SI24094B - Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba - Google Patents
Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba Download PDFInfo
- Publication number
- SI24094B SI24094B SI201200204A SI201200204A SI24094B SI 24094 B SI24094 B SI 24094B SI 201200204 A SI201200204 A SI 201200204A SI 201200204 A SI201200204 A SI 201200204A SI 24094 B SI24094 B SI 24094B
- Authority
- SI
- Slovenia
- Prior art keywords
- antibacterial activity
- materials
- composite
- metal
- composites
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title claims abstract 9
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract 8
- 239000000463 material Substances 0.000 title abstract 8
- 239000002184 metal Substances 0.000 title abstract 2
- 229910052751 metal Inorganic materials 0.000 title abstract 2
- 239000000919 ceramic Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract 7
- 239000010931 gold Substances 0.000 claims abstract 7
- 229910052737 gold Inorganic materials 0.000 claims abstract 7
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract 5
- 238000000034 method Methods 0.000 claims abstract 2
- 239000002105 nanoparticle Substances 0.000 claims 6
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- YKFROQCFVXOUPW-UHFFFAOYSA-N 4-(methylthio) aniline Chemical compound CSC1=CC=C(N)C=C1 YKFROQCFVXOUPW-UHFFFAOYSA-N 0.000 claims 2
- JPWXLRZTRDTFMR-UHFFFAOYSA-N 5-bromo-1h-pyridine-2-thione Chemical compound SC1=CC=C(Br)C=N1 JPWXLRZTRDTFMR-UHFFFAOYSA-N 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000003462 bioceramic Substances 0.000 abstract 2
- 239000002082 metal nanoparticle Substances 0.000 abstract 2
- 239000012071 phase Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000006557 surface reaction Methods 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Ceramic Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
Na osnovi novega koncepta smo izdelali človeku in naravi prijazen material, ki izkazuje antibakterijsko aktivnost. Ta material je kompozit, sestavljen iz biokeramične faze (hidroksiapatit), kovinske faze (zlato) in organske faze, ki vsebuje amino in tiolne skupine (aminokisline). Biokeramični del kompozita je nosilec (angl. templating agent), ki kontrolira rast in stabilnost kovinskih nano delcev. Kovinski nano delci imajo funkcionalizirano površino in so nosilci antibakterijske aktivnosti kompozitnega materiala. Učinkovitost antibakterijske aktivnosti kompozita zavisi od izbire površinske funkcionalizacije, ki zagotavlja antibakterijsko aktivnost proti gram-pozitivnim in gram-negativnim bakterijam. Izumljeni materiali izkazujejo višjo antibakterijsko aktivnost kot HAp/Ag kompoziti, kar kaže na možnost zamenjave strupenih materialov, ki vsebujejo Ag. Materiale smo pripravljali s sonokemijsko metodo, ki je bila razvita kot nova sintezna metoda za te materiale in spada v t.i. zeleno kemijo.
Claims (2)
- Patentni zahtevki1. Antibakterijski kompozit, pripravljen s sonokemijsko precipitacijo, pri čemer kompozit vključuje:a) hidroksiapatitni substrat,b) nanodelce zlata inc) organske molekule, pri čemer so nanodelci zlata pritrjeni na površino hidroksiapatitnega substrata; nanodelci zlata so prekriti z organskimi molekulami; organske molekule so izbrane iz skupine, ki jo sestavljajo arginin, glicin, anilin, histidin, 4 (metiltio) anilin in 5-bromopiridin-2-tioL
- 2. Postopek za pripravo antibakterijskega kompozita, ki vključuje:a) hidroksiapatitni substrat,b) nanodelce zlata inc) organske molekule, pri čemer so nanodelci zlata pritrjeni na površino hidroksiapatitnega substrata; nanodelci zlata so prekriti z organskimi molekulam; organske molekule so izbrane iz skupine, ki jo sestavljajo arginin, glicin, anilin, histidin, 4 (metiltio) anilin in 5-bromopiridin-2-tiol; priprava pa se izvaja s sonokemično precipitacijo.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI201200204A SI24094B (sl) | 2012-06-15 | 2012-06-15 | Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba |
