BR112013012697A2 - "method for decreasing expression, production or secretion of an angiogenic factor or hypertrophic factor or both by mesenchymal stem cells, methods for decreasing an inhibitory effect, a deleterious effect, and a mesenchymal stem cell apoptosis effect, a method for increasing a mesenchymal stem cell stimulating effect, composition, and method for preparing cartilage in an individual diagnosed with diseased or damaged cartilage. " - Google Patents
"method for decreasing expression, production or secretion of an angiogenic factor or hypertrophic factor or both by mesenchymal stem cells, methods for decreasing an inhibitory effect, a deleterious effect, and a mesenchymal stem cell apoptosis effect, a method for increasing a mesenchymal stem cell stimulating effect, composition, and method for preparing cartilage in an individual diagnosed with diseased or damaged cartilage. "Info
- Publication number
- BR112013012697A2 BR112013012697A2 BR112013012697A BR112013012697A BR112013012697A2 BR 112013012697 A2 BR112013012697 A2 BR 112013012697A2 BR 112013012697 A BR112013012697 A BR 112013012697A BR 112013012697 A BR112013012697 A BR 112013012697A BR 112013012697 A2 BR112013012697 A2 BR 112013012697A2
- Authority
- BR
- Brazil
- Prior art keywords
- effect
- mesenchymal stem
- stem cell
- decreasing
- cartilage
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/74—Alginate
Abstract
método para diminuir expressão, produção ou secreção de um fator angiogênico ou fator hipertrófico ou ambos por células-tronco mesenquimais, métodos para diminuir um efeito inibidor, um efeito deletério, e um efeito de apoptose de células-tronco mesenquimais, método para aumentar um efeito estimulador de células-tronco mesenquimais, composição, e, método para preparar cartilagem em um indivíduo diagnosticado com cartilagem doente ou danificada. são divulgados métodos e composições de carreadores de microconta para distribuição de células e outras substâncias biologicamente ativas para tecido doente ou danificado em um indivíduo em necessidade das mesmas.method for decreasing expression, production or secretion of an angiogenic factor or hypertrophic factor or both by mesenchymal stem cells, methods for decreasing an inhibitory effect, a deleterious effect, and a mesenchymal stem cell apoptosis effect, method for enhancing an effect mesenchymal stem cell stimulator, composition, and method for preparing cartilage in an individual diagnosed with diseased or damaged cartilage. Methods and compositions of microcount carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in an individual in need thereof are disclosed.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41646310P | 2010-11-23 | 2010-11-23 | |
US201061426018P | 2010-12-22 | 2010-12-22 | |
PCT/US2011/062068 WO2012071527A2 (en) | 2010-11-23 | 2011-11-23 | Protein delivery from stem cell microcarriers |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013012697A2 true BR112013012697A2 (en) | 2016-09-06 |
Family
ID=46146426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013012697A BR112013012697A2 (en) | 2010-11-23 | 2011-11-23 | "method for decreasing expression, production or secretion of an angiogenic factor or hypertrophic factor or both by mesenchymal stem cells, methods for decreasing an inhibitory effect, a deleterious effect, and a mesenchymal stem cell apoptosis effect, a method for increasing a mesenchymal stem cell stimulating effect, composition, and method for preparing cartilage in an individual diagnosed with diseased or damaged cartilage. " |
Country Status (7)
Country | Link |
---|---|
US (1) | US10441610B2 (en) |
EP (1) | EP2643012B1 (en) |
BR (1) | BR112013012697A2 (en) |
CA (1) | CA2818894C (en) |
CO (1) | CO6761392A2 (en) |
IL (1) | IL226501A (en) |
WO (1) | WO2012071527A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2643012B1 (en) | 2010-11-23 | 2019-07-10 | Georgia Tech Research Corporation | Protein delivery from stem cell microcarriers |
