D0 (en) 2004-04-21
ES2604951T3 (en) 2017-03-10
ATE431354T1 (en) 2009-05-15
EP3147292B1 (en) 2018-09-26
WO2004018493A1 (en) 2004-03-04
DK3147292T3 (en) 2018-12-03
EP3147292A1 (en) 2017-03-29
ES2864086T3 (en) 2021-10-13
EP3438116B1 (en) 2021-02-17
EP1560838B1 (en) 2009-05-13
PT3147292T (en) 2018-11-22
ES2694651T3 (en) 2018-12-26

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