SI2243030T1 - Metode za identifikacijo protitelesa ali tarče - Google Patents

Metode za identifikacijo protitelesa ali tarče

Info

Publication number
SI2243030T1
SI2243030T1 SI200931209T SI200931209T SI2243030T1 SI 2243030 T1 SI2243030 T1 SI 2243030T1 SI 200931209 T SI200931209 T SI 200931209T SI 200931209 T SI200931209 T SI 200931209T SI 2243030 T1 SI2243030 T1 SI 2243030T1
Authority
SI
Slovenia
Prior art keywords
antibody
identification
target
methods
Prior art date
Application number
SI200931209T
Other languages
English (en)
Other versions
SI2243030T2 (sl
Inventor
Markus Enzelberger
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39284131&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2243030(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of SI2243030T1 publication Critical patent/SI2243030T1/sl
Publication of SI2243030T2 publication Critical patent/SI2243030T2/sl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
SI200931209T 2008-02-11 2009-02-11 Metode za identifikacijo protitelesa ali tarče SI2243030T2 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2750708P 2008-02-11 2008-02-11
EP08151276A EP2088432A1 (en) 2008-02-11 2008-02-11 Methods for identification of an antibody or a target
US4503908P 2008-04-15 2008-04-15
PCT/EP2009/000953 WO2009100896A1 (en) 2008-02-11 2009-02-11 Methods for identification of an antibody or a target
EP09710996.1A EP2243030B2 (en) 2008-02-11 2009-02-11 Methods for identification of an antibody or a target

Publications (2)

Publication Number Publication Date
SI2243030T1 true SI2243030T1 (sl) 2015-07-31
SI2243030T2 SI2243030T2 (sl) 2018-05-31

Family

ID=39284131

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200931209T SI2243030T2 (sl) 2008-02-11 2009-02-11 Metode za identifikacijo protitelesa ali tarče

Country Status (9)

Country Link
US (1) US9404929B2 (sl)
EP (2) EP2088432A1 (sl)
JP (1) JP2011523348A (sl)
AU (1) AU2009214332B2 (sl)
CA (1) CA2714641C (sl)
DK (1) DK2243030T4 (sl)
ES (1) ES2541934T5 (sl)
SI (1) SI2243030T2 (sl)
WO (1) WO2009100896A1 (sl)

