SG169254A1 - Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo - Google Patents

Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo

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Publication number
SG169254A1
SG169254A1 SG200905843-9A SG2009058439A SG169254A1 SG 169254 A1 SG169254 A1 SG 169254A1 SG 2009058439 A SG2009058439 A SG 2009058439A SG 169254 A1 SG169254 A1 SG 169254A1
Authority
SG
Singapore
Prior art keywords
tat
hoxb4h
protein
vivo
hematopoiesis
Prior art date
Application number
SG200905843-9A
Inventor
Kou-Juey Wu
Chi-Hung Huang
Original Assignee
Taiwan Advance Bio Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiwan Advance Bio Pharm Inc filed Critical Taiwan Advance Bio Pharm Inc
Priority to SG200905843-9A priority Critical patent/SG169254A1/en
Publication of SG169254A1 publication Critical patent/SG169254A1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a new and nonobvious method of producing the C-terminal histidine tagged TAT-HOXB4 fusion protein (TAT-HOXB4H), providing unexpected benefits of increased yield and stability to allow for in vivo administration of this protein, and pharmaceutical composition comprising an effective ingredient, TAT-HOXB4H, having stimulatory activity on the production of hematopoietic cells. More specifically, recombinant TAT-HOXB4H protein enhances engraftment of bone marrow transplants, hematopoietic reconstruction, bone marrow re- population and number of circulating stem cells, particularly after chemotherapy or irradiation. Fig. 11
SG200905843-9A 2009-09-03 2009-09-03 Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo SG169254A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SG200905843-9A SG169254A1 (en) 2009-09-03 2009-09-03 Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG200905843-9A SG169254A1 (en) 2009-09-03 2009-09-03 Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo

Publications (1)

Publication Number Publication Date
SG169254A1 true SG169254A1 (en) 2011-03-30

Family

ID=43875193

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200905843-9A SG169254A1 (en) 2009-09-03 2009-09-03 Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo

Country Status (1)

Country Link
SG (1) SG169254A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1889916A1 (en) * 2006-02-10 2008-02-20 Taiwan Advance Bio-Pharm Inc. A method for the production of the recombinant hoxb4 protein containing his tag at c-terminal and use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1889916A1 (en) * 2006-02-10 2008-02-20 Taiwan Advance Bio-Pharm Inc. A method for the production of the recombinant hoxb4 protein containing his tag at c-terminal and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1995 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY *

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