SI24094B - Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba - Google Patents

Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba Download PDF

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Publication number
SI24094B
SI24094B SI201200204A SI201200204A SI24094B SI 24094 B SI24094 B SI 24094B SI 201200204 A SI201200204 A SI 201200204A SI 201200204 A SI201200204 A SI 201200204A SI 24094 B SI24094 B SI 24094B
Authority
SI
Slovenia
Prior art keywords
antibacterial activity
materials
composite
metal
composites
Prior art date
Application number
SI201200204A
Other languages
English (en)
Other versions
SI24094A (sl
Inventor
Marija Vukomanović
Srečo Davor Škapin
Danilo Suvorov
Original Assignee
Institut "Jožef Stefan"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut "Jožef Stefan" filed Critical Institut "Jožef Stefan"
Priority to SI201200204A priority Critical patent/SI24094B/sl
Priority to PCT/SI2013/000025 priority patent/WO2013187846A1/en
Priority to EP13735469.2A priority patent/EP2863751B1/en
Publication of SI24094A publication Critical patent/SI24094A/sl
Publication of SI24094B publication Critical patent/SI24094B/sl

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

Na osnovi novega koncepta smo izdelali človeku in naravi prijazen material, ki izkazuje antibakterijsko aktivnost. Ta material je kompozit, sestavljen iz biokeramične faze (hidroksiapatit), kovinske faze (zlato) in organske faze, ki vsebuje amino in tiolne skupine (aminokisline). Biokeramični del kompozita je nosilec (angl. templating agent), ki kontrolira rast in stabilnost kovinskih nano delcev. Kovinski nano delci imajo funkcionalizirano površino in so nosilci antibakterijske aktivnosti kompozitnega materiala. Učinkovitost antibakterijske aktivnosti kompozita zavisi od izbire površinske funkcionalizacije, ki zagotavlja antibakterijsko aktivnost proti gram-pozitivnim in gram-negativnim bakterijam. Izumljeni materiali izkazujejo višjo antibakterijsko aktivnost kot HAp/Ag kompoziti, kar kaže na možnost zamenjave strupenih materialov, ki vsebujejo Ag. Materiale smo pripravljali s sonokemijsko metodo, ki je bila razvita kot nova sintezna metoda za te materiale in spada v t.i. zeleno kemijo.

Claims (2)

  1. Patentni zahtevki
    1. Antibakterijski kompozit, pripravljen s sonokemijsko precipitacijo, pri čemer kompozit vključuje:
    a) hidroksiapatitni substrat,
    b) nanodelce zlata in
    c) organske molekule, pri čemer so nanodelci zlata pritrjeni na površino hidroksiapatitnega substrata; nanodelci zlata so prekriti z organskimi molekulami; organske molekule so izbrane iz skupine, ki jo sestavljajo arginin, glicin, anilin, histidin, 4 (metiltio) anilin in 5-bromopiridin-2-tioL
  2. 2. Postopek za pripravo antibakterijskega kompozita, ki vključuje:
    a) hidroksiapatitni substrat,
    b) nanodelce zlata in
    c) organske molekule, pri čemer so nanodelci zlata pritrjeni na površino hidroksiapatitnega substrata; nanodelci zlata so prekriti z organskimi molekulam; organske molekule so izbrane iz skupine, ki jo sestavljajo arginin, glicin, anilin, histidin, 4 (metiltio) anilin in 5-bromopiridin-2-tiol; priprava pa se izvaja s sonokemično precipitacijo.
SI201200204A 2012-06-15 2012-06-15 Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba SI24094B (sl)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SI201200204A SI24094B (sl) 2012-06-15 2012-06-15 Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba
PCT/SI2013/000025 WO2013187846A1 (en) 2012-06-15 2013-05-08 Functionalized hydroxyapatite/gold composites as "green" materials with antibacterial activity and the process for preparing and use thereof
EP13735469.2A EP2863751B1 (en) 2012-06-15 2013-05-08 Functionalized hydroxyapatite/gold composites as "green" materials with antibacterial activity and the process for preparing and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI201200204A SI24094B (sl) 2012-06-15 2012-06-15 Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba

