SI1212428T1 - Cell-specific and/or tumor-specific promoter retargeting of herpes gamma 34.5 gene expression - Google Patents
Cell-specific and/or tumor-specific promoter retargeting of herpes gamma 34.5 gene expressionInfo
- Publication number
- SI1212428T1 SI1212428T1 SI200030611T SI200030611T SI1212428T1 SI 1212428 T1 SI1212428 T1 SI 1212428T1 SI 200030611 T SI200030611 T SI 200030611T SI 200030611 T SI200030611 T SI 200030611T SI 1212428 T1 SI1212428 T1 SI 1212428T1
- Authority
- SI
- Slovenia
- Prior art keywords
- specific
- tumor
- cell
- retargeting
- gene expression
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16041—Use of virus, viral particle or viral elements as a vector
- C12N2710/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention relates to herpes viral mutants and methods of using these viral mutants for selectively targeting tumor cells or other populations of target cells. The viral mutants of the invention are capable of selective targeting due to the use of tumor-specific and/or cell-specific promoters to drive expression of the herpes gamma 34.5 gene.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15162199P | 1999-08-31 | 1999-08-31 | |
PCT/US2000/002409 WO2001016331A1 (en) | 1999-08-31 | 2000-02-02 | Cell-specific and/or tumor-specific promoter retargeting of herpes gamma 34.5 gene expression |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1212428T1 true SI1212428T1 (en) | 2005-06-30 |
Family
ID=22539547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200030611T SI1212428T1 (en) | 1999-08-31 | 2000-02-02 | Cell-specific and/or tumor-specific promoter retargeting of herpes gamma 34.5 gene expression |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1212428B1 (en) |
JP (1) | JP4551042B2 (en) |
KR (1) | KR100701905B1 (en) |
AT (1) | ATE283921T1 (en) |
AU (1) | AU781219B2 (en) |
CA (1) | CA2383372C (en) |
DE (1) | DE60016429T2 (en) |
ES (1) | ES2233349T3 (en) |
IL (2) | IL148360A0 (en) |
MX (1) | MXPA02002142A (en) |
PT (1) | PT1212428E (en) |
SI (1) | SI1212428T1 (en) |
WO (1) | WO2001016331A1 (en) |
ZA (1) | ZA200202413B (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6897057B1 (en) * | 1999-08-31 | 2005-05-24 | The General Hospital Corporation | Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression |
EP1486212A1 (en) * | 2000-06-01 | 2004-12-15 | Sloan-Kettering Institute For Cancer Research | Combination of a mutant herepes virus and irinotecan for the treatment of cancer |
GB0203285D0 (en) * | 2002-02-12 | 2002-03-27 | Brown Susanne M | An herpes simplex virus complex |
EP2305710A3 (en) | 2002-06-03 | 2013-05-29 | Genentech, Inc. | Synthetic antibody phage libraries |
GB0326798D0 (en) | 2003-11-17 | 2003-12-24 | Crusade Lab Ltd | Methods for generating mutant virus |
US7897146B2 (en) | 2003-11-17 | 2011-03-01 | Crusade Laboratories Limited | Treatment using herpes simplex virus |
JP2007511216A (en) | 2003-11-17 | 2007-05-10 | クルセイド ラボラトリーズ リミテッド | Mutant virus |
JPWO2011101912A1 (en) * | 2010-02-19 | 2013-06-17 | 国立大学法人 東京大学 | Recombinant herpes virus and pharmaceutical composition comprising recombinant herpes virus |
EP3011964A1 (en) * | 2014-10-24 | 2016-04-27 | Karcinolys | Compounds and associations for treating pancreatic cancer |
EP3429633B1 (en) | 2016-04-15 | 2021-02-24 | Cellectis | A method of engineering drug-specific hypersensitive t-cells for immunotherapy by gene inactivation |
EP3429634A1 (en) * | 2016-04-15 | 2019-01-23 | Cellectis | A method of engineering prodrug-specific hypersensitive t-cells for immunotherapy by gene expression |
CN116135972A (en) * | 2021-11-16 | 2023-05-19 | 中国科学院深圳先进技术研究院 | Oncolytic virus based on Chinese HSV clinical isolate and construction method and application thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585096A (en) * | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
GB9415320D0 (en) * | 1994-07-29 | 1994-09-21 | Medical Res Council | Cancer treatment |
IL118942A (en) * | 1995-07-27 | 2002-09-12 | American Cyanamid Co | Avirulent herpetic viruses useful as tumoricidal agents and vaccines |
CA2284611A1 (en) * | 1997-03-27 | 1998-10-01 | Richard B. Pyles | Replication-competent herpes simplex viruses |
-
2000
- 2000-02-02 AU AU34774/00A patent/AU781219B2/en not_active Expired
- 2000-02-02 SI SI200030611T patent/SI1212428T1/en unknown
- 2000-02-02 IL IL14836000A patent/IL148360A0/en active IP Right Grant
- 2000-02-02 EP EP00913305A patent/EP1212428B1/en not_active Expired - Lifetime
- 2000-02-02 KR KR1020027002714A patent/KR100701905B1/en active IP Right Grant
- 2000-02-02 DE DE60016429T patent/DE60016429T2/en not_active Expired - Lifetime
- 2000-02-02 WO PCT/US2000/002409 patent/WO2001016331A1/en active IP Right Grant
- 2000-02-02 AT AT00913305T patent/ATE283921T1/en active
- 2000-02-02 ES ES00913305T patent/ES2233349T3/en not_active Expired - Lifetime
- 2000-02-02 JP JP2001520877A patent/JP4551042B2/en not_active Expired - Lifetime
- 2000-02-02 MX MXPA02002142A patent/MXPA02002142A/en active IP Right Grant
- 2000-02-02 PT PT00913305T patent/PT1212428E/en unknown
- 2000-02-02 CA CA2383372A patent/CA2383372C/en not_active Expired - Lifetime
-
2002
- 2002-02-25 IL IL148360A patent/IL148360A/en not_active IP Right Cessation
- 2002-03-26 ZA ZA200202413A patent/ZA200202413B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1212428B1 (en) | 2004-12-01 |
PT1212428E (en) | 2005-03-31 |
MXPA02002142A (en) | 2003-04-10 |
DE60016429T2 (en) | 2005-11-24 |
DE60016429D1 (en) | 2005-01-05 |
ZA200202413B (en) | 2003-06-25 |
KR100701905B1 (en) | 2007-04-02 |
EP1212428A1 (en) | 2002-06-12 |
IL148360A (en) | 2007-12-03 |
JP2003508055A (en) | 2003-03-04 |
ATE283921T1 (en) | 2004-12-15 |
IL148360A0 (en) | 2002-09-12 |
AU781219B2 (en) | 2005-05-12 |
KR20020092905A (en) | 2002-12-12 |
WO2001016331A1 (en) | 2001-03-08 |
CA2383372C (en) | 2010-04-13 |
ES2233349T3 (en) | 2005-06-16 |
CA2383372A1 (en) | 2001-03-08 |
JP4551042B2 (en) | 2010-09-22 |
AU3477400A (en) | 2001-03-26 |
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