SG11202112666YA - Methods of characterizing and utilizing agent-condensate interactions - Google Patents

Methods of characterizing and utilizing agent-condensate interactions

Info

Publication number
SG11202112666YA
SG11202112666YA SG11202112666YA SG11202112666YA SG11202112666YA SG 11202112666Y A SG11202112666Y A SG 11202112666YA SG 11202112666Y A SG11202112666Y A SG 11202112666YA SG 11202112666Y A SG11202112666Y A SG 11202112666YA SG 11202112666Y A SG11202112666Y A SG 11202112666YA
Authority
SG
Singapore
Prior art keywords
condensate
characterizing
interactions
methods
utilizing agent
Prior art date
Application number
SG11202112666YA
Inventor
Richard A Young
Ann Boija
Isaac Klein
Original Assignee
Whitehead Inst Biomedical Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Inst Biomedical Res filed Critical Whitehead Inst Biomedical Res
Publication of SG11202112666YA publication Critical patent/SG11202112666YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10—Detection mode being characterised by the assay principle
    • C12Q2565/113—Detection mode being characterised by the assay principle based on agglutination/precipitation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
SG11202112666YA 2019-05-15 2020-05-15 Methods of characterizing and utilizing agent-condensate interactions SG11202112666YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962848539P 2019-05-15 2019-05-15
US201962927073P 2019-10-28 2019-10-28
PCT/US2020/033295 WO2020232416A1 (en) 2019-05-15 2020-05-15 Methods of characterizing and utilizing agent-condensate interactions

Publications (1)

Publication Number Publication Date
SG11202112666YA true SG11202112666YA (en) 2021-12-30

Family

ID=73289267

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202112666YA SG11202112666YA (en) 2019-05-15 2020-05-15 Methods of characterizing and utilizing agent-condensate interactions

Country Status (10)

Country Link
US (1) US20220390432A1 (en)
EP (1) EP3969122A4 (en)
JP (1) JP2022532661A (en)
KR (1) KR20220027845A (en)
CN (1) CN114173879A (en)
AU (1) AU2020274530A1 (en)
CA (1) CA3140651A1 (en)
IL (1) IL288091A (en)
SG (1) SG11202112666YA (en)
WO (1) WO2020232416A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210124374A (en) 2019-02-08 2021-10-14 듀포인트 테라퓨틱스, 인크. Methods for characterizing condensate-associated properties of compounds and uses thereof
WO2021055644A1 (en) 2019-09-18 2021-03-25 Dewpoint Therapeutics, Inc. Methods of screening for condensate-associated specificity and uses thereof
WO2022115539A2 (en) * 2020-11-25 2022-06-02 Whitehead Institute For Biomedical Research Modulating transcriptional condensates
CN116940845A (en) * 2021-01-22 2023-10-24 普林斯顿大学理事会 Method of screening for inhibitors of biomolecular interactions using phase separation as an intracellular reading
CN116801872A (en) * 2021-02-10 2023-09-22 上海奕拓医药科技有限责任公司 Methods of modulating androgen receptor coacervates
WO2024001989A1 (en) * 2022-06-27 2024-01-04 Etern Biopharma (Shanghai) Co., Ltd. Compositions and methods for modulating molecules

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1349961A4 (en) * 2000-11-13 2005-01-26 Cistem Molecular Corp Methods for determining the biological effects of compounds on gene expression
US7981842B2 (en) * 2001-06-08 2011-07-19 Panomics, Inc. Method for detecting transcription factor-protein interactions
WO2004029247A1 (en) * 2002-09-26 2004-04-08 Centre For Translational Research In Cancer Nuclear receptor transcriptional corepressor and uses thereof
US20070178537A1 (en) * 2003-06-30 2007-08-02 Sloan-Kettering Institute For Cancer Research Assays for detection of bioactive compounds that interact with heat shock protein 90
CN102321584B (en) * 2003-12-31 2014-01-08 宾夕法尼亚州研究基金会 Methods for predicting and overcoming resistance to chemotherapy in ovarian cancer and for predicting colon cancer occurrence
JP6218147B2 (en) * 2011-07-08 2017-10-25 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ Use of labeled HSP90 inhibitors
KR101671020B1 (en) * 2015-04-10 2016-11-02 충북대학교 산학협력단 Pharmaceutical Composition for Treating Cancer Comprising 2-Methoxy-4-(3-(4-Methoxyphenyl)Prop-1-en-1-yl)Phenol As Active Ingredient
GB201518477D0 (en) * 2015-10-19 2015-12-02 Isis Innovation Biomolecule separation and modification
SG11202009359WA (en) * 2018-03-23 2020-10-29 Whitehead Inst Biomedical Res Methods and assays for modulating gene transcription by modulating condensates
EP3867641A1 (en) * 2018-10-15 2021-08-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Compounds for treatment of diseases and methods of screening therefor

Also Published As

Publication number Publication date
EP3969122A1 (en) 2022-03-23
CN114173879A (en) 2022-03-11
WO2020232416A1 (en) 2020-11-19
US20220390432A1 (en) 2022-12-08
IL288091A (en) 2022-01-01
CA3140651A1 (en) 2020-11-19
EP3969122A4 (en) 2024-01-17
KR20220027845A (en) 2022-03-08
AU2020274530A1 (en) 2021-12-16
JP2022532661A (en) 2022-07-15

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