FR3029790B1 (en) * | 2014-12-12 | 2017-01-13 | Synolyne Pharma | CHITOSAN HYDROGEL MICROBELL |
WO2016112111A1 (en) * | 2015-01-08 | 2016-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Factors and cells that provide for induction of bone, bone marrow, and cartilage |
US11384328B2 (en) | 2015-11-18 | 2022-07-12 | President And Fellows Of Harvard College | Cartridge-based system for long term culture of cell clusters |
CA3025308A1 (en) * | 2016-05-24 | 2017-11-30 | The Regents Of The University Of California | Growth-factor nanocapsules with tunable release capability for bone regeneration |
CN110114092A (en) * | 2016-09-27 | 2019-08-09 | 崔东桓 | For delivering aqueous bait to control the biodegradable hydrogel of pest ant |
US11629318B2 (en) | 2017-10-20 | 2023-04-18 | President And Fellows Of Harvard College | Methods for producing mature adipocytes and methods of use thereof |
US11167375B2 (en) | 2018-08-10 | 2021-11-09 | The Research Foundation For The State University Of New York | Additive manufacturing processes and additively manufactured products |
US20220265831A1 (en) * | 2019-08-27 | 2022-08-25 | Crannmed Limited | Alginate Based Particles as a Temporary Embolic Agent |
US20230002750A1 (en) * | 2019-12-04 | 2023-01-05 | Amano Enzyme Inc. | Preparation of adipose tissue-derived cell population |
US20230405179A1 (en) | 2021-03-03 | 2023-12-21 | Crannmed Limited | Alginate Based Particles as a Temporary Embolic Agent |
CN114767662A (en) * | 2022-03-28 | 2022-07-22 | 江苏大学 | Controlled-release microsphere encapsulating human mesenchymal stem cells and preparation method and storage method thereof |
WO2024052780A1 (en) | 2022-09-07 | 2024-03-14 | Crannmed Limited | Self-degrading enzyme loaded biologically derived particles |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6849594B1 (en) * | 1999-06-30 | 2005-02-01 | John Lawler | Purification and use of human recombinant cartilage oligomeric matrix protein |
US20050282733A1 (en) * | 2002-06-27 | 2005-12-22 | Prins Johannes B | Differentiation modulating agents and uses therefor |
US7273756B2 (en) * | 2004-10-01 | 2007-09-25 | Isto Technologies, Inc. | Method for chondrocyte expansion with phenotype retention |
US8202701B2 (en) * | 2004-10-08 | 2012-06-19 | Georgia Tech Research Corporation | Microencapsulation of cells in hydrogels using electrostatic potentials |
WO2007099337A1 (en) * | 2006-03-01 | 2007-09-07 | Cartela R&D Ab | Expansion and differentiation of mesenchymal stem cells |
US8273373B2 (en) * | 2008-12-30 | 2012-09-25 | Case Western Reserve University | Photocrosslinked biodegradable hydrogel |
US9393267B2 (en) * | 2009-02-19 | 2016-07-19 | University Of Southern California | Gel delivery system for tissue repair |
US20130039990A1 (en) * | 2010-04-30 | 2013-02-14 | University Of Maryland, Baltimore | Injectable, load-bearing cell/microbead/calcium phosphate bone paste for bone tissue engineering |
EP2643012B1 (en) | 2010-11-23 | 2019-07-10 | Georgia Tech Research Corporation | Protein delivery from stem cell microcarriers |
-
2011
- 2011-11-23 EP EP11843022.2A patent/EP2643012B1/en not_active Not-in-force
- 2011-11-23 BR BR112013012697A patent/BR112013012697A2/en not_active Application Discontinuation
- 2011-11-23 WO PCT/US2011/062068 patent/WO2012071527A2/en active Application Filing
- 2011-11-23 CA CA2818894A patent/CA2818894C/en active Active
- 2011-11-23 US US13/988,929 patent/US10441610B2/en not_active Expired - Fee Related
-
2013
- 2013-05-22 IL IL226501A patent/IL226501A/en active IP Right Grant
- 2013-06-21 CO CO13148257A patent/CO6761392A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2012071527A3 (en) | 2012-10-04 |
CA2818894A1 (en) | 2012-05-31 |
CA2818894C (en) | 2019-02-12 |
EP2643012B1 (en) | 2019-07-10 |
CO6761392A2 (en) | 2013-09-30 |
US10441610B2 (en) | 2019-10-15 |
IL226501A0 (en) | 2013-07-31 |
US20140370111A1 (en) | 2014-12-18 |
IL226501A (en) | 2017-10-31 |
EP2643012A4 (en) | 2014-05-14 |
WO2012071527A2 (en) | 2012-05-31 |
EP2643012A2 (en) | 2013-10-02 |
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