SG188598A1 - System and method for determination of a brainstem response state development - Google Patents
System and method for determination of a brainstem response state development Download PDFInfo
- Publication number
- SG188598A1 SG188598A1 SG2013020219A SG2013020219A SG188598A1 SG 188598 A1 SG188598 A1 SG 188598A1 SG 2013020219 A SG2013020219 A SG 2013020219A SG 2013020219 A SG2013020219 A SG 2013020219A SG 188598 A1 SG188598 A1 SG 188598A1
- Authority
- SG
- Singapore
- Prior art keywords
- subject
- sound
- train
- sound pulses
- brainstem
- Prior art date
Links
- 230000004044 response Effects 0.000 title claims abstract description 342
- 210000000133 brain stem Anatomy 0.000 title claims abstract description 216
- 238000000034 method Methods 0.000 title claims abstract description 87
- 238000011161 development Methods 0.000 title claims abstract description 50
- 210000002569 neuron Anatomy 0.000 claims abstract description 68
- 230000000763 evoking effect Effects 0.000 claims abstract description 67
- 238000004590 computer program Methods 0.000 claims abstract description 9
- 238000001514 detection method Methods 0.000 claims abstract description 6
- 230000000694 effects Effects 0.000 claims description 155
- 239000000126 substance Substances 0.000 claims description 124
- 150000001875 compounds Chemical class 0.000 claims description 93
- 229940079593 drug Drugs 0.000 claims description 53
- 239000003814 drug Substances 0.000 claims description 52
- 230000000506 psychotropic effect Effects 0.000 claims description 48
- 238000005259 measurement Methods 0.000 claims description 40
- 210000004556 brain Anatomy 0.000 claims description 19
- 239000000902 placebo Substances 0.000 claims description 17
- 229940068196 placebo Drugs 0.000 claims description 17
- 238000012544 monitoring process Methods 0.000 claims description 15
- 238000002560 therapeutic procedure Methods 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 14
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 11
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 11
- 230000004048 modification Effects 0.000 claims description 9
- 238000012986 modification Methods 0.000 claims description 9
- 238000011866 long-term treatment Methods 0.000 claims description 8
- 238000012076 audiometry Methods 0.000 claims description 7
- 239000003205 fragrance Substances 0.000 claims description 6
- 230000002045 lasting effect Effects 0.000 claims description 6
- 230000001537 neural effect Effects 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 5
- 230000001965 increasing effect Effects 0.000 claims description 4
- 230000001550 time effect Effects 0.000 claims description 4
- 230000018109 developmental process Effects 0.000 description 31
- 238000012360 testing method Methods 0.000 description 30
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 description 15
- 229960001344 methylphenidate Drugs 0.000 description 15
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 12
- 229960002715 nicotine Drugs 0.000 description 12
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 12
- 230000008859 change Effects 0.000 description 9
- 230000007774 longterm Effects 0.000 description 9
- 210000003754 fetus Anatomy 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 230000000638 stimulation Effects 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 230000004936 stimulating effect Effects 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 230000003930 cognitive ability Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 230000002739 subcortical effect Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 238000012876 topography Methods 0.000 description 4
- 206010063292 Brain stem syndrome Diseases 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 210000005069 ears Anatomy 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 230000000926 neurological effect Effects 0.000 description 3
- 230000003252 repetitive effect Effects 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 206010011878 Deafness Diseases 0.000 description 2
