SI3019621T1 - Proizvodnja glikoproteinov, ki imajo povečano zasedenost N-glikozilacijskega mesta - Google Patents

Proizvodnja glikoproteinov, ki imajo povečano zasedenost N-glikozilacijskega mesta

Info

Publication number
SI3019621T1
SI3019621T1 SI201431065T SI201431065T SI3019621T1 SI 3019621 T1 SI3019621 T1 SI 3019621T1 SI 201431065 T SI201431065 T SI 201431065T SI 201431065 T SI201431065 T SI 201431065T SI 3019621 T1 SI3019621 T1 SI 3019621T1
Authority
SI
Slovenia
Prior art keywords
glycoproteins
production
increased
glycosylation site
site occupancy
Prior art date
Application number
SI201431065T
Other languages
English (en)
Inventor
Jari Natunen
Christopher Landowski
Markku Saloheimo
Christian Ostermeier
Benjamin Patrick Sommer
Ramon Wahl
Original Assignee
Glykos Finland Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glykos Finland Oy filed Critical Glykos Finland Oy
Publication of SI3019621T1 publication Critical patent/SI3019621T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI201431065T 2013-07-10 2014-07-10 Proizvodnja glikoproteinov, ki imajo povečano zasedenost N-glikozilacijskega mesta SI3019621T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13175997 2013-07-10
PCT/EP2014/064818 WO2015004239A1 (en) 2013-07-10 2014-07-10 Production of glycoproteins having increased n-glycosylation site occupancy
EP14738496.0A EP3019621B1 (en) 2013-07-10 2014-07-10 Production of glycoproteins having increased n-glycosylation site occupancy

Publications (1)

Publication Number Publication Date
SI3019621T1 true SI3019621T1 (sl) 2019-03-29

Family

ID=48748052

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201431065T SI3019621T1 (sl) 2013-07-10 2014-07-10 Proizvodnja glikoproteinov, ki imajo povečano zasedenost N-glikozilacijskega mesta

Country Status (11)

Country Link
US (2) US20160153019A1 (sl)
EP (1) EP3019621B1 (sl)
CN (1) CN105492620A (sl)
CA (1) CA2916899C (sl)
DK (1) DK3019621T3 (sl)
ES (1) ES2711165T3 (sl)
HR (1) HRP20190218T1 (sl)
PL (1) PL3019621T3 (sl)
SG (1) SG11201600098RA (sl)
SI (1) SI3019621T1 (sl)
WO (1) WO2015004239A1 (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201700446XA (en) * 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
EP3788164A4 (en) * 2018-05-01 2022-01-26 Conagen Inc. RECOMBINANT ORGANISMS AND METHODS FOR PRODUCTION OF HIGH GLYCAN OCCUPANCY GLYCOMOLECULES
CN112041456A (zh) * 2018-05-01 2020-12-04 科纳根公司 用于产生具有低硫酸化的糖分子的重组生物体和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4743546A (en) 1985-02-13 1988-05-10 Biotechnica International, Inc. Controlled gene excision
GB2276169A (en) 1990-07-05 1994-09-21 Celltech Ltd Antibodies specific for carcinoembryonic antigen
DE19754622A1 (de) 1997-12-09 1999-06-10 Antje Von Dr Schaewen Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität
TW201028431A (en) * 2008-10-31 2010-08-01 Lonza Ag Novel tools for the production of glycosylated proteins in host cells
CN102858949B (zh) 2010-02-24 2016-07-06 默沙东公司 用于增加在巴氏毕赤酵母中生产的治疗性糖蛋白上的n-糖基化位点占据的方法
SG190321A1 (en) 2010-11-24 2013-06-28 Novartis Int Pharm Ltd Fusion enzymes having n-acetylglucosaminyltransferase activity
WO2013062939A2 (en) 2011-10-28 2013-05-02 Merck Sharp & Dohme Corp. Methods for increasing n-glycan occupancy and reducing production of hybrid n-glycans in pichia pastoris strains lacking alg3 expression

Also Published As

Publication number Publication date
ES2711165T3 (es) 2019-04-30
SG11201600098RA (en) 2016-02-26
US20160153019A1 (en) 2016-06-02
PL3019621T3 (pl) 2019-05-31
CA2916899C (en) 2020-03-10
US20190276867A1 (en) 2019-09-12
CA2916899A1 (en) 2015-01-15
DK3019621T3 (en) 2019-03-04
EP3019621A1 (en) 2016-05-18
WO2015004239A1 (en) 2015-01-15
CN105492620A (zh) 2016-04-13
HRP20190218T1 (hr) 2019-03-22
EP3019621B1 (en) 2018-11-28

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