SI1572169T1 - Odkrivanje in modulacija slit in robo posredovane angiogeneze ter njuni načini uporabe - Google Patents

Odkrivanje in modulacija slit in robo posredovane angiogeneze ter njuni načini uporabe

Info

Publication number
SI1572169T1
SI1572169T1 SI200332312T SI200332312T SI1572169T1 SI 1572169 T1 SI1572169 T1 SI 1572169T1 SI 200332312 T SI200332312 T SI 200332312T SI 200332312 T SI200332312 T SI 200332312T SI 1572169 T1 SI1572169 T1 SI 1572169T1
Authority
SI
Slovenia
Prior art keywords
roundabount
robo
slit
modulation
detection
Prior art date
Application number
SI200332312T
Other languages
English (en)
Inventor
Jian-Guo Geng
Original Assignee
Shanghai Institutes For Biological Sciences, Cas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institutes For Biological Sciences, Cas filed Critical Shanghai Institutes For Biological Sciences, Cas
Publication of SI1572169T1 publication Critical patent/SI1572169T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Eye Examination Apparatus (AREA)
SI200332312T 2002-03-08 2003-03-10 Odkrivanje in modulacija slit in robo posredovane angiogeneze ter njuni načini uporabe SI1572169T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36248502P 2002-03-08 2002-03-08
PCT/US2003/007458 WO2003075860A2 (en) 2002-03-08 2003-03-10 Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof
EP03716469.6A EP1572169B1 (en) 2002-03-08 2003-03-10 Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof

Publications (1)

Publication Number Publication Date
SI1572169T1 true SI1572169T1 (sl) 2013-12-31

Family

ID=27805180

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200332312T SI1572169T1 (sl) 2002-03-08 2003-03-10 Odkrivanje in modulacija slit in robo posredovane angiogeneze ter njuni načini uporabe

Country Status (8)

Country Link
US (1) US7939497B2 (sl)
EP (2) EP2316853A3 (sl)
AU (1) AU2003220173A1 (sl)
DK (1) DK1572169T3 (sl)
ES (1) ES2431040T3 (sl)
PT (1) PT1572169E (sl)
SI (1) SI1572169T1 (sl)
WO (1) WO2003075860A2 (sl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1790728T3 (da) * 2000-11-06 2010-12-06 Cancer Rec Tech Ltd Billeddannelse, diagnose og behandling af sygdom
AU2003247828B2 (en) * 2002-06-27 2010-05-20 University Of Utah Research Foundation Methods and compositions for manipulating the guided navigation of endothelial tubes during angiogenesis
SI1565491T1 (sl) * 2002-11-20 2010-08-31 Cancer Rec Tech Ltd Protitelesa, ki se veĹľejo na humani "magic roundabout (MR)", polipeptidi in njihove uporabe za inhibiranje angiogeneze
US20060025335A1 (en) * 2004-01-30 2006-02-02 Kinane Thomas B Netrin compositions and methods of using the same
US8940488B2 (en) 2004-03-31 2015-01-27 Hiroyuki Aburatani Cancer diagnosis and treatment of cancer using anti-robo 1 antibody
EP2226636B1 (en) 2004-03-31 2012-03-21 Hiroyuki Aburatani Cancer diagnosis and treatment using anti-robo1 antibody
BRPI0720038A2 (pt) 2006-12-11 2013-12-24 Univ Utah Res Found Métodos para inibir a permeabilidade vascular em tecido, para triar ou avaliar um agente que inibe a permeabilidade vascular, para tratar ou prevenir a síndrome da angústia respiratória, a retinopatia de prematuridade, a retinopatia diabética e a degeneração macular úmida em um indivíduo, para tratar indivíduos com sugestões repulsivas ou miméticos e para promover a angiogênese em um tecido, polipeptídeo isolado, ácido nucleico isolado, e, vetor
US7834154B2 (en) * 2007-02-09 2010-11-16 Genentech, Inc. Anti-ROBO4 antibodies and uses therefor
CA2693001A1 (en) * 2008-04-16 2009-10-22 University Of Utah Research Foundation Compositions and methods for treating pathologic angiogenesis and vascular permeability
CA2750785A1 (en) * 2009-01-06 2010-07-15 Functional Genetics, Inc. Random homozygous gene perburbation (rhgp) with thermal assymetric interlaced (tail)-pcr
FR2958936A1 (fr) 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
CN102233134A (zh) * 2010-04-30 2011-11-09 中国科学院上海生命科学研究院 Slit-robo介导的淋巴管形成及其应用
WO2012042289A1 (en) * 2010-09-28 2012-04-05 Inserm ( Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of bone density related diseases
EP2655408B1 (en) * 2010-12-23 2016-07-06 Sanofi Robo1-fc fusion protein for use in the treatment of hepatocarcinoma
DK2800578T3 (en) * 2012-01-05 2019-03-25 Boston Medical Ct Corp SLIT-ROBO SIGNAL FOR DIAGNOSIS AND TREATMENT OF Kidney Diseases
KR101897322B1 (ko) * 2015-01-21 2018-09-10 재단법인 아산사회복지재단 원발성 갑상선암 전이의 진단방법 및 이를 이용한 진단키트
CN104711279B (zh) * 2015-03-17 2018-03-02 山东一达启航生物科技有限公司 一种血管内皮生长因子检测试剂盒及其原料制备
BR112019024742A2 (pt) 2017-06-02 2020-06-16 Pfizer Inc. Proteínas robo2 recombinantes, composições, métodos e usos das mesmas

