SI0932617T1 - Inhibitorji serin proteaz, še zlasti NS3-proteaze virusa hepatitisa C - Google Patents
Inhibitorji serin proteaz, še zlasti NS3-proteaze virusa hepatitisa CInfo
- Publication number
- SI0932617T1 SI0932617T1 SI9730302T SI9730302T SI0932617T1 SI 0932617 T1 SI0932617 T1 SI 0932617T1 SI 9730302 T SI9730302 T SI 9730302T SI 9730302 T SI9730302 T SI 9730302T SI 0932617 T1 SI0932617 T1 SI 0932617T1
- Authority
- SI
- Slovenia
- Prior art keywords
- protease
- virus
- inhibitors
- serine proteases
- particularly hepatitis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2829096P | 1996-10-18 | 1996-10-18 | |
PCT/US1997/018968 WO1998017679A1 (en) | 1996-10-18 | 1997-10-17 | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
EP97946273A EP0932617B1 (en) | 1996-10-18 | 1997-10-17 | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0932617T1 true SI0932617T1 (sl) | 2002-06-30 |
Family
ID=26148871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9730302T SI0932617T1 (sl) | 1996-10-18 | 1997-10-17 | Inhibitorji serin proteaz, še zlasti NS3-proteaze virusa hepatitisa C |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1136498A1 (sl) |
SI (1) | SI0932617T1 (sl) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10109763A1 (de) * | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
JP5616569B2 (ja) | 2004-04-15 | 2014-10-29 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | 酵素阻害のための化合物 |
US8198270B2 (en) | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
ES2510840T3 (es) | 2004-05-10 | 2014-10-21 | Onyx Therapeutics, Inc. | Compuestos para la inhibición enzimática del proteosoma |
US7608592B2 (en) * | 2005-06-30 | 2009-10-27 | Virobay, Inc. | HCV inhibitors |
CN101242816B (zh) * | 2005-06-30 | 2012-10-31 | 维罗贝股份有限公司 | Hcv抑制剂 |
HUE034863T2 (en) | 2005-11-09 | 2018-03-28 | Onyx Therapeutics Inc | Compound for inhibiting enzyme |
NZ603303A (en) | 2006-06-19 | 2014-05-30 | Onyx Therapeutics Inc | Peptide epoxyketones for proteasome inhibition |
WO2009045497A1 (en) | 2007-10-04 | 2009-04-09 | Proteolix, Inc. | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
EA035100B1 (ru) | 2008-10-21 | 2020-04-28 | Оникс Терапьютикс, Инк. | Комбинированная терапия с применением пептид эпоксикетонов |
TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
WO2011060179A1 (en) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
CA2791651C (en) | 2010-03-01 | 2019-08-20 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
AU2011245630B2 (en) | 2010-04-07 | 2014-07-03 | Onyx Therapeutics, Inc. | Crystalline peptide epoxyketone immunoproteasome inhibitor |
MX357561B (es) | 2012-02-16 | 2018-07-13 | Rqx Pharmaceuticals Inc | Antibióticos peptídicos lineales. |
UY34897A (es) | 2012-07-09 | 2014-01-31 | Onyx Therapeutics Inc | Profarmacos de inhibidores peptidicos de expoxi cetona proteasa |
CA2921082A1 (en) * | 2013-08-14 | 2015-02-19 | Rqx Pharmaceuticals, Inc. | Linear peptide antibiotics |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL77748A (en) * | 1985-02-04 | 1991-11-21 | Merrell Dow Pharma | Amino acid and peptide derivatives as peptidase inhibitors |
ZA897515B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
JP2668003B2 (ja) * | 1992-06-12 | 1997-10-27 | ファイザー インク. | ヒトの心臓キマーゼを含むアンギオテンシンiキマーゼに関する阻害剤 |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
-
1997
- 1997-10-17 SI SI9730302T patent/SI0932617T1/sl unknown
- 1997-10-17 EP EP01109433A patent/EP1136498A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1136498A1 (en) | 2001-09-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1023779A1 (en) | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease | |
AU2933797A (en) | Synthetic inhibitors of hepatitis c virus ns3 protease | |
AU2055301A (en) | Alpha-ketoamide inhibitors of hepatitis c virus ns3 protease | |
AU2002230763A1 (en) | Inhibitors of hepatitis c virus ns3 protease | |
AU2001245356A1 (en) | Inhibitors of hepatitis c virus ns3 protease | |
GB9707659D0 (en) | Hepatitis C NS3 Protease inhibitors | |
AU6371900A (en) | Lactam inhibitors of hepatitis c virus ns3 protease | |
HU229997B1 (en) | Peptides as ns3-serine protease inhibitors of hepatitis c virus | |
IL153669A0 (en) | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus | |
GB0107924D0 (en) | Inhibitor of hepatitis C virus NS3 protease | |
AU2001280640A1 (en) | Peptides as ns3-serine protease inhibitors of hepatitis c virus | |
AU2001277967A1 (en) | Peptides as ns3-serine protease inhibitors of hepatitis c virus | |
SI0932617T1 (sl) | Inhibitorji serin proteaz, še zlasti NS3-proteaze virusa hepatitisa C | |
ATE430166T1 (de) | Diarylrest entfassende peptide als inhibitoren des ns-3 serinproteases von hepatitis c virus | |
HK1081196A1 (en) | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease | |
EP1141255A4 (en) | MODIFIED FORMS OF HEPATITIS C VIRUS NS3 PROTEASE | |
AU2002350322A1 (en) | Inhibitors of hepatitis c virus protease | |
DK1268519T3 (da) | Inhibitorer af serinproteaser, især hepatitis C-virus NS3-protease |