SG11202112792WA - Neutralizing anti-sars-cov-2 antibodies and methods of use thereof - Google Patents
Neutralizing anti-sars-cov-2 antibodies and methods of use thereofInfo
- Publication number
- SG11202112792WA SG11202112792WA SG11202112792WA SG11202112792WA SG11202112792WA SG 11202112792W A SG11202112792W A SG 11202112792WA SG 11202112792W A SG11202112792W A SG 11202112792WA SG 11202112792W A SG11202112792W A SG 11202112792WA SG 11202112792W A SG11202112792W A SG 11202112792WA
- Authority
- SG
- Singapore
- Prior art keywords
- cov
- sars
- antibodies
- methods
- neutralizing anti
- Prior art date
Links
- 230000003472 neutralizing effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063016569P | 2020-04-28 | 2020-04-28 | |
US202063021387P | 2020-05-07 | 2020-05-07 | |
US202063032112P | 2020-05-29 | 2020-05-29 | |
US202063038384P | 2020-06-12 | 2020-06-12 | |
US202063119088P | 2020-11-30 | 2020-11-30 | |
PCT/US2021/070472 WO2021222935A2 (en) | 2020-04-28 | 2021-04-28 | Neutralizing anti-sars-cov-2 antibodies and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202112792WA true SG11202112792WA (en) | 2021-12-30 |
Family
ID=76076561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202112792WA SG11202112792WA (en) | 2020-04-28 | 2021-04-28 | Neutralizing anti-sars-cov-2 antibodies and methods of use thereof |
Country Status (9)
Country | Link |
---|---|
US (1) | US11634477B2 (en) |
EP (1) | EP3921034A2 (en) |
JP (1) | JP2023523480A (en) |
KR (1) | KR20230002261A (en) |
IL (1) | IL285472A (en) |
MX (1) | MX2021015024A (en) |
SG (1) | SG11202112792WA (en) |
TW (1) | TW202216757A (en) |
WO (1) | WO2021222935A2 (en) |
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CN113766928A (en) | 2020-04-02 | 2021-12-07 | 瑞泽恩制药公司 | anti-SARS-COV-2 fiber process glycoprotein antibody and antigen binding fragment |
EP4182687A2 (en) * | 2020-07-20 | 2023-05-24 | Bio-Rad Laboratories, Inc. | Immunoassay for sars-cov-2 neutralizing antibodies and materials therefor |
EP4240758A1 (en) | 2020-11-04 | 2023-09-13 | The Rockefeller University | Neutralizing anti-sars-cov-2 antibodies |
WO2022122788A1 (en) * | 2020-12-09 | 2022-06-16 | Institute For Research In Biomedicine | Multispecific antibodies against severe acute respiratory syndrome coronavirus 2 |
WO2022155324A1 (en) * | 2021-01-15 | 2022-07-21 | The Rockefeller University | Neutralizing anti-sars-cov-2 antibodies |
WO2022263638A1 (en) * | 2021-06-17 | 2022-12-22 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection |
CA3225575A1 (en) * | 2021-07-14 | 2023-01-19 | Regeneron Pharmaceuticals, Inc. | Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments |
CN114276422B (en) * | 2021-11-09 | 2023-07-07 | 中国人民解放军总医院 | Novel coronavirus S protein polypeptide antigen and application thereof |
WO2023099688A1 (en) * | 2021-12-01 | 2023-06-08 | Universität Zu Köln | Neutralizing antibodies against sars-related coronavirus |
EP4190810A1 (en) * | 2021-12-01 | 2023-06-07 | Universität zu Köln | Neutralizing antibodies against sars-related coronavirus |
TW202342510A (en) * | 2022-02-18 | 2023-11-01 | 英商Rq生物科技有限公司 | Antibodies |
WO2023172890A2 (en) * | 2022-03-07 | 2023-09-14 | Agenus Inc. | Anti-ilt2 antibodies and uses thereof |
CN116813757A (en) * | 2022-03-21 | 2023-09-29 | 中国科学院微生物研究所 | Construction body of nano antibody R14 and application thereof |
WO2023193017A2 (en) * | 2022-04-01 | 2023-10-05 | Invivyd, Inc. | Sars-cov2 antibodies and uses thereof |
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JP2017509319A (en) | 2014-01-15 | 2017-04-06 | カドモン コーポレイション,リミティド ライアビリティ カンパニー | Immunomodulator |
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-
2021
- 2021-04-28 WO PCT/US2021/070472 patent/WO2021222935A2/en active Application Filing
- 2021-04-28 JP JP2021547079A patent/JP2023523480A/en active Pending
- 2021-04-28 EP EP21727770.6A patent/EP3921034A2/en active Pending
- 2021-04-28 KR KR1020227003598A patent/KR20230002261A/en unknown
- 2021-04-28 MX MX2021015024A patent/MX2021015024A/en unknown
- 2021-04-28 SG SG11202112792WA patent/SG11202112792WA/en unknown
- 2021-04-28 TW TW110115436A patent/TW202216757A/en unknown
- 2021-04-28 US US17/242,583 patent/US11634477B2/en active Active
- 2021-08-09 IL IL285472A patent/IL285472A/en unknown
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WO2021222935A2 (en) | 2021-11-04 |
WO2021222935A3 (en) | 2022-03-10 |
US11634477B2 (en) | 2023-04-25 |
KR20230002261A (en) | 2023-01-05 |
US20210332110A1 (en) | 2021-10-28 |
EP3921034A2 (en) | 2021-12-15 |
IL285472A (en) | 2021-10-31 |
JP2023523480A (en) | 2023-06-06 |
TW202216757A (en) | 2022-05-01 |
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