- 230000036626 alertness Effects 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 230000001054 cortical effect Effects 0.000 description 2
- 238000009223 counseling Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 208000016354 hearing loss disease Diseases 0.000 description 2
- 230000000147 hypnotic effect Effects 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000003447 ipsilateral effect Effects 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000036640 Asperger disease Diseases 0.000 description 1
- 201000006062 Asperger syndrome Diseases 0.000 description 1
- 208000020925 Bipolar disease Diseases 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 241000711981 Sais Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 210000000860 cochlear nerve Anatomy 0.000 description 1
- 210000003952 cochlear nucleus Anatomy 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000009246 food effect Effects 0.000 description 1
- 235000021471 food effect Nutrition 0.000 description 1
- 231100000888 hearing loss Toxicity 0.000 description 1
- 230000010370 hearing loss Effects 0.000 description 1
- 239000002117 illicit drug Substances 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 210000003552 inferior colliculi Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000013208 measuring procedure Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000001259 mesencephalon Anatomy 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000008906 neuronal response Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000009117 preventive therapy Methods 0.000 description 1
- 229940124811 psychiatric drug Drugs 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 238000001671 psychotherapy Methods 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 230000005236 sound signal Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000009120 supportive therapy Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000003461 thalamocortical effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/377—Electroencephalography [EEG] using evoked responses
- A61B5/38—Acoustic or auditory stimuli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/12—Audiometering
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychology (AREA)
- Acoustics & Sound (AREA)
- Psychiatry (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37974810P | 2010-09-03 | 2010-09-03 | |
| EP10175201A EP2425769A1 (en) | 2010-09-03 | 2010-09-03 | System and method for determination of a brainstem response state development |
| PCT/EP2011/065340 WO2012028749A2 (en) | 2010-09-03 | 2011-09-05 | System and method for determination of a brainstem response state development |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG188598A1 true SG188598A1 (en) | 2013-04-30 |
Family
ID=43498646
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013020219A SG188598A1 (en) | 2010-09-03 | 2011-09-05 | System and method for determination of a brainstem response state development |
| SG10201400779QA SG10201400779QA (en) | 2010-09-03 | 2011-09-05 | System and method for determination of a brainstem response state development |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201400779QA SG10201400779QA (en) | 2010-09-03 | 2011-09-05 | System and method for determination of a brainstem response state development |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10575752B2 (enExample) |
| EP (2) | EP2425769A1 (enExample) |
| JP (1) | JP5989647B2 (enExample) |
| CN (1) | CN103298398B (enExample) |
| AU (1) | AU2011298226B2 (enExample) |
| CA (1) | CA2810105C (enExample) |
| DK (1) | DK2611357T3 (enExample) |
| EA (1) | EA026021B1 (enExample) |
| NZ (1) | NZ608484A (enExample) |
| SG (2) | SG188598A1 (enExample) |
| WO (1) | WO2012028749A2 (enExample) |
| ZA (1) | ZA201301614B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2572640B1 (en) * | 2011-09-21 | 2014-10-29 | Jacoti BVBA | Method and device for conducting a pure tone audiometry screening |
