SG49049A1 - 5-(-2-Imidazolinylamino) benzimidazole derivatives their preparation and their use as alpha-2 adrenoceptor agonists - Google Patents

5-(-2-Imidazolinylamino) benzimidazole derivatives their preparation and their use as alpha-2 adrenoceptor agonists

Info

Publication number
SG49049A1
SG49049A1 SG1996005531A SG1996005531A SG49049A1 SG 49049 A1 SG49049 A1 SG 49049A1 SG 1996005531 A SG1996005531 A SG 1996005531A SG 1996005531 A SG1996005531 A SG 1996005531A SG 49049 A1 SG49049 A1 SG 49049A1
Authority
SG
Singapore
Prior art keywords
imidazolinylamino
alpha
preparation
unsubstituted
benzimidazole derivatives
Prior art date
Application number
SG1996005531A
Inventor
Sophie Eva Bogdan
Thomas Lee Cupps
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26865464&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG49049(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of SG49049A1 publication Critical patent/SG49049A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The subject invention involves compounds having the following structure: <IMAGE> wherein: (a) R is unsubstituted C1-C3 alkanyl or alkenyl; (b) R' is selected from hydrogen; unsubstituted C1-C3 alkanyl or alkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thiol; cyano; and halo; and (c) R'' is selected from hydrogen, methyl, ethyl and i-propyl. The subject invention also involves pharmaceutical compositions containing such novel compounds, and the use of such compounds for preventing or treating respiratory, ocular and/or gastrointestinal disorders.
SG1996005531A 1993-12-17 1994-12-15 5-(-2-Imidazolinylamino) benzimidazole derivatives their preparation and their use as alpha-2 adrenoceptor agonists SG49049A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16986893A 1993-12-17 1993-12-17
US08/349,558 US5478858A (en) 1993-12-17 1994-12-08 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists

Publications (1)

Publication Number Publication Date
SG49049A1 true SG49049A1 (en) 1998-05-18

Family

ID=26865464

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996005531A SG49049A1 (en) 1993-12-17 1994-12-15 5-(-2-Imidazolinylamino) benzimidazole derivatives their preparation and their use as alpha-2 adrenoceptor agonists

Country Status (23)

Country Link
US (3) US5478858A (en)
EP (1) EP0736022B1 (en)
JP (1) JPH09507216A (en)
KR (1) KR100385195B1 (en)
CN (1) CN1076352C (en)
AT (1) ATE250598T1 (en)
AU (1) AU699631B2 (en)
BR (1) BR9408343A (en)
CA (1) CA2179008C (en)
CZ (1) CZ286816B6 (en)
DE (1) DE69433181T2 (en)
ES (1) ES2202352T3 (en)
FI (1) FI962494A0 (en)
HU (1) HU224016B1 (en)
MY (1) MY131696A (en)
NO (1) NO309325B1 (en)
NZ (1) NZ333371A (en)
PL (1) PL180903B1 (en)
RU (1) RU2143430C1 (en)
SG (1) SG49049A1 (en)
SK (1) SK282566B6 (en)
TW (1) TW393469B (en)
WO (1) WO1995016685A1 (en)

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DE69732244T2 (en) * 1996-11-25 2006-06-29 The Board Of Regents Of The University Of Nebraska, Lincoln GUANIDYL-HETEROCYCLIC COMPOUNDS AS ALPHA-2 ADRENOCEPTOR AGONISTS
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Also Published As

Publication number Publication date
US5541210A (en) 1996-07-30
WO1995016685A1 (en) 1995-06-22
CA2179008C (en) 1999-08-17
NZ333371A (en) 2001-12-21
AU699631B2 (en) 1998-12-10
PL315059A1 (en) 1996-09-30
US5478858A (en) 1995-12-26
KR100385195B1 (en) 2003-08-21
DE69433181D1 (en) 2003-10-30
HU224016B1 (en) 2005-04-28
RU2143430C1 (en) 1999-12-27
ES2202352T3 (en) 2004-04-01
JPH09507216A (en) 1997-07-22
HUT76473A (en) 1997-09-29
ATE250598T1 (en) 2003-10-15
CN1076352C (en) 2001-12-19
AU1306295A (en) 1995-07-03
NO962539L (en) 1996-08-13
CZ286816B6 (en) 2000-07-12
PL180903B1 (en) 2001-04-30
CN1137794A (en) 1996-12-11
SK282566B6 (en) 2002-10-08
EP0736022B1 (en) 2003-09-24
HU9601663D0 (en) 1996-08-28
FI962494A (en) 1996-06-14
TW393469B (en) 2000-06-11
DE69433181T2 (en) 2004-07-01
MY131696A (en) 2007-08-30
SK77196A3 (en) 1997-03-05
BR9408343A (en) 1997-08-19
NO309325B1 (en) 2001-01-15
CA2179008A1 (en) 1995-06-22
NO962539D0 (en) 1996-06-14
EP0736022A1 (en) 1996-10-09
FI962494A0 (en) 1996-06-14
CZ175196A3 (en) 1996-11-13
US5691370A (en) 1997-11-25

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