SI2879696T1 - Zunajcelična DNA kot terapevtska tarča za žensko neplodnost in diagnostični marker - Google Patents

Zunajcelična DNA kot terapevtska tarča za žensko neplodnost in diagnostični marker

Info

Publication number
SI2879696T1
SI2879696T1 SI201330280A SI201330280A SI2879696T1 SI 2879696 T1 SI2879696 T1 SI 2879696T1 SI 201330280 A SI201330280 A SI 201330280A SI 201330280 A SI201330280 A SI 201330280A SI 2879696 T1 SI2879696 T1 SI 2879696T1
Authority
SI
Slovenia
Prior art keywords
cell
free dna
therapeutic target
diagnostic marker
female infertility
Prior art date
Application number
SI201330280A
Other languages
English (en)
Inventor
Andre Hazout
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of SI2879696T1 publication Critical patent/SI2879696T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/21Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001Deoxyribonuclease I (3.1.21.1)
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
SI201330280A 2012-08-03 2013-08-01 Zunajcelična DNA kot terapevtska tarča za žensko neplodnost in diagnostični marker SI2879696T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12179265 2012-08-03
EP13156626 2013-02-25
EP13762279.1A EP2879696B1 (en) 2012-08-03 2013-08-01 Cell-free dna as a therapeutic target for female infertility and diagnostic marker
PCT/IB2013/056321 WO2014020564A1 (en) 2012-08-03 2013-08-01 Cell-free dna as a therapeutic target for female infertility and diagnostic marker

Publications (1)

Publication Number Publication Date
SI2879696T1 true SI2879696T1 (sl) 2016-10-28

Family

ID=49165809

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201330280A SI2879696T1 (sl) 2012-08-03 2013-08-01 Zunajcelična DNA kot terapevtska tarča za žensko neplodnost in diagnostični marker

Country Status (22)

Country Link
US (1) US9950040B2 (sl)
EP (1) EP2879696B1 (sl)
JP (1) JP6285436B2 (sl)
KR (1) KR102082735B1 (sl)
CN (1) CN104519906B (sl)
AU (1) AU2013298144B2 (sl)
CA (1) CA2880261C (sl)
DK (1) DK2879696T3 (sl)
EA (1) EA028855B1 (sl)
ES (1) ES2588387T3 (sl)
HK (1) HK1210592A1 (sl)
HR (1) HRP20161108T1 (sl)
HU (1) HUE030690T2 (sl)
IL (1) IL236924B (sl)
LT (1) LT2879696T (sl)
MX (1) MX359291B (sl)
NZ (1) NZ704039A (sl)
PL (1) PL2879696T3 (sl)
PT (1) PT2879696T (sl)
RS (1) RS55087B1 (sl)
SI (1) SI2879696T1 (sl)
WO (1) WO2014020564A1 (sl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388951B2 (en) 2003-07-14 2013-03-05 Cls Therapeutics Limited Method for treating systemic DNA mutation disease
US8710012B2 (en) 2003-07-14 2014-04-29 Cls Therapeutics Limited Method for treating oncological diseases
US8916151B2 (en) 2005-04-25 2014-12-23 Cls Therapeutics Limited Method for treating a reduction of fertility
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US10617743B2 (en) * 2014-06-19 2020-04-14 Cls Therapeutics Limited Method to improve safety and efficacy of anti-cancer therapy
EP3161149B1 (en) * 2014-06-27 2020-06-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods employing circulating dna and mirna as biomarkers for female infertility
EP3161148B1 (en) * 2014-06-27 2020-02-12 Institut National de la Sante et de la Recherche Medicale (INSERM) Use of free nucleic acids and microrna in a non-invasive method for determining embryo quality
KR101751962B1 (ko) 2015-04-30 2017-06-30 주식회사 넥스바이오 세포-유리형 dna의 위암 진단 용도
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
ES2799515T3 (es) 2015-05-22 2020-12-18 Dmitry Dmitrievich Genkin ADN extracelular como una diana terapéutica en la neurodegeneración
WO2018237075A1 (en) 2017-06-20 2018-12-27 The Medical College Of Wisconsin, Inc. ASSESSING THE RISK OF GRAFT COMPLICATION WITH TOTAL ACELLULAR DNA
CN111433605B (zh) 2017-09-18 2023-09-08 圣特萨斯股份公司 用于针对循环无细胞dna纯化血液的方法和装置
US11905522B2 (en) 2018-01-16 2024-02-20 Cls Therapeutics Limited Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
CN110144345B (zh) * 2019-05-10 2022-07-15 上海交通大学 一种从卵泡液中提取cfDNA的方法
EP3760740A1 (fr) 2019-07-05 2021-01-06 Hazout, André Utilisation du niveau d'adn libre comme marqueur de l'endometriose
WO2021207244A1 (en) * 2020-04-06 2021-10-14 The Medical College Of Wisconsin, Inc. Methods for assessing the severity of, and for inhibiting, pro-inflammatory responses with total cell-free dna
EP4026557A1 (fr) 2021-01-06 2022-07-13 Endolife Utilisation d'une désoxyribonucléase i dans le traitement de l'endométriose chez des patientes présentant une signature épigénétique de l'endométriose sur l'adn acellulaire
WO2023126672A1 (en) 2021-12-27 2023-07-06 Santersus Ag Method and device for removal of circulating cell free dna

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007131108A2 (en) * 2006-05-03 2007-11-15 Tmi Laboratories International, Inc. Method to diagnose and increase fertility of mammalian semen using dnase as diagnostic marker and therapeutic agent
WO2008047364A2 (en) * 2006-10-18 2008-04-24 Periness Ltd. Method and pharmacological composition for the diagnosis and treatment of male sub-fertility
EP1944611A1 (en) * 2007-01-11 2008-07-16 Université de la Méditerranée Biomarker for the medicine and the biology of the reproduction
EP2809780B1 (en) * 2012-02-01 2018-05-02 Protalix Ltd. Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy

Also Published As

Publication number Publication date
PT2879696T (pt) 2016-09-09
CN104519906B (zh) 2016-10-05
JP6285436B2 (ja) 2018-02-28
MX359291B (es) 2018-09-24
PL2879696T3 (pl) 2016-12-30
HK1210592A1 (zh) 2016-04-29
US20150246103A1 (en) 2015-09-03
EA201590115A1 (ru) 2015-07-30
MX2015001538A (es) 2015-05-11
EA028855B1 (ru) 2018-01-31
IL236924B (en) 2018-05-31
CA2880261C (en) 2021-02-02
HUE030690T2 (en) 2017-05-29
JP2015526079A (ja) 2015-09-10
CN104519906A (zh) 2015-04-15
NZ704039A (en) 2018-04-27
WO2014020564A1 (en) 2014-02-06
AU2013298144A1 (en) 2015-02-19
LT2879696T (lt) 2016-09-26
ES2588387T3 (es) 2016-11-02
KR102082735B1 (ko) 2020-02-28
CA2880261A1 (en) 2014-02-06
AU2013298144B2 (en) 2018-03-08
EP2879696B1 (en) 2016-06-08
HRP20161108T1 (hr) 2016-11-04
EP2879696A1 (en) 2015-06-10
RS55087B1 (sr) 2016-12-30
US9950040B2 (en) 2018-04-24
EA201590115A8 (ru) 2016-04-29
DK2879696T3 (en) 2016-09-12
KR20150036776A (ko) 2015-04-07

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