| EP2636364A1 (en) * | 2012-03-05 | 2013-09-11 | Sensodetect AB | System and method for improved determination of a brain response state |
| US10357175B2 (en) | 2012-03-12 | 2019-07-23 | Centre Hospitalier Universitaire Vaudois(C.H.U.V.) | Method for predicting awakening in a comatose patient and computer-implemented method thereof |
| US20150351657A1 (en) * | 2013-01-17 | 2015-12-10 | Sensodetect Ab | Method And System For Monitoring Depth Of Anaesthesia And Sensory Functioning |
| DE102019220224B4 (de) | 2019-12-19 | 2025-11-20 | Siemens Healthineers Ag | Überwachungssystem zur Überwachung eines Patienten und Verfahren zum Betrieb des Überwachungssystems |
| CN113419626B (zh) * | 2021-06-17 | 2023-03-28 | 深圳大学 | 基于声音刺激序列的稳态认知响应分析的方法、装置 |
| TWI816611B (zh) * | 2022-11-24 | 2023-09-21 | 何明宗 | 腦動力音頻刺激之音頻產生設備與方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5287859A (en) * | 1992-09-25 | 1994-02-22 | New York University | Electroencephalograph instrument for mass screening |
| US5995868A (en) * | 1996-01-23 | 1999-11-30 | University Of Kansas | System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject |
| US6493576B1 (en) * | 1996-06-17 | 2002-12-10 | Erich Jaeger Gmbh | Method and apparatus for measuring stimulus-evoked potentials of the brain |
| GB0003853D0 (en) | 2000-02-19 | 2000-04-05 | Diagnostic Potentials Limited | Method for investigating neurological function |
| US6331164B1 (en) * | 2000-03-17 | 2001-12-18 | Etymotic Research, Inc. | Hearing test apparatus and method having adaptive artifact rejection |
| US7399282B2 (en) * | 2000-05-19 | 2008-07-15 | Baycrest Center For Geriatric Care | System and method for objective evaluation of hearing using auditory steady-state responses |
| TW456610U (en) * | 2000-07-12 | 2001-09-21 | Hon Hai Prec Ind Co Ltd | Socket connector |
| US6556861B1 (en) * | 2000-11-20 | 2003-04-29 | New York University | Fetal brain monitor |
| CA2752782A1 (en) * | 2001-07-11 | 2003-01-23 | Cns Response, Inc. | Electroencephalography based systems and methods for selecting therapies and predicting outcomes |
| US8147544B2 (en) * | 2001-10-30 | 2012-04-03 | Otokinetics Inc. | Therapeutic appliance for cochlea |
| US6743183B1 (en) * | 2002-04-17 | 2004-06-01 | Massachusetts Eye & Ear Infirmary | Simultaneous stimulation of an auditory system |
| JP4096652B2 (ja) * | 2002-07-30 | 2008-06-04 | 三菱ふそうトラック・バス株式会社 | 増圧型燃料噴射装置 |
| SE527967C2 (sv) * | 2004-12-08 | 2006-07-25 | Schizodetect Ab | Ett system för att detektera schizofreni hos en person |
| JP2008539977A (ja) * | 2005-05-11 | 2008-11-20 | バイオ−ロジック システムズ コーポレイション | 神経生理学的中枢聴覚処理評価システム及び方法 |
| JP4287416B2 (ja) * | 2005-08-03 | 2009-07-01 | 株式会社東芝 | 電子放出装置 |
| WO2007050780A2 (en) | 2005-10-24 | 2007-05-03 | John Bell | Neurologic system and associated methods |
| US7647098B2 (en) | 2005-10-31 | 2010-01-12 | New York University | System and method for prediction of cognitive decline |
| WO2007084979A2 (en) | 2006-01-19 | 2007-07-26 | Drexel University | Method to quantitatively measure effect of psychotropic drugs on sensory discrimination |
| US20080016757A1 (en) * | 2006-06-02 | 2008-01-24 | Kriech Anthony J | Reagent composition and method for reclaiming carbonaceous materials from settling ponds and coal preparation plants |
| EP2046199A4 (en) | 2006-07-12 | 2010-06-16 | Univ Queensland | METHOD FOR DETECTING A PHYSIOLOGICAL ANSWER |
| US20080167571A1 (en) * | 2006-12-19 | 2008-07-10 | Alan Gevins | Determination of treatment results prior to treatment or after few treatment events |
| US20100286549A1 (en) * | 2007-12-18 | 2010-11-11 | New York University | System and Method for Assessing Efficacy of Therapeutic Agents |
| US20090312663A1 (en) * | 2008-06-13 | 2009-12-17 | New York University | System and Method for Neurometric Analysis |
| JP2011251058A (ja) * | 2010-06-03 | 2011-12-15 | Panasonic Corp | 聴性定常反応測定方法および測定装置 |
-
2010
- 2010-09-03 EP EP10175201A patent/EP2425769A1/en not_active Withdrawn
-
2011
- 2011-09-05 EA EA201390331A patent/EA026021B1/ru not_active IP Right Cessation
- 2011-09-05 CN CN201180054856.1A patent/CN103298398B/zh active Active