| PCT/SI2013/000025 WO2013187846A1 (en) | 2012-06-15 | 2013-05-08 | Functionalized hydroxyapatite/gold composites as "green" materials with antibacterial activity and the process for preparing and use thereof |
| EP13735469.2A EP2863751B1 (en) | 2012-06-15 | 2013-05-08 | Functionalized hydroxyapatite/gold composites as "green" materials with antibacterial activity and the process for preparing and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI201200204A SI24094B (sl) | 2012-06-15 | 2012-06-15 | Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI24094A SI24094A (sl) | 2013-12-31 |
| SI24094B true SI24094B (sl) | 2021-07-30 |
Family
ID=48782583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201200204A SI24094B (sl) | 2012-06-15 | 2012-06-15 | Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2863751B1 (sl) |
| SI (1) | SI24094B (sl) |
| WO (1) | WO2013187846A1 (sl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2013002101A1 (es) * | 2013-07-23 | 2014-08-29 | Univ Chile | Aditivo que confiere propiedades biocidas a distintos materiales que comprende un material de soporte o portador modificado con un agente bacteriano que forma estructuras nanometricas sobre la superficie externa de dicho material de soporte; y metodo para preparacion de dicho aditivo. |
| CN114681481B (zh) * | 2021-09-30 | 2023-05-02 | 合肥工业大学 | 一种用于选择性对抗革兰氏阳性细菌的手性二维硫纳米片及其制备方法和应用 |
| CN113826643B (zh) * | 2021-11-01 | 2022-07-05 | 烟台大学 | 银离子空间分布可控的载银羟基磷灰石微粒及其制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482444B1 (en) | 1999-06-14 | 2002-11-19 | Imperial College Innovations | Silver-containing, sol/gel derived bioglass compositions |
| JPWO2002030365A1 (ja) | 2000-10-06 | 2004-02-19 | 株式会社サンギ | 抗菌性樹脂 |
| DE60228763D1 (de) | 2002-06-04 | 2008-10-16 | Fujitsu Ltd | Antibakterielle und gegen flecken gerichtete farbe für baustoff und damit beschichteter baustoff |
| ITTO20040854A1 (it) | 2004-12-02 | 2005-03-02 | Torino Politecnico | Procedimento di funzionamento di superfici vetrose, vetroceramiche e ceramiche per la realizzazione di dispositivi impiantabili ad azione antibatterica |
| WO2007015105A2 (en) | 2005-08-04 | 2007-02-08 | Thomas William Rademacher | Nanoparticles comprising antibacterial ligands |
| WO2008066965A2 (en) | 2006-06-23 | 2008-06-05 | The Regents Of The University Of California | Articles comprising large-surface-area bio-compatible materials and methods for making and using them |
| WO2008122131A1 (en) | 2007-04-04 | 2008-10-16 | Perlen Converting Ag | Antimicrobial material |
| JP2009233653A (ja) | 2008-03-06 | 2009-10-15 | Daicel Chem Ind Ltd | 表面銀固定化ハイドロキシアパタイト |
| JP2010082776A (ja) * | 2008-10-01 | 2010-04-15 | Tohoku Univ | 有機溶媒ソノケミストリーによるナノ粒子合成法 |
| US20100104652A1 (en) | 2008-10-27 | 2010-04-29 | University Of Arkansas | Use of advanced nanomaterials for increasing sepecific cell functions |
| EP2229962A1 (en) | 2009-03-20 | 2010-09-22 | Laura Martelli | Medical-surgical devices with antibacterial coating for human or animal implant and a method for their production |
| GB0906999D0 (en) | 2009-04-23 | 2009-06-03 | Promethean Particles Ltd | Ceramic materials and method fo production |
| DE102009023459B4 (de) | 2009-06-02 | 2017-08-31 | Aap Implantate Ag | Osteosynthese mit Nanosilber |
| US9192626B2 (en) | 2009-06-10 | 2015-11-24 | American Silver, Llc | Dental uses of silver hydrosol |
| WO2011022642A1 (en) | 2009-08-21 | 2011-02-24 | Malshe Ajay P | Nanostructured hydroxyapatite coating for dental and orthopedic implants |
-
2012
- 2012-06-15 SI SI201200204A patent/SI24094B/sl active Search and Examination
-
2013
- 2013-05-08 EP EP13735469.2A patent/EP2863751B1/en active Active
- 2013-05-08 WO PCT/SI2013/000025 patent/WO2013187846A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013187846A1 (en) | 2013-12-19 |
| EP2863751B1 (en) | 2018-07-25 |
| SI24094A (sl) | 2013-12-31 |
| EP2863751A1 (en) | 2015-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OO00 | Grant of patent |
Effective date: 20140115 |
|
| OU02 | Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims |
Effective date: 20210616 |