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US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP2088432A1 (en) 2008-02-11 2009-08-12 MorphoSys AG Methods for identification of an antibody or a target
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
ES2781754T3 (es) 2008-11-07 2020-09-07 Adaptive Biotechnologies Corp Métodos para supervisar las condiciones por análisis de secuencia
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
DK2387627T3 (en) * 2009-01-15 2016-07-04 Adaptive Biotechnologies Corp Adaptive immunity profiling and methods for producing monoclonal antibodies
DK2435568T3 (da) 2009-05-29 2014-09-08 Morphosys Ag Samling af syntetiske antistoffer til behandling af sygdom
KR20120044941A (ko) 2009-06-25 2012-05-08 프레드 헛친슨 켄서 리서치 센터 적응 면역의 측정방법
CN103003697A (zh) 2010-05-17 2013-03-27 得克萨斯系统大学董事会 来自动物的单克隆抗体的快速分离
US9146241B2 (en) 2011-11-23 2015-09-29 Board Of Regents, The University Of Texas System Proteomic identification of antibodies
RU2603080C2 (ru) 2010-11-19 2016-11-20 МорфоСис АГ Коллекция и способы ее применения
US9920110B2 (en) 2011-03-09 2018-03-20 Cell Signaling Technology, Inc. Methods and reagents for creating monoclonal antibodies
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
CA2791109C (en) * 2011-09-26 2021-02-16 Merus B.V. Generation of binding molecules
EP2768982A4 (en) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS
EP3388535B1 (en) 2011-12-09 2021-03-24 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP2823060B1 (en) 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits
AU2013259544B9 (en) 2012-05-08 2017-09-28 Adaptive Biotechnologies Corporation Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions
DK2861760T3 (da) 2012-06-15 2020-03-09 Univ Texas Sekventering med høj kapacitet af flere udskrifter af en enkelt celle
US20160002731A1 (en) 2012-10-01 2016-01-07 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
EP3498866A1 (en) 2014-11-25 2019-06-19 Adaptive Biotechnologies Corp. Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
AU2016222788B2 (en) 2015-02-24 2022-03-31 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
US10513733B2 (en) 2015-03-23 2019-12-24 Board Of Regents, The University Of Texas System High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
WO2019084538A1 (en) 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010049107A1 (en) 1994-01-31 2001-12-06 Boston University Polyclonal antibody libraries
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6828422B1 (en) 1995-08-18 2004-12-07 Morphosys Ag Protein/(poly)peptide libraries
DE69834032T2 (de) * 1997-04-23 2006-12-07 Universität Zürich Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren
US6897028B1 (en) 1997-07-07 2005-05-24 Florida State University Identification of molecular targets
EP1157041B1 (en) 1999-03-01 2005-06-01 Genentech, Inc. Antibodies for cancer therapy and diagnosis
US7117096B2 (en) 2001-04-17 2006-10-03 Abmaxis, Inc. Structure-based selection and affinity maturation of antibody library
AU2002351896A1 (en) * 2001-12-11 2003-06-23 Ablynx N.V. Method for displaying loops from immunoglobulin domains in different contexts
GB0130267D0 (en) * 2001-12-19 2002-02-06 Neutec Pharma Plc Focussed antibody technology
AU2002360068B2 (en) 2001-12-21 2009-09-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Method for cloning of variable domain sequences
WO2003070979A2 (en) 2002-02-20 2003-08-28 Ncc Technology Ventures Pte Limited Materials and methods relating to cancer diagnosis
JP2004222055A (ja) 2003-01-16 2004-08-05 Fujitsu Ltd 多重化装置及びその使用方法
GB0309126D0 (en) * 2003-04-17 2003-05-28 Neutec Pharma Plc Clostridium difficile focussed antibodies
WO2004109447A2 (en) 2003-05-30 2004-12-16 Rosetta Inpharmatics Llc Computer systems and methods for identifying surrogate markers
WO2005094159A2 (en) 2003-11-12 2005-10-13 Oncomab Gmbh Methods of identifying neoplasm-specific antibodies and uses thereof
US20050266425A1 (en) * 2003-12-31 2005-12-01 Vaccinex, Inc. Methods for producing and identifying multispecific antibodies
EP1718765A2 (en) 2004-01-26 2006-11-08 Isis Innovation Limited Molecular analysis
ATE505727T1 (de) 2004-05-26 2011-04-15 Fraunhofer Ges Forschung Isolation allergen-spezifischer immunoglobulin- gene aus humanen b-zellen von atopikern
WO2006014498A2 (en) * 2004-07-06 2006-02-09 Bioren, Inc. Universal antibody libraries
WO2006028987A2 (en) 2004-09-02 2006-03-16 Bioarray Solutions Ltd. Nucleic acid amplification with integrated multiplex detection
US7348153B2 (en) 2004-11-24 2008-03-25 Health Research, Inc. Method for identifying and designing immunogenic peptides
DK3620171T3 (da) * 2005-05-18 2022-06-07 Morphosys Ag Anti-GM-CSF-antistoffer og anvendelser af disse
EP2088432A1 (en) 2008-02-11 2009-08-12 MorphoSys AG Methods for identification of an antibody or a target
EP2100970B1 (en) * 2008-03-13 2017-05-10 National Institute of Immunology Ig genes specific oligonucleotides and uses thereof

Also Published As

Publication number Publication date
EP2243030B1 (en) 2015-04-15
AU2009214332A1 (en) 2009-08-20
JP2011523348A (ja) 2011-08-11
EP2243030B2 (en) 2018-02-21
ES2541934T3 (es) 2015-07-28
ES2541934T5 (es) 2018-05-30
EP2088432A1 (en) 2009-08-12
US20100330577A1 (en) 2010-12-30
DK2243030T3 (en) 2015-06-08
CA2714641A1 (en) 2009-08-20
WO2009100896A1 (en) 2009-08-20
US9404929B2 (en) 2016-08-02
CA2714641C (en) 2016-09-13
EP2243030A1 (en) 2010-10-27
DK2243030T4 (en) 2018-05-28
AU2009214332B2 (en) 2015-01-15
SI2243030T2 (sl) 2018-05-31

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