- 2011-09-05 SG SG2013020219A patent/SG188598A1/en unknown
- 2011-09-05 DK DK11760430.6T patent/DK2611357T3/en active
- 2011-09-05 AU AU2011298226A patent/AU2011298226B2/en not_active Ceased
- 2011-09-05 CA CA2810105A patent/CA2810105C/en not_active Expired - Fee Related
- 2011-09-05 WO PCT/EP2011/065340 patent/WO2012028749A2/en not_active Ceased
- 2011-09-05 EP EP11760430.6A patent/EP2611357B1/en active Active
- 2011-09-05 SG SG10201400779QA patent/SG10201400779QA/en unknown
- 2011-09-05 JP JP2013526506A patent/JP5989647B2/ja not_active Expired - Fee Related
- 2011-09-05 US US13/820,470 patent/US10575752B2/en active Active
- 2011-09-05 NZ NZ608484A patent/NZ608484A/en not_active IP Right Cessation
-
2013
- 2013-03-04 ZA ZA2013/01614A patent/ZA201301614B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012028749A3 (en) | 2012-06-07 |
| US10575752B2 (en) | 2020-03-03 |
| EP2611357A2 (en) | 2013-07-10 |
| JP5989647B2 (ja) | 2016-09-07 |
| EA201390331A1 (ru) | 2013-08-30 |
| CN103298398A (zh) | 2013-09-11 |
| EA026021B1 (ru) | 2017-02-28 |
| CA2810105A1 (en) | 2012-03-08 |
| CN103298398B (zh) | 2016-10-19 |
| DK2611357T3 (en) | 2018-07-16 |
| CA2810105C (en) | 2018-09-18 |
| AU2011298226B2 (en) | 2014-11-27 |
| NZ608484A (en) | 2015-05-29 |
| JP2013538611A (ja) | 2013-10-17 |
| EP2611357B1 (en) | 2018-04-18 |
| WO2012028749A2 (en) | 2012-03-08 |
| SG10201400779QA (en) | 2014-07-30 |
| US20130231581A1 (en) | 2013-09-05 |
| AU2011298226A1 (en) | 2013-03-28 |
| EP2425769A1 (en) | 2012-03-07 |
| ZA201301614B (en) | 2014-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2810105C (en) | System and method for determination of a brainstem response state development | |
| Hillyard et al. | Evoked potential correlates of auditory signal detection | |
| Legatt | Electrophysiologic auditory tests | |
| WO2006122304A1 (en) | Neurophysiological central auditory processing evaluation system and method | |
| WO2006122349A1 (en) | Method and apparatus for monitoring consciousness during anaesthesia | |
| Rimmele et al. | Electrophysiological evidence for age effects on sensory memory processing of tonal patterns. | |
| D’Agostini et al. | Effects of transcutaneous auricular vagus nerve stimulation on P300 magnitudes and salivary alpha-amylase during an auditory oddball task | |
| Grimm et al. | Pre-attentive and attentive processing of temporal and frequency characteristics within long sounds | |
| US10098562B2 (en) | System and method for improved determination of a brain response state | |
| JP2008511347A (ja) | 神経イベント処理 | |
| Axe | The effects of hair-cell specific dysfunction on neural coding in the auditory periphery | |
| Schaefer | Cortical auditory evoked potential morphology: response characteristics of the P1-N1-P2-N2 waves as determined by stimulus and subject parameters | |
| Tavartkiladeze et al. | Objective Measures at Different Stages of Cochlear Implantation: A Data Analysis. Medical Research Archives,[online] 13 (1) | |
| Bell | Improving acquisition of auditory evoked potentials for clinical diagnosis and monitoring | |
| Kelly | Estimation of Behavioral Thresholds in Normal Hearing Listeners Using Auditory Steady State Responses | |
| McKenzie | Sound representations underlying the duration mismatch negativity (MMN) in a rapid dichotic listening task | |
| Woolnough | Cortical adaptation and frequency selectivity: from single neurons to evoked potentials | |
| Paul et al. | Top-down attention modifies a spectral estimate of phase shifts during resets of the auditory steady state response. | |
| Repucci | Linear and nonlinear dynamics of receptive fields in primary visual cortex | |
| Pigorini | BREAKDOWN OF CAUSALITY AND CORTICAL DOWNSTATE WITHIN THE SLEEPING BRAIN | |
| Loftus | Spectral and temporal properties of neurons in the A1 and the posterior field of cat auditory cortex | |
| Minces | Acetylcholine, brain activation, and processing of temporal stimuli | |
| Towell | Electrophysiologic detection of the neurotoxic effects of acrylamide and 2, 5-hexanedione in rats |