SG11202009359WA - Methods and assays for modulating gene transcription by modulating condensates - Google Patents

Methods and assays for modulating gene transcription by modulating condensates

Info

Publication number
SG11202009359WA
SG11202009359WA SG11202009359WA SG11202009359WA SG11202009359WA SG 11202009359W A SG11202009359W A SG 11202009359WA SG 11202009359W A SG11202009359W A SG 11202009359WA SG 11202009359W A SG11202009359W A SG 11202009359WA SG 11202009359W A SG11202009359W A SG 11202009359WA
Authority
SG
Singapore
Prior art keywords
modulating
condensates
assays
methods
gene transcription
Prior art date
Application number
SG11202009359WA
Inventor
Richard A Young
Phillip A Sharp
Arup K Chakraborty
Alessandra Dall'agnese
Krishna Shrinivas
Brian J Abraham
Ann Boija
Eliot Coffey
Daniel S Day
Yang E Guo
Nancy M Hannett
Tong Ihn Lee
Charles H Li
Isaac Klein
John C Manteiga
Benjamin R Sabari
Jurian Schuijers
Abraham S Weintraub
Alicia V Zamudio
Lena K Afeyan
Ozgur Oksuz
Jonathan E Henninger
Original Assignee
Whitehead Inst Biomedical Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Inst Biomedical Res filed Critical Whitehead Inst Biomedical Res
Publication of SG11202009359WA publication Critical patent/SG11202009359WA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/535Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11202009359WA 2018-03-23 2019-03-22 Methods and assays for modulating gene transcription by modulating condensates SG11202009359WA (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862647613P 2018-03-23 2018-03-23
US201862648377P 2018-03-26 2018-03-26
US201862722825P 2018-08-24 2018-08-24
US201862752332P 2018-10-29 2018-10-29
US201962819662P 2019-03-17 2019-03-17
US201962820237P 2019-03-18 2019-03-18
PCT/US2019/023694 WO2019183552A2 (en) 2018-03-23 2019-03-22 Methods and assays for modulating gene transcription by modulating condensates

Publications (1)

Publication Number Publication Date
SG11202009359WA true SG11202009359WA (en) 2020-10-29

Family

ID=67987575

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202009359WA SG11202009359WA (en) 2018-03-23 2019-03-22 Methods and assays for modulating gene transcription by modulating condensates

Country Status (11)

Country Link
US (1) US20220120736A1 (en)
EP (1) EP3768329A4 (en)
JP (2) JP2021535737A (en)
KR (1) KR20210070233A (en)
CN (1) CN113164622A (en)
AU (1) AU2019239084A1 (en)
CA (1) CA3094974A1 (en)
IL (1) IL277533A (en)
SG (1) SG11202009359WA (en)
TW (1) TW202003051A (en)
WO (1) WO2019183552A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020061251A1 (en) * 2018-09-20 2020-03-26 The Trustees On Princeton University High throughput method and system for mapping intracellular phase diagrams
CA3127237A1 (en) 2019-02-08 2020-08-13 Dewpoint Therapeutics, Inc. Methods of characterizing condensate-associated characteristics of compounds and uses thereof
CN114173879A (en) * 2019-05-15 2022-03-11 怀特黑德生物医学研究所 Methods of characterizing and utilizing agent-aggregate interactions
WO2021055644A1 (en) 2019-09-18 2021-03-25 Dewpoint Therapeutics, Inc. Methods of screening for condensate-associated specificity and uses thereof
WO2021150937A1 (en) * 2020-01-23 2021-07-29 The Rockefeller University Phase separation sensors and uses thereof
CN111269976A (en) * 2020-02-03 2020-06-12 清华大学 Application of MeCP2 mutation detection substance in detecting whether MeCP2 mutation is pathogenic mutation or not and screening drugs
CN111487399B (en) * 2020-03-26 2021-09-17 湖南师范大学 Application of protein molecular marker in research on fish germ cell development
CN111471713A (en) * 2020-04-23 2020-07-31 北京大学 Method for controlling intracellular mRNA positioning and translation process based on controllable phase separation liquid drops
US20230236190A1 (en) * 2020-06-18 2023-07-27 Whitehead Institute For Biomedical Research Viral condensates and methods of use thereof
IL301029A (en) 2020-09-01 2023-05-01 Univ Brown Targeting enhancer rnas for the treatment of primary brain tumors
US20240309365A1 (en) * 2020-11-25 2024-09-19 Whitehead Institute For Biomedical Research Modulating transcriptional condensates
WO2022171163A1 (en) * 2021-02-10 2022-08-18 Etern Biopharma (Shanghai) Co., Ltd. Methods of modulating androgen receptor condensates
KR20230174216A (en) * 2021-03-02 2023-12-27 듀포인트 테라퓨틱스, 인크. Condensate phenotypic identification methods and uses thereof
WO2022187202A1 (en) * 2021-03-02 2022-09-09 Dewpoint Therapeutics, Inc. New condensate paradigms
WO2022212872A1 (en) * 2021-04-02 2022-10-06 Case Western Reserve University Methods and compositions for accelerating oligodendrocyte maturation
CN113254499B (en) * 2021-05-21 2023-09-29 国家卫星气象中心(国家空间天气监测预警中心) Climate data set production method based on long-sequence historical data recalibration
WO2023014989A1 (en) * 2021-08-05 2023-02-09 Whitehead Institute For Biomedical Research Methods and agents for decreasing insulin resistance
WO2024001989A1 (en) * 2022-06-27 2024-01-04 Etern Biopharma (Shanghai) Co., Ltd. Compositions and methods for modulating molecules
WO2024174065A1 (en) * 2023-02-20 2024-08-29 清华大学 Dual transcription factor, and transcription regulation system and transcription regulation method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2431047A1 (en) * 2000-11-13 2002-05-16 Christopher C. Adams Methods for determining the biological effects of compounds on gene expression
WO2006063356A1 (en) * 2004-12-10 2006-06-15 Isis Phamaceuticals, Inc. Regulation of epigenetic control of gene expression
US20170233762A1 (en) * 2014-09-29 2017-08-17 The Regents Of The University Of California Scaffold rnas
EP3233846A4 (en) * 2014-12-17 2018-07-18 Zenith Epigenetics Ltd. Inhibitors of bromodomains
US20190194150A1 (en) * 2016-07-01 2019-06-27 Arrakis Therapeutics, Inc. Compounds and methods for modulating rna function

Also Published As

Publication number Publication date
EP3768329A2 (en) 2021-01-27
KR20210070233A (en) 2021-06-14
CA3094974A1 (en) 2019-09-26
JP2021535737A (en) 2021-12-23
WO2019183552A3 (en) 2019-10-31
US20220120736A1 (en) 2022-04-21
EP3768329A4 (en) 2022-01-05
IL277533A (en) 2020-11-30
WO2019183552A2 (en) 2019-09-26
TW202003051A (en) 2020-01-16
CN113164622A (en) 2021-07-23
AU2019239084A1 (en) 2020-11-05
JP2024029228A (en) 2024-03-05

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