SG175658A1 - USE OF ESTRADIOL VALERATE OR 17β-ESTRADIOL IN COMBINATION WITH DIENOGEST FOR ORAL THERAPY FOR MAINTAINING AND/OR INCREASING THE FEMALE LIBIDO - Google Patents
USE OF ESTRADIOL VALERATE OR 17β-ESTRADIOL IN COMBINATION WITH DIENOGEST FOR ORAL THERAPY FOR MAINTAINING AND/OR INCREASING THE FEMALE LIBIDO Download PDFInfo
- Publication number
- SG175658A1 SG175658A1 SG2011076619A SG2011076619A SG175658A1 SG 175658 A1 SG175658 A1 SG 175658A1 SG 2011076619 A SG2011076619 A SG 2011076619A SG 2011076619 A SG2011076619 A SG 2011076619A SG 175658 A1 SG175658 A1 SG 175658A1
- Authority
- SG
- Singapore
- Prior art keywords
- estradiol
- combination
- daily dose
- dienogest
- dose units
- Prior art date
Links
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 title claims abstract description 38
- 229960004766 estradiol valerate Drugs 0.000 title claims abstract description 37
- 229960005309 estradiol Drugs 0.000 title claims abstract description 30
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 title claims abstract description 28
- 229960003309 dienogest Drugs 0.000 title claims abstract description 28
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title claims abstract description 27
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 12
- 229930182833 estradiol Natural products 0.000 claims abstract description 25
- 229940068196 placebo Drugs 0.000 claims abstract description 11
- 239000000902 placebo Substances 0.000 claims abstract description 11
- 239000013066 combination product Substances 0.000 claims description 9
- 229940127555 combination product Drugs 0.000 claims description 9
- 229940083544 estradiol 2 mg Drugs 0.000 claims 1
- 238000011282 treatment Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 3
- 229940008227 dienogest and estradiol Drugs 0.000 description 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 206010024419 Libido decreased Diseases 0.000 description 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 1
- 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 208000017020 hypoactive sexual desire disease Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003217 oral combined contraceptive Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000009933 reproductive health Effects 0.000 description 1
- 230000035946 sexual desire Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06022091 | 2006-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG175658A1 true SG175658A1 (en) | 2011-11-28 |
Family
ID=37491810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2011076619A SG175658A1 (en) | 2006-10-20 | 2007-10-12 | USE OF ESTRADIOL VALERATE OR 17β-ESTRADIOL IN COMBINATION WITH DIENOGEST FOR ORAL THERAPY FOR MAINTAINING AND/OR INCREASING THE FEMALE LIBIDO |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN101553234A (ru) |
| SG (1) | SG175658A1 (ru) |
| UA (1) | UA97960C2 (ru) |
-
2007
- 2007-10-12 SG SG2011076619A patent/SG175658A1/en unknown
- 2007-10-12 UA UAA200904273A patent/UA97960C2/ru unknown
- 2007-10-12 CN CNA2007800389446A patent/CN101553234A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101553234A (zh) | 2009-10-07 |
| UA97960C2 (ru) | 2012-04-10 |
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