Publications (2)

Publication Number Publication Date
SI24094A SI24094A (sl) 2013-12-31
SI24094B true SI24094B (sl) 2021-07-30

Family

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Family Applications (1)

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SI201200204A SI24094B (sl) 2012-06-15 2012-06-15 Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba

Country Status (3)

Country Link
EP (1) EP2863751B1 (sl)
SI (1) SI24094B (sl)
WO (1) WO2013187846A1 (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2013002101A1 (es) * 2013-07-23 2014-08-29 Univ Chile Aditivo que confiere propiedades biocidas a distintos materiales que comprende un material de soporte o portador modificado con un agente bacteriano que forma estructuras nanometricas sobre la superficie externa de dicho material de soporte; y metodo para preparacion de dicho aditivo.
CN114681481B (zh) * 2021-09-30 2023-05-02 合肥工业大学 一种用于选择性对抗革兰氏阳性细菌的手性二维硫纳米片及其制备方法和应用
CN113826643B (zh) * 2021-11-01 2022-07-05 烟台大学 银离子空间分布可控的载银羟基磷灰石微粒及其制备方法

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
CA2377402C (en) 1999-06-14 2011-01-18 Imperial College Innovations Silver-containing, sol-gel derived bioglass compositions
EP1329211A4 (en) 2000-10-06 2005-01-05 Sangi Kk ANTIBACTERIAL RESIN
CN1317346C (zh) 2002-06-04 2007-05-23 富士通株式会社 建筑材料用的抗菌防污涂料以及用其涂装的建筑材料
ITTO20040854A1 (it) 2004-12-02 2005-03-02 Torino Politecnico Procedimento di funzionamento di superfici vetrose, vetroceramiche e ceramiche per la realizzazione di dispositivi impiantabili ad azione antibatterica
US9034380B2 (en) 2005-08-04 2015-05-19 Midatech Ltd. Nanoparticles comprising antibacterial ligands
WO2008066965A2 (en) 2006-06-23 2008-06-05 The Regents Of The University Of California Articles comprising large-surface-area bio-compatible materials and methods for making and using them
JP5777337B2 (ja) 2007-04-04 2015-09-09 パーレン コンヴァーティング アクチェンゲゼルシャフトＰｅｒｌｅｎ Ｃｏｎｖｅｒｔｉｎｇ ＡＧ 抗菌性材料
JP2009233653A (ja) 2008-03-06 2009-10-15 Daicel Chem Ind Ltd 表面銀固定化ハイドロキシアパタイト
JP2010082776A (ja) * 2008-10-01 2010-04-15 Tohoku Univ 有機溶媒ソノケミストリーによるナノ粒子合成法
US20100104652A1 (en) 2008-10-27 2010-04-29 University Of Arkansas Use of advanced nanomaterials for increasing sepecific cell functions
EP2229962A1 (en) 2009-03-20 2010-09-22 Laura Martelli Medical-surgical devices with antibacterial coating for human or animal implant and a method for their production
GB0906999D0 (en) 2009-04-23 2009-06-03 Promethean Particles Ltd Ceramic materials and method fo production
DE102009023459B4 (de) 2009-06-02 2017-08-31 Aap Implantate Ag Osteosynthese mit Nanosilber
US9192626B2 (en) 2009-06-10 2015-11-24 American Silver, Llc Dental uses of silver hydrosol
WO2011022642A1 (en) 2009-08-21 2011-02-24 Malshe Ajay P Nanostructured hydroxyapatite coating for dental and orthopedic implants

Also Published As

Publication number Publication date
EP2863751A1 (en) 2015-04-29
SI24094A (sl) 2013-12-31
EP2863751B1 (en) 2018-07-25
WO2013187846A1 (en) 2013-12-19

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OO00 Grant of patent

Effective date: 20140115

OU02 Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims

Effective date: 20210616