SG135186A1 - Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase c regulation - Google Patents
Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase c regulationInfo
- Publication number
- SG135186A1 SG135186A1 SG200705930-6A SG2007059306A SG135186A1 SG 135186 A1 SG135186 A1 SG 135186A1 SG 2007059306 A SG2007059306 A SG 2007059306A SG 135186 A1 SG135186 A1 SG 135186A1
- Authority
- SG
- Singapore
- Prior art keywords
- glimepiride
- glycosylphosphatidylinositol
- insulin
- induced
- regulation
- Prior art date
Links
- 108010042204 Glycosylphosphatidylinositol diacylglycerol-lyase Proteins 0.000 title abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 abstract 1
- 229960004346 glimepiride Drugs 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/02—Separating microorganisms from their culture media
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04003897A EP1566447A1 (en) | 2004-02-20 | 2004-02-20 | Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG135186A1 true SG135186A1 (en) | 2007-09-28 |
Family
ID=34707348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200705930-6A SG135186A1 (en) | 2004-02-20 | 2005-02-16 | Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase c regulation |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP1566447A1 (ja) |
| JP (3) | JP5514395B2 (ja) |
| KR (1) | KR101191676B1 (ja) |
| CN (1) | CN1981048B (ja) |
| AT (1) | ATE551430T1 (ja) |
| AU (1) | AU2005215886B2 (ja) |
| BR (1) | BRPI0507889A (ja) |
| CA (1) | CA2556868C (ja) |
| IL (3) | IL177257A (ja) |
| SG (1) | SG135186A1 (ja) |
| WO (1) | WO2005080587A2 (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018074889A2 (pt) | 2016-06-03 | 2019-03-06 | Lonza Ag | biorreator de uso único |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1244546B (it) * | 1991-02-01 | 1994-07-15 | Mediolanum Farmaceutici Spa | Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica |
| US5519163A (en) * | 1993-10-15 | 1996-05-21 | Merck & Co., Inc. | Inhibitors of phosphoinositide-specific phospholipase C |
| JPH07206887A (ja) * | 1994-01-24 | 1995-08-08 | Asahi Chem Ind Co Ltd | 新規ホスホリパーゼｃ阻害物質ａｍ６２１１及びその製造法 |
| US20030190651A1 (en) * | 2000-07-31 | 2003-10-09 | Sophia Kossida | Regulation of human phosphatidylinositol-specific phospholipase c-like enzyme |
| DK1379235T3 (da) * | 2000-10-10 | 2007-01-29 | Univ North Carolina | Sammensætninger og fremgangsmåder til forbedring af paracellulær permeabilitet over epithel- og endothelbarrierer |
-
2004
- 2004-02-20 EP EP04003897A patent/EP1566447A1/en not_active Withdrawn
-
2005
- 2005-02-16 CA CA2556868A patent/CA2556868C/en not_active Expired - Fee Related
- 2005-02-16 SG SG200705930-6A patent/SG135186A1/en unknown
- 2005-02-16 BR BRPI0507889-0A patent/BRPI0507889A/pt active Search and Examination
- 2005-02-16 KR KR1020067016694A patent/KR101191676B1/ko not_active IP Right Cessation
- 2005-02-16 EP EP05707425A patent/EP1718757B1/en not_active Not-in-force
- 2005-02-16 AT AT05707425T patent/ATE551430T1/de active
- 2005-02-16 JP JP2006553524A patent/JP5514395B2/ja not_active Expired - Fee Related
- 2005-02-16 CN CN200580004356.1A patent/CN1981048B/zh not_active Expired - Fee Related
- 2005-02-16 AU AU2005215886A patent/AU2005215886B2/en not_active Ceased
- 2005-02-16 WO PCT/EP2005/001553 patent/WO2005080587A2/en not_active Application Discontinuation
-
2006
- 2006-08-03 IL IL177257A patent/IL177257A/en not_active IP Right Cessation
-
2009
- 2009-12-06 IL IL202543A patent/IL202543A/en not_active IP Right Cessation
- 2009-12-06 IL IL202544A patent/IL202544A/en not_active IP Right Cessation
-
2011
- 2011-01-19 JP JP2011008777A patent/JP5337825B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-01 JP JP2012044943A patent/JP2012135318A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL177257A (en) | 2010-12-30 |
| KR101191676B1 (ko) | 2012-10-18 |
| JP2011140492A (ja) | 2011-07-21 |
| IL202544A (en) | 2011-02-28 |
| WO2005080587A3 (en) | 2006-12-28 |
| EP1718757B1 (en) | 2012-03-28 |
| JP5514395B2 (ja) | 2014-06-04 |
| CN1981048A (zh) | 2007-06-13 |
| JP2012135318A (ja) | 2012-07-19 |
| CA2556868A1 (en) | 2005-09-01 |
| BRPI0507889A (pt) | 2007-08-07 |
| CN1981048B (zh) | 2014-06-18 |
| CA2556868C (en) | 2013-10-15 |
| AU2005215886A1 (en) | 2005-09-01 |
| EP1566447A1 (en) | 2005-08-24 |
| WO2005080587A2 (en) | 2005-09-01 |
| KR20060131845A (ko) | 2006-12-20 |
| AU2005215886B2 (en) | 2010-07-22 |
| IL177257A0 (en) | 2006-12-10 |
| IL202543A (en) | 2013-02-28 |
| JP5337825B2 (ja) | 2013-11-06 |
| ATE551430T1 (de) | 2012-04-15 |
| EP1718757A2 (en) | 2006-11-08 |
| JP2007522811A (ja) | 2007-08-16 |
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