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE463851B (sv) * 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE4221256C2 (de) * 1992-06-26 1997-07-10 Lancaster Group Ag Galenische Zusammensetzung für die topische Anwendung
US5869305A (en) * 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5741511A (en) * 1995-04-12 1998-04-21 Sam Yang Co., Ltd. Transdermal drug delivery device for treating erectile dysfunction
US5888767A (en) * 1996-11-27 1999-03-30 The Johns Hopkins University School Of Medicine Method of using a conditionally replicating viral vector to express a gene
EP0871512A1 (en) * 1995-12-22 1998-10-21 Localmed, Inc. Localized intravascular delivery of growth factors for promotion of angiogenesis
US5736154A (en) * 1996-03-11 1998-04-07 Fuisz Technologies Ltd. Transdermal delivery system
SE9703226D0 (sv) * 1997-09-08 1997-09-08 Astra Ab New pharmaceutical composition
AU729496B2 (en) * 1997-10-20 2001-02-01 Regents Of The University Of California, The Robo: a novel family of polypeptides and nucleic acids
US6197801B1 (en) * 1998-01-14 2001-03-06 Usa Doctors Products, Inc. Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction
US5962274A (en) * 1998-03-13 1999-10-05 Wake Forest University Viral vector directed to predetermined target cells
AU3767300A (en) * 1999-03-26 2000-10-16 Human Genome Sciences, Inc. 47 human secreted proteins
US6811788B2 (en) * 2000-01-19 2004-11-02 Baofa Yu Combinations and methods for treating neoplasms
SI1565491T1 (sl) 2002-11-20 2010-08-31 Cancer Rec Tech Ltd Protitelesa, ki se veĹľejo na humani "magic roundabout (MR)", polipeptidi in njihove uporabe za inhibiranje angiogeneze

Also Published As

Publication number Publication date
WO2003075860A2 (en) 2003-09-18
EP2316853A3 (en) 2011-10-05
DK1572169T3 (da) 2013-10-21
AU2003220173A8 (en) 2003-09-22
EP1572169B1 (en) 2013-07-17
US20030236210A1 (en) 2003-12-25
AU2003220173A1 (en) 2003-09-22
PT1572169E (pt) 2013-10-08
ES2431040T3 (es) 2013-11-22
US7939497B2 (en) 2011-05-10
EP1572169A4 (en) 2007-07-25
WO2003075860A3 (en) 2006-08-17
EP1572169A2 (en) 2005-09-14
EP2316853A2 (en) 2